エストロゲン/プロゲストゲン受容体

シグナル伝達経路

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S8372 AZD9496 <1 mg/mL 88 mg/mL 88 mg/mL
S5364 DY131 <1 mg/mL 62 mg/mL <1 mg/mL
S1191 Fulvestrant <1 mg/mL 100 mg/mL 100 mg/mL
S1972 Tamoxifen Citrate <1 mg/mL 100 mg/mL 100 mg/mL
S1227 Raloxifene HCl <1 mg/mL 100 mg/mL <1 mg/mL
S2606 Mifepristone <1 mg/mL 85 mg/mL 19 mg/mL
S5437 4,4'-DDE -1 mg/mL 63 mg/mL -1 mg/mL
S4896 Elagolix Sodium 100 mg/mL 100 mg/mL 100 mg/mL
S7855 Brilanestrant (GDC-0810, ARN-810) <1 mg/mL 89 mg/mL 89 mg/mL
S8686 PHTPP <1 mg/mL 50 mg/mL 84 mg/mL
S2466 Estriol <1 mg/mL 57 mg/mL 10 mg/mL
S1238 Tamoxifen <1 mg/mL 74 mg/mL 74 mg/mL
S7839 Endoxifen HCl <1 mg/mL 74 mg/mL 74 mg/mL
S1709 Estradiol <1 mg/mL 54 mg/mL 5 mg/mL
S5288 Estropipate -1 mg/mL 87 mg/mL -1 mg/mL
S5676 Zearalenone <1 mg/mL 64 mg/mL 64 mg/mL
S5464 Psoralidin <1 mg/mL 67 mg/mL 1 mg/mL
S5469 Bavachin <1 mg/mL 64 mg/mL 45 mg/mL
S4883 Lynestrenol -1 mg/mL 56 mg/mL -1 mg/mL
S3929 Liquiritigenin -1 mg/mL 51 mg/mL -1 mg/mL
S2604 Dehydroepiandrosterone (DHEA) <1 mg/mL 57 mg/mL 57 mg/mL
S2450 Equol <1 mg/mL 48 mg/mL 48 mg/mL
S1727 Levonorgestrel <1 mg/mL 45 mg/mL 2 mg/mL
S2567 Medroxyprogesterone acetate <1 mg/mL 12 mg/mL 12 mg/mL
S2473 Hexestrol <1 mg/mL 42 mg/mL 42 mg/mL
S1705 Progesterone <1 mg/mL 22 mg/mL 63 mg/mL
S1859 Diethylstilbestrol <1 mg/mL 54 mg/mL 54 mg/mL
S1625 Ethinyl Estradiol <1 mg/mL 59 mg/mL 59 mg/mL
S3149 Estradiol valerate <1 mg/mL 71 mg/mL <1 mg/mL
S2125 Mestranol <1 mg/mL 15 mg/mL 25 mg/mL
S4110 Estradiol Benzoate <1 mg/mL 75 mg/mL <1 mg/mL
S3167 Altrenogest <1 mg/mL 62 mg/mL 2 mg/mL
S4046 Estradiol Cypionate <1 mg/mL 79 mg/mL 55 mg/mL
S4638 Desogestrel <1 mg/mL 62 mg/mL 62 mg/mL
S3657 Promestriene 3 mg/mL 65 mg/mL 65 mg/mL
S3635 Medroxyprogesterone <1 mg/mL 68 mg/mL 14 mg/mL
S4674 Hydroxyprogesterone caproate <1 mg/mL 85 mg/mL 85 mg/mL
S3671 Quinestrol <1 mg/mL 72 mg/mL 72 mg/mL
S3718 Leuprolide Acetate 100 mg/mL 100 mg/mL 100 mg/mL
S4507 17-Hydroxyprogesterone <1 mg/mL 66 mg/mL 66 mg/mL
S4673 Etonogestrel <1 mg/mL 64 mg/mL 64 mg/mL
S7828 Licochalcone A <1 mg/mL 67 mg/mL 67 mg/mL
S3160 Ethynodiol diacetate 77 mg/mL 77 mg/mL <1 mg/mL
S2611 Ethisterone <1 mg/mL 0.05 mg/mL <1 mg/mL
S5393 Cyclofenil -1 mg/mL 21 mg/mL -1 mg/mL
S1776 Toremifene Citrate <1 mg/mL 100 mg/mL <1 mg/mL
S2128 Bazedoxifene HCl <1 mg/mL 101 mg/mL <1 mg/mL
S2561 Clomifene citrate <1 mg/mL 120 mg/mL 11 mg/mL
S3081 Ulipristal <1 mg/mL 83 mg/mL 14 mg/mL
S1914 Pregnenolone <1 mg/mL 22 mg/mL 22 mg/mL
S2167 Bazedoxifene Acetate <1 mg/mL 100 mg/mL 25 mg/mL
S4629 Chlorotrianisene <1 mg/mL 76 mg/mL <1 mg/mL
S7827 4-Hydroxytamoxifen <1 mg/mL 77 mg/mL <1 mg/mL
S2314 Kaempferol <1 mg/mL 57 mg/mL 3 mg/mL
S4285 Ospemifene <1 mg/mL 75 mg/mL 71 mg/mL
S1376 Gestodene <1 mg/mL 62 mg/mL 8 mg/mL
S1377 Drospirenone <1 mg/mL 73 mg/mL 11 mg/mL
S1665 Estrone <1 mg/mL 54 mg/mL <1 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S9506

Danazol

Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins.

S8372

AZD9496

AZD9496 is an oral estrogen receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models.

S5364

DY131

DY131 is a potent and selective ERRβ/γ activator. It has no effect on the structurally related receptors ERRalpha or the estrogen receptors alpha and beta (ERalpha/beta).

S1191

Fulvestrant

Fulvestrant is an estrogen receptor (ER) antagonist with IC50 of 0.94 nM in a cell-free assay.

S1972

Tamoxifen Citrate

Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding.

S1227

Raloxifene HCl

Raloxifene is an estrogen antagonist, which inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.

S2606

Mifepristone

Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively.

S5437

4,4'-DDE

DDE, a breakdown product of DDT, is an organochlorine pesticide and may behave as a potent androgen receptor antagonist.

S4896

Elagolix Sodium

Elagolix Soidum is a potent, selective, orally active, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with Kd value of 54 pM. Concentration at 10 μM shows no significant activity on ion channels, enzymes, and transporters (inhibition <50%).

S7855

Brilanestrant (GDC-0810, ARN-810)

Brilanestrant (GDC-0810, ARN-810) is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors.

S8686

PHTPP

PHTPP is an ERβ selective antagonist with 36-fold selective for ER βover ERα.

S2466

Estriol

Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

S1238

Tamoxifen

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

S7839

Endoxifen HCl

Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2.

S1709

Estradiol

Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone.

S5288

Estropipate

Estropipate is a natural estrogenic substance composed of estrone sulfate and piperazine and is used mainly in menopausal hormone therapy in the treatment of menopausal symptoms.

S5676

Zearalenone

Zearalenone is a non-steroidal estrogenic mycotoxin that acts by binding the estrogen receptor (ER).

S5464

Psoralidin

Psoralidin, a naturally occurring coumestan isolated from the fractions of organic solvents such as ethylacetate, hexane, or n-butanol of the seed extract of Psoralea corylifolia L., has a variety of biological activities such as anticancer, antioxidant, antibacterial, antidepressant, anti-inflammatory activities, and regulation of insulin signaling. It is an agonist for both estrogen receptor (ER)α and ERβ with binding affinities (IC50s) of 1.03 and 24.6 μM, respectively.

S5469

Bavachin

Bavachin is a phytoestrogen purified from natural herbal plants such as Psoralea corylifolia. It acts as a weak phytoestrogen by binding and activating the ER.

S4883

Lynestrenol

Lynestrenol is a synthetic progestational hormone, an agonist of the progesterone receptor and has weak androgenic and estrogenic activity.

S3929

Liquiritigenin

Liquiritigenin, the most active estrogenic compound from the root of Glycyrrhizae uralensis Fisch, selectively binds to ERβ with an IC50 value of 7.5 μM and activates multiple ER regulatory elements and native target genes with Erβ but not ERα.

S2604

Dehydroepiandrosterone (DHEA)

Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.

S2450

Equol

Equol ,a metabolite of soybeans, is an important isoflavone in humans,specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.

S1727

Levonorgestrel

Levonorgestrel is a female hormone that prevents ovulation.

S2567

Medroxyprogesterone acetate

Medroxyprogesterone acetate (MPA) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.

S2473

Hexestrol

Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

S1705

Progesterone

Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.

S1859

Diethylstilbestrol

Diethylstilbestrol is a synthetic nonsteroidal estrogen, used to prevent miscarriage and other pregnancy complications.

S1625

Ethinyl Estradiol

Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.

S3149

Estradiol valerate

Estradiol is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.

S2125

Mestranol

Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives.

S4110

Estradiol Benzoate

Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.

S3167

Altrenogest

Altrenogest is a progestogen structurally related to veterinary steroid trenbolone.

S4046

Estradiol Cypionate

Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.

S4638

Desogestrel

Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.

S3657

Promestriene

Promestriene (3-propyl ethyl, 17B-methyl estradiol) is a synthetic estrogen analog that has been reported to significantly improve the symptoms of vaginal atrophy caused by estrogen deprivation in topical application.

S3635

Medroxyprogesterone

Medroxyprogesterone (MP) is a synthetic pregnane steroid and a derivative of progesterone. It is a potent progesterone receptor agonist.

S4674

Hydroxyprogesterone caproate

Hydroxyprogesterone Caproate is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibits ovulation and an alteration in the cervical mucus and endometrium.

S3671

Quinestrol

Quinestrol is a synthetic, steroidal estrogen which is used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer.

S3718

Leuprolide Acetate

Leuprolide acetate is a synthetic nonapeptide that is a potent gonadotropin-releasing hormone receptor (GnRHR) agonist used for diverse clinical applications, including the treatment of prostate cancer, endometriosis, uterine fibroids, central precocious puberty and in vitro fertilization techniques.

S4507

17-Hydroxyprogesterone

17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

S4673

Etonogestrel

Etonogestrel is a synthetic form of the naturally occurring female sex hormone progesterone. It binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression.

S7828

Licochalcone A

Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.

S3160

Ethynodiol diacetate

Ethynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills.

S2611

Ethisterone

Ethisterone is a progestogen hormone being considered to treat prostate cancer.

S5393

Cyclofenil

Cyclofenil is a selective estrogen receptor modulator showing a higher affinity for ERβ than Erα.

S1776

Toremifene Citrate

Toremifene Citrate is an oral selective estrogen receptor modulator (SERM), used in the treatment of advanced breast cancer.

S2128

Bazedoxifene HCl

Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.

S2561

Clomifene citrate

Clomifene Citrate is a selective estrogen receptor modulator, used in the treatment of ovulation induction.

S3081

Ulipristal

Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.

S1914

Pregnenolone

Pregnenolone is an endogenous steroid hormone, used in the treatment of fatigue, Alzheimer’s disease, trauma and injuries.

S2167

Bazedoxifene Acetate

Bazedoxifene Acetate is a third generation selective estrogen receptor modulator (SERM).

S4629

Chlorotrianisene

Chlorotrianisene is a synthetic, non-steroidal estrogen. It is a selective estrogen receptor modulator.

S7827

4-Hydroxytamoxifen

4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.

S2314

Kaempferol

Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.

S4285

Ospemifene

Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM), used for the treatment of dyspareunia.

S9122

Tectorigenin

Tectorigenin (TEC) is an isoflavone isolated from various medicinal plants, such as Pueraria thunbergiana Benth, Belamcanda chinensis, and Iris unguicularis. It has been reported to exert pharmacological actions, including antitumor and antibacterial effects, free radical neutralization, and selective estrogen receptor modulation.

S1376

Gestodene

Gestodene is a progestogen hormonal contraceptive.

S1377

Drospirenone

Drospirenone is a synthetic progestin that is an analog to spironolactone.

S1665

Estrone

Estrone is an estrogenic hormone.

×

平素は、格別のご愛顧を賜り厚く御礼申し上げます。
誠に勝手ながら、弊社では下記の期間を年末年始による休業とさせていただきます。
【休業期間】
2018年12月29日(土)から2019年1月6日(日)
休業期間中にいただきましたお問合せ等につきましては、2019年1月7日(月)以降の対応とさせていただきます。また、年内の出荷業務は2018年12月26日(水)までとさせていただきます。
ご不便をお掛けいたしますが、ご了承のほど何卒よろしくお願いいたします。