カルシウムチャネル
阻害剤の選択性比較
カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
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水 | DMSO | アルコール | ||
S1573 | Fasudil (HA-1077) HCl | 65 mg/mL | 5 mg/mL | '<1 mg/mL |
S1356 | Levetiracetam (UCB-L059) | 34 mg/mL | 34 mg/mL | '34 mg/mL |
S1813 | Amlodipine Besylate | <1 mg/mL | 113 mg/mL | 14 mg/mL |
S1293 | Cilnidipine (FRC-8653) | <1 mg/mL | 99 mg/mL | '15 mg/mL |
S1811 | Amiloride (MK-870) HCl | 6 mg/mL | 53 mg/mL | '''5 mg/mL |
E0778 | o-3M3FBS | <1 mg/mL | 69 mg/mL | 34 mg/mL |
S1425 | Ranolazine 2HCl | 100 mg/mL | 100 mg/mL | <1 mg/mL |
S4202 | Verapamil (CP-16533-1) HCl | 50 mg/mL | 98 mg/mL | ''12 mg/mL |
S2482 | Manidipine 2HCl | <1 mg/mL | 21 mg/mL | <1 mg/mL |
S1799 | Ranolazine | <1 mg/mL | 86 mg/mL | 20 mg/mL |
S1662 | Isradipine | <1 mg/mL | 74 mg/mL | 74 mg/mL |
S1905 | Amlodipine | <1 mg/mL | 82 mg/mL | 82 mg/mL |
S1885 | Felodipine | <1 mg/mL | 77 mg/mL | 72 mg/mL |
S2481 | Manidipine | <1 mg/mL | 122 mg/mL | 3 mg/mL |
S1748 | Nisoldipine | <1 mg/mL | 77 mg/mL | 60 mg/mL |
S1747 | Nimodipine | <1 mg/mL | 84 mg/mL | 84 mg/mL |
S2721 | Nilvadipine | <1 mg/mL | 77 mg/mL | 33 mg/mL |
S1994 | Lacidipine | <1 mg/mL | 91 mg/mL | 22 mg/mL |
S2114 | Dronedarone HCl | <1 mg/mL | 80 mg/mL | 40 mg/mL |
S4181 | Nicardipine HCl | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S1808 | Nifedipine (BAY-a-1040) | <1 mg/mL | 69 mg/mL | ''15 mg/mL |
S2080 | Clevidipine Butyrate | <1 mg/mL | 91 mg/mL | 3 mg/mL |
S2017 | Benidipine HCl | <1 mg/mL | 8 mg/mL | <1 mg/mL |
S2030 | Flunarizine 2HCl | <1 mg/mL | 5 mg/mL | '3 mg/mL |
S2491 | Nitrendipine | <1 mg/mL | 72 mg/mL | <1 mg/mL |
S3053 | Azelnidipine | <1 mg/mL | 117 mg/mL | 7 mg/mL |
S2573 | Tetracaine HCl | 60 mg/mL | 60 mg/mL | 30 mg/mL |
S0000 | Cav 2.2 blocker 1 | <1 mg/mL | 12 mg/mL | 15 mg/mL |
S1865 | Diltiazem HCl | 90 mg/mL | 90 mg/mL | 4 mg/mL |
S3045 | Cinepazide maleate | 107 mg/mL | 107 mg/mL | <1 mg/mL |
S5255 | Nicardipine | 30 mg/mL | 95 mg/mL | 95 mg/mL |
S3242 | Loureirin B | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S8380 | YM-58483 (BTP2) | <1 mg/mL | 84 mg/mL | 84 mg/mL |
S6657 | 2-Aminoethyl Diphenylborinate (2-APB) | <1 mg/mL | 45 mg/mL | 23 mg/mL |
S4626 | Ethosuximide | 28 mg/mL | 28 mg/mL | 28 mg/mL |
S5966 | Amlodipine maleate | <1 mg/mL | 100 mg/mL | '<1 mg/mL |
S4597 | Lercanidipine hydrochloride | <1 mg/mL | 66 mg/mL | 1 mg/mL |
S4977 | Efonidipine | -1 mg/mL | 100 mg/mL | 40 mg/mL |
S5279 | Fendiline hydrochloride | -1 mg/mL | 70 mg/mL | -1 mg/mL |
S3845 | Panaxadiol | <1 mg/mL | <1 mg/mL | 22 mg/mL |
S5898 | Efonidipine hydrochloride monoethanolate | <1 mg/mL | 100 mg/mL | ''<1 mg/mL |
S3700 | DHBP dibromide | 100 mg/mL | 100 mg/mL | '100 mg/mL |
S6834 | CM 4620 | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S9017 | Columbianadin | -1 mg/mL | 65 mg/mL | '''-1 mg/mL |
S2403 | Tetrandrine (NSC-77037) | <1 mg/mL | 1 mg/mL | 2 mg/mL |
S9315 | Praeruptorin A | -1 mg/mL | 77 mg/mL | -1 mg/mL |
S6920 | SEA0400 | <1 mg/mL | 74 mg/mL | '74 mg/mL |
S3931 | Ginsenoside Rd | -1 mg/mL | 90 mg/mL | -1 mg/mL |
S5514 | Lanthanum(III) chloride heptahydrate | -1 mg/mL | 50 mg/mL | -1 mg/mL |
S3766 | Tanshinone IIA sulfonate sodium | -1 mg/mL | 79 mg/mL | -1 mg/mL |
S4084 | Lomerizine 2HCl | <1 mg/mL | 100 mg/mL | 52 mg/mL |
S4648 | Dantrolene sodium hemiheptahydrate | <1 mg/mL | 14 mg/mL | <1 mg/mL |
S3682 | Ethyl 3-Aminobenzoate methanesulfonate | 52 mg/mL | 52 mg/mL | 52 mg/mL |
S9400 | Rhynchophylline | -1 mg/mL | 76 mg/mL | -1 mg/mL |
S3674 | Levamlodipine | 81 mg/mL | 81 mg/mL | 81 mg/mL |
S3883 | Protopine | -1 mg/mL | 30 mg/mL | -1 mg/mL |
S5567 | Trimethadione | -1 mg/mL | 28 mg/mL | -1 mg/mL |
S9566 | Bepridil hydrochloride | -1 mg/mL | 41 mg/mL | -1 mg/mL |
S6847 | ML-9 HCl | 10 mg/mL | 72 mg/mL | 6 mg/mL |
S0452 | NP118809 | <1 mg/mL | 92 mg/mL | 3 mg/mL |
S0016 | SN-6 | <1 mg/mL | 80 mg/mL | '''<1 mg/mL |
S6473 | Pinaverium bromide | 16 mg/mL | 100 mg/mL | '100 mg/mL |
S4727 | Cinnarizine | <1 mg/mL | 73 mg/mL | '<1 mg/mL |
S9842 | MCU-i4 | <1 mg/mL | 10 mg/mL | '''76 mg/mL |
S2050 | Strontium Ranelate | <1 mg/mL | <1 mg/mL | <1 mg/mL |
S7924 | Bay K 8644 | <1 mg/mL | 71 mg/mL | 71 mg/mL |
S4209 | Chlorocresol | <1 mg/mL | 29 mg/mL | 29 mg/mL |
S4931 | Propiverine hydrochloride | -1 mg/mL | 80 mg/mL | -1 mg/mL |
S0870 | Barnidipine | <1 mg/mL | 98 mg/mL | '''<1 mg/mL |
S3809 | Imperatorin | -1 mg/mL | 54 mg/mL | -1 mg/mL |
S2436 | Pranidipine | <1 mg/mL | 90 mg/mL | '2 mg/mL |
S5861 | Lercanidipine | <1 mg/mL | 55 mg/mL | <1 mg/mL |
E0137 | GV-58 | <1 mg/mL | 75 mg/mL | ''75 mg/mL |
S5191 | Cinacalcet | ' mg/mL | ||
S9151 | Praeruptorin E | -1 mg/mL | 34.6 mg/mL | -1 mg/mL |
S2535 | Econazole nitrate | <1 mg/mL | 89 mg/mL | ''5 mg/mL |
S0713 | S107 hydrochloride | 49 mg/mL | 24 mg/mL | '''10 mg/mL |
S3236 | Mesaconitine | -1 mg/mL | 12 mg/mL | -1 mg/mL |
S0973 | Wilforgine | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S2415 | Astragaloside A | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S3191 | Azumolene | <1 mg/mL | 70 mg/mL | ''<1 mg/mL |
S4353 | Terfenadine | <1 mg/mL | 94 mg/mL | '27 mg/mL |
S2446 | Levosimendan | <1 mg/mL | 56 mg/mL | <1 mg/mL |
S1911 | Disodium Cromoglycate | 2 mg/mL | <1 mg/mL | <1 mg/mL |
S6994 | TD-165 | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S5478 | Dantrolene sodium | -1 mg/mL | 67 mg/mL | -1 mg/mL |
Calcium Channel製品
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S1573 |
Fasudil (HA-1077) HClFasudil (HA-1077, AT-877), a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively. Fasudil is also a calcium channel blocker. |
![]() ![]() The ROCK inhibitors fasudil and Y27632 prevented SCP2 cell bone metastasis in nude mice (n = 10 per group). Shown are BLI images of bone metastases, IHC analyses of SMAD3 C-tail phosphorylation and PTHLH, osteoclast TRAP staining, and BLI quantitation. |
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S1356 |
Levetiracetam (UCB-L059)Levetiracetam (UCB-L059, SIB-S1) is an anticonvulsant medication used to treat epilepsy. Levetiracetam (UCB-L059, SIB-S1) is an agonist of muscarinic acetylcholine receptors (mAChR). Levetiracetam modulates the presynaptic P/Q-type voltage-dependent calcium (Ca2+) channel. |
![]() ![]() Levetiracetam reduces DNA, synaptic, and neurite damage caused by Dox. (A) An example of cortical cultures pre-treated with 5 μ M Lev and then Dox (0.01 μ M, overnight), fixed and stained with antibodies against MAP2c. Scale bar is 20 μ m. (B) Cortical neurons at 28–32 DIV were pre-treated with 5 μ M Lev, and then a vehicle or with Dox (0.01 μ M for 3 days, or 0.1 μ M, overnight) was added. Neurons were fixed, and stained for MAP2c, synapsin, and with the Hoechst dye, and imaged. Note that red MAP2c staining also includes Dox's red fluorescence. (C) Synaptically developed primary cortical cultures at 28−32 DIV were pretreated with 5 mM Lev, and then a vehicle or with Dox (0.01 μM for 3 days, or 0.1 μM, overnight) was added. Neurons were then fixed, and stained with antibodies against γH2A.X and MAP2c, and with the Hoechst dye. Blue staining was used by the algorithm to identify and analyze γH2A.X.
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S1813 |
Amlodipine BesylateAmlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain. |
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S1293 |
Cilnidipine (FRC-8653)Cilnidipine (FRC-8653) is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment. |
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S1811 |
Amiloride (MK-870) HClAmiloride (MK-870) is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM). |
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E0778新 |
o-3M3FBSO-3M3FBS, the negative control of m-3M3FBS, inhibits inward and outward currents via mechanisms independent of PLC acting in an antagonistic manner, reversibly inhibits delayed rectifier K+ channels, increases in [Ca2+](i) in an agonistic manner with m-3M3FBS. |
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E0826新 |
Levamlodipine BesylateLevamlodipine Besylate is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina. |
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S1425 |
Ranolazine 2HClRanolazine 2HCl (RS-43285) is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina. |
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S4202 |
Verapamil (CP-16533-1) HClVerapamil HCl (CP-16533-1) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4. |
![]() ![]() The proportion of SP cells in HepG2 and HCCLM3 cell lines were 0.16% and 32.2%, which reduced to 0% and 0.28% in the presence of verapamil.
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S2482 |
Manidipine 2HClManidipine 2HCl (CV-4093) is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4. |
![]() ![]() Manidipine decreases the accumulation of HCMV Early and Late proteins. HFFs were infected with HCMV AD169 and then treated with test compounds or DMSO as a control. NTZ-treated samples were also included as a control for inhibition of E and L protein expression. At the indicated times p.i., total cell extracts were prepared and analyzed by WB with anti-IEA, anti-UL44, and anti-UL99 antibodies. Tubulin immunodetection served as a loading control. Images are representative of three independent experiments.
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S1799 |
RanolazineRanolazine (CVT 303, RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. |
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S1662 |
IsradipineIsradipine (PN 200-110) is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure. |
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S1905 |
AmlodipineAmlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain. |
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S1885 |
FelodipineFelodipine (CGH-869) is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM. |
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S2481 |
ManidipineManidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. |
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S1748 |
NisoldipineNisoldipine (Sular, BAY K 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM. |
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S1747 |
NimodipineNimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure. |
![]() ![]() Assessment of the role of Ca2+ channels during RSV replication. HEp-2 cells were infected with RSV strain long at an MOI of 0.1, and treated with calcium channel blockers nifedipine, nimodipine, and tetrandrine (A), at indicated concentrations. Supernatants were collected at 48 h postinfection and viral titers were determined by immunoplaque assay. Grey bars represent cytotoxicity of the compounds. The data presented were obtained from two independent experiments. Error bars represent the standard deviations from two independent experiments. NS, no differences at a significance level of 0.05. |
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S2721 |
NilvadipineNilvadipine (ARC029, FR34235) is a potent calcium channel blocker with an IC50 of 0.03 nM. |
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S1994 |
LacidipineLacidipine (GX-1048, GR-43659X, SN-305) is a L-type calcium channel blocker, used for treating high blood pressure. |
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S2114 |
Dronedarone HClDronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF). |
![]() ![]() Results of hit validation experiments for these four compounds for animals treated at L1 stage at four different concentrations (0.5, 5, 25, and 50 μM). The blue bars represent the values obtained from the original screen as reference points. Error bars are standard error of the mean. Statistical significance for all different doses for individual compounds was calculated with respect to the lowest concentration using two-tailed, t-test (nZ70 animals except n = 37 for Geld 25 μM). The statistical significance values are represented as P<0.05 (*) and P<0.005 (**).
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S4181 |
Nicardipine HClNicardipine HCl (RS-69216) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders. |
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S1808 |
Nifedipine (BAY-a-1040)Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina. |
![]() ![]() The fold change of C-peptide content after octreotide, nicorandil and nifedipine treatment. Octreotide, nicorandil and nifedipine decreased insulin secretion in wild-type, heterozygous mutated and homozygous mutated cells.
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S2080 |
Clevidipine ButyrateClevidipine Butyrate is a dihydropyridine calcium channel blocker, uses as an agent for the reduction of blood pressure. |
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S2017 |
Benidipine HClBenidipine HCl (KW-3049) is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker. |
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S2030 |
Flunarizine 2HClFlunarizine 2HCl (KW-3149, R14950) is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM. |
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S2491 |
NitrendipineNitrendipine (Bayotensin) is a dihydropyridine calcium channel blocker with an IC50 of 95 nM. |
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S3053 |
AzelnidipineAzelnidipine (UR-12592) is a dihydropyridine calcium channel blocker. |
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S2573 |
Tetracaine HClTetracaine HCl (Amethocalne) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor. |
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S0000 |
Cav 2.2 blocker 1Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain with IC50 of 0.001 μM. |
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S1865 |
Diltiazem HClDiltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. |
![]() ![]() Gentisic acid reduces interstitial and perivascular fibrosis in mice with transverse aortic constriction (TAC). Representative images of Masson's trichrome staining of the hearts of mice in the sham and TAC + vehicle, gentisic acid, bisoprolol, or diltiazem groups. Scale bar = 50 μm. A, Interstitial fibrosis and B, perivascular fibrosis are shown. Fibrotic areas are stained blue.
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S3045 |
Cinepazide maleateCinepazide maleate is a maleate salt form of cinepazide which is a vasodilator. |
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S5255 |
NicardipineNicardipine is a potent calcium channel blockader with marked vasodilator action. |
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S3242 |
Loureirin BLoureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular. |
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S8380 |
YM-58483 (BTP2)YM-58483/BTP2 is a blocker of store-operated Ca2+ entry (SOCE), which regulates the activation of non-excitable cells such as lymphocytes. |
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S6657 |
2-Aminoethyl Diphenylborinate (2-APB)2-Aminoethyl Diphenylborinate (2-APB) is an IP3 receptor inhibitor and regulate IP3-induced calcium release.2-APB also inhibits the SOC channel activity and activates TRP channel at higher concentrations. |
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S4626 |
EthosuximideEthosuximide is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker. |
![]() ![]() Antidepressant effects caused by systemic ethosuximide injection (200 mg kg−1, i.p.; c, d) in the FST(forced swim test) and SPT (sucrose preference test) 1 h after treatment.
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S5966 |
Amlodipine maleateAmlodipine (Amvaz, UK-48340) maleate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain. |
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S4597 |
Lercanidipine hydrochlorideLercanidipine is a calcium channel blocker of the dihydropyridine class. |
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S4977 |
EfonidipineEfonidipine (NZ-105) is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal. |
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S5279 |
Fendiline hydrochlorideFendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras. |
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S3845 |
PanaxadiolPanaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential. |
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S5898 |
Efonidipine hydrochloride monoethanolateEfonidipine (NZ-105) hydrochloride monoethanolate is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. Efonidipine hydrochloride monoethanolate also suppresses aldosterone secretion from the adrenal. |
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S3700 |
DHBP dibromideDHBP (1,1'-diheptyl-4,4'-bipyridinium), a viologen for electrochromic memory display agent, inhibits the calcium release induced by 2 mM caffeine and 2 μg/ml polylysine with an IC50 value of 5 μg/ml and 4 μg/ml respectively. |
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S6834 |
CM 4620CM 4620 is an inhibitor of calcium-release activated calcium-channel (CRAC channel). CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively. |
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S9017 |
ColumbianadinColumbianadin (Zosimin, 2-Butenoic acid), a natural coumarin from Angelica decursiva, is known to have various biological activities including calcium-channel blocking activity, cytotoxic activity against various cancer cell lines, analgesic activities, intestinal absorption and transportation, anti-inflammatory and anti-cancer effects. |
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S2403 |
Tetrandrine (NSC-77037)Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker. |
![]() ![]() BMMs were seeded in a collage I-coated plate and incubated with RANKL (100 ng/ml) and M-CSF (50 ng/ml) for 5 d. When mature osteoclasts were observed, they were digested by collagenase and seeded on bovine bone slices. The bone slices were treated with or without tetrandrine for an additional 2 d. Then, the cells were stained with rhodamine–phalloidin to observe the F-actin rings, and the areas of F-actin rings were calculated by Image-Pro Plus 6.0 software.
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S9315 |
Praeruptorin APraeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. Praeruptorin A inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Praeruptorin A can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction. |
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S6920 |
SEA0400SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner. |
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S3931 |
Ginsenoside RdGinsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively. |
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S5514 |
Lanthanum(III) chloride heptahydrateLanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels. |
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S3766 |
Tanshinone IIA sulfonate sodiumSodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen. Sodium tanshinone IIA sulfonate (STS) is a potent negative allosteric modulator of the human purinergic receptor P2X7. Sodium tanshinone IIA sulfonate (STS) inhibits the activity of CYP3A4 and store-operated Ca2+ entry (SOCE) through store-operated Ca2+ channels (SOCC) via downregulating the expression of transient receptor potential canonical proteins (TRPC). |
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S4084 |
Lomerizine 2HClLomerizine dihydrochloride (KB-2796) is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine. |
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S4648 |
Dantrolene sodium hemiheptahydrateDantrolene sodium hemiheptahydrate (Dantrium) ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. |
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S3682 |
Ethyl 3-Aminobenzoate methanesulfonateEthyl 3-Aminobenzoate (Ethyl m-Aminobenzoate, NSC 93790, Tricaine) can block the generation of action potentials via voltage-dependent Na+-channels and usually used for anesthesia, sedation, or euthanasia of fish. |
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S9400 |
RhynchophyllineRhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension. |
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S3674 |
LevamlodipineLevamlodipine (S-amlodipine) is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure. |
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S3883 |
ProtopineProtopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities. |
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S5567 |
TrimethadioneTrimethadione is an oxazolidinedione anticonvulsant and often used to treat epileptic conditions that are resistant to other treatments. |
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S9566 |
Bepridil hydrochlorideBepridil hydrochloride is an anti-anginal drug classified as a calcium channel blocker. It also blocks multiple other ion channels, including sodium and potassium channels. |
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S6847 |
ML-9 HClML-9 HCl (ML-9 hydrochloride) is a selective and potent inhibitor of Akt kinase, myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1). ML-9 HCl is also a potent inhibitor of Ca2+-permeable channels. ML-9 HCl is a lysosomotropic agent targeting autophagy and cell death. |
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S0452 |
NP118809NP118809(39-1B4) is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM, also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM. |
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S0016 |
SN-6SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation. |
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S6473 |
Pinaverium bromidePinaverium bromide (Icosapentaenoic acid) acts as a calcium channel blocker and is useful for functional gastrointestinal disorders. |
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S4727 |
CinnarizineCinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine) is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker. |
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S9842 |
MCU-i4MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU) complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx. |
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S2050 |
Strontium RanelateStrontium Ranelate is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM. |
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S7924 |
Bay K 8644Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM. |
![]() ![]() Western blot analysis of myocardium lysate at 4 weeks. Hypertrophic markers were tested in mouse cardiomyocyte cell line HL-1 Bay-K-8644.
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S4209 |
ChlorocresolChlorocresol is an activator of ryanodine receptor. |
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S4931 |
Propiverine hydrochloridePropiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. |
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S0870 |
BarnidipineBarnidipine (Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca) is an antihypertensive drug that belongs to the dihydropyridine (DHP) group of calcium antagonist (CaA) with Ki of 0.21 nM for [3H]nitrendipine binding sites. |
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S3809 |
ImperatorinImperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle. |
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S2436 |
PranidipinePranidipine (Acalas, OPC 13340) is a new 1,4-dihydropyridine calcium channel blocker. Pranidipine can enhance cyclic GMP-independent nitric oxide-induced relaxation of the rat aorta. |
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S5861 |
LercanidipineLercanidipine is a vasoselective dihydropyridine calcium antagonist used for the treatment of essential hypertension. |
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E0137新 |
GV-58GV-58 is a novel, selective N-type and P/Q-type Ca2+ channels agonist with IC50s of 7.21 μM and 8.81 μM, respectively. |
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S5191 |
CinacalcetCinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca. |
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S9151 |
Praeruptorin EPraeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect. |
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S2535 |
Econazole nitrateEconazole Nitrate (NSC 243115) is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus. |
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S0713 |
S107 hydrochlorideS107 hydrochloride is a specific stabilizer of RyR2 (type 2 ryanodine receptor)/FKBP12.6 (FK506 binding protein 12.6) complex that affects Ca2+ signaling. |
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S3236 |
MesaconitineMesaconitine, one of the aconite alkaloids in Aconiti tuber, increases the [Ca2+]i level in endothelial cells by influx of Ca2+ from extracellular spaces. |
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S0973 |
WilforgineWilforgine, one of the major bioactive sesquiterpene alkaloids in Tripterygium wilfordii Hook. F., induces microstructural and ultrastructural changes in the muscles of M. separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system. |
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S2415 |
Astragaloside AAstragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. |
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S3191 |
AzumoleneAzumolene (EU4093 free base), an equipotent dantrolene analog, is a ryanodine receptor (RyR) modulator that inhibits the calcium-release. |
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S4353 |
TerfenadineTerfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9. |
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S2446 |
LevosimendanLevosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure. |
![]() ![]() (B-E) The % of GFP-positive cells upon compound treatment were determined for the indicated HIV-1 latency cell lines (B. J-LAT 6.3; C. JLAT 10.6; D. CA5; E. EF7). Results were normalized to DMSO control. Values represent the mean ± s.d. (n = 4-6). * p < 0.05, one-way ANOVA followed by Tukey’s multiplecomparison test |
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S1911 |
Disodium CromoglycateDisodium Cromoglycate (FPL 670, Cromolyn) is an antiallergic drug with IC50 of 39 μg/mL. |
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S6994 |
TD-165TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. |
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S5478 |
Dantrolene sodiumDantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S1573 |
Fasudil (HA-1077) HClFasudil (HA-1077, AT-877), a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively. Fasudil is also a calcium channel blocker. |
![]() ![]() The ROCK inhibitors fasudil and Y27632 prevented SCP2 cell bone metastasis in nude mice (n = 10 per group). Shown are BLI images of bone metastases, IHC analyses of SMAD3 C-tail phosphorylation and PTHLH, osteoclast TRAP staining, and BLI quantitation. |
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S1356 |
Levetiracetam (UCB-L059)Levetiracetam (UCB-L059, SIB-S1) is an anticonvulsant medication used to treat epilepsy. Levetiracetam (UCB-L059, SIB-S1) is an agonist of muscarinic acetylcholine receptors (mAChR). Levetiracetam modulates the presynaptic P/Q-type voltage-dependent calcium (Ca2+) channel. |
![]() ![]() Levetiracetam reduces DNA, synaptic, and neurite damage caused by Dox. (A) An example of cortical cultures pre-treated with 5 μ M Lev and then Dox (0.01 μ M, overnight), fixed and stained with antibodies against MAP2c. Scale bar is 20 μ m. (B) Cortical neurons at 28–32 DIV were pre-treated with 5 μ M Lev, and then a vehicle or with Dox (0.01 μ M for 3 days, or 0.1 μ M, overnight) was added. Neurons were fixed, and stained for MAP2c, synapsin, and with the Hoechst dye, and imaged. Note that red MAP2c staining also includes Dox's red fluorescence. (C) Synaptically developed primary cortical cultures at 28−32 DIV were pretreated with 5 mM Lev, and then a vehicle or with Dox (0.01 μM for 3 days, or 0.1 μM, overnight) was added. Neurons were then fixed, and stained with antibodies against γH2A.X and MAP2c, and with the Hoechst dye. Blue staining was used by the algorithm to identify and analyze γH2A.X.
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S1813 |
Amlodipine BesylateAmlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain. |
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S1293 |
Cilnidipine (FRC-8653)Cilnidipine (FRC-8653) is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment. |
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S1811 |
Amiloride (MK-870) HClAmiloride (MK-870) is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM). |
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E0778新 |
o-3M3FBSO-3M3FBS, the negative control of m-3M3FBS, inhibits inward and outward currents via mechanisms independent of PLC acting in an antagonistic manner, reversibly inhibits delayed rectifier K+ channels, increases in [Ca2+](i) in an agonistic manner with m-3M3FBS. |
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E0826新 |
Levamlodipine BesylateLevamlodipine Besylate is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina. |
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S1425 |
Ranolazine 2HClRanolazine 2HCl (RS-43285) is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina. |
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S4202 |
Verapamil (CP-16533-1) HClVerapamil HCl (CP-16533-1) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4. |
![]() ![]() The proportion of SP cells in HepG2 and HCCLM3 cell lines were 0.16% and 32.2%, which reduced to 0% and 0.28% in the presence of verapamil.
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S2482 |
Manidipine 2HClManidipine 2HCl (CV-4093) is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4. |
![]() ![]() Manidipine decreases the accumulation of HCMV Early and Late proteins. HFFs were infected with HCMV AD169 and then treated with test compounds or DMSO as a control. NTZ-treated samples were also included as a control for inhibition of E and L protein expression. At the indicated times p.i., total cell extracts were prepared and analyzed by WB with anti-IEA, anti-UL44, and anti-UL99 antibodies. Tubulin immunodetection served as a loading control. Images are representative of three independent experiments.
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S1799 |
RanolazineRanolazine (CVT 303, RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. |
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S1662 |
IsradipineIsradipine (PN 200-110) is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure. |
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S1905 |
AmlodipineAmlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain. |
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S1885 |
FelodipineFelodipine (CGH-869) is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM. |
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S2481 |
ManidipineManidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. |
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S1748 |
NisoldipineNisoldipine (Sular, BAY K 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM. |
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S1747 |
NimodipineNimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure. |
![]() ![]() Assessment of the role of Ca2+ channels during RSV replication. HEp-2 cells were infected with RSV strain long at an MOI of 0.1, and treated with calcium channel blockers nifedipine, nimodipine, and tetrandrine (A), at indicated concentrations. Supernatants were collected at 48 h postinfection and viral titers were determined by immunoplaque assay. Grey bars represent cytotoxicity of the compounds. The data presented were obtained from two independent experiments. Error bars represent the standard deviations from two independent experiments. NS, no differences at a significance level of 0.05. |
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S2721 |
NilvadipineNilvadipine (ARC029, FR34235) is a potent calcium channel blocker with an IC50 of 0.03 nM. |
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S1994 |
LacidipineLacidipine (GX-1048, GR-43659X, SN-305) is a L-type calcium channel blocker, used for treating high blood pressure. |
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S2114 |
Dronedarone HClDronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF). |
![]() ![]() Results of hit validation experiments for these four compounds for animals treated at L1 stage at four different concentrations (0.5, 5, 25, and 50 μM). The blue bars represent the values obtained from the original screen as reference points. Error bars are standard error of the mean. Statistical significance for all different doses for individual compounds was calculated with respect to the lowest concentration using two-tailed, t-test (nZ70 animals except n = 37 for Geld 25 μM). The statistical significance values are represented as P<0.05 (*) and P<0.005 (**).
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S4181 |
Nicardipine HClNicardipine HCl (RS-69216) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders. |
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S1808 |
Nifedipine (BAY-a-1040)Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina. |
![]() ![]() The fold change of C-peptide content after octreotide, nicorandil and nifedipine treatment. Octreotide, nicorandil and nifedipine decreased insulin secretion in wild-type, heterozygous mutated and homozygous mutated cells.
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S2080 |
Clevidipine ButyrateClevidipine Butyrate is a dihydropyridine calcium channel blocker, uses as an agent for the reduction of blood pressure. |
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S2017 |
Benidipine HClBenidipine HCl (KW-3049) is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker. |
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S2030 |
Flunarizine 2HClFlunarizine 2HCl (KW-3149, R14950) is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM. |
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S2491 |
NitrendipineNitrendipine (Bayotensin) is a dihydropyridine calcium channel blocker with an IC50 of 95 nM. |
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S3053 |
AzelnidipineAzelnidipine (UR-12592) is a dihydropyridine calcium channel blocker. |
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S2573 |
Tetracaine HClTetracaine HCl (Amethocalne) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor. |
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S0000 |
Cav 2.2 blocker 1Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain with IC50 of 0.001 μM. |
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S1865 |
Diltiazem HClDiltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. |
![]() ![]() Gentisic acid reduces interstitial and perivascular fibrosis in mice with transverse aortic constriction (TAC). Representative images of Masson's trichrome staining of the hearts of mice in the sham and TAC + vehicle, gentisic acid, bisoprolol, or diltiazem groups. Scale bar = 50 μm. A, Interstitial fibrosis and B, perivascular fibrosis are shown. Fibrotic areas are stained blue.
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S3045 |
Cinepazide maleateCinepazide maleate is a maleate salt form of cinepazide which is a vasodilator. |
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S5255 |
NicardipineNicardipine is a potent calcium channel blockader with marked vasodilator action. |
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S3242 |
Loureirin BLoureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular. |
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S8380 |
YM-58483 (BTP2)YM-58483/BTP2 is a blocker of store-operated Ca2+ entry (SOCE), which regulates the activation of non-excitable cells such as lymphocytes. |
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S6657 |
2-Aminoethyl Diphenylborinate (2-APB)2-Aminoethyl Diphenylborinate (2-APB) is an IP3 receptor inhibitor and regulate IP3-induced calcium release.2-APB also inhibits the SOC channel activity and activates TRP channel at higher concentrations. |
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S4626 |
EthosuximideEthosuximide is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker. |
![]() ![]() Antidepressant effects caused by systemic ethosuximide injection (200 mg kg−1, i.p.; c, d) in the FST(forced swim test) and SPT (sucrose preference test) 1 h after treatment.
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S5966 |
Amlodipine maleateAmlodipine (Amvaz, UK-48340) maleate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain. |
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S4597 |
Lercanidipine hydrochlorideLercanidipine is a calcium channel blocker of the dihydropyridine class. |
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S4977 |
EfonidipineEfonidipine (NZ-105) is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal. |
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S5279 |
Fendiline hydrochlorideFendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras. |
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S3845 |
PanaxadiolPanaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential. |
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S5898 |
Efonidipine hydrochloride monoethanolateEfonidipine (NZ-105) hydrochloride monoethanolate is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. Efonidipine hydrochloride monoethanolate also suppresses aldosterone secretion from the adrenal. |
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S3700 |
DHBP dibromideDHBP (1,1'-diheptyl-4,4'-bipyridinium), a viologen for electrochromic memory display agent, inhibits the calcium release induced by 2 mM caffeine and 2 μg/ml polylysine with an IC50 value of 5 μg/ml and 4 μg/ml respectively. |
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S6834 |
CM 4620CM 4620 is an inhibitor of calcium-release activated calcium-channel (CRAC channel). CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively. |
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S9017 |
ColumbianadinColumbianadin (Zosimin, 2-Butenoic acid), a natural coumarin from Angelica decursiva, is known to have various biological activities including calcium-channel blocking activity, cytotoxic activity against various cancer cell lines, analgesic activities, intestinal absorption and transportation, anti-inflammatory and anti-cancer effects. |
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S2403 |
Tetrandrine (NSC-77037)Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker. |
![]() ![]() BMMs were seeded in a collage I-coated plate and incubated with RANKL (100 ng/ml) and M-CSF (50 ng/ml) for 5 d. When mature osteoclasts were observed, they were digested by collagenase and seeded on bovine bone slices. The bone slices were treated with or without tetrandrine for an additional 2 d. Then, the cells were stained with rhodamine–phalloidin to observe the F-actin rings, and the areas of F-actin rings were calculated by Image-Pro Plus 6.0 software.
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S9315 |
Praeruptorin APraeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. Praeruptorin A inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Praeruptorin A can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction. |
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S6920 |
SEA0400SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner. |
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S3931 |
Ginsenoside RdGinsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively. |
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S5514 |
Lanthanum(III) chloride heptahydrateLanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels. |
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S3766 |
Tanshinone IIA sulfonate sodiumSodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen. Sodium tanshinone IIA sulfonate (STS) is a potent negative allosteric modulator of the human purinergic receptor P2X7. Sodium tanshinone IIA sulfonate (STS) inhibits the activity of CYP3A4 and store-operated Ca2+ entry (SOCE) through store-operated Ca2+ channels (SOCC) via downregulating the expression of transient receptor potential canonical proteins (TRPC). |
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S4084 |
Lomerizine 2HClLomerizine dihydrochloride (KB-2796) is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine. |
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S4648 |
Dantrolene sodium hemiheptahydrateDantrolene sodium hemiheptahydrate (Dantrium) ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. |
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S3682 |
Ethyl 3-Aminobenzoate methanesulfonateEthyl 3-Aminobenzoate (Ethyl m-Aminobenzoate, NSC 93790, Tricaine) can block the generation of action potentials via voltage-dependent Na+-channels and usually used for anesthesia, sedation, or euthanasia of fish. |
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S9400 |
RhynchophyllineRhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension. |
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S3674 |
LevamlodipineLevamlodipine (S-amlodipine) is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure. |
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S3883 |
ProtopineProtopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities. |
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S5567 |
TrimethadioneTrimethadione is an oxazolidinedione anticonvulsant and often used to treat epileptic conditions that are resistant to other treatments. |
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S9566 |
Bepridil hydrochlorideBepridil hydrochloride is an anti-anginal drug classified as a calcium channel blocker. It also blocks multiple other ion channels, including sodium and potassium channels. |
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S6847 |
ML-9 HClML-9 HCl (ML-9 hydrochloride) is a selective and potent inhibitor of Akt kinase, myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1). ML-9 HCl is also a potent inhibitor of Ca2+-permeable channels. ML-9 HCl is a lysosomotropic agent targeting autophagy and cell death. |
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S0452 |
NP118809NP118809(39-1B4) is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM, also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM. |
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S0016 |
SN-6SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation. |
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S6473 |
Pinaverium bromidePinaverium bromide (Icosapentaenoic acid) acts as a calcium channel blocker and is useful for functional gastrointestinal disorders. |
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S4727 |
CinnarizineCinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine) is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker. |
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S9842 |
MCU-i4MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU) complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S2050 |
Strontium RanelateStrontium Ranelate is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM. |
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S7924 |
Bay K 8644Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM. |
2021, 10.1021/acsnano.1c03517 2021, 10.1007/s10565-021-09615-y 2020, 10.1016/j.jare.2020.10.005 |
![]() ![]() Western blot analysis of myocardium lysate at 4 weeks. Hypertrophic markers were tested in mouse cardiomyocyte cell line HL-1 Bay-K-8644.
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S4209 |
ChlorocresolChlorocresol is an activator of ryanodine receptor. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S4931 |
Propiverine hydrochloridePropiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. |
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S0870 |
BarnidipineBarnidipine (Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca) is an antihypertensive drug that belongs to the dihydropyridine (DHP) group of calcium antagonist (CaA) with Ki of 0.21 nM for [3H]nitrendipine binding sites. |
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S3809 |
ImperatorinImperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle. |
2020, 8:592433 2020, 7(16):2000925 2019, 10.1016/j.theriogenology |
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S2436 |
PranidipinePranidipine (Acalas, OPC 13340) is a new 1,4-dihydropyridine calcium channel blocker. Pranidipine can enhance cyclic GMP-independent nitric oxide-induced relaxation of the rat aorta. |
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S5861 |
LercanidipineLercanidipine is a vasoselective dihydropyridine calcium antagonist used for the treatment of essential hypertension. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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E0137新 |
GV-58GV-58 is a novel, selective N-type and P/Q-type Ca2+ channels agonist with IC50s of 7.21 μM and 8.81 μM, respectively. |
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S5191 |
CinacalcetCinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca. |
2022, 23(8)4323 |
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S9151 |
Praeruptorin EPraeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S2535 |
Econazole nitrateEconazole Nitrate (NSC 243115) is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus. |
2020, 25 |
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S0713 |
S107 hydrochlorideS107 hydrochloride is a specific stabilizer of RyR2 (type 2 ryanodine receptor)/FKBP12.6 (FK506 binding protein 12.6) complex that affects Ca2+ signaling. |
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S3236 |
MesaconitineMesaconitine, one of the aconite alkaloids in Aconiti tuber, increases the [Ca2+]i level in endothelial cells by influx of Ca2+ from extracellular spaces. |
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S0973 |
WilforgineWilforgine, one of the major bioactive sesquiterpene alkaloids in Tripterygium wilfordii Hook. F., induces microstructural and ultrastructural changes in the muscles of M. separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system. |
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S2415 |
Astragaloside AAstragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. |
2022, 12(1):7 2020, 41(7):993-1004 2019, 91(8):1440-1447 |
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S3191 |
AzumoleneAzumolene (EU4093 free base), an equipotent dantrolene analog, is a ryanodine receptor (RyR) modulator that inhibits the calcium-release. |
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S4353 |
TerfenadineTerfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S2446 |
LevosimendanLevosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure. |
2017, 146:76-85 |
![]() ![]() (B-E) The % of GFP-positive cells upon compound treatment were determined for the indicated HIV-1 latency cell lines (B. J-LAT 6.3; C. JLAT 10.6; D. CA5; E. EF7). Results were normalized to DMSO control. Values represent the mean ± s.d. (n = 4-6). * p < 0.05, one-way ANOVA followed by Tukey’s multiplecomparison test |
S1911 |
Disodium CromoglycateDisodium Cromoglycate (FPL 670, Cromolyn) is an antiallergic drug with IC50 of 39 μg/mL. |
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S6994 |
TD-165TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. |
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S5478 |
Dantrolene sodiumDantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. |
2022, 10.1007/s12975-022-01021-8 2021, 2021:8810698 2019, 9(1):3487 |