PDE

シグナル伝達経路

研究分野

阻害剤の選択性比較
溶解度

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S2131	Roflumilast	<1 mg/mL	81 mg/mL	15 mg/mL
S1431	Sildenafil Citrate	<1 mg/mL	20 mg/mL	<1 mg/mL
S1512	Tadalafil	<1 mg/mL	78 mg/mL	<1 mg/mL
S2515	Vardenafil HCl Trihydrate	10 mg/mL	100 mg/mL	20 mg/mL
S1550	Pimobendan	<1 mg/mL	67 mg/mL	5 mg/mL
S5837	BRL-50481	<1 mg/mL	49 mg/mL	49 mg/mL
S5836	IBMX	<1 mg/mL	44 mg/mL	7 mg/mL
S5806	Cilostamide	<1 mg/mL	6 mg/mL	5 mg/mL
S9436	Pinoresinol dimethyl ether	-1 mg/mL	77 mg/mL	-1 mg/mL
S2620	GSK256066	<1 mg/mL	5 mg/mL	<1 mg/mL
S2687	PF-2545920	<1 mg/mL	78 mg/mL	78 mg/mL
S1430	Rolipram	<1 mg/mL	55 mg/mL	55 mg/mL
S8034	Apremilast (CC-10004)	<1 mg/mL	92 mg/mL	<1 mg/mL
S1294	Cilostazol	<1 mg/mL	74 mg/mL	6 mg/mL
S4019	Avanafil	<1 mg/mL	97 mg/mL	<1 mg/mL
S2127	S- (+)-Rolipram	<1 mg/mL	55 mg/mL	55 mg/mL
S3172	Anagrelide HCl	<1 mg/mL	14 mg/mL	<1 mg/mL
S1504	Dyphylline	51 mg/mL	51 mg/mL	<1 mg/mL
S1895	Dipyridamole	<1 mg/mL	101 mg/mL	50 mg/mL
S4164	Doxofylline	24 mg/mL	53 mg/mL	2 mg/mL
S4090	Fenspiride HCl	59 mg/mL	9 mg/mL	<1 mg/mL
S4837	Ibudilast	30 mg/mL	46 mg/mL	46 mg/mL
S7224	Deltarasin	<1 mg/mL	100 mg/mL	100 mg/mL
S8459	TAK-063	<1 mg/mL	85 mg/mL	<1 mg/mL
S2291	Diosgenin	<1 mg/mL	<1 mg/mL	5 mg/mL
S2312	Icariin	<1 mg/mL	50 mg/mL	<1 mg/mL
S4683	Sildenafil Mesylate	100 mg/mL	100 mg/mL	4 mg/mL
S4684	Sildenafil	14 mg/mL	<1 mg/mL	<1 mg/mL
S2320	Luteolin	<1 mg/mL	57 mg/mL	3 mg/mL
S8218	PF-8380	<1 mg/mL	95 mg/mL	<1 mg/mL
S2368	Theobromine	<1 mg/mL	<1 mg/mL	<1 mg/mL
S9229	Linderane	-1 mg/mL	52 mg/mL	-1 mg/mL

亜型選択性的な製品

PDE製品

All (32) PDE阻害剤(31) PDE活性剤(1) 新PDE製品

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2131	Roflumilast Roflumilast is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM in a cell-free assay.	Cell Rep, 2014, 8(5):1265-70 Mol Cancer Ther, 2014, 13(10):2463-73 Int Immunopharmacol, 2016, 35:174-84	Mean plasma concentration versus time after single dose oral administration of IC87114 and RFM in wistar rats( n = 6).
S1431	Sildenafil Citrate Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.	Cancer Lett, 2016, 370(2):279-85 Mol Pharmacol, 2014, 85(3):408-19 Mol Pharmacol, 2014, 85(3):408-19	ADOR lung cancer cells (a July 2015 PDX model) were transfected with an empty vector plasmid or plasmids to express GRP78 and HSP27 together. Twenty-four hours after transfection cells were treated with vehicle control or with OSU-03012 (2.0mM) sildenafil (2mM) for 6 h after which cells were fixed in place and permeabilized using 0.5% Triton X100. Immuno-fluorescence was performed to detect the expression levels of Calnexin; glucosidase I; and glucosidase IIa at 10 magnification using a Hermes WiScan system.
S1512	Tadalafil Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM in a cell-free assay. Tadalafil is at least 9000 times more selective for PDE5 than most of the other families of PDEs, with the exception of PDE11. It can partial inhibits PDE11	J Hepatol, 2018, 10.1016/j.jhep.2018.10.040 Cancer Lett, 2016, 370(2):279-85 Cell Death Dis, 2014, 5:e1544	(a): E. coli bacteria transformed to be resistant to ampicillin and kayamycin (AMPr KAYAr) were grown in AMPt KAYAt media and cells treated with OSU-03012 (2 μM); sildenafil (2 μM); tadalafil (2 μM), or in combination as indicated. Bacterial cell numbers were determined by assessing the protein concentration of the bacterial cell pellet 3 h, 6h and 12 h after drug exposure * P<0.05 less than corresponding vehicle value. The total protein content of each treatment condition was determined 3 h after addition of antibiotic. Portions of bacteria from each treatment condition were isolated and SDS PAGE and immuno-blotting performed to determine the expression of Dna J, Dna K, RecA and GrpE. (b): E. coli bacteria Gram stained and examined under a X100 oil immersion magnification.
S2515	Vardenafil HCl Trihydrate Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.	Cancer Lett, 2016, 378(1):38-50 Cell Death Dis, 2014, 5:e1544 J Cell Physiol, 2014, 10.1002/jcp.24919	(G) Immunoblot analysis for TAZ and Nanog in PCSC after vardenafil treatments. (H) Cytotoxicity to DDP in PCSC treated with indicated concentrations of vardenafil. *p < 0.01, p < 0.05 versus PC3 cells, vardenafil at 0 μM, or DDP at 0 μM; ++p < 0.01, +p < 0.05 versus vardenafil at 0 μM.
S1550	Pimobendan Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
S5837^新	BRL-50481
S5836^新	IBMX Isobutylmethylxanthine (IBMX) is a nonspecific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an adenosine (A1) receptor antagonist.
S5806^新	Cilostamide Cilostamide is an inhibitor of type III phosphodiesterases with IC50 values of 27 nM and 50 nM for PDE3A and PDE3B, respectively.
S9436^新	Pinoresinol dimethyl ether Pinoresinol dimethyl ether, which could be isolated from the wood of the basal tree Humbertieae, show a variety of activities as the inhibitor of cyclic AMP phosphodiesterase.
S2620	GSK256066 GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.
S2687	PF-2545920 PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.	Oncogene, 2014, 10.1038/onc.2014.94 Front Mol Neurosci, 2017, 10:100 Biol Reprod, 2016, 94(5):110
S1430	Rolipram The PDE4 selective inhibitor, rolipram, inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.	Mol Cancer Ther, 2014, 13(10):2463-73 Mol Nutr Food Res, 2017, 10.1002/mnfr.201600966 Brain Res Bull, 2016, 121:255-62	D, average percentage difference of cell growth by PDE4D inhibitors between STK11 mutant and wild-type cell lines. The sensitivity on STK11mt cell lines represents the difference of average percentage growth between STK11-mutant (NCI-H1993 and NCI-H1395) and wild-type cell lines (NCI-H82 and NCI-H524). Average percentage growth of each cell line by a PDE4D inhibitor was based on the DMSO control. Cells were treated with a 20 μmol/L of PDE4D inhibitors for 3, 7, and 10 days incubation, respectively. The cell viability was determined using CellTiter-Blue fluorescence. , P < 0.01 and *, P < 0.05 in the difference between STK11-mutant and wild-type cell lines. All cells used in the experiment were cultured in normal conditioned RPMI medium with 10% FBS and 1% penicillin/streptavidin.
S8034	Apremilast (CC-10004) Apremilast (CC-10004) is a potent and orally active PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively.	Pharmacol Res, 2018, 128:244-251
S1294	Cilostazol Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
S4019	Avanafil Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.
S2127	S- (+)-Rolipram S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.
S3172	Anagrelide HCl Anagrelide is a drug used for the treatment of essential thrombocytosis.
S1504	Dyphylline Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects.
S1895	Dipyridamole Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.	Am J Hum Genet, 2017, 100(1):5-20
S4164	Doxofylline Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma.
S4090	Fenspiride HCl Fenspiride is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi.
S4837	Ibudilast Ibudilast is a relatively non-selective phosphodiesterase inhibitor with anti-inflammatory and neuroprotective activities.
S7224	Deltarasin Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with K_d of 38 nM for binding to purified PDEδ.
S8459	TAK-063 TAK-063 is a novel and selective phosphodiesterase 10A(PDE10A) inhibitor with an IC50 of 0.30 nM.
S2291	Diosgenin Diosgenin is a steroid sapogenin and the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills; A weak PDE inhibitor.
S2312	Icariin Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4.	Shandong University, 2014, Haoran Cui
S4683	Sildenafil Mesylate Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
S4684	Sildenafil Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.	Exp Ther Med, 2017, 13(6):2645-2650 J Cell Physiol, 2019, 234(4):4874-4887 Anticancer Res, 2018, 38(9):5149-5157	mRNA and protein expression levels of Id‑1 following treatment with 5 μM sildenafil for 24 h. (A) Relative mRNA expression levels of Id‑1 in the HemECs were significantly decreased by 44.2%, according to the 2‑ΔΔCq method (***P=0.0006 vs. control). (B) Western blotting revealed that the protein expression levels of Id‑1 markedly decreased following treatment with sildenafil when compared with the negative control. The TCA 8113 cell line was used as a positive control. HemECs, hemangioma endothelial cells; SIL, sildenafil; ID‑1, inhibitor of differentiation 1.
S2320	Luteolin Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.	Mol Nutr Food Res, 2017, 10.1002/mnfr.201600744 EBioMedicine, 2018, 36:18-28	Bioactive compounds inhibit recombinant HDAC activity. Recombinant HDACs were incubated with flavonoid Luteolin (C) for 2 h prior to the addition of cell permeable HDAC substrates. Luteolin inhibited activity of most classes I, IIa, and IIb HDAC isoforms.
S8218	PF-8380 PF-8380 is a potent autotaxin inhibitor with IC50 of 2.8nM in an in vitro enzyme assay.
S2368	Theobromine Theobromine is a xanthine alkaloid widely consumed as stimulants and snacks in coffee and cocoa based foods and most often as part of ingredients in drugs.
S9229^新	Linderane Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2131	Roflumilast Roflumilast is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM in a cell-free assay.	Cell Rep, 2014, 8(5):1265-70 Mol Cancer Ther, 2014, 13(10):2463-73 Int Immunopharmacol, 2016, 35:174-84	Mean plasma concentration versus time after single dose oral administration of IC87114 and RFM in wistar rats( n = 6).
S1431	Sildenafil Citrate Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.	Cancer Lett, 2016, 370(2):279-85 Mol Pharmacol, 2014, 85(3):408-19 Mol Pharmacol, 2014, 85(3):408-19	ADOR lung cancer cells (a July 2015 PDX model) were transfected with an empty vector plasmid or plasmids to express GRP78 and HSP27 together. Twenty-four hours after transfection cells were treated with vehicle control or with OSU-03012 (2.0mM) sildenafil (2mM) for 6 h after which cells were fixed in place and permeabilized using 0.5% Triton X100. Immuno-fluorescence was performed to detect the expression levels of Calnexin; glucosidase I; and glucosidase IIa at 10 magnification using a Hermes WiScan system.
S1512	Tadalafil Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM in a cell-free assay. Tadalafil is at least 9000 times more selective for PDE5 than most of the other families of PDEs, with the exception of PDE11. It can partial inhibits PDE11	J Hepatol, 2018, 10.1016/j.jhep.2018.10.040 Cancer Lett, 2016, 370(2):279-85 Cell Death Dis, 2014, 5:e1544	(a): E. coli bacteria transformed to be resistant to ampicillin and kayamycin (AMPr KAYAr) were grown in AMPt KAYAt media and cells treated with OSU-03012 (2 μM); sildenafil (2 μM); tadalafil (2 μM), or in combination as indicated. Bacterial cell numbers were determined by assessing the protein concentration of the bacterial cell pellet 3 h, 6h and 12 h after drug exposure * P<0.05 less than corresponding vehicle value. The total protein content of each treatment condition was determined 3 h after addition of antibiotic. Portions of bacteria from each treatment condition were isolated and SDS PAGE and immuno-blotting performed to determine the expression of Dna J, Dna K, RecA and GrpE. (b): E. coli bacteria Gram stained and examined under a X100 oil immersion magnification.
S2515	Vardenafil HCl Trihydrate Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.	Cancer Lett, 2016, 378(1):38-50 Cell Death Dis, 2014, 5:e1544 J Cell Physiol, 2014, 10.1002/jcp.24919	(G) Immunoblot analysis for TAZ and Nanog in PCSC after vardenafil treatments. (H) Cytotoxicity to DDP in PCSC treated with indicated concentrations of vardenafil. *p < 0.01, p < 0.05 versus PC3 cells, vardenafil at 0 μM, or DDP at 0 μM; ++p < 0.01, +p < 0.05 versus vardenafil at 0 μM.
S1550	Pimobendan Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
S5837^新	BRL-50481
S5836^新	IBMX Isobutylmethylxanthine (IBMX) is a nonspecific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an adenosine (A1) receptor antagonist.
S5806^新	Cilostamide Cilostamide is an inhibitor of type III phosphodiesterases with IC50 values of 27 nM and 50 nM for PDE3A and PDE3B, respectively.
S9436^新	Pinoresinol dimethyl ether Pinoresinol dimethyl ether, which could be isolated from the wood of the basal tree Humbertieae, show a variety of activities as the inhibitor of cyclic AMP phosphodiesterase.
S2620	GSK256066 GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.
S2687	PF-2545920 PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.	Oncogene, 2014, 10.1038/onc.2014.94 Front Mol Neurosci, 2017, 10:100 Biol Reprod, 2016, 94(5):110
S1430	Rolipram The PDE4 selective inhibitor, rolipram, inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.	Mol Cancer Ther, 2014, 13(10):2463-73 Mol Nutr Food Res, 2017, 10.1002/mnfr.201600966 Brain Res Bull, 2016, 121:255-62	D, average percentage difference of cell growth by PDE4D inhibitors between STK11 mutant and wild-type cell lines. The sensitivity on STK11mt cell lines represents the difference of average percentage growth between STK11-mutant (NCI-H1993 and NCI-H1395) and wild-type cell lines (NCI-H82 and NCI-H524). Average percentage growth of each cell line by a PDE4D inhibitor was based on the DMSO control. Cells were treated with a 20 μmol/L of PDE4D inhibitors for 3, 7, and 10 days incubation, respectively. The cell viability was determined using CellTiter-Blue fluorescence. , P < 0.01 and *, P < 0.05 in the difference between STK11-mutant and wild-type cell lines. All cells used in the experiment were cultured in normal conditioned RPMI medium with 10% FBS and 1% penicillin/streptavidin.
S8034	Apremilast (CC-10004) Apremilast (CC-10004) is a potent and orally active PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively.	Pharmacol Res, 2018, 128:244-251
S1294	Cilostazol Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
S4019	Avanafil Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.
S2127	S- (+)-Rolipram S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.
S3172	Anagrelide HCl Anagrelide is a drug used for the treatment of essential thrombocytosis.
S1504	Dyphylline Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects.
S1895	Dipyridamole Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.	Am J Hum Genet, 2017, 100(1):5-20
S4164	Doxofylline Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma.
S4090	Fenspiride HCl Fenspiride is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi.
S4837	Ibudilast Ibudilast is a relatively non-selective phosphodiesterase inhibitor with anti-inflammatory and neuroprotective activities.
S7224	Deltarasin Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with K_d of 38 nM for binding to purified PDEδ.
S8459	TAK-063 TAK-063 is a novel and selective phosphodiesterase 10A(PDE10A) inhibitor with an IC50 of 0.30 nM.
S2291	Diosgenin Diosgenin is a steroid sapogenin and the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills; A weak PDE inhibitor.
S2312	Icariin Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4.	Shandong University, 2014, Haoran Cui
S4683	Sildenafil Mesylate Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
S4684	Sildenafil Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.	Exp Ther Med, 2017, 13(6):2645-2650 J Cell Physiol, 2019, 234(4):4874-4887 Anticancer Res, 2018, 38(9):5149-5157	mRNA and protein expression levels of Id‑1 following treatment with 5 μM sildenafil for 24 h. (A) Relative mRNA expression levels of Id‑1 in the HemECs were significantly decreased by 44.2%, according to the 2‑ΔΔCq method (***P=0.0006 vs. control). (B) Western blotting revealed that the protein expression levels of Id‑1 markedly decreased following treatment with sildenafil when compared with the negative control. The TCA 8113 cell line was used as a positive control. HemECs, hemangioma endothelial cells; SIL, sildenafil; ID‑1, inhibitor of differentiation 1.
S2320	Luteolin Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.	Mol Nutr Food Res, 2017, 10.1002/mnfr.201600744 EBioMedicine, 2018, 36:18-28	Bioactive compounds inhibit recombinant HDAC activity. Recombinant HDACs were incubated with flavonoid Luteolin (C) for 2 h prior to the addition of cell permeable HDAC substrates. Luteolin inhibited activity of most classes I, IIa, and IIb HDAC isoforms.
S8218	PF-8380 PF-8380 is a potent autotaxin inhibitor with IC50 of 2.8nM in an in vitro enzyme assay.
S2368	Theobromine Theobromine is a xanthine alkaloid widely consumed as stimulants and snacks in coffee and cocoa based foods and most often as part of ingredients in drugs.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S9229^新	Linderane Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache.

製品コード

製品説明

文献中Selleckの製品使用例

お客様のフィードバック

S9229^新

Linderane

Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache.

研究分野別

製品類型

PDE

シグナル伝達経路

研究分野

亜型選択性的な製品

PDE製品