Palbociclib (PD-0332991) HCl

Licensed by Pfizer 製品コードS1116

Palbociclib (PD-0332991) HCl化学構造

分子量(MW):483.99

Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.

サイズ 価格(税別)  
JPY 20200
JPY 30200
JPY 96600
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文献中Selleckの製品使用例(48)

製品安全説明書

CDK阻害剤の選択性比較

生物活性

製品説明 Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.
特性 Non-cytotoxic, and halts cancer cell growth & could be used in glioblastoma that has relapsed after temozolomide treatment (a chemotherapeutic used to treat many cancers).
ターゲット
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外試験

PD 0332991 has little effect on other protein kinases including EGFR, FGFR, PGFR, IR. PD 0332991 is a non-ATP competitive inhibitor of Cdk4. PD 0332991 inhibits MDA-MB-435 breast carcinoma cells with IC50 of 66 nM, which is due to reduced Rb phosphorylation at Ser780. PD 0332991 inhibits thymidine incorporation into the DNA of Rb-positive human breast, colon, and lung carcinomas as well as human leukemias, with IC50 values ranging from 0.04-0.17 μM. PD 0332991 shows no activity in Rb-negative cells. PD 0332991 causes an accumulation of cells in G1 in MDA-MB-453 breast and Colo-205 carcinoma cells. [1] PD 0332991 also shows activity in 5T33MM myeloma cells (immunocompetent model) and sensitizes the cells to killing by bortezomib. [2] PD 0332991 inhibits luminal ER-positive as well as HER2-amplified breast cancer cell lines including MDA-MB-175, ZR-75-30, CAMA-1, MDA-MB-134, HCC-202 and UACC-893. PD 0332991 enhances the activity of tamoxifen and trastuzumab in these cell lines. PD 0332991 enhances the sensitivity of tamoxifen in the MCF7 tamoxifen-resistant cells. [3] A recent study shows that PD 0332991 could suppress malignant rhabdoid tumor (MRT) cell lines including MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS and the sensitivity of the MRT cell lines to PD 0332991 is inversely correlated with expression of p16. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 NXz0O5FtU2mwYYPlJGF{e2G7 MVuyOEBp NXnjZnFwUW6qaXLpeIlwdiCxZjDDSGs1KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhWmJicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxOiEQvF2= NFTPe|AzPDZ2MUGwNy=>
COLO205 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LsN|czKGh? NYTSVGhHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX7jc5Jxd3KjdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlvfG9iRF7BJJdqfGhiSVO1NEBw\iByLkCzOkDPxE1? M4jQZ|I1PjRzMUCz
U937 M{fzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjBfY04OiCq NFXXW3FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMUSg{txO M1vtblI1PjRzMUCz
MOLM13 NXzqXIx[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDSO|IhcA>? MoLBRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPT1zNNVMh[2WubIOgbIFz[m:{aX7nJGZNXDNiSWTEJI12fGGwdDDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmViaX70c{BFVkFid3n0bEBKSzVyIH;mJFAvODl4IN88US=> NIP1ZYszPDZ2MUGwNy=>
MOLM13 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkX1O|IhcA>? MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IIPvdoFn\W6rYj3y[ZNqe3SjboSgbJVu[W5iTV;MUVE{KGOnbHzzJIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5yOU[g{txO NXr2U2pzOjR4NEGxNFM>
MDA-MB-435 M3TwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzKNlQhcA>? MUHJR|UxRTBwMU[g{txO MlLnNVU5ODF6M{G=
K562 M17NO2N6fG:2b4jpZ{BCe3OjeR?= NUT2eFRSQTZiaB?= MkS4SG1UVw>? MmGzTWM2OD1{IN88US=> MWOyOFQyPzV4Nh?=
DU145 M1zCXWN6fG:2b4jpZ{BCe3OjeR?= MWS5OkBp M3TXfGROW09? MnWxTWM2OD15LkWg{txO NUO4TWdCOjR2MUe1OlY>
MDA-MB-231 M2TIXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHxNUDPxE1? MXGyOEBp NYTtOG9LTE2VTx?= MV3D[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgS|EheGijc3W= NITnfFUzPDRzN{W2Oi=>
MCF7 NUC0dFhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfjXHV{OSEQvF2= M2XCWVI1KGh? MVvEUXNQ Mn:0R4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JGcyKHCqYYPl MkfENlQ1OTd3Nk[=
MCF7 NXPwUmVUU2mwYYPlJGF{e2G7 MlnWOUDPxE1? NXTD[|BmOjRiaB?= MULEUXNQ M{my[GlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgR2RMPC:leXPsbY5FOSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHKndHnuc4Jt[XO2b33hJJBpd3OyaH;yfYxifGmxbjDheEBU\XJ5OEC= NEX1VG0zPDRzN{W2Oi=>
MDA-MB-231 M{[4cmtqdmG|ZTDBd5NigQ>? MmXpOUDPxE1? NH;NN2ozPCCq MVvEUXNQ MWDJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFPET|Qw[3mlbHnuSFEh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBz\XSrbn;icIF{fG:vYTDwbI9{eGixconsZZRqd25iYYSgV4VzPzhy NX3h[mtHOjR2MUe1OlY>
MDA-MB-231 MV7GeY5kfGmxbjDBd5NigQ>? MkLZNU0yOCEQvF2= M{PHT|I1KGh? MkTJSG1UVw>? M360[4Rw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhWEGUUDDjcIVifmGpZR?= NHLOTVQzPDRzN{W2Oi=>
MCF7 MUTGeY5kfGmxbjDBd5NigQ>? MXmxMVExKM7:TR?= M4DqU|I1KGh? M4LwZWROW09? MXTkc4V{KG6xdDDpcoR2[2ViYYDvdJRwe2m|IHHzd4V{e2WmIHHzJHBCWlBiY3zlZZZi\2V? M33Lb|I1PDF5NU[2
MDA-MB-231 M1\MfmZ2dmO2aX;uJGF{e2G7 M3LSTlAvPS1zIN88US=> M2\BXlQ5KGh? MVHEUXNQ MVLoZZMhdm9iQ3XscEBkgWOuZTDhdpJme3RiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IIP1Zk1IOSCyaHHz[S=> MljiNlQ1OTd3Nk[=
MCF7 MV;GeY5kfGmxbjDBd5NigQ>? M37afVAvPS1zIN88US=> M4rXTVQ5KGh? NV3DUohoTE2VTx?= MlvHbIF{KG6xIFPlcIwh[3mlbHWgZZJz\XO2IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDzeYIuTzFicHjhd4U> NHjGSGIzPDRzN{W2Oi=>
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SK-NEP-1 M3iybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJ{MD6wNkBvVQ>? NWj4UVk6W0GQR1XS
MHH-NB-11 NELkdGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfBTWM2OD1{MkCuNVkhdk1? MoPsV2FPT0WU
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LAMA-84 MlLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TRW2lEPTB;MkW4MlE6KG6P M1e1Z3NCVkeHUh?=
MOLT-16 M3Pwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:1T4NKSzVyPUK1PE41QSCwTR?= M1fSbHNCVkeHUh?=
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RT-112 M2Lnd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzaTWM2OD1|MkGuNFUhdk1? NH3y[FhUSU6JRWK=
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MOLT-4 NVvtRlBrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDETWM2OD1|NEWuNVMhdk1? MWPTRW5ITVJ?
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SK-N-AS MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4OyV2lEPTB;M{i3Mlg{KG6P M3viSnNCVkeHUh?=
CTB-1 MoTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTRyNT6wNkBvVQ>? NHL6OXpUSU6JRWK=
NKM-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTRzMT64PUBvVQ>? NFzYSZpUSU6JRWK=
HTC-C3 MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzPU4tKSzVyPUSzNk46PSCwTR?= MoKzV2FPT0WU
BE-13 M{TGfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnm3TWM2OD12NESuNlchdk1? MoHxV2FPT0WU
KOSC-2 NX\ZWIlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrpWm5RUUN3ME20OlYvQSCwTR?= NV[4dXc2W0GQR1XS
NB14 NYG1T2o5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjxTYtKSzVyPUS4N{42QCCwTR?= MoXEV2FPT0WU
CAL-27 M3;m[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4T5W2lEPTB;NEm0MlU6KG6P M2PUbXNCVkeHUh?=
H9 M1fFXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVG0ZYNVUUN3ME20PVUvPDNibl2= MWDTRW5ITVJ?
RS4-11 NHfTPZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPnN45lUUN3ME21NFQvPzNibl2= NUW0bVY4W0GQR1XS
PA-1 NEDBSIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3OVYNKSzVyPUWwPU45PiCwTR?= M36yNHNCVkeHUh?=
MV-4-11 NXnzbY5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLVTWM2OD13MUOuPFUhdk1? NYHDOYsyW0GQR1XS
OS-RC-2 Ml3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv3TWM2OD13MkGuOlIhdk1? MVjTRW5ITVJ?
RPMI-8226 NETVRW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTV{Nj64OkBvVQ>? MUfTRW5ITVJ?
HGC-27 NE\tNXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\6ZnJLUUN3ME21OlQvQTlibl2= M4q5VnNCVkeHUh?=
CHP-212 NX7WdXVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPhOXRKSzVyPUW5N{42QSCwTR?= NGPJPXFUSU6JRWK=
NB10 M2fL[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTV7OT6xPEBvVQ>? NHfmcI9USU6JRWK=
HH MlHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTV7OT60N{BvVQ>? M1vjZnNCVkeHUh?=
EW-16 NFn4THpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInZTWVKSzVyPU[wN{42OiCwTR?= NFLPe3dUSU6JRWK=
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HAL-01 NVzkcWpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofzTWM2OD14MEWuOlchdk1? NHTKUmxUSU6JRWK=
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MHH-PREB-1 NWfPc4JbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS5W2dKSzVyPU[zOk46QSCwTR?= NGHUdVFUSU6JRWK=
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NBsusSR M3r6cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\DN2lEPTB;N{SyMlk6KG6P NFLMNmtUSU6JRWK=
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RXF393 M2nF[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTITWM2OD16MUKuO|khdk1? M4\pTnNCVkeHUh?=
U251 M4nWfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LyPGlEPTB;OEGzMlg5KG6P M1rPeXNCVkeHUh?=
CAMA-1 NILWdHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXNTWM2OD16M{OuPVQhdk1? MlO4V2FPT0WU
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COLO-800 M3vPemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTh7Nz63PEBvVQ>? MXHTRW5ITVJ?
OVCAR-5 MnTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmT6TWM2OD17MECuNUBvVQ>? MlfXV2FPT0WU
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J-RT3-T3-5 M{nYTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rIR2lEPTB;OUO2MlA3KG6P M1HZRnNCVkeHUh?=
Mewo NGPaTVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jGTmlEPTB;OUO2MlYhdk1? MWjTRW5ITVJ?
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CAL-39 MnTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjDUnB2UUN3ME2xMlA4PTJ{IN88US=> NUPwSpg6W0GQR1XS
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QIMR-WIL NXWwb3FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDHOZdpUUN3ME2xMlE{OTN2IN88US=> NIOwWpdUSU6JRWK=
NCI-SNU-1 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\BNpZZUUN3ME2xMlE3OzV2IN88US=> NVHTNJdpW0GQR1XS
CGTH-W-1 NWfOZ5dTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFwMUexPFYh|ryP M1\hc3NCVkeHUh?=
MHH-ES-1 MkK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHRRYRKSzVyPUGuNVc6QDZizszN MXXTRW5ITVJ?
LB2241-RCC NFO1UWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHPTWM2OD1zLkG4OlIh|ryP M{\PfHNCVkeHUh?=
ML-2 NF\pNHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf3RXBwUUN3ME2xMlIxPzN2IN88US=> NGHGe|lUSU6JRWK=
COR-L23 NXrYSXJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;PTWM2OD1zLkKyPVM{KM7:TR?= NHrs[FRUSU6JRWK=
BFTC-905 M1zVPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTFwMkSyOlch|ryP MXPTRW5ITVJ?
Hs-578-T NY\Ze4VQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFwMkW4NVch|ryP NVLtWGltW0GQR1XS
KG-1 MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjhPJFyUUN3ME2xMlI3Pjh4IN88US=> MVzTRW5ITVJ?
HEL NHHEbHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDITWM2OD1zLkK5N|M5KM7:TR?= M4\pTnNCVkeHUh?=
A549 MnTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV74fXdTUUN3ME2xMlI6Ozl7IN88US=> NE\CXXlUSU6JRWK=
COLO-741 M1joUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzLTWM2OD1zLkOyNFg6KM7:TR?= NIrKRmpUSU6JRWK=
PC-3 M2DoVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1K1U2lEPTB;MT6zOVIzOSEQvF2= NVj2Z3loW0GQR1XS
HOS M4\OO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Tk[mlEPTB;MT6zOVI6PiEQvF2= M1rLenNCVkeHUh?=
HT-1080 NGr3UYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq2TWM2OD1zLkO3OVE6KM7:TR?= MlXrV2FPT0WU
TE-8 NHPYXI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETaVoFKSzVyPUGuOFE4PzRizszN MVLTRW5ITVJ?
BHY MnL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTFwNE[5NlMh|ryP MkfNV2FPT0WU
BB65-RCC MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHidpFKSzVyPUGuOVA2OjhizszN MX;TRW5ITVJ?
HN MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfGc3pKUUN3ME2xMlU1ODdzIN88US=> NFmxd3dUSU6JRWK=
NCI-H441 M1PsUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTsXYlKSzVyPUGuOVQ6ODdizszN NI\jSIFUSU6JRWK=
RPMI-8866 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLhNpJKSzVyPUGuOVg2ODdizszN MknXV2FPT0WU
CAL-62 NX7RbXF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXFTWM2OD1zLk[wPFYzKM7:TR?= MmP4V2FPT0WU
MG-63 M4\5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTUfHNyUUN3ME2xMlYyQDF|IN88US=> Mo\TV2FPT0WU
SK-LU-1 M4L2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HwWGlEPTB;MT62NlE2OiEQvF2= M33EdXNCVkeHUh?=
BCPAP M37ycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHiwc4FKSzVyPUGuOlY1PTdizszN M{j3V3NCVkeHUh?=
22RV1 NFy3UGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTnTWM2OD1zLk[3PFQ{KM7:TR?= NUTkeGNoW0GQR1XS
T47D MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTFwNkiwOlEh|ryP MmTmV2FPT0WU
MSTO-211H MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LNXWlEPTB;MT62PVYxOyEQvF2= NHPQdolUSU6JRWK=
DEL NWTYdXdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XDcmlEPTB;MT63NFI4OyEQvF2= M{O3dXNCVkeHUh?=
H4 Mkm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTFwN{OyNVIh|ryP M4PCRnNCVkeHUh?=
CAL-51 NV7xWWdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTFwN{S4OVUh|ryP MXXTRW5ITVJ?
ABC-1 NE\NUZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTFwN{i1PFIh|ryP NYflOJBOW0GQR1XS
MZ2-MEL MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HESWlEPTB;MT63PVU1OiEQvF2= NI\DWGhUSU6JRWK=
YKG-1 NIPJfIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzXcGljUUN3ME2xMlgyODZzIN88US=> MYXTRW5ITVJ?
KM12 NXHrcIl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP5TWM2OD1zLkixOlAzKM7:TR?= MUPTRW5ITVJ?
L-363 NY\YTY51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkCzTWM2OD1zLki3OFEzKM7:TR?= NHvr[ZZUSU6JRWK=
KU812 M1XvWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LPT2lEPTB;MT64PVI5OiEQvF2= MXnTRW5ITVJ?
LOXIMVI MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MortTWM2OD1zLkmxNlI5KM7:TR?= MUjTRW5ITVJ?
G-401 Mk\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEj5ZVdKSzVyPUGuPVI1OjhizszN M4fRfnNCVkeHUh?=
SW780 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLYVW1qUUN3ME2xMlk3OjR4IN88US=> NVnLUpBlW0GQR1XS
SW872 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF61SppKSzVyPUGuPVg{OyEQvF2= NHvLWppUSU6JRWK=
NB7 NVzFfnRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjoW45jUUN3ME2xMlk6OzJ|IN88US=> NFrqcZVUSU6JRWK=
T98G M3Xw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\CUWlEPTB;Mj6wNFY3PiEQvF2= MXHTRW5ITVJ?
SW1710 M1X1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1W0V2lEPTB;Mj6wOlk1PSEQvF2= MoLCV2FPT0WU
NCI-H1573 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTJwMEeyPVgh|ryP MoDGV2FPT0WU
KE-37 NEX5W5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJwMEi5OVEh|ryP NFvBOo1USU6JRWK=
786-0 M1XrV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJwMUW0N|kh|ryP NYfGbld[W0GQR1XS
SAS NIfaU2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLOSIJKSzVyPUKuNlA{PzRizszN Ml3HV2FPT0WU
CAL-54 NXXCS2lWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHJ[25KSzVyPUKuNlA1OTNizszN NW\SdGFPW0GQR1XS
SF268 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTJwMkOxNlIh|ryP MmTrV2FPT0WU
SW620 MlXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fzTWlEPTB;Mj6yOlE3QSEQvF2= NW\IPWd3W0GQR1XS
MN-60 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTnTWM2OD1{LkOxNFYh|ryP MUfTRW5ITVJ?
EFO-27 NGf4NnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVj0PZhbUUN3ME2yMlMzODV6IN88US=> MV;TRW5ITVJ?
NCI-H747 M3Pwdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj2TWM2OD1{LkOyNVk6KM7:TR?= NGnISoFUSU6JRWK=
HCC2218 NYnHfHJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLJfHVxUUN3ME2yMlM2Ozd2IN88US=> NXi0S2FHW0GQR1XS
MIA-PaCa-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjJTWM2OD1{LkO2OFM4KM7:TR?= NHXaOJdUSU6JRWK=
SJSA-1 MlP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H2SmlEPTB;Mj6zO|c6PiEQvF2= NFzxXYdUSU6JRWK=
RKO NYXMS3l4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf2dplKSzVyPUKuN|g1QTZizszN MWrTRW5ITVJ?
NB6 MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LmZWlEPTB;Mj60NFM4PCEQvF2= M1LIRXNCVkeHUh?=
ES4 NH7ITIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjoWIpKSzVyPUKuOFU1OjJizszN NYi0UYU{W0GQR1XS
EGI-1 Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DzdmlEPTB;Mj60Olg5OyEQvF2= MnPGV2FPT0WU
CTV-1 MmLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojDTWM2OD1{LkWyO|c{KM7:TR?= M{LIZXNCVkeHUh?=
NCI-H1355 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJwNUW5OVEh|ryP MUTTRW5ITVJ?
GT3TKB NXz2[FhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknDTWM2OD1{LkW5NVk6KM7:TR?= NYT5UJI1W0GQR1XS
SK-HEP-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DLZmlEPTB;Mj61PVI3PiEQvF2= NI\vT2dUSU6JRWK=
GAMG M4PNXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnrfFZKSzVyPUKuOVk{QTRizszN MnP5V2FPT0WU
SK-MES-1 NHf4TXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPCbHZwUUN3ME2yMlYyQDB|IN88US=> MkjtV2FPT0WU
RO82-W-1 NIDpO4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13oWmlEPTB;Mj62NlA2PyEQvF2= MlXGV2FPT0WU
ECC10 MkK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkC1TWM2OD1{LkewNlA3KM7:TR?= M4m1WHNCVkeHUh?=
MCF7 MnjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;lVWlEPTB;Mj63NVQ3PCEQvF2= M4jqfHNCVkeHUh?=
D-283MED MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfxTWM2OD1{LkeyOFMh|ryP Ml33V2FPT0WU
RPMI-7951 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrJTWM2OD1{Lke1Olk1KM7:TR?= NWnaTZFbW0GQR1XS
Ramos-2G6-4C10 NWrrW41vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn32TWM2OD1{Lke3NFk6KM7:TR?= NYfwUXo5W0GQR1XS
KGN NIDyfFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr5TWM2OD1{LkixPFg1KM7:TR?= MUjTRW5ITVJ?
NUGC-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu1ZYh1UUN3ME2yMlgzPTB3IN88US=> NYXDSlJpW0GQR1XS
NCI-H292 NETEdmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz0fWhKSzVyPUKuPFUxPTNizszN MX\TRW5ITVJ?
Becker NHnYfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2C4d2lEPTB;Mj65OVg{OiEQvF2= M2rnWnNCVkeHUh?=
NCI-H1299 MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYD1WVFEUUN3ME2zMlA2OjZ|IN88US=> MYTTRW5ITVJ?
ETK-1 NEDpVmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTpTWM2OD1|LkC1OFMh|ryP M4iycHNCVkeHUh?=
TK10 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTNwMkCxOlUh|ryP M1n4XXNCVkeHUh?=
VMRC-RCZ M33Nb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnYTWM2OD1|LkO2OFg5KM7:TR?= MmrIV2FPT0WU
YH-13 NHvmZ5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml2xTWM2OD1|LkS0NFc6KM7:TR?= M1z3PHNCVkeHUh?=
DU-145 NE\LVnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTNwNE[yOlkh|ryP MmDoV2FPT0WU
SW1088 NVv0NG5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvyVplKSzVyPUOuOFc1PyEQvF2= M1T2UXNCVkeHUh?=
HOP-92 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTNwNUCzOFIh|ryP MoT2V2FPT0WU
KP-N-YS NHr5R3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTNwNkKxN|kh|ryP NUnXdll7W0GQR1XS
NCI-H460 NFjDe|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvFdoxHUUN3ME2zMlY3PzNizszN NYfIfmZKW0GQR1XS
U-2-OS MnPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTNwN{K1N|Uh|ryP NVvo[3NQW0GQR1XS
A101D MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTNwN{[5N|Yh|ryP M3HjVHNCVkeHUh?=
MDA-MB-231 M{[wU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXqU2NKSzVyPUOuPFE6PTFizszN MVrTRW5ITVJ?
IST-MES1 M1LWSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLUTWM2OD1|LkizNkDPxE1? MY\TRW5ITVJ?
COR-L105 NUm2WXpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7mTWM2OD12LkCxPEDPxE1? M3:yZnNCVkeHUh?=
NCI-H1437 MmfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYThflk5UUN3ME20MlAzOzB{IN88US=> M4PwPHNCVkeHUh?=
CAL-85-1 MnvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHPTWM2OD12LkCyOFYyKM7:TR?= MlfmV2FPT0WU
MZ1-PC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXx[JhKSzVyPUSuNVg2PTZizszN NIrONHlUSU6JRWK=
VM-CUB-1 NX7S[JRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfsPI5KSzVyPUSuN|EzQDRizszN NX3NWIJ4W0GQR1XS
CHL-1 Mo\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnFNpBQUUN3ME20MlMzOTZ7IN88US=> M3LiR3NCVkeHUh?=
MDA-MB-361 MkHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfOUmVHUUN3ME20MlM{OTV|IN88US=> NXfqXHZHW0GQR1XS
NCI-H661 NXjsd2FzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXGw[HcxUUN3ME20MlUxODl{IN88US=> MUXTRW5ITVJ?
EW-11 NYP2OZVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf0W5pZUUN3ME20MlUzOjNzIN88US=> M1nFW3NCVkeHUh?=
BEN M4fKdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vmfWlEPTB;ND61NlgyPSEQvF2= MnTMV2FPT0WU
BFTC-909 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXSybWdiUUN3ME20MlU3Ojd3IN88US=> MmC4V2FPT0WU
NCI-H2087 NHfNeodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvC[YxWUUN3ME20MlU5OTZ2IN88US=> NWrCPYw5W0GQR1XS
RVH-421 M3j3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTRwNk[2PUDPxE1? MmryV2FPT0WU
P30-OHK NEfyb|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnSNZdKSzVyPUSuOlgxODhizszN MmTEV2FPT0WU
NCI-H28 MnTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP2d2c5UUN3ME20MlgyPjZzIN88US=> NVLucolsW0GQR1XS
ES6 NGX2U5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTYTWM2OD12LkizNFE3KM7:TR?= NYW3RoJ[W0GQR1XS
769-P NUXnToN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nZb2lEPTB;ND64OVkzPiEQvF2= NYD0VoVKW0GQR1XS
OE33 M3L5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\PU5NkUUN3ME20Mlg5OTZzIN88US=> MormV2FPT0WU
SW982 Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NED1S41KSzVyPUSuPVUxPjFizszN M3nNVXNCVkeHUh?=
A388 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLKTYtTUUN3ME21MlAzQTh|IN88US=> MnPyV2FPT0WU
TI-73 NGC1VIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTVwME[xPVQh|ryP NHnp[2tUSU6JRWK=
HCT-116 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTVwMEm4PFkh|ryP NWXZfVhxW0GQR1XS
HuP-T3 NV;L[ZUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTVwMUi3NFkh|ryP NEPM[FFUSU6JRWK=
G-402 NHXwRWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;qWWVKSzVyPUWuNVk1OTZizszN M1q0UnNCVkeHUh?=
NCI-H1792 MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVyySGFNUUN3ME21MlI1PjJ{IN88US=> M33vPXNCVkeHUh?=
NCI-H209 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTVwMkW5OFIh|ryP Mn2wV2FPT0WU
NCI-H1650 NVHUUVE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;sTWM2OD13LkOwOlM1KM7:TR?= NWPwXnl[W0GQR1XS
LCLC-97TM1 NHjW[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P1NWlEPTB;NT6zNVgxQCEQvF2= MWjTRW5ITVJ?
S-117 M4rWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjsTWM2OD13LkO2PVc3KM7:TR?= MmrGV2FPT0WU
GI-ME-N MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmezTWM2OD13LkO5OlgyKM7:TR?= M4XvVXNCVkeHUh?=
NCI-H2122 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTVwNEmzPVch|ryP MmDCV2FPT0WU
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C32 MoK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLQTWM2OD1zOT6wOFUh|ryP NFj3WXhUSU6JRWK=
UMC-11 M1S2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXX2Npd3UUN3ME2xPU4zOTJ|IN88US=> MkX2V2FPT0WU
CaR-1 NIPVZmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlj1TWM2OD1zOT62PFA1KM7:TR?= NXnC[2dTW0GQR1XS
KYSE-410 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\4NoI3UUN3ME2xPU46OTN7IN88US=> MlfQV2FPT0WU
HuCCT1 NGfpUpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXyzZYFlUUN3ME2yNE43Ojl2IN88US=> NGPTOJBUSU6JRWK=
LB996-RCC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj0d5FKSzVyPUKwMlcyPjhizszN M4XBUHNCVkeHUh?=
KYSE-70 Ml3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX72d5FwUUN3ME2yNE45ODV7IN88US=> NXKzc|lVW0GQR1XS
CAL-72 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfXSWJKSzVyPUKwMlkyPSEQvF2= NUH6NpUzW0GQR1XS
Capan-2 M3fQTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJzLkC0NVMh|ryP MnvzV2FPT0WU
PANC-08-13 NInpOWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHiNGRKSzVyPUKxMlI2OTVizszN NGfJN5VUSU6JRWK=
SBC-1 M1fZcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;qN2lEPTB;MkGuN|A5OSEQvF2= MlX0V2FPT0WU
MFM-223 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXn4d2JxUUN3ME2yNU4{OzR{IN88US=> NYjlXpQ6W0GQR1XS
BB49-HNC NXvzUFFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDXTWM2OD1{MT61O|E3KM7:TR?= NEDhdHRUSU6JRWK=
SH-4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fLeGlEPTB;MkGuOlYyQCEQvF2= M3nxZnNCVkeHUh?=
HuO9 M3fQTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITEOpRKSzVyPUKxMlk5OjVizszN M1nUZnNCVkeHUh?=
AM-38 Ml3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJ{LkC0PFUh|ryP MkDaV2FPT0WU
A431 NInxNo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJ|LkKxNVkh|ryP NVTqVnZNW0GQR1XS
YAPC NYn3U|VmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPt[4RKSzVyPUKzMlI3PTFizszN MnHoV2FPT0WU
LU-139 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJ|LkS4NFkh|ryP NF33[nhUSU6JRWK=
HEC-1 NHjEb5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7TTWM2OD1{Mz60PVM4KM7:TR?= NF7CcJZUSU6JRWK=
SCC-25 M1viNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYq3PW9mUUN3ME2yOE4{ODB4IN88US=> MnzOV2FPT0WU
HT-29 NFPIZlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlywTWM2OD1{ND6zPFI{KM7:TR?= M1zTfXNCVkeHUh?=
PC-14 Mo\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\lOFRKSzVyPUK0MlY2PzFizszN NFfT[plUSU6JRWK=
Calu-6 NGDM[|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJ3LkWwO|Eh|ryP NHv2OlZUSU6JRWK=
SJRH30 NIXrUlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLGToZWUUN3ME2yOU43PDl4IN88US=> MXvTRW5ITVJ?
ChaGo-K-1 M{HXe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWH0NI1lUUN3ME2yOk4yPjJ7IN88US=> NVH1WFFiW0GQR1XS
IA-LM NIG1UlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTyVWpKSzVyPUK2MlM3PDVizszN NHnVcHpUSU6JRWK=
GP5d NWDsUW1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPmTWM2OD1{Nj60OFkyKM7:TR?= MkT3V2FPT0WU
NCI-H2291 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\6VmtKSzVyPUK2MlY2PDFizszN NYfPc5FMW0GQR1XS
BALL-1 NVLBcWJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTlWW9KSzVyPUK2Mlk{QTdizszN MnfHV2FPT0WU
HCC1954 Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\tW|hxUUN3ME2yOk46QDB6IN88US=> NX:0V5VlW0GQR1XS
NCI-H2452 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJ5LkSxOlMh|ryP MVPTRW5ITVJ?
LU-99A MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJ5LkW1PFIh|ryP MnfrV2FPT0WU
NTERA-S-cl-D1 Mn;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXpNI1RUUN3ME2yO{44Ojl7IN88US=> NFG5SXZUSU6JRWK=
PANC-10-05 M{TaPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHpW2ZEUUN3ME2yO{44Pzd3IN88US=> NVfHUmU3W0GQR1XS
NCI-H2405 M{XhcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P6dWlEPTB;MkeuPVM5PyEQvF2= M3nIOXNCVkeHUh?=
MDA-MB-415 M{nCTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHFXG1EUUN3ME2yPE41OTN5IN88US=> M3TnXnNCVkeHUh?=
NCI-H2342 NF;ZfY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJ6LkWyPFEh|ryP MXTTRW5ITVJ?
TGBC24TKB M4Tob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf5ZoRKSzVyPUK4MlcyOTdizszN M32xUHNCVkeHUh?=
LU-134-A M2D4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT0eFBKSzVyPUK4MlkzPjFizszN M{jLdXNCVkeHUh?=
SCC-4 NVHuRWY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHVbY1KSzVyPUOxMlA1QTRizszN NFnzNVZUSU6JRWK=
Saos-2 NVXIcmp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTNzLkmzNFYh|ryP Mn7GV2FPT0WU
RERF-LC-MS MkftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoqzTWM2OD1|Mj64NlMyKM7:TR?= M123S3NCVkeHUh?=
M14 M{izWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTN{Lkm3OlQh|ryP NIHvXW5USU6JRWK=
HPAF-II MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TaW2lEPTB;M{OuOVAyOSEQvF2= MXfTRW5ITVJ?
NCI-H1755 MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XYVGlEPTB;M{SuN|MxPSEQvF2= M{DZU3NCVkeHUh?=
D-392MG NF\sfVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTN3Lki2O|Qh|ryP NWrMNGxxW0GQR1XS
A704 MmLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHoUJc2UUN3ME2zOk4xPDJ5IN88US=> MkDoV2FPT0WU
CP50-MEL-B M3;XZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUmxW2FmUUN3ME2zOk4yQTFzIN88US=> M1HSXHNCVkeHUh?=
EW-18 MoH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37pdWlEPTB;M{[uOFUzKM7:TR?= M1G0dHNCVkeHUh?=
WM-115 NXzYUpFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPQfI1KSzVyPUO2MlgxQTlizszN MUXTRW5ITVJ?
LU-65 NVrWenBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTN5LkG0NVch|ryP MojsV2FPT0WU
NCI-H1563 NXvkZnBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHEUpJuUUN3ME2zO{4zPDh2IN88US=> M2Tsb3NCVkeHUh?=
DBTRG-05MG MlHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofDTWM2OD1|OD6wOlkyKM7:TR?= MXPTRW5ITVJ?
NCI-H630 NW\Xd3htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj3dWRKSzVyPUO4MlQ4OTRizszN NYTSXY1FW0GQR1XS
NCI-H1155 NI\Sdm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXzV5pKSzVyPUO5MlI1OiEQvF2= MX7TRW5ITVJ?
OVACR-3 NHLKS|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIj5Z4FKSzVyPUO5MlkyQTVizszN NFWyTYFUSU6JRWK=
OAW-42 MlroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;YTWM2OD12MD60NlU5KM7:TR?= NW\BNHhRW0GQR1XS
JVM-2 M1W2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;lTWM2OD12MT6yOFE2KM7:TR?= NE\jTYtUSU6JRWK=
C3A M3jUTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHqUmdTUUN3ME20NU4{PDR5IN88US=> NH[1XIhUSU6JRWK=
HT55 M1nBT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zzfmlEPTB;NEKuNlg1OSEQvF2= NX7wVpVpW0GQR1XS
OVCAR-4 NUTvfGlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rUfmlEPTB;NEKuNlk4PCEQvF2= MV3TRW5ITVJ?
MEG-01 M3LsTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUntXVRwUUN3ME20Nk41PjF4IN88US=> NFXsfG9USU6JRWK=
NCI-H82 NIH3cJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTR|Lkm4PVIh|ryP M4HaSXNCVkeHUh?=
JEG-3 NGrmdHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL5TWM2OD12ND65OFch|ryP NWP2SG5UW0GQR1XS
BPH-1 Mne2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3lUpBKSzVyPUS2MlM6QThizszN MlflV2FPT0WU
MPP-89 NVHoVZk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTR5LkK4PVgh|ryP MYHTRW5ITVJ?
ALL-PO MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELIUHJKSzVyPUS3MlQyQDhizszN NHPx[oFUSU6JRWK=
HT NUKwZoV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDiNoRKSzVyPUS3MlQ6OiEQvF2= MUPTRW5ITVJ?
NCI-H2347 NIXwW2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XEWmlEPTB;NEiuNFcyPSEQvF2= NFPZdmFUSU6JRWK=
A2780 NWnjU3JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13MVmlEPTB;NEmuOFIzQCEQvF2= Mnq5V2FPT0WU
KARPAS-299 MojIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvmcXJKSzVyPUS5MlUyOTlizszN MVjTRW5ITVJ?
NCI-H1651 MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTR7Lki4NlEh|ryP NIfvdVJUSU6JRWK=

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ
Methods Test Index PMID
Western blot
RB1 (pT821) / RB1 (pS780) / RB1 / CDK6 / CCND2 / RUNX1 / ETO; 

PubMed: 30300583     


Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells.

pRb(S807, 811) / CDK4 / CDK6 / PARP; 

PubMed: 28453226     


Effects of palbociclib on CDK4/6-Rb pathway. HCC cells were treated with different doses of palbociclib for 24 h, and then, the cells were subjected to western blot analysis. CF, cleaved fragment. 

LC3-I / LC3-II; 

PubMed: 28453226     


Palbociclib increases LC3-II amount in a dose-dependent manner in HCC cell lines. 

pAMPKα(T172) / pULK1(S317); 

PubMed: 28453226     


Dose-dependent response of palbociclib on AMPK-related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. 

SMAD2 (pS255); 

PubMed: 30343527     


T47D cells were treated with indicated concentrations of palbociclib for 24 h to evaluate substrate phosphorylation.

30300583 28453226 30343527
Growth inhibition assay
Cell viability; 

PubMed: 29670090     


Cell viability was determined by MTT assays after palbociclib exposure for 2, 4, and 6 days. The cell cycle of SYO-1 and Fuji cells was assessed after exposure to palbociclib (1 µM) for 24 h by flow cytometry analysis.

29670090
Immunofluorescence
SAHF/ATRX; 

PubMed: 26988987     


DAPI staining for senescence-associated heterochromatic foci (SAHF, left panel) and ATRX staining (right panel) in 1205Lu cells +/− palbociclib for 8 days. 

LC3B; 

PubMed: 28453226     


LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3-positive autophagosomes. Nuclei were counterstained with DAPI (blue).

26988987 28453226
ELISA
PGE2; 

PubMed: 26540629     


The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.

26540629
体内試験 PD 0332991 indicates complete tumor stasis in a MDA-MB-435 xenograft at 150 mg/kg. PD 0332991 also shows broad-spectrum antitumor activity in multiple human tumor xenografts by eliminating phospho-Rb and the proliferative marker Ki-67 from tumor tissue and down-regulation of genes under the transcriptional control of E2F. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

Cdk Assays:

A stock solution of PD0332991 is prepared in DMSO. CDK assays are performed in 96-well filter plates. All CDK-cyclin kinase complexes are expressed in insect cells through baculovirus infection and purified. The substrate for the assays is a fragment (amino acids 792–928) of pRb fused to GST (GST·RB-Cterm). The total volume in each well is 0.1 mL containing a final concentration of 20 mM Tris-HCl, pH 7.4, 50 mM NaCl, 1 mM dithiothreitol, 10 mM MgCl2, 25 μM ATP (for CDK4-cyclin D1, CDK6-cyclin D2, and CDK6-cyclin D3) or 12 μM ATP (for CDK2-cyclin E, CDK2-cyclin A, and CDC2-cyclin B) containing 0.25 μCi of [γ-32P]ATP, 20 ng of enzyme, 1 μg of GST·RB-Cterm, and PD 0332991 (0.001-0.1μM). All components except the [γ-32P]ATP are added to the wells, and the plate is placed on a plate mixer for 2 min. The reaction is started by adding the [γ-32P]ATP and the plate is incubated at 25 °C for 15 min. The reaction is terminated by addition of 0.1 mL of 20% trichloroacetic acid and the plate is kept at 4  °C for at least 1 hour to allow the substrate to precipitate. The wells are then washed 5 times with 0.2 mL of 10% trichloroacetic acid and radioactive incorporation is determined with a β plate counter.
細胞試験:

[1]

+ 展開
  • 細胞株: Tumor cell lines including MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM and K562
  • 濃度: 0.01-1 μM
  • 反応時間: 24 hours
  • 実験の流れ:

    Cells are seeded at 2 × 104 per well in a 96-well plate and incubated overnight. PD 0332991 (0.01-1 μM) is added to the wells and incubated at 37 °C for another 24 hours. [14C]Thymidine (0.1 μCi) is added to each well and incorporation of the radiolabel is allowed to proceed for 72 hours. Incorporated radioactivity is determined with a β plate counter.


    (参考用のみ)
動物試験:

[1]

+ 展開
  • 動物モデル: Advanced stage human tumor xenografts including Colo-205, MDA-MB-435 breast, SF-295 glioblastoma, ZR-75-1 breast, PC-3 prostate, H125 lung, SW-620 colon, H23 lung and MDA-MB-468 breast (Rb negative) are established in severe combined immunodeficient mice.
  • 製剤: Dissolved in sodium lactate buffer (50 mM, pH 4.0)
  • 投薬量: 0-150 mg/kg
  • 投与方法: Given by gavage
    (参考用のみ)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
Saline
混合させたのち直ちに使用することを推奨します。
6 mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 483.99
化学式

C24H29N7O2.HCl

CAS No. 827022-32-2
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03870919 Not yet recruiting Breast Cancer Stage IV|Radiotherapy|Surgery UNICANCER|Pfizer May 15 2019 Not Applicable
NCT03870919 Not yet recruiting Breast Cancer Stage IV|Radiotherapy|Surgery UNICANCER|Pfizer May 15 2019 Not Applicable
NCT03820830 Not yet recruiting Breast Cancer Recurrent International Breast Cancer Study Group|Pfizer May 1 2019 Phase 3
NCT03820830 Not yet recruiting Breast Cancer Recurrent International Breast Cancer Study Group|Pfizer May 1 2019 Phase 3
NCT03609047 Not yet recruiting Breast Cancer Stage II|Breast Cancer Stage III European Organisation for Research and Treatment of Cancer - EORTC|Pfizer May 7 2019 Phase 2
NCT03609047 Not yet recruiting Breast Cancer Stage II|Breast Cancer Stage III European Organisation for Research and Treatment of Cancer - EORTC|Pfizer May 7 2019 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

CDKシグナル伝達経路

CDK Inhibitors with Unique Features

相関CDK製品

Tags: Palbociclib (PD-0332991) HClを買う | Palbociclib (PD-0332991) HCl ic50 | Palbociclib (PD-0332991) HCl供給者 | Palbociclib (PD-0332991) HClを購入する | Palbociclib (PD-0332991) HCl費用 | Palbociclib (PD-0332991) HCl生産者 | オーダーPalbociclib (PD-0332991) HCl | Palbociclib (PD-0332991) HCl化学構造 | Palbociclib (PD-0332991) HCl分子量 | Palbociclib (PD-0332991) HCl代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID