カルシウムチャネル

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1573	Fasudil (HA-1077) HCl	65 mg/mL	5 mg/mL	'<1 mg/mL
S1356	Levetiracetam	34 mg/mL	34 mg/mL	34 mg/mL
S1813	Amlodipine Besylate	<1 mg/mL	113 mg/mL	14 mg/mL
S1293	Cilnidipine	<1 mg/mL	99 mg/mL	15 mg/mL
S1811	Amiloride HCl	6 mg/mL	53 mg/mL	5 mg/mL
S6834	CM 4620	-1 mg/mL	100 mg/mL	'''-1 mg/mL
S0016	SN-6	<1 mg/mL	80 mg/mL	'<1 mg/mL
S1425	Ranolazine 2HCl	100 mg/mL	100 mg/mL	<1 mg/mL
S4202	Verapamil HCl	50 mg/mL	98 mg/mL	12 mg/mL
S2482	Manidipine 2HCl	<1 mg/mL	21 mg/mL	<1 mg/mL
S1799	Ranolazine	<1 mg/mL	86 mg/mL	20 mg/mL
S1662	Isradipine	<1 mg/mL	74 mg/mL	74 mg/mL
S1905	Amlodipine	<1 mg/mL	82 mg/mL	82 mg/mL
S1885	Felodipine	<1 mg/mL	77 mg/mL	72 mg/mL
S2481	Manidipine	<1 mg/mL	122 mg/mL	3 mg/mL
S1748	Nisoldipine	<1 mg/mL	77 mg/mL	60 mg/mL
S1747	Nimodipine	<1 mg/mL	84 mg/mL	84 mg/mL
S2721	Nilvadipine	<1 mg/mL	77 mg/mL	33 mg/mL
S1994	Lacidipine	<1 mg/mL	91 mg/mL	22 mg/mL
S2114	Dronedarone HCl	<1 mg/mL	80 mg/mL	40 mg/mL
S4181	Nicardipine HCl	<1 mg/mL	100 mg/mL	<1 mg/mL
S1808	Nifedipine	<1 mg/mL	69 mg/mL	15 mg/mL
S2080	Clevidipine Butyrate	<1 mg/mL	91 mg/mL	3 mg/mL
S2017	Benidipine HCl	<1 mg/mL	8 mg/mL	<1 mg/mL
S2030	Flunarizine 2HCl	<1 mg/mL	5 mg/mL	3 mg/mL
S2491	Nitrendipine	<1 mg/mL	72 mg/mL	<1 mg/mL
S3053	Azelnidipine	<1 mg/mL	117 mg/mL	7 mg/mL
S2573	Tetracaine HCl	60 mg/mL	60 mg/mL	30 mg/mL
S1865	Diltiazem HCl	90 mg/mL	90 mg/mL	4 mg/mL
S3045	Cinepazide maleate	107 mg/mL	107 mg/mL	<1 mg/mL
S5255	Nicardipine	30 mg/mL	95 mg/mL	95 mg/mL
S8380	YM-58483 (BTP2)	<1 mg/mL	84 mg/mL	84 mg/mL
S4626	Ethosuximide	28 mg/mL	28 mg/mL	28 mg/mL
S4597	Lercanidipine (hydrochloride)	<1 mg/mL	66 mg/mL	1 mg/mL
S4977	Efonidipine	-1 mg/mL	100 mg/mL	40 mg/mL
S5279	Fendiline hydrochloride	-1 mg/mL	70 mg/mL	'-1 mg/mL
S3845	Panaxadiol	<1 mg/mL	<1 mg/mL	22 mg/mL
S3700	DHBP dibromide	100 mg/mL	100 mg/mL	100 mg/mL
S2403	Tetrandrine	<1 mg/mL	1 mg/mL	2 mg/mL
S9315	Praeruptorin A	-1 mg/mL	77 mg/mL	-1 mg/mL
S3931	Ginsenoside Rd	-1 mg/mL	90 mg/mL	-1 mg/mL
S5514	Lanthanum(III) chloride heptahydrate	-1 mg/mL	50 mg/mL	-1 mg/mL
S4084	Lomerizine 2HCl	<1 mg/mL	100 mg/mL	52 mg/mL
S4648	Dantrolene sodium hemiheptahydrate	<1 mg/mL	14 mg/mL	<1 mg/mL
S3682	Ethyl 3-Aminobenzoate methanesulfonate	52 mg/mL	52 mg/mL	52 mg/mL
S9400	Rhynchophylline	-1 mg/mL	76 mg/mL	-1 mg/mL
S3674	Levamlodipine	81 mg/mL	81 mg/mL	81 mg/mL
S3883	Protopine	-1 mg/mL	30 mg/mL	-1 mg/mL
S5567	Trimethadione	-1 mg/mL	28 mg/mL	-1 mg/mL
S9566	Bepridil hydrochloride	-1 mg/mL	41 mg/mL	-1 mg/mL
S6473	Pinaverium bromide	16 mg/mL	100 mg/mL	100 mg/mL
S4727	Cinnarizine	<1 mg/mL	73 mg/mL	<1 mg/mL
S6657	2-Aminoethyl Diphenylborinate (2-APB)	<1 mg/mL	45 mg/mL	23 mg/mL
S2050	Strontium Ranelate	<1 mg/mL	<1 mg/mL	<1 mg/mL
S7924	Bay K 8644	<1 mg/mL	71 mg/mL	71 mg/mL
S4209	Chlorocresol	<1 mg/mL	29 mg/mL	29 mg/mL
S2436	Pranidipine	<1 mg/mL	90 mg/mL	2 mg/mL
S4931	Propiverine hydrochloride	-1 mg/mL	80 mg/mL	-1 mg/mL
S3809	Imperatorin	-1 mg/mL	54 mg/mL	-1 mg/mL
S5861	Lercanidipine	<1 mg/mL	55 mg/mL	<1 mg/mL
S9151	Praeruptorin E	-1 mg/mL	34.6 mg/mL	-1 mg/mL
S2535	Econazole nitrate	<1 mg/mL	89 mg/mL	5 mg/mL
S2415	Astragaloside A	<1 mg/mL	100 mg/mL	<1 mg/mL
S2446	Levosimendan	<1 mg/mL	56 mg/mL	<1 mg/mL
S1911	Disodium Cromoglycate	2 mg/mL	<1 mg/mL	<1 mg/mL
S5478	Dantrolene sodium	-1 mg/mL	67 mg/mL	-1 mg/mL

Calcium Channel製品

All (66) Calcium Channel阻害剤(52) Calcium Channel活性剤(4) Calcium Channel拮抗剤(4) Calcium Channel作動薬(1) Calcium Channelモジュレータ(2)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1573	Fasudil (HA-1077) HCl Fasudil(HA-1077), a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively. Fasudil is also a calcium channel blocker.	Nat Cell Biol, 2020, 25 Nat Commun, 2020, 11(1):71 Cell Rep, 2020, 30(11):3864-3874	The ROCK inhibitors fasudil and Y27632 prevented SCP2 cell bone metastasis in nude mice (n = 10 per group). Shown are BLI images of bone metastases, IHC analyses of SMAD3 C-tail phosphorylation and PTHLH, osteoclast TRAP staining, and BLI quantitation.
S1356	Levetiracetam Levetiracetam is an anticonvulsant medication used to treat epilepsy.	PLoS One, 2019, 14(2):e0211644 Sci Rep, 2016, 6:25705 Sci Rep, 2016, 6:25705	Levetiracetam reduces DNA, synaptic, and neurite damage caused by Dox. (A) An example of cortical cultures pre-treated with 5 μ M Lev and then Dox (0.01 μ M, overnight), fixed and stained with antibodies against MAP2c. Scale bar is 20 μ m. (B) Cortical neurons at 28–32 DIV were pre-treated with 5 μ M Lev, and then a vehicle or with Dox (0.01 μ M for 3 days, or 0.1 μ M, overnight) was added. Neurons were fixed, and stained for MAP2c, synapsin, and with the Hoechst dye, and imaged. Note that red MAP2c staining also includes Dox's red fluorescence. (C) Synaptically developed primary cortical cultures at 28−32 DIV were pretreated with 5 mM Lev, and then a vehicle or with Dox (0.01 μM for 3 days, or 0.1 μM, overnight) was added. Neurons were then fixed, and stained with antibodies against γH2A.X and MAP2c, and with the Hoechst dye. Blue staining was used by the algorithm to identify and analyze γH2A.X.
S1813	Amlodipine Besylate Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.	Oncogene, 2019, 38(1):120-139
S1293	Cilnidipine Cilnidipine is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.	J Mol Neurosci, 2018, 64(2):175-184 Curr Protoc Neurosci, 2017, 79:5
S1811	Amiloride HCl Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).	Int J Pharm, 2019, 567:118436 Int J Oncol, 2019, 54(3):1061-1070 Proc Natl Acad Sci U S A, 2018, 115(32):E7469-E7477
S6834^新	CM 4620 CM 4620 is an inhibitor of calcium-release activated calcium-channel (CRAC channel). CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively.
S0016^新	SN-6 SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation.
S1425	Ranolazine 2HCl Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.
S4202	Verapamil HCl Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.	Nat Commun, 2019, 10(1):3838 Clin Cancer Res, 2019, clincanres.1768.2019 EBioMedicine, 2019, 48:70-80	The proportion of SP cells in HepG2 and HCCLM3 cell lines were 0.16% and 32.2%, which reduced to 0% and 0.28% in the presence of verapamil.
S2482	Manidipine 2HCl Manidipine 2HCl is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4.		Manidipine decreases the accumulation of HCMV Early and Late proteins. HFFs were infected with HCMV AD169 and then treated with test compounds or DMSO as a control. NTZ-treated samples were also included as a control for inhibition of E and L protein expression. At the indicated times p.i., total cell extracts were prepared and analyzed by WB with anti-IEA, anti-UL44, and anti-UL99 antibodies. Tubulin immunodetection served as a loading control. Images are representative of three independent experiments.
S1799	Ranolazine Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.
S1662	Isradipine Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.	Drug Metab Dispos, 2015, 43(12):1934-7
S1905	Amlodipine Amlodipine is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.	J Med Toxicol, 2020, 16(1):61-66 Oncogene, 2019, 38(1):120-139 Int J Oncol, 2019, 55(5):1090-1096
S1885	Felodipine Felodipine is a selective L-type Ca²⁺ channel blocker with IC50 of 0.15 nM.
S2481	Manidipine Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.	Antiviral Res, 2018, 150:130-136
S1748	Nisoldipine Nisoldipine (Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Ca_v1.2 with IC50 of 10 nM.	bioRxiv, 2020, 2020/9/20.4.7.30734
S1747	Nimodipine Nimodipine is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.	G3 (Bethesda), 2020, 4;10(5):1585-1597 Antiviral Res, 2016, 132:38-45	Assessment of the role of Ca2+ channels during RSV replication. HEp-2 cells were infected with RSV strain long at an MOI of 0.1, and treated with calcium channel blockers nifedipine, nimodipine, and tetrandrine (A), at indicated concentrations. Supernatants were collected at 48 h postinfection and viral titers were determined by immunoplaque assay. Grey bars represent cytotoxicity of the compounds. The data presented were obtained from two independent experiments. Error bars represent the standard deviations from two independent experiments. NS, no differences at a significance level of 0.05.
S2721	Nilvadipine Nilvadipine is a potent calcium channel blocker with an IC50 of 0.03 nM.	Cancer Cell Int, 2020, 19;20:58
S1994	Lacidipine Lacidipine is a L-type calcium channel blocker, used for treating high blood pressure.
S2114	Dronedarone HCl Dronedarone HCl is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).	Cell Syst, 2019, 8(2):97-108 Nat Commun, 2016, 7:13023	Results of hit validation experiments for these four compounds for animals treated at L1 stage at four different concentrations (0.5, 5, 25, and 50 μM). The blue bars represent the values obtained from the original screen as reference points. Error bars are standard error of the mean. Statistical significance for all different doses for individual compounds was calculated with respect to the lowest concentration using two-tailed, t-test (nZ70 animals except n = 37 for Geld 25 μM). The statistical significance values are represented as P<0.05 () and P<0.005 (*).
S4181	Nicardipine HCl Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.
S1808	Nifedipine Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.	Front Pharmacol, 2019, 10:381 Biochem Biophys Res Commun, 2019, 509(1):76-81 Immunol Res, 2018, 66(1):44-51	The fold change of C-peptide content after octreotide, nicorandil and nifedipine treatment. Octreotide, nicorandil and nifedipine decreased insulin secretion in wild-type, heterozygous mutated and homozygous mutated cells.
S2080	Clevidipine Butyrate Clevidipine Butyrate is a dihydropyridine calcium channel blocker, uses as an agent for the reduction of blood pressure.
S2017	Benidipine HCl Benidipine HCl is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.	Life Sci, 2019, 227:74-81
S2030	Flunarizine 2HCl Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blocker with a K_i of 68 nM.	Cancer Cell Int, 2020, 19;20:58
S2491	Nitrendipine Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.
S3053	Azelnidipine Azelnidipine is a dihydropyridine calcium channel blocker.
S2573	Tetracaine HCl Tetracaine HCl is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.
S1865	Diltiazem HCl Diltiazem HCl (Tiazac) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.	J Cell Mol Med, 2018, 22(12):5964-5977 FASEB J, 2017, 31(2):625-635	Gentisic acid reduces interstitial and perivascular fibrosis in mice with transverse aortic constriction (TAC). Representative images of Masson's trichrome staining of the hearts of mice in the sham and TAC + vehicle, gentisic acid, bisoprolol, or diltiazem groups. Scale bar = 50 μm. A, Interstitial fibrosis and B, perivascular fibrosis are shown. Fibrotic areas are stained blue.
S3045	Cinepazide maleate Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.
S5255	Nicardipine Nicardipine is a potent calcium channel blockader with marked vasodilator action.
S8380	YM-58483 (BTP2) YM-58483/BTP2 is a blocker of store-operated Ca2+ entry (SOCE), which regulates the activation of non-excitable cells such as lymphocytes.	Cell Stem Cell, 2018, 22(6):865-878
S4626	Ethosuximide Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker.	Nature, 2018, 554(7692):317-322	Antidepressant effects caused by systemic ethosuximide injection (200 mg kg−1, i.p.; c, d) in the FST(forced swim test) and SPT (sucrose preference test) 1 h after treatment.
S4597	Lercanidipine (hydrochloride) Lercanidipine is a calcium channel blocker of the dihydropyridine class.	J Phys Chem B, 2013, 117(23):6868-73
S4977	Efonidipine Efonidipine is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.
S5279	Fendiline hydrochloride Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.
S3845	Panaxadiol Panaxadiol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.
S3700	DHBP dibromide DHBP, a viologen for electrochromic memory display agent, inhibits the calcium release induced by 2 mM caffeine and 2 μg/ml polylysine with an IC50 value of 5 μg/ml and 4 μg/ml respectively.
S2403	Tetrandrine Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.	Nat Commun, 2020, 27;11(1):1620 Cell Death Dis, 2019, 10(2):38 FASEB J, 2018, 32(6):3398-3410	BMMs were seeded in a collage I-coated plate and incubated with RANKL (100 ng/ml) and M-CSF (50 ng/ml) for 5 d. When mature osteoclasts were observed, they were digested by collagenase and seeded on bovine bone slices. The bone slices were treated with or without tetrandrine for an additional 2 d. Then, the cells were stained with rhodamine–phalloidin to observe the F-actin rings, and the areas of F-actin rings were calculated by Image-Pro Plus 6.0 software.
S9315	Praeruptorin A Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. It is reported to induce apoptosis in human multidrug resistant (MDR) KB-V1 cells.
S3931	Ginsenoside Rd Ginsenoside Rd, a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity.
S5514	Lanthanum(III) chloride heptahydrate Lanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels.
S4084	Lomerizine 2HCl Lomerizine dihydrochloride is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine.
S4648	Dantrolene sodium hemiheptahydrate Dantrolene sodium hemiheptahydrate ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.
S3682	Ethyl 3-Aminobenzoate methanesulfonate Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels and usually used for anesthesia, sedation, or euthanasia of fish.
S9400	Rhynchophylline Rhynchophylline, an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension.
S3674	Levamlodipine Levamlodipine is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.
S3883	Protopine Protopine, an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.
S5567	Trimethadione Trimethadione is an oxazolidinedione anticonvulsant and often used to treat epileptic conditions that are resistant to other treatments.
S9566	Bepridil hydrochloride Bepridil hydrochloride is an anti-anginal drug classified as a calcium channel blocker. It also blocks multiple other ion channels, including sodium and potassium channels.
S6473	Pinaverium bromide Pinaverium bromide acts as a calcium channel blocker and is useful for functional gastrointestinal disorders.
S4727	Cinnarizine Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.
S6657^新	2-Aminoethyl Diphenylborinate (2-APB) 2-Aminoethyl Diphenylborinate (2-APB) is an IP3 receptor inhibitor and regulate IP3-induced calcium release.2-APB also inhibits the SOC channel activity and activates TRP channel at higher concentrations.
S2050	Strontium Ranelate Strontium Ranelate is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM.
S7924	Bay K 8644 Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.	J Cell Physiol, 2018, 10.1002/jcp.27791	Western blot analysis of myocardium lysate at 4 weeks. Hypertrophic markers were tested in mouse cardiomyocyte cell line HL-1 Bay-K-8644.
S4209	Chlorocresol Chlorocresol is an activator of ryanodine receptor.
S2436^新	Pranidipine Pranidipine is a new 1,4-dihydropyridine calcium channel blocker. Pranidipine can enhance cyclic GMP-independent nitric oxide-induced relaxation of the rat aorta.
S4931	Propiverine hydrochloride Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence.
S3809	Imperatorin Imperatorin, a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.	Theriogenology, 2019, 10.1016/j.theriogenology
S5861	Lercanidipine Lercanidipine is a vasoselective dihydropyridine calcium antagonist used for the treatment of essential hypertension.
S9151	Praeruptorin E Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect.
S2535	Econazole nitrate Econazole Nitrate is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.	Biomol Ther (Seoul), 2020, 25
S2415	Astragaloside A Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.
S2446	Levosimendan Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.	Antiviral Res, 2017, 146:76-85	(B-E) The % of GFP-positive cells upon compound treatment were determined for the indicated HIV-1 latency cell lines (B. J-LAT 6.3; C. JLAT 10.6; D. CA5; E. EF7). Results were normalized to DMSO control. Values represent the mean ± s.d. (n = 4-6). * p < 0.05, one-way ANOVA followed by Tukey’s multiplecomparison test
S1911	Disodium Cromoglycate Disodium Cromoglycate is an antiallergic drug with IC50 of 39 μg/mL.
S5478	Dantrolene sodium Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.	Sci Rep, 2019, 9(1):3487

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1573	Fasudil (HA-1077) HCl Fasudil(HA-1077), a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively. Fasudil is also a calcium channel blocker.	Nat Cell Biol, 2020, 25 Nat Commun, 2020, 11(1):71 Cell Rep, 2020, 30(11):3864-3874	The ROCK inhibitors fasudil and Y27632 prevented SCP2 cell bone metastasis in nude mice (n = 10 per group). Shown are BLI images of bone metastases, IHC analyses of SMAD3 C-tail phosphorylation and PTHLH, osteoclast TRAP staining, and BLI quantitation.
S1356	Levetiracetam Levetiracetam is an anticonvulsant medication used to treat epilepsy.	PLoS One, 2019, 14(2):e0211644 Sci Rep, 2016, 6:25705 Sci Rep, 2016, 6:25705	Levetiracetam reduces DNA, synaptic, and neurite damage caused by Dox. (A) An example of cortical cultures pre-treated with 5 μ M Lev and then Dox (0.01 μ M, overnight), fixed and stained with antibodies against MAP2c. Scale bar is 20 μ m. (B) Cortical neurons at 28–32 DIV were pre-treated with 5 μ M Lev, and then a vehicle or with Dox (0.01 μ M for 3 days, or 0.1 μ M, overnight) was added. Neurons were fixed, and stained for MAP2c, synapsin, and with the Hoechst dye, and imaged. Note that red MAP2c staining also includes Dox's red fluorescence. (C) Synaptically developed primary cortical cultures at 28−32 DIV were pretreated with 5 mM Lev, and then a vehicle or with Dox (0.01 μM for 3 days, or 0.1 μM, overnight) was added. Neurons were then fixed, and stained with antibodies against γH2A.X and MAP2c, and with the Hoechst dye. Blue staining was used by the algorithm to identify and analyze γH2A.X.
S1813	Amlodipine Besylate Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.	Oncogene, 2019, 38(1):120-139
S1293	Cilnidipine Cilnidipine is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.	J Mol Neurosci, 2018, 64(2):175-184 Curr Protoc Neurosci, 2017, 79:5
S1811	Amiloride HCl Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).	Int J Pharm, 2019, 567:118436 Int J Oncol, 2019, 54(3):1061-1070 Proc Natl Acad Sci U S A, 2018, 115(32):E7469-E7477
S6834^新	CM 4620 CM 4620 is an inhibitor of calcium-release activated calcium-channel (CRAC channel). CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively.
S0016^新	SN-6 SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation.
S1425	Ranolazine 2HCl Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.
S4202	Verapamil HCl Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.	Nat Commun, 2019, 10(1):3838 Clin Cancer Res, 2019, clincanres.1768.2019 EBioMedicine, 2019, 48:70-80	The proportion of SP cells in HepG2 and HCCLM3 cell lines were 0.16% and 32.2%, which reduced to 0% and 0.28% in the presence of verapamil.
S2482	Manidipine 2HCl Manidipine 2HCl is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4.		Manidipine decreases the accumulation of HCMV Early and Late proteins. HFFs were infected with HCMV AD169 and then treated with test compounds or DMSO as a control. NTZ-treated samples were also included as a control for inhibition of E and L protein expression. At the indicated times p.i., total cell extracts were prepared and analyzed by WB with anti-IEA, anti-UL44, and anti-UL99 antibodies. Tubulin immunodetection served as a loading control. Images are representative of three independent experiments.
S1799	Ranolazine Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.
S1662	Isradipine Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.	Drug Metab Dispos, 2015, 43(12):1934-7
S1905	Amlodipine Amlodipine is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.	J Med Toxicol, 2020, 16(1):61-66 Oncogene, 2019, 38(1):120-139 Int J Oncol, 2019, 55(5):1090-1096
S1885	Felodipine Felodipine is a selective L-type Ca²⁺ channel blocker with IC50 of 0.15 nM.
S2481	Manidipine Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.	Antiviral Res, 2018, 150:130-136
S1748	Nisoldipine Nisoldipine (Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Ca_v1.2 with IC50 of 10 nM.	bioRxiv, 2020, 2020/9/20.4.7.30734
S1747	Nimodipine Nimodipine is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.	G3 (Bethesda), 2020, 4;10(5):1585-1597 Antiviral Res, 2016, 132:38-45	Assessment of the role of Ca2+ channels during RSV replication. HEp-2 cells were infected with RSV strain long at an MOI of 0.1, and treated with calcium channel blockers nifedipine, nimodipine, and tetrandrine (A), at indicated concentrations. Supernatants were collected at 48 h postinfection and viral titers were determined by immunoplaque assay. Grey bars represent cytotoxicity of the compounds. The data presented were obtained from two independent experiments. Error bars represent the standard deviations from two independent experiments. NS, no differences at a significance level of 0.05.
S2721	Nilvadipine Nilvadipine is a potent calcium channel blocker with an IC50 of 0.03 nM.	Cancer Cell Int, 2020, 19;20:58
S1994	Lacidipine Lacidipine is a L-type calcium channel blocker, used for treating high blood pressure.
S2114	Dronedarone HCl Dronedarone HCl is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).	Cell Syst, 2019, 8(2):97-108 Nat Commun, 2016, 7:13023	Results of hit validation experiments for these four compounds for animals treated at L1 stage at four different concentrations (0.5, 5, 25, and 50 μM). The blue bars represent the values obtained from the original screen as reference points. Error bars are standard error of the mean. Statistical significance for all different doses for individual compounds was calculated with respect to the lowest concentration using two-tailed, t-test (nZ70 animals except n = 37 for Geld 25 μM). The statistical significance values are represented as P<0.05 () and P<0.005 (*).
S4181	Nicardipine HCl Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.
S1808	Nifedipine Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.	Front Pharmacol, 2019, 10:381 Biochem Biophys Res Commun, 2019, 509(1):76-81 Immunol Res, 2018, 66(1):44-51	The fold change of C-peptide content after octreotide, nicorandil and nifedipine treatment. Octreotide, nicorandil and nifedipine decreased insulin secretion in wild-type, heterozygous mutated and homozygous mutated cells.
S2080	Clevidipine Butyrate Clevidipine Butyrate is a dihydropyridine calcium channel blocker, uses as an agent for the reduction of blood pressure.
S2017	Benidipine HCl Benidipine HCl is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.	Life Sci, 2019, 227:74-81
S2030	Flunarizine 2HCl Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blocker with a K_i of 68 nM.	Cancer Cell Int, 2020, 19;20:58
S2491	Nitrendipine Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.
S3053	Azelnidipine Azelnidipine is a dihydropyridine calcium channel blocker.
S2573	Tetracaine HCl Tetracaine HCl is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.
S1865	Diltiazem HCl Diltiazem HCl (Tiazac) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.	J Cell Mol Med, 2018, 22(12):5964-5977 FASEB J, 2017, 31(2):625-635	Gentisic acid reduces interstitial and perivascular fibrosis in mice with transverse aortic constriction (TAC). Representative images of Masson's trichrome staining of the hearts of mice in the sham and TAC + vehicle, gentisic acid, bisoprolol, or diltiazem groups. Scale bar = 50 μm. A, Interstitial fibrosis and B, perivascular fibrosis are shown. Fibrotic areas are stained blue.
S3045	Cinepazide maleate Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.
S5255	Nicardipine Nicardipine is a potent calcium channel blockader with marked vasodilator action.
S8380	YM-58483 (BTP2) YM-58483/BTP2 is a blocker of store-operated Ca2+ entry (SOCE), which regulates the activation of non-excitable cells such as lymphocytes.	Cell Stem Cell, 2018, 22(6):865-878
S4626	Ethosuximide Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker.	Nature, 2018, 554(7692):317-322	Antidepressant effects caused by systemic ethosuximide injection (200 mg kg−1, i.p.; c, d) in the FST(forced swim test) and SPT (sucrose preference test) 1 h after treatment.
S4597	Lercanidipine (hydrochloride) Lercanidipine is a calcium channel blocker of the dihydropyridine class.	J Phys Chem B, 2013, 117(23):6868-73
S4977	Efonidipine Efonidipine is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.
S5279	Fendiline hydrochloride Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.
S3845	Panaxadiol Panaxadiol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.
S3700	DHBP dibromide DHBP, a viologen for electrochromic memory display agent, inhibits the calcium release induced by 2 mM caffeine and 2 μg/ml polylysine with an IC50 value of 5 μg/ml and 4 μg/ml respectively.
S2403	Tetrandrine Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.	Nat Commun, 2020, 27;11(1):1620 Cell Death Dis, 2019, 10(2):38 FASEB J, 2018, 32(6):3398-3410	BMMs were seeded in a collage I-coated plate and incubated with RANKL (100 ng/ml) and M-CSF (50 ng/ml) for 5 d. When mature osteoclasts were observed, they were digested by collagenase and seeded on bovine bone slices. The bone slices were treated with or without tetrandrine for an additional 2 d. Then, the cells were stained with rhodamine–phalloidin to observe the F-actin rings, and the areas of F-actin rings were calculated by Image-Pro Plus 6.0 software.
S9315	Praeruptorin A Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. It is reported to induce apoptosis in human multidrug resistant (MDR) KB-V1 cells.
S3931	Ginsenoside Rd Ginsenoside Rd, a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity.
S5514	Lanthanum(III) chloride heptahydrate Lanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels.
S4084	Lomerizine 2HCl Lomerizine dihydrochloride is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine.
S4648	Dantrolene sodium hemiheptahydrate Dantrolene sodium hemiheptahydrate ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.
S3682	Ethyl 3-Aminobenzoate methanesulfonate Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels and usually used for anesthesia, sedation, or euthanasia of fish.
S9400	Rhynchophylline Rhynchophylline, an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension.
S3674	Levamlodipine Levamlodipine is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.
S3883	Protopine Protopine, an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.
S5567	Trimethadione Trimethadione is an oxazolidinedione anticonvulsant and often used to treat epileptic conditions that are resistant to other treatments.
S9566	Bepridil hydrochloride Bepridil hydrochloride is an anti-anginal drug classified as a calcium channel blocker. It also blocks multiple other ion channels, including sodium and potassium channels.
S6473	Pinaverium bromide Pinaverium bromide acts as a calcium channel blocker and is useful for functional gastrointestinal disorders.
S4727	Cinnarizine Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.

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S6657^新	2-Aminoethyl Diphenylborinate (2-APB) 2-Aminoethyl Diphenylborinate (2-APB) is an IP3 receptor inhibitor and regulate IP3-induced calcium release.2-APB also inhibits the SOC channel activity and activates TRP channel at higher concentrations.
S2050	Strontium Ranelate Strontium Ranelate is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM.
S7924	Bay K 8644 Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.	J Cell Physiol, 2018, 10.1002/jcp.27791	Western blot analysis of myocardium lysate at 4 weeks. Hypertrophic markers were tested in mouse cardiomyocyte cell line HL-1 Bay-K-8644.
S4209	Chlorocresol Chlorocresol is an activator of ryanodine receptor.

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S2436^新	Pranidipine Pranidipine is a new 1,4-dihydropyridine calcium channel blocker. Pranidipine can enhance cyclic GMP-independent nitric oxide-induced relaxation of the rat aorta.
S4931	Propiverine hydrochloride Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence.
S3809	Imperatorin Imperatorin, a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.	Theriogenology, 2019, 10.1016/j.theriogenology
S5861	Lercanidipine Lercanidipine is a vasoselective dihydropyridine calcium antagonist used for the treatment of essential hypertension.

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S9151	Praeruptorin E Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect.

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S9151

Praeruptorin E

Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect.

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S2535	Econazole nitrate Econazole Nitrate is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.	Biomol Ther (Seoul), 2020, 25
S2415	Astragaloside A Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.

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S2535

Econazole nitrate

Econazole Nitrate is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.

Biomol Ther (Seoul), 2020, 25

S2415

Astragaloside A

Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.

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S2446	Levosimendan Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.	Antiviral Res, 2017, 146:76-85	(B-E) The % of GFP-positive cells upon compound treatment were determined for the indicated HIV-1 latency cell lines (B. J-LAT 6.3; C. JLAT 10.6; D. CA5; E. EF7). Results were normalized to DMSO control. Values represent the mean ± s.d. (n = 4-6). * p < 0.05, one-way ANOVA followed by Tukey’s multiplecomparison test
S1911	Disodium Cromoglycate Disodium Cromoglycate is an antiallergic drug with IC50 of 39 μg/mL.
S5478	Dantrolene sodium Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.	Sci Rep, 2019, 9(1):3487

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S2446

Levosimendan

Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.

Antiviral Res, 2017, 146:76-85

S1911

Disodium Cromoglycate

Disodium Cromoglycate is an antiallergic drug with IC50 of 39 μg/mL.

S5478

Dantrolene sodium

Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

Sci Rep, 2019, 9(1):3487

研究分野別

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カルシウムチャネル

シグナル伝達経路

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阻害剤の選択性比較

Calcium Channel製品