Immunology & Inflammation related

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S2286 Cyclosporin A <1 mg/mL 100 mg/mL 100 mg/mL
S5004 Pimecrolimus <1 mg/mL 100 mg/mL 100 mg/mL
S3032 Bindarit <1 mg/mL 64 mg/mL 64 mg/mL
S1591 Bestatin <1 mg/mL 0.4 mg/mL <1 mg/mL
S8660 GI254023X <1 mg/mL 78 mg/mL 78 mg/mL
S5661 Tiaprofenic acid <1 mg/mL 52 mg/mL 52 mg/mL
S5412 Loxoprofen Sodium 53 mg/mL <1 mg/mL <1 mg/mL
S5361 Bendazac <1 mg/mL 56 mg/mL 56 mg/mL
S5360 Diflorasone <1 mg/mL 82 mg/mL 2 mg/mL
S5466 Saikosaponin A <1 mg/mL 100 mg/mL 100 mg/mL
S7732 ISO-1 <1 mg/mL 47 mg/mL 47 mg/mL
S3778 Patchouli alcohol -1 mg/mL 44 mg/mL -1 mg/mL
S3892 Isopsoralen -1 mg/mL 14 mg/mL -1 mg/mL
S3758 Cucoline hydrochloride, Kukoline hydrochloride, Sabianine A hydrochloride -1 mg/mL 73 mg/mL -1 mg/mL
S3827 Royal jelly acid -1 mg/mL 37 mg/mL -1 mg/mL
S3680 NLRP3 Inflammasome Inhibitor I <1 mg/mL 73 mg/mL <1 mg/mL
S3622 Diammonium Glycyrrhizinate 100 mg/mL 100 mg/mL <1 mg/mL
S3608 Demethylzeylasteral (T-96) <1 mg/mL 96 mg/mL 33 mg/mL
S1622 Prednisone <1 mg/mL 71 mg/mL <1 mg/mL
S1514 Cyclosporine <1 mg/mL 100 mg/mL 100 mg/mL
S1576 Sulfasalazine <1 mg/mL 80 mg/mL <1 mg/mL
S1654 Phenylbutazone <1 mg/mL 62 mg/mL 62 mg/mL
S2512 Tenoxicam <1 mg/mL 68 mg/mL <1 mg/mL
S4268 Flufenamic acid <1 mg/mL 56 mg/mL 56 mg/mL
S7809 MCC950(CP-456773) 85 mg/mL <1 mg/mL 40 mg/mL
S8291 Atractylenolide I <1 mg/mL 46 mg/mL 46 mg/mL
S8522 Compstatin 100 mg/mL -1 mg/mL -1 mg/mL
S4753 Ganoderic acid A <1 mg/mL 100 mg/mL 100 mg/mL
S7434 TAPI-1 60 mg/mL 99 mg/mL 99 mg/mL
S1829 Pranlukast <1 mg/mL 11 mg/mL <1 mg/mL
S7211 PF-04418948 <1 mg/mL 81 mg/mL <1 mg/mL
S3726 Selexipag <1 mg/mL 99 mg/mL 49 mg/mL
S1407 Bimatoprost <1 mg/mL 36 mg/mL 83 mg/mL
S1508 Alprostadil <1 mg/mL 71 mg/mL 71 mg/mL
S4529 Idramantone 33 mg/mL 33 mg/mL 33 mg/mL
S2286 Cyclosporin A <1 mg/mL 100 mg/mL 100 mg/mL
S5004 Pimecrolimus <1 mg/mL 100 mg/mL 100 mg/mL
S3032 Bindarit <1 mg/mL 64 mg/mL 64 mg/mL
S1591 Bestatin <1 mg/mL 0.4 mg/mL <1 mg/mL
S8660 GI254023X <1 mg/mL 78 mg/mL 78 mg/mL
S5661 Tiaprofenic acid <1 mg/mL 52 mg/mL 52 mg/mL
S5412 Loxoprofen Sodium 53 mg/mL <1 mg/mL <1 mg/mL
S5361 Bendazac <1 mg/mL 56 mg/mL 56 mg/mL
S5360 Diflorasone <1 mg/mL 82 mg/mL 2 mg/mL
S5466 Saikosaponin A <1 mg/mL 100 mg/mL 100 mg/mL
S7732 ISO-1 <1 mg/mL 47 mg/mL 47 mg/mL
S3778 Patchouli alcohol -1 mg/mL 44 mg/mL -1 mg/mL
S3892 Isopsoralen -1 mg/mL 14 mg/mL -1 mg/mL
S3758 Cucoline hydrochloride, Kukoline hydrochloride, Sabianine A hydrochloride -1 mg/mL 73 mg/mL -1 mg/mL
S3827 Royal jelly acid -1 mg/mL 37 mg/mL -1 mg/mL
S3680 NLRP3 Inflammasome Inhibitor I <1 mg/mL 73 mg/mL <1 mg/mL
S3622 Diammonium Glycyrrhizinate 100 mg/mL 100 mg/mL <1 mg/mL
S3608 Demethylzeylasteral (T-96) <1 mg/mL 96 mg/mL 33 mg/mL
S1622 Prednisone <1 mg/mL 71 mg/mL <1 mg/mL
S1514 Cyclosporine <1 mg/mL 100 mg/mL 100 mg/mL
S1576 Sulfasalazine <1 mg/mL 80 mg/mL <1 mg/mL
S1654 Phenylbutazone <1 mg/mL 62 mg/mL 62 mg/mL
S2512 Tenoxicam <1 mg/mL 68 mg/mL <1 mg/mL
S4268 Flufenamic acid <1 mg/mL 56 mg/mL 56 mg/mL
S7809 MCC950(CP-456773) 85 mg/mL <1 mg/mL 40 mg/mL
S8291 Atractylenolide I <1 mg/mL 46 mg/mL 46 mg/mL
S8522 Compstatin 100 mg/mL -1 mg/mL -1 mg/mL
S4753 Ganoderic acid A <1 mg/mL 100 mg/mL 100 mg/mL
S7434 TAPI-1 60 mg/mL 99 mg/mL 99 mg/mL
S1211 Imiquimod <1 mg/mL 1 mg/mL <1 mg/mL
S5737 Diclofenac Epolamine 82 mg/mL 82 mg/mL 82 mg/mL
S5501 Hydrocortisone acetate -1 mg/mL 80 mg/mL -1 mg/mL
S5500 Amodiaquine hydrochloride -1 mg/mL 56 mg/mL -1 mg/mL
S3969 Veratric acid -1 mg/mL 36 mg/mL -1 mg/mL
S5322 Sodium gualenate 18 mg/mL 60 mg/mL 1 mg/mL
S5579 Chelidonic acid -1 mg/mL 4 mg/mL -1 mg/mL
S5451 Ferulic acid methyl ester 41 mg/mL 41 mg/mL 41 mg/mL
S5457 Curculigoside 15 mg/mL 93 mg/mL 93 mg/mL
S5458 Verbascoside 100 mg/mL 100 mg/mL 23 mg/mL
S5459 Aucubin 15 mg/mL 69 mg/mL <1 mg/mL
S5463 Curcurbitacin IIA <1 mg/mL 100 mg/mL 5 mg/mL
S5471 Monotropein 78 mg/mL 78 mg/mL <1 mg/mL
S5517 Fenamic acid -1 mg/mL 42 mg/mL -1 mg/mL
S3776 Sophoricoside <1 mg/mL 86 mg/mL <1 mg/mL
S5043 Benorylate -1 mg/mL 62 mg/mL -1 mg/mL
S5016 Isoprinosine 100 mg/mL 100 mg/mL 2 mg/mL
S5044 Isoxepac <1 mg/mL 53 mg/mL 53 mg/mL
S5046 Clonixin <1 mg/mL 52 mg/mL 15 mg/mL
S4966 4-Methylesculetin -1 mg/mL 38 mg/mL -1 mg/mL
S4832 Tolmetin -1 mg/mL 51 mg/mL -1 mg/mL
S4835 Aceclofenac -1 mg/mL 70 mg/mL -1 mg/mL
S3997 Oxaceprol -1 mg/mL 34 mg/mL -1 mg/mL
S4789 5-Acetylsalicylic acid -1 mg/mL 36 mg/mL -1 mg/mL
S5157 Thymol -1 mg/mL 30 mg/mL -1 mg/mL
S3982 Batyl alcohol -1 mg/mL 68 mg/mL -1 mg/mL
S3906 Astragalus polyphenols -1 mg/mL 81 mg/mL -1 mg/mL
S3877 Lysionotin -1 mg/mL 68 mg/mL -1 mg/mL
S3881 Scopoletin -1 mg/mL 38 mg/mL -1 mg/mL
S3790 Methyl gallate -1 mg/mL 36 mg/mL -1 mg/mL
S3799 Gentisic acid -1 mg/mL 30 mg/mL -1 mg/mL
S3765 Picroside II -1 mg/mL 100 mg/mL -1 mg/mL
S3774 Dehydroandrographolide Succinate Potasium Salt -1 mg/mL 10 mg/mL -1 mg/mL
S3775 Ligustrazine hydrochloride -1 mg/mL 34 mg/mL -1 mg/mL
S3932 Astilbin -1 mg/mL 100 mg/mL -1 mg/mL
S3837 Echinocystic acid -1 mg/mL 94 mg/mL -1 mg/mL
S3824 Quercitrin -1 mg/mL 89 mg/mL -1 mg/mL
S3841 Eleutheroside B -1 mg/mL 74 mg/mL -1 mg/mL
S3956 Tetramethylpyrazine -1 mg/mL 27 mg/mL -1 mg/mL
S3614 Lupeol <1 mg/mL 1 mg/mL <1 mg/mL
S3685 4-Biphenylacetic acid <1 mg/mL 42 mg/mL 42 mg/mL
S3745 Balsalazide disodium 87 mg/mL 87 mg/mL <1 mg/mL
S1439 Tranilast <1 mg/mL 66 mg/mL <1 mg/mL
S2413 Geniposidic acid <1 mg/mL 16 mg/mL 2 mg/mL
S1681 Mesalamine <1 mg/mL 31 mg/mL 31 mg/mL
S2910 Tempol 34 mg/mL 34 mg/mL 34 mg/mL
S1679 Flurbiprofen <1 mg/mL 49 mg/mL 49 mg/mL
S3062 Diclofenac Potassium 10 mg/mL 69 mg/mL <1 mg/mL
S4098 Halcinonide <1 mg/mL 90 mg/mL 4 mg/mL
S1823 Fenoprofen Calcium <1 mg/mL 105 mg/mL 10 mg/mL
S4152 Ethamsylate 53 mg/mL 53 mg/mL <1 mg/mL
S2383 Gastrodin <1 mg/mL 50 mg/mL <1 mg/mL
S2387 Lappaconite HBr <1 mg/mL 28 mg/mL <1 mg/mL
S4165 Benzydamine HCl 69 mg/mL 69 mg/mL 69 mg/mL
S4170 Coumarin <1 mg/mL 29 mg/mL 29 mg/mL
S2400 Rheic Acid <1 mg/mL <1 mg/mL <1 mg/mL
S4188 Sasapyrine <1 mg/mL 52 mg/mL 52 mg/mL
S7448 CORM-3 <1 mg/mL 38 mg/mL <1 mg/mL
S4682 Loxoprofen <1 mg/mL 49 mg/mL 49 mg/mL
S8141 Cl-amidine 70 mg/mL 84 mg/mL 84 mg/mL
S3027 Fenoprofen calcium hydrate <1 mg/mL 48 mg/mL 18 mg/mL
S8097 C-DIM12 <1 mg/mL 71 mg/mL 71 mg/mL
S2350 Rutin <1 mg/mL 100 mg/mL 2 mg/mL
S3106 Pidotimod 10 mg/mL 49 mg/mL <1 mg/mL
S4515 Ademetionine disulfate tosylate 79 mg/mL 79 mg/mL <1 mg/mL
S4690 Escin <1 mg/mL 66 mg/mL <1 mg/mL
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
A2009

Rituximab

Rituximab is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD.

A2001

Ipilimumab

Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD.

S2286

Cyclosporin A

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

S5004

Pimecrolimus

Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.

S3032

Bindarit

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

S1591

Bestatin

Bestatin is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.

S8660

GI254023X

GI254023X is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.

S5661

Tiaprofenic acid

Tiaprofenic acid is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.

S5412

Loxoprofen Sodium

Loxoprofen sodium is a non-steroidal anti-inflammatory drug.

S5361

Bendazac

Bendazac is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation.

S5360

Diflorasone

Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties.

S5466

Saikosaponin A

Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inflammatory, immunomodulatory, and anti-bacterial activities.

S7732

ISO-1

ISO-1 is an inhibitor of MIF (Macrophage migration inhibitory factor) D-dopachrome tautomerase activity with an IC50 of ~7 μM.

S3778

Patchouli alcohol

Patchouli alcohol, an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.

S3892

Isopsoralen

Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.

S3758

Cucoline hydrochloride, Kukoline hydrochloride, Sabianine A hydrochloride

Sinomenine (SN), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.

S3827

Royal jelly acid

Royal jelly acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.

S3680

NLRP3 Inflammasome Inhibitor I

NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.

S3622

Diammonium Glycyrrhizinate

Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.

S3608

Demethylzeylasteral (T-96)

Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.

S1622

Prednisone

Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

S1514

Cyclosporine

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

S1576

Sulfasalazine

Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis.

S1654

Phenylbutazone

Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.

S2512

Tenoxicam

Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM.

S4268

Flufenamic acid

Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.

S8559

INF39

INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.

S7809

MCC950(CP-456773)

MCC950 sodium salt is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.

S8291

Atractylenolide I

Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.

S8522

Compstatin

Compstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.

S4753

Ganoderic acid A

Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.

S7434

TAPI-1

TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.

S1829

Pranlukast

Pranlukast is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.

S7211

PF-04418948

PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.

S3726

Selexipag

Selexipag is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).

S1407

Bimatoprost

Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

S1508

Alprostadil

Alprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.

S4529

Idramantone

Idramantone is an immune agonist.

S4709

Latanoprost

Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.

A2009

Rituximab

Rituximab is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD.

A2001

Ipilimumab

Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD.

S2286

Cyclosporin A

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

S5004

Pimecrolimus

Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.

S3032

Bindarit

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

S1591

Bestatin

Bestatin is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.

S8660

GI254023X

GI254023X is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.

S5661

Tiaprofenic acid

Tiaprofenic acid is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.

S5412

Loxoprofen Sodium

Loxoprofen sodium is a non-steroidal anti-inflammatory drug.

S5361

Bendazac

Bendazac is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation.

S5360

Diflorasone

Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties.

S5466

Saikosaponin A

Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inflammatory, immunomodulatory, and anti-bacterial activities.

S7732

ISO-1

ISO-1 is an inhibitor of MIF (Macrophage migration inhibitory factor) D-dopachrome tautomerase activity with an IC50 of ~7 μM.

S3778

Patchouli alcohol

Patchouli alcohol, an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.

S3892

Isopsoralen

Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.

S3758

Cucoline hydrochloride, Kukoline hydrochloride, Sabianine A hydrochloride

Sinomenine (SN), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.

S3827

Royal jelly acid

Royal jelly acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.

S3680

NLRP3 Inflammasome Inhibitor I

NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.

S3622

Diammonium Glycyrrhizinate

Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.

S3608

Demethylzeylasteral (T-96)

Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.

S1622

Prednisone

Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

S1514

Cyclosporine

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

S1576

Sulfasalazine

Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis.

S1654

Phenylbutazone

Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.

S2512

Tenoxicam

Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM.

S4268

Flufenamic acid

Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.

S8559

INF39

INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.

S7809

MCC950(CP-456773)

MCC950 sodium salt is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.

S8291

Atractylenolide I

Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.

S8522

Compstatin

Compstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.

S4753

Ganoderic acid A

Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.

S7434

TAPI-1

TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.

S1211

Imiquimod

Imiquimod is a novel synthetic agent with immune response modifying activity.

S5737

Diclofenac Epolamine

Diclofenac Epolamine is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.

S5648

Iguratimod

Iguratimod is a small molecule compound with anti-inflammatory and immunomodulatory actions and used for the treatment of rheumatoid arthritis.

S5501

Hydrocortisone acetate

Hydrocortisone Acetate is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.

S5500

Amodiaquine hydrochloride

Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.

S3969

Veratric acid

Veratric acid, a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects.

S5322

Sodium gualenate

Sodium gualenate (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound, which is gradually decomposed in the solid state at room temperature. It has anti-inflammatory and wound-healing effects.

S5579

Chelidonic acid

Chelidonic acid is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals.

S5451

Ferulic acid methyl ester

Methyl ferulate is a lipophilic derivative of ferulic acid, which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer.

S5457

Curculigoside

Curculigoside, a diterpenoid triepoxide, is one of the main bioactive phenolic compounds isolated from the rhizome of Curculigo orchioides Gaertn. and has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects.

S5458

Verbascoside

Verbascoside, a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant.

S5459

Aucubin

Aucubin, an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages.

S5463

Curcurbitacin IIA

Cucurbitacin IIa (CuIIa) is the major active component of the Helmseya amabilis root and is known to have antiviral and anti-inflammatory effects.

S5471

Monotropein

Monotropein, an iridoids glycoside isolated from the roots of Morinda officinalis How, has been demonstrated to exhibit anti-inflammatory activity.

S5517

Fenamic acid

Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid.

S5261

Ufenamate

Ufenamate is an anthranilic acid derivative with anti-inflammatory activity.

S5318

Acacetin

Acacetin is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.

S3776

Sophoricoside

Sophoricoside (SOPH) is an isoflavone isolated from Sophora japonica (Leguminosae) with numerous pharmacological effects, including anti- inflammatory, anti-cancer and immunosuppressive effects.

S5043

Benorylate

Benorylate is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.

S5016

Isoprinosine

Isoprinosine is an immunopharmacologic agent with antiviral activities.

S5044

Isoxepac

Isoxepac is a non-steroidal arylacetic acid derivative with anti-inflammatory, analgesic and antipyretic activity.

S5046

Clonixin

Clonixin is a nonsteroidal anti-inflammatory drug with analgesic, antipyretic, and platelet-inhibitory actions.

S4966

4-Methylesculetin

4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.

S4832

Tolmetin

Tolmetin is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.

S4835

Aceclofenac

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.

S3997

Oxaceprol

Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis.

S4789

5-Acetylsalicylic acid

5-Acetylsalicylic acid, also known as Mesalazine or Mesalamine, is an aminosalicylate anti-inflammatory drug used to treat inflammatory bowel disease.

S5157

Thymol

Thymol, a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.

S3982

Batyl alcohol

Batyl alcohol, isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent.

S3906

Astragalus polyphenols

Astragalus is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body. It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions.

S3877

Lysionotin

Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.

S3881

Scopoletin

Scopoletin is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.

S3813

Bakuchiol

Bakuchiol is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.

S3790

Methyl gallate

Methyl Gallate is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.

S3799

Gentisic acid

Gentisic acid, an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties.

S3765

Picroside II

Picroside II is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

S3774

Dehydroandrographolide Succinate Potasium Salt

Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.

S3775

Ligustrazine hydrochloride

Tetramethylpyrazine, also known as ligustrazine, is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

S3932

Astilbin

Astilbin, a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.

S3871

Muscone

Muscone, a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent.

S3837

Echinocystic acid

Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.

S3893

Bornyl acetate

Bornyl acetate, the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.

S3824

Quercitrin

Quercitrin (3-rhamnosyl quercetin), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.

S3841

Eleutheroside B

Eleutheroside B (syringin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.

S3761

Eucalyptol

Eucalyptol is a natural organic compound which controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.

S3956

Tetramethylpyrazine

Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

S3614

Lupeol

Lupeol is a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms with anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties.

S3685

4-Biphenylacetic acid

4-Biphenylacetic acid (BPA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Its interaction with quinolone antibacterial agents can induce functional blockade of the γ-aminobutyric acid receptors.

S3745

Balsalazide disodium

Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine.

S1439

Tranilast

Tranilast is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.

S2413

Geniposidic acid

Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders.

S1681

Mesalamine

Mesalamine is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.

S2910

Tempol

Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.

S1679

Flurbiprofen

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).

S3062

Diclofenac Potassium

Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

S4098

Halcinonide

Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.

S1823

Fenoprofen Calcium

Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.

S4152

Ethamsylate

Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.

S2383

Gastrodin

Gastrodin, an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.

S2387

Lappaconite HBr

Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.

S4165

Benzydamine HCl

Benzydamine hydrochloride is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.

S4170

Coumarin

Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.

S2400

Rheic Acid

Rhein (Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities.

S4188

Sasapyrine

Sasapyrine (salsalate) is a nonsteroidal oral anti-inflammatory agent.

S7448

CORM-3

CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

S4682

Loxoprofen

Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.

S8141

Cl-amidine

Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively.

S3027

Fenoprofen calcium hydrate

Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).

S4706

Eugenol

Eugenol is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity.

S8097

C-DIM12

C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.

S2350

Rutin

Rutin, a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.

S3106

Pidotimod

Pidotimod is an immunostimulant.

S4515

Ademetionine disulfate tosylate

Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.

S4690

Escin

Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut).

S4524

2-Ethoxybenzamide

2-Ethoxybenzamide is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains.