Palbociclib (PD-0332991) HCl

For research use only. Not for use in humans.

Licensed by Pfizer 製品コードS1116

Palbociclib (PD-0332991) HCl化学構造

分子量(MW):483.99

Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.

サイズ 価格(税別) 在庫  
JPY 20200 あり
JPY 30200 あり
JPY 96600 あり
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文献中Selleckの製品使用例(155)

製品安全説明書

CDK阻害剤の選択性比較

生物活性

製品説明 Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.
特性 Non-cytotoxic, and halts cancer cell growth & could be used in glioblastoma that has relapsed after temozolomide treatment (a chemotherapeutic used to treat many cancers).
ターゲット
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外試験

PD 0332991 has little effect on other protein kinases including EGFR, FGFR, PGFR, IR. PD 0332991 is a non-ATP competitive inhibitor of Cdk4. PD 0332991 inhibits MDA-MB-435 breast carcinoma cells with IC50 of 66 nM, which is due to reduced Rb phosphorylation at Ser780. PD 0332991 inhibits thymidine incorporation into the DNA of Rb-positive human breast, colon, and lung carcinomas as well as human leukemias, with IC50 values ranging from 0.04-0.17 μM. PD 0332991 shows no activity in Rb-negative cells. PD 0332991 causes an accumulation of cells in G1 in MDA-MB-453 breast and Colo-205 carcinoma cells. [1] PD 0332991 also shows activity in 5T33MM myeloma cells (immunocompetent model) and sensitizes the cells to killing by bortezomib. [2] PD 0332991 inhibits luminal ER-positive as well as HER2-amplified breast cancer cell lines including MDA-MB-175, ZR-75-30, CAMA-1, MDA-MB-134, HCC-202 and UACC-893. PD 0332991 enhances the activity of tamoxifen and trastuzumab in these cell lines. PD 0332991 enhances the sensitivity of tamoxifen in the MCF7 tamoxifen-resistant cells. [3] A recent study shows that PD 0332991 could suppress malignant rhabdoid tumor (MRT) cell lines including MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS and the sensitivity of the MRT cell lines to PD 0332991 is inversely correlated with expression of p16. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 NHjNcplMcW6jc3WgRZN{[Xl? NUDxc3FMOjRiaB?= NIKwU5FKdmirYnn0bY9vKG:oIFPET|Qh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBT[iCyaH;zdIhwenmuYYTpc44hf2m2aDDJR|UxKG:oIECuNFAzKM7:TR?= MViyOFY1OTFyMx?=
COLO205 NVvXPXJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHCO|IhcA>? MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmViaX70c{BFVkFid3n0bEBKSzVyIH;mJFAvODN4IN88US=> NHrH[mczPDZ2MUGwNy=>
U937 NGLoW2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL5PIZ5PzJiaB?= MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmViaX70c{BFVkFid3n0bEBKSzVyIH;mJFAvOTRizszN M2q3V|I1PjRzMUCz
MOLM13 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\YO|IhcA>? M3KwNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTV;MUVE{KGOnbHzzJIhiemKxcnnu[{BHVFR|IFnUSEBufXSjboSgZZN{\XO|ZXSgZZMhcW6lb4Lwc5JifGmxbjDv[kBcO0ifdHj5cYllcW6nIHnueI8hTE6DIIfpeIghUUN3MDDv[kAxNjB7NjFOwG0> MUKyOFY1OTFyMx?=
MOLM13 NV3hWpVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV23NkBp MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IIPvdoFn\W6rYj3y[ZNqe3SjboSgbJVu[W5iTV;MUVE{KGOnbHzzJIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5yOU[g{txO MlPXNlQ3PDFzMEO=
MDA-MB-435 NYLobm9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPHWYl4OjRiaB?= MX;JR|UxRTBwMU[g{txO MnfiNVU5ODF6M{G=
K562 NEf4eVFEgXSxdH;4bYMhSXO|YYm= Mnn6PVYhcA>? NWK5eXNkTE2VTx?= NU\CbItCUUN3ME2yJO69VQ>? MVyyOFQyPzV4Nh?=
DU145 MlTWR5l1d3SxeHnjJGF{e2G7 MknFPVYhcA>? M1rT[mROW09? M3PqcmlEPTB;Nz61JO69VQ>? MUKyOFQyPzV4Nh?=
MDA-MB-231 MnXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjyNUDPxE1? M2DTT|I1KGh? M2XNWmROW09? MVLD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgS|EheGijc3W= MnLpNlQ1OTd3Nk[=
MCF7 NIPve4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnQNUDPxE1? MX2yOEBp MkD4SG1UVw>? NHrOV|NE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzFicHjhd4U> M1vCdlI1PDF5NU[2
MCF7 MYfLbY5ie2ViQYPzZZk> MoD1OUDPxE1? MYKyOEBp Mlj4SG1UVw>? MU\Jcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFPET|Qw[3mlbHnuSFEh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBz\XSrbn;icIF{fG:vYTDwbI9{eGixconsZZRqd25iYYSgV4VzPzhy Ml\SNlQ1OTd3Nk[=
MDA-MB-231 NV3yTXNPU2mwYYPlJGF{e2G7 M{juUFUh|ryP NV3VZndUOjRiaB?= MkTOSG1UVw>? NGjtVIZKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGNFUzRxY4njcIlvTDFiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC{ZYTpco9jdGG|dH;tZUBxcG:|cHjvdplt[XSrb36gZZQhW2W{N{iw M4jwZ|I1PDF5NU[2
MDA-MB-231 Mk\uSpVv[3Srb36gRZN{[Xl? NGC5UHMyNTFyIN88US=> NEPJSFMzPCCq NYmyRZVPTE2VTx?= MkCy[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BRSVKSIHPs[YF3[Wen M1jTcVI1PDF5NU[2
MCF7 NUTZV3duTnWwY4Tpc44hSXO|YYm= NV;BbWN3OS1zMDFOwG0> MWeyOEBp M1HKb2ROW09? M171XYRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhWEGUUDDjcIVifmGpZR?= Mo\QNlQ1OTd3Nk[=
MDA-MB-231 NHTlXolHfW6ldHnvckBCe3OjeR?= M1:1SFAvPS1zIN88US=> NV\HdWh4PDhiaB?= NVqyUJZSTE2VTx?= NX\6ZYdDcGG|IH7vJGNmdGxiY4njcIUh[XK{ZYP0JIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEB{fWJvR{GgdIhie2V? M{K1ZVI1PDF5NU[2
MCF7 MWHGeY5kfGmxbjDBd5NigQ>? MmL0NE42NTFizszN MUm0PEBp NF7HempFVVOR MXHoZZMhdm9iQ3XscEBkgWOuZTDhdpJme3RiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IIP1Zk1IOSCyaHHz[S=> NYizRnRlOjR2MUe1OlY>
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P12-ICHIKAWA NGjGWlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPCTWM2OD17Nj6wOEBvVQ>? NUHDbnJPW0GQR1XS
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BHT-101 M1TGS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHsSHh6UUN3ME2xPVgvOjVibl2= M3;aOnNCVkeHUh?=
SK-NEP-1 NYDBXpl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYqwV5huUUN3ME2yNlAvODJibl2= NIPEbFNUSU6JRWK=
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ES1 MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzaZlJFUUN3ME2yOVYvOjVibl2= Ml;OV2FPT0WU
LAMA-84 Mlf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJ3OD6xPUBvVQ>? M2fsV3NCVkeHUh?=
MOLT-16 NUe3TlFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ3OD60PUBvVQ>? MVnTRW5ITVJ?
ES7 Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJ5Mz6wPUBvVQ>? MUnTRW5ITVJ?
KY821 MlL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvR[FVjUUN3ME2zNVQvOSCwTR?= NXzjNYFKW0GQR1XS
RT-112 NXPNc3JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NICycHlKSzVyPUOyNU4xPSCwTR?= MVXTRW5ITVJ?
HL-60 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfVTWM2OD1|NECuOlYhdk1? MkLoV2FPT0WU
MOLT-4 NIj6WXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;pcmlEPTB;M{S1MlE{KG6P NX3r[HBPW0GQR1XS
KARPAS-45 NXLsXlI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGixNGJKSzVyPUO3Ok4yPiCwTR?= MUnTRW5ITVJ?
SK-N-AS MlK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTN6Nz64N{BvVQ>? NXv3XVljW0GQR1XS
CTB-1 NH\pUolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjXTnZKSzVyPUSwOU4xOiCwTR?= NUnjc5lTW0GQR1XS
NKM-1 M1niO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PQUmlEPTB;NEGxMlg6KG6P M3X6eXNCVkeHUh?=
HTC-C3 MmPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTR|Mj65OUBvVQ>? NF3JSpdUSU6JRWK=
BE-13 M33wNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnXVGJrUUN3ME20OFQvOjdibl2= MlnVV2FPT0WU
KOSC-2 NWmzVIg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH20XY5KSzVyPUS2Ok46KG6P MWDTRW5ITVJ?
NB14 MkDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkO4TWM2OD12OEOuOVghdk1? M2XBUHNCVkeHUh?=
CAL-27 M1PSU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\EUHlWUUN3ME20PVQvPTlibl2= MXTTRW5ITVJ?
H9 NFLqb|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\I[JRVUUN3ME20PVUvPDNibl2= M1vufHNCVkeHUh?=
RS4-11 M1HjU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTVyND63N{BvVQ>? M{m3bXNCVkeHUh?=
PA-1 NGfuSFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF35boxKSzVyPUWwPU45PiCwTR?= MVHTRW5ITVJ?
MV-4-11 Ml7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H3e2lEPTB;NUGzMlg2KG6P MnT4V2FPT0WU
OS-RC-2 NVmyRmpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;NTWM2OD13MkGuOlIhdk1? M2PsUXNCVkeHUh?=
RPMI-8226 M37acWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\JVFBKSzVyPUWyOk45PiCwTR?= NHLZNYVUSU6JRWK=
HGC-27 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTV4ND65PUBvVQ>? MX7TRW5ITVJ?
CHP-212 NVjkZVFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K2bWlEPTB;NUmzMlU6KG6P MXHTRW5ITVJ?
NB10 Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXOZ49KSzVyPUW5PU4yQCCwTR?= MXrTRW5ITVJ?
HH MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HMemlEPTB;NUm5MlQ{KG6P MYHTRW5ITVJ?
EW-16 NGPhNnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDqOGRKSzVyPU[wN{42OiCwTR?= NIrWS2FUSU6JRWK=
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HAL-01 NGHNcFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTiTWM2OD14MEWuOlchdk1? MXzTRW5ITVJ?
A204 M3ntcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrHd4dKSzVyPU[zN{46OSCwTR?= NF\0SlZUSU6JRWK=
MHH-PREB-1 Mn;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHESXBKSzVyPU[zOk46QSCwTR?= M13UU3NCVkeHUh?=
EM-2 MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTZ3MD62OEBvVQ>? NVnrNoRyW0GQR1XS
BV-173 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHF[|ZKSzVyPU[1Nk41QCCwTR?= NUD1d2VHW0GQR1XS
ONS-76 Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmThTWM2OD14N{euPFIhdk1? MV3TRW5ITVJ?
KM-H2 NELYb5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzCflVKSzVyPU[5OU42PCCwTR?= MlLmV2FPT0WU
D-263MG NVHkdWNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4i3OGlEPTB;N{G3MlEzKG6P MljMV2FPT0WU
ES3 NY\L[XJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTd{OD65N{BvVQ>? NWjmelZ6W0GQR1XS
VA-ES-BJ NGXLO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTd|Mj6yO{BvVQ>? M{niWHNCVkeHUh?=
NBsusSR NF65b3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ryOGlEPTB;N{SyMlk6KG6P MVTTRW5ITVJ?
NCI-H520 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XJfmlEPTB;N{S2MlUzKG6P MWXTRW5ITVJ?
ES5 NH21TJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jUSmlEPTB;N{WyMlghdk1? M2rsZXNCVkeHUh?=
T-24 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Dy[GlEPTB;N{e4MlcyKG6P MXfTRW5ITVJ?
SW962 MnLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnmxTWM2OD16MEiuOlMhdk1? NVjJNXdRW0GQR1XS
EW-3 NEmyVHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XKbGlEPTB;OEC4Mlc3KG6P Ml\FV2FPT0WU
RXF393 NEnuNIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRThzMj63PUBvVQ>? Ml3nV2FPT0WU
U251 MnzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3m0U2lEPTB;OEGzMlg5KG6P M4rjdHNCVkeHUh?=
CAMA-1 M2[wU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PIUWlEPTB;OEOzMlk1KG6P NUTF[pZXW0GQR1XS
JVM-3 M1\3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXhUJZLUUN3ME24OVEvPzhibl2= MnrlV2FPT0WU
COLO-800 NFPJPVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki4TWM2OD16OUeuO|ghdk1? MkPrV2FPT0WU
OVCAR-5 M4HuSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D6N2lEPTB;OUCwMlEhdk1? NIDpfYFUSU6JRWK=
LB1047-RCC NFfqVWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTl{Nz61OkBvVQ>? NYnaV3VQW0GQR1XS
SW954 M2CwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nnSmlEPTB;OUK5MlQyKG6P MUHTRW5ITVJ?
J-RT3-T3-5 M2HNfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\y[mFKSzVyPUmzOk4xPiCwTR?= M1nNR3NCVkeHUh?=
Mewo NH[zTIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLtTGNKSzVyPUmzOk43KG6P MoDRV2FPT0WU
NCI-H1770 MnzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7yO2tjUUN3ME25OFAvPTVibl2= MnXjV2FPT0WU
HO-1-N-1 M{LXcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmm4TWM2OD17NkKuPFEhdk1? NVTsc|RMW0GQR1XS
HSC-3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17IbGlEPTB;OU[2MlQ5KG6P NILQZ21USU6JRWK=
TYK-nu MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHufWVKSzVyPUm5PE4zPSCwTR?= MlHUV2FPT0WU
KYSE-150 Ml;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknvTWM2OD1zLkCwNFc3KM7:TR?= NEjsUYdUSU6JRWK=
SN12C Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HPeWlEPTB;MT6wNFg4PSEQvF2= NEnq[ldUSU6JRWK=
MOLT-13 NHTYSZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7NTWM2OD1zLkCxOFIyKM7:TR?= NXz6SpMyW0GQR1XS
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DB Mn[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT0XGlKSzVyPUGuNFczPzNizszN MknNV2FPT0WU
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QIMR-WIL NX\KR4ViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHQTWM2OD1zLkGzNVM1KM7:TR?= MXvTRW5ITVJ?
NCI-SNU-1 NVyzWVJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jDdmlEPTB;MT6xOlM2PCEQvF2= NH3SN3hUSU6JRWK=
CGTH-W-1 MlLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnDNFVKSzVyPUGuNVcyQDZizszN NVraW2VDW0GQR1XS
MHH-ES-1 NVLPdHZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTFwMUe5PFYh|ryP NX65d5NlW0GQR1XS
LB2241-RCC MlnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrYVm0{UUN3ME2xMlE5PjJizszN NVO0NXBqW0GQR1XS
ML-2 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4G4XmlEPTB;MT6yNFc{PCEQvF2= M1HBS3NCVkeHUh?=
COR-L23 MmTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vWeGlEPTB;MT6yNlk{OyEQvF2= NXrE[XRxW0GQR1XS
BFTC-905 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrXcJpKSzVyPUGuNlQzPjdizszN MoH4V2FPT0WU
Hs-578-T M{fGU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzsTWM2OD1zLkK1PFE4KM7:TR?= NInJOIdUSU6JRWK=
KG-1 M4jPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXITWM2OD1zLkK2Olg3KM7:TR?= M1PNbHNCVkeHUh?=
HEL NVna[YpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:5coJKSzVyPUGuNlk{OzhizszN MlXwV2FPT0WU
A549 M3jXU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrFXJRKSzVyPUGuNlk{QTlizszN MXHTRW5ITVJ?
COLO-741 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTFwM{KwPFkh|ryP NX\3OGdZW0GQR1XS
PC-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonFTWM2OD1zLkO1NlIyKM7:TR?= MnjvV2FPT0WU
HOS MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2THV2lEPTB;MT6zOVI6PiEQvF2= NUWydGk2W0GQR1XS
HT-1080 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTFwM{e1NVkh|ryP MX3TRW5ITVJ?
TE-8 MnjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PhU2lEPTB;MT60NVc4PCEQvF2= M4nk[3NCVkeHUh?=
BHY NVrieJQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfnVVB3UUN3ME2xMlQ3QTJ|IN88US=> MkTCV2FPT0WU
BB65-RCC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPWb2pKSzVyPUGuOVA2OjhizszN MmTwV2FPT0WU
HN MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjhU|dDUUN3ME2xMlU1ODdzIN88US=> M{C0THNCVkeHUh?=
NCI-H441 M3HXRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\ZTWM2OD1zLkW0PVA4KM7:TR?= M3TpOHNCVkeHUh?=
RPMI-8866 NWnDZndkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTFwNUi1NFch|ryP Mm\QV2FPT0WU
CAL-62 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LZdGlEPTB;MT62NFg3OiEQvF2= NFrqdo5USU6JRWK=
MG-63 Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe3U4dnUUN3ME2xMlYyQDF|IN88US=> MXHTRW5ITVJ?
SK-LU-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELTbHBKSzVyPUGuOlIyPTJizszN MlvaV2FPT0WU
BCPAP Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X1XmlEPTB;MT62OlQ2PyEQvF2= M1vZc3NCVkeHUh?=
22RV1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTFwNke4OFMh|ryP MXnTRW5ITVJ?
T47D MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\nRWlEPTB;MT62PFA3OSEQvF2= M3i3UHNCVkeHUh?=
MSTO-211H NYnvcFlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnZTWM2OD1zLk[5OlA{KM7:TR?= MXvTRW5ITVJ?
DEL M4TJNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjBTWM2OD1zLkewNlc{KM7:TR?= MVzTRW5ITVJ?
H4 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\FVoVKSzVyPUGuO|MzOTJizszN M3HUU3NCVkeHUh?=
CAL-51 NVXxcm9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;ISmlEPTB;MT63OFg2PSEQvF2= M3nPTHNCVkeHUh?=
ABC-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPaTWM2OD1zLke4OVgzKM7:TR?= NHq3UYRUSU6JRWK=
MZ2-MEL MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\aVWlEPTB;MT63PVU1OiEQvF2= MVPTRW5ITVJ?
YKG-1 NVH1cZZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkntTWM2OD1zLkixNFYyKM7:TR?= MV;TRW5ITVJ?
KM12 M3zhTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XnSmlEPTB;MT64NVYxOiEQvF2= NVHETW5uW0GQR1XS
L-363 NEHJdFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjRbm9kUUN3ME2xMlg4PDF{IN88US=> NHzaNINUSU6JRWK=
KU812 NXLITJB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDlTWM2OD1zLki5NlgzKM7:TR?= M2jkNHNCVkeHUh?=
LOXIMVI MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnTeJVKSzVyPUGuPVEzOjhizszN NIHnOo1USU6JRWK=
G-401 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;XOVZKSzVyPUGuPVI1OjhizszN MoDTV2FPT0WU
SW780 NYTkT3F7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWe0W3oyUUN3ME2xMlk3OjR4IN88US=> MnnZV2FPT0WU
SW872 MoWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DLPGlEPTB;MT65PFM{KM7:TR?= NHrq[pRUSU6JRWK=
NB7 NY\IUnlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTFwOUmzNlMh|ryP NYC3TWg6W0GQR1XS
T98G MoLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvCZmx[UUN3ME2yMlAxPjZ4IN88US=> M3;HU3NCVkeHUh?=
SW1710 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrGXlFOUUN3ME2yMlA3QTR3IN88US=> NEPoZW5USU6JRWK=
NCI-H1573 NV;2d4hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTJwMEeyPVgh|ryP NHvl[|dUSU6JRWK=
KE-37 M1nlV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLEO4xKSzVyPUKuNFg6PTFizszN MXrTRW5ITVJ?
786-0 MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJwMUW0N|kh|ryP M1yyVXNCVkeHUh?=
SAS M2PYRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\sTWM2OD1{LkKwN|c1KM7:TR?= NX;GPWxKW0GQR1XS
CAL-54 M4\WSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DIW2lEPTB;Mj6yNFQyOyEQvF2= NXTvXpBXW0GQR1XS
SF268 MmjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\NcWlEPTB;Mj6yN|EzOiEQvF2= M4TYSnNCVkeHUh?=
SW620 NGnCeWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\lVVZ[UUN3ME2yMlI3OTZ7IN88US=> MXzTRW5ITVJ?
MN-60 MmPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTJwM{GwOkDPxE1? MkLKV2FPT0WU
EFO-27 NX;pOYM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TSWWlEPTB;Mj6zNlA2QCEQvF2= M{fXbXNCVkeHUh?=
NCI-H747 NFW2OIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTJwM{KxPVkh|ryP M1\qTHNCVkeHUh?=
HCC2218 MkmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG2TWM2OD1{LkO1N|c1KM7:TR?= NWrSOIo{W0GQR1XS
MIA-PaCa-2 NHu2S2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJwM{[0N|ch|ryP MYDTRW5ITVJ?
SJSA-1 M4XvdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfKWYpIUUN3ME2yMlM4Pzl4IN88US=> NIrJOJNUSU6JRWK=
RKO NHf0foNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[1TlRKSzVyPUKuN|g1QTZizszN Ml7jV2FPT0WU
NB6 NGXuNFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJwNECzO|Qh|ryP MYHTRW5ITVJ?
ES4 M13Hb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLXO2lKSzVyPUKuOFU1OjJizszN NHvQcG9USU6JRWK=
EGI-1 NFjPUGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnRc4dbUUN3ME2yMlQ3QDh|IN88US=> NU\Fb3c1W0GQR1XS
CTV-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJwNUK3O|Mh|ryP MWTTRW5ITVJ?
NCI-H1355 NUfGe5l2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXhSYdKSzVyPUKuOVU6PTFizszN NEXONplUSU6JRWK=
GT3TKB MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJwNUmxPVkh|ryP MlfvV2FPT0WU
SK-HEP-1 MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJwNUmyOlYh|ryP MXfTRW5ITVJ?
GAMG MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwNUmzPVQh|ryP MUDTRW5ITVJ?
SK-MES-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJwNkG4NFMh|ryP NITFWXBUSU6JRWK=
RO82-W-1 MmPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFy1U2hKSzVyPUKuOlIxPTdizszN NGjwfZhUSU6JRWK=
ECC10 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrGNGxMUUN3ME2yMlcxOjB4IN88US=> MVHTRW5ITVJ?
MCF7 M1fGWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3FTWM2OD1{LkexOFY1KM7:TR?= NGH6RlJUSU6JRWK=
D-283MED M2\K[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTJwN{K0N{DPxE1? NHvrPHJUSU6JRWK=
RPMI-7951 NX;mcm5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWi3THhjUUN3ME2yMlc2Pjl2IN88US=> M4DxN3NCVkeHUh?=
Ramos-2G6-4C10 MkTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInZ[|BKSzVyPUKuO|cxQTlizszN M2riZ3NCVkeHUh?=
KGN MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PVbmlEPTB;Mj64NVg5PCEQvF2= MW\TRW5ITVJ?
NUGC-3 M4ewVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\zO4tKSzVyPUKuPFI2ODVizszN MlfpV2FPT0WU
NCI-H292 NUDQUWRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2W2TGlEPTB;Mj64OVA2OyEQvF2= NWryXVVSW0GQR1XS
Becker MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWmyWW1NUUN3ME2yMlk2QDN{IN88US=> MoWyV2FPT0WU
NCI-H1299 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf3Xo02UUN3ME2zMlA2OjZ|IN88US=> NGDLdXRUSU6JRWK=
ETK-1 NUPrSHVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjjeoNKSzVyPUOuNFU1OyEQvF2= NF3EeodUSU6JRWK=
TK10 NXHnOXdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrTTWM2OD1|LkKwNVY2KM7:TR?= MX7TRW5ITVJ?
VMRC-RCZ NUmydXI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfZTWM2OD1|LkO2OFg5KM7:TR?= MULTRW5ITVJ?
YH-13 MmjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPLR2ZXUUN3ME2zMlQ1ODd7IN88US=> MmDxV2FPT0WU
DU-145 NXK1TnA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDXfWhKSzVyPUOuOFYzPjlizszN M4Ti[nNCVkeHUh?=
SW1088 NHnTcXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEH4NFlKSzVyPUOuOFc1PyEQvF2= MYPTRW5ITVJ?
HOP-92 NXTLPFZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\I[mlEPTB;Mz61NFM1OiEQvF2= NFS2XIdUSU6JRWK=
KP-N-YS MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTNwNkKxN|kh|ryP NEXHcoZUSU6JRWK=
NCI-H460 NWjtU3U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTNwNk[3N{DPxE1? M{OzUnNCVkeHUh?=
U-2-OS NEDUdGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\BTWM2OD1|LkeyOVM2KM7:TR?= MXrTRW5ITVJ?
A101D MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTNwN{[5N|Yh|ryP M{XCfnNCVkeHUh?=
MDA-MB-231 M4X0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37POGlEPTB;Mz64NVk2OSEQvF2= MmLqV2FPT0WU
IST-MES1 MlmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTNwOEOyJO69VQ>? MUPTRW5ITVJ?
COR-L105 NHrDN4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTRwMEG4JO69VQ>? NIDMT3JUSU6JRWK=
NCI-H1437 NInJSXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLVTWM2OD12LkCyN|AzKM7:TR?= NVLRc3IzW0GQR1XS
CAL-85-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTRwMEK0OlEh|ryP M121NnNCVkeHUh?=
MZ1-PC MnHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLrTWM2OD12LkG4OVU3KM7:TR?= M4S2ZXNCVkeHUh?=
VM-CUB-1 NX3qV2VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLtTWM2OD12LkOxNlg1KM7:TR?= M1fIUHNCVkeHUh?=
CHL-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n6[2lEPTB;ND6zNlE3QSEQvF2= MoLKV2FPT0WU
MDA-MB-361 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorTTWM2OD12LkOzNVU{KM7:TR?= MkLXV2FPT0WU
NCI-H661 MlTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVntfGY5UUN3ME20MlUxODl{IN88US=> MnLDV2FPT0WU
EW-11 NVr0TmxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrJNFJPUUN3ME20MlUzOjNzIN88US=> MkDjV2FPT0WU
BEN MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoS1TWM2OD12LkWyPFE2KM7:TR?= NHe4[4hUSU6JRWK=
BFTC-909 NVLLblJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTRwNU[yO|Uh|ryP NYrCS24zW0GQR1XS
NCI-H2087 M4Hr[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojmTWM2OD12LkW4NVY1KM7:TR?= NIe5eI5USU6JRWK=
RVH-421 NUC3foI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTRwNk[2PUDPxE1? M4rUPXNCVkeHUh?=
P30-OHK NYXmVnhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTRwNkiwNFgh|ryP M3;3WXNCVkeHUh?=
NCI-H28 NEHKbXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHQOGtKSzVyPUSuPFE3PjFizszN MnPCV2FPT0WU
ES6 MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlexTWM2OD12LkizNFE3KM7:TR?= MWfTRW5ITVJ?
769-P Mn\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTRwOEW5NlYh|ryP MYHTRW5ITVJ?
OE33 MlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTRwOEixOlEh|ryP NWPrNYtOW0GQR1XS
SW982 NX2xXWJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2SxWWlEPTB;ND65OVA3OSEQvF2= M1HuS3NCVkeHUh?=
A388 NHX5RnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLwfW5KSzVyPUWuNFI6QDNizszN MYXTRW5ITVJ?
TI-73 NHnLepRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\CNpRSUUN3ME21MlA3OTl2IN88US=> MV\TRW5ITVJ?
HCT-116 NVfYZnFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[5TWM2OD13LkC5PFg6KM7:TR?= Mn\IV2FPT0WU
HuP-T3 M3fxdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTDTWM2OD13LkG4O|A6KM7:TR?= NFHzbnBUSU6JRWK=
G-402 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLpTFRKSzVyPUWuNVk1OTZizszN MlvIV2FPT0WU
NCI-H1792 NG[wd4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;lRWlEPTB;NT6yOFYzOiEQvF2= NFnSb4hUSU6JRWK=
NCI-H209 NVTEZVc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnMT3BKSzVyPUWuNlU6PDJizszN NI\o[IFUSU6JRWK=
NCI-H1650 Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnoZYZKSzVyPUWuN|A3OzRizszN M1n5OnNCVkeHUh?=
LCLC-97TM1 M2XF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S0bmlEPTB;NT6zNVgxQCEQvF2= NXjGV4JjW0GQR1XS
S-117 NUL6[GFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrQUXpKSzVyPUWuN|Y6PzZizszN Mm\1V2FPT0WU
GI-ME-N NEPLOpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTOVYF[UUN3ME21MlM6PjhzIN88US=> MY\TRW5ITVJ?
NCI-H2122 NXLNeoZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[yNlJKSzVyPUWuOFk{QTdizszN MYPTRW5ITVJ?
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C32 M3PVdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnkfVdNUUN3ME2xPU4xPDVizszN NHu0eVBUSU6JRWK=
UMC-11 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTF7LkKxNlMh|ryP NID5UINUSU6JRWK=
CaR-1 M1jvXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPDc25KSzVyPUG5MlY5ODRizszN M{LCfHNCVkeHUh?=
KYSE-410 NGHSeI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV2yT5NuUUN3ME2xPU46OTN7IN88US=> MnH6V2FPT0WU
HuCCT1 NXHsNXJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmOzTWM2OD1{MD62Nlk1KM7:TR?= Mon4V2FPT0WU
LB996-RCC M1TFXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fEVGlEPTB;MkCuO|E3QCEQvF2= NWKzd2JIW0GQR1XS
KYSE-70 MkPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PndmlEPTB;MkCuPFA2QSEQvF2= NYHtfZROW0GQR1XS
CAL-72 MojvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHUUHVKSzVyPUKwMlkyPSEQvF2= NWDlTGdqW0GQR1XS
Capan-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\qTWM2OD1{MT6wOFE{KM7:TR?= MWDTRW5ITVJ?
PANC-08-13 NXvI[FhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnUeVlrUUN3ME2yNU4zPTF3IN88US=> NYi3PYhzW0GQR1XS
SBC-1 M4HYSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfwc3hUUUN3ME2yNU4{ODhzIN88US=> NYPzcnlWW0GQR1XS
MFM-223 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJzLkOzOFIh|ryP MVPTRW5ITVJ?
BB49-HNC M2mzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJzLkW3NVYh|ryP MmS3V2FPT0WU
SH-4 NYG4b20xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;pVWlEPTB;MkGuOlYyQCEQvF2= NFLIbY9USU6JRWK=
HuO9 M3\tSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTJzLkm4NlUh|ryP MYLTRW5ITVJ?
AM-38 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfNUXdpUUN3ME2yNk4xPDh3IN88US=> NGLVdI1USU6JRWK=
A431 MmXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPyVIxKSzVyPUKzMlIyOTlizszN NVzxVJBCW0GQR1XS
YAPC MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjleYFKSzVyPUKzMlI3PTFizszN M1GwcnNCVkeHUh?=
LU-139 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTZTWM2OD1{Mz60PFA6KM7:TR?= M1jNXHNCVkeHUh?=
HEC-1 M3Psbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i3O2lEPTB;MkOuOFk{PyEQvF2= MWHTRW5ITVJ?
SCC-25 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrNWoZKSzVyPUK0MlMxODZizszN M3fx[XNCVkeHUh?=
HT-29 M33zOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT6Xm9bUUN3ME2yOE4{QDJ|IN88US=> MWXTRW5ITVJ?
PC-14 NWnhSmg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJ2Lk[1O|Eh|ryP MWfTRW5ITVJ?
Calu-6 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTJ3LkWwO|Eh|ryP NU\uNmRPW0GQR1XS
SJRH30 NXPDS|B6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJ3Lk[0PVYh|ryP NEXMd41USU6JRWK=
ChaGo-K-1 MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjObHhKSzVyPUK2MlE3OjlizszN MXLTRW5ITVJ?
IA-LM NVGxSml1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJ4LkO2OFUh|ryP Ml\rV2FPT0WU
GP5d Mom1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnqXmR7UUN3ME2yOk41PDlzIN88US=> NInQco1USU6JRWK=
NCI-H2291 NHzDTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkezTWM2OD1{Nj62OVQyKM7:TR?= MXLTRW5ITVJ?
BALL-1 NUi1W4Z[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[1eY9KSzVyPUK2Mlk{QTdizszN M1;mSXNCVkeHUh?=
HCC1954 NVTVZ45XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJ4Lkm4NFgh|ryP NUGzXIdiW0GQR1XS
NCI-H2452 Ml7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zM[mlEPTB;MkeuOFE3OyEQvF2= MYfTRW5ITVJ?
LU-99A NHnTTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJ5LkW1PFIh|ryP M2PJWXNCVkeHUh?=
NTERA-S-cl-D1 NF64[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[5dW9QUUN3ME2yO{44Ojl7IN88US=> M1m0XnNCVkeHUh?=
PANC-10-05 MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrqRlVKSzVyPUK3Mlc4PzVizszN NHP5[3hUSU6JRWK=
NCI-H2405 NXPHcXh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPSTWM2OD1{Nz65N|g4KM7:TR?= MlzLV2FPT0WU
MDA-MB-415 MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DkNmlEPTB;MkiuOFE{PyEQvF2= NI\TXYFUSU6JRWK=
NCI-H2342 M2PPWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj1ZWFiUUN3ME2yPE42OjhzIN88US=> MWTTRW5ITVJ?
TGBC24TKB M3ThfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XiVmlEPTB;MkiuO|EyPyEQvF2= NVzBV|FkW0GQR1XS
LU-134-A NHv5b5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvlUGlHUUN3ME2yPE46OjZzIN88US=> NI\GfoFUSU6JRWK=
SCC-4 NILmSm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTNzLkC0PVQh|ryP MV\TRW5ITVJ?
Saos-2 NIn6ZXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fReGlEPTB;M{GuPVMxPiEQvF2= NVHMSldJW0GQR1XS
RERF-LC-MS MoLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTN{LkiyN|Eh|ryP M{HXUnNCVkeHUh?=
M14 M3HYPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIK1PWlKSzVyPUOyMlk4PjRizszN M{nmN3NCVkeHUh?=
HPAF-II NXXEdFFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;3RWlEPTB;M{OuOVAyOSEQvF2= MWPTRW5ITVJ?
NCI-H1755 M2[2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkmzTWM2OD1|ND6zN|A2KM7:TR?= MmrYV2FPT0WU
D-392MG MoGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLoTWM2OD1|NT64Olc1KM7:TR?= MVPTRW5ITVJ?
A704 Mn\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LIcGlEPTB;M{[uNFQzPyEQvF2= MlXuV2FPT0WU
CP50-MEL-B M3zYeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTN4LkG5NVEh|ryP MnjJV2FPT0WU
EW-18 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrx[|lKSzVyPUO2MlQ2OiEQvF2= NX7JeIJpW0GQR1XS
WM-115 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDQTWM2OD1|Nj64NFk6KM7:TR?= MVjTRW5ITVJ?
LU-65 NUXYdnFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPiTWM2OD1|Nz6xOFE4KM7:TR?= NYTEO3VqW0GQR1XS
NCI-H1563 NFfZflhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT1TWM2OD1|Nz6yOFg1KM7:TR?= NHzlO5BUSU6JRWK=
DBTRG-05MG M3HIZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDNTWM2OD1|OD6wOlkyKM7:TR?= MnvsV2FPT0WU
NCI-H630 NXrOW|d[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\VO25KSzVyPUO4MlQ4OTRizszN NWTkcIVRW0GQR1XS
NCI-H1155 NGrPfXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rSZWlEPTB;M{muNlQzKM7:TR?= M1jFRXNCVkeHUh?=
OVACR-3 NEj1OmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXuc5BbUUN3ME2zPU46OTl3IN88US=> MU\TRW5ITVJ?
OAW-42 MmfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF62[3dKSzVyPUSwMlQzPThizszN Mm\qV2FPT0WU
JVM-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXoTWM2OD12MT6yOFE2KM7:TR?= NXHiOHZ5W0GQR1XS
C3A NICzZ2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rRNGlEPTB;NEGuN|Q1PyEQvF2= M4nOTnNCVkeHUh?=
HT55 NHWwXVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfVZVdKSzVyPUSyMlI5PDFizszN NXr2WIlWW0GQR1XS
OVCAR-4 MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLmTWM2OD12Mj6yPVc1KM7:TR?= M2T3RXNCVkeHUh?=
MEG-01 MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXWNXVKSzVyPUSyMlQ3OTZizszN NFjpb|FUSU6JRWK=
NCI-H82 NH3EOnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTR|Lkm4PVIh|ryP M4\VcnNCVkeHUh?=
JEG-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfmTWM2OD12ND65OFch|ryP M2C2U3NCVkeHUh?=
BPH-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTR4LkO5PVgh|ryP M3fPSXNCVkeHUh?=
MPP-89 MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLYS3B6UUN3ME20O{4zQDl6IN88US=> NVvTZYwzW0GQR1XS
ALL-PO NF7mWYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfwTWM2OD12Nz60NVg5KM7:TR?= M{nDUXNCVkeHUh?=
HT NHrmTYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\tcGlEPTB;NEeuOFkzKM7:TR?= M4\zO3NCVkeHUh?=
NCI-H2347 M1[zOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHVTWM2OD12OD6wO|E2KM7:TR?= MnTmV2FPT0WU
A2780 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nhZWlEPTB;NEmuOFIzQCEQvF2= M1HqfXNCVkeHUh?=
KARPAS-299 M2PBOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX61TG9EUUN3ME20PU42OTF7IN88US=> MoX2V2FPT0WU
NCI-H1651 MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTR7Lki4NlEh|ryP MWfTRW5ITVJ?

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ
Methods Test Index PMID
Western blot
RB1 (pT821) / RB1 (pS780) / RB1 / CDK6 / CCND2 / RUNX1 / ETO; 

PubMed: 30300583     


Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells.

pRb(S807, 811) / CDK4 / CDK6 / PARP; 

PubMed: 28453226     


Effects of palbociclib on CDK4/6-Rb pathway. HCC cells were treated with different doses of palbociclib for 24 h, and then, the cells were subjected to western blot analysis. CF, cleaved fragment. 

LC3-I / LC3-II; 

PubMed: 28453226     


Palbociclib increases LC3-II amount in a dose-dependent manner in HCC cell lines. 

pAMPKα(T172) / pULK1(S317); 

PubMed: 28453226     


Dose-dependent response of palbociclib on AMPK-related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. 

SMAD2 (pS255); 

PubMed: 30343527     


T47D cells were treated with indicated concentrations of palbociclib for 24 h to evaluate substrate phosphorylation.

30300583 28453226 30343527
Growth inhibition assay
Cell viability; 

PubMed: 29670090     


Cell viability was determined by MTT assays after palbociclib exposure for 2, 4, and 6 days. The cell cycle of SYO-1 and Fuji cells was assessed after exposure to palbociclib (1 µM) for 24 h by flow cytometry analysis.

29670090
Immunofluorescence
SAHF/ATRX; 

PubMed: 26988987     


DAPI staining for senescence-associated heterochromatic foci (SAHF, left panel) and ATRX staining (right panel) in 1205Lu cells +/− palbociclib for 8 days. 

LC3B; 

PubMed: 28453226     


LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3-positive autophagosomes. Nuclei were counterstained with DAPI (blue).

26988987 28453226
ELISA
PGE2; 

PubMed: 26540629     


The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.

26540629
体内試験 PD 0332991 indicates complete tumor stasis in a MDA-MB-435 xenograft at 150 mg/kg. PD 0332991 also shows broad-spectrum antitumor activity in multiple human tumor xenografts by eliminating phospho-Rb and the proliferative marker Ki-67 from tumor tissue and down-regulation of genes under the transcriptional control of E2F. [1]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

- 合併

Cdk Assays:

A stock solution of PD0332991 is prepared in DMSO. CDK assays are performed in 96-well filter plates. All CDK-cyclin kinase complexes are expressed in insect cells through baculovirus infection and purified. The substrate for the assays is a fragment (amino acids 792–928) of pRb fused to GST (GST·RB-Cterm). The total volume in each well is 0.1 mL containing a final concentration of 20 mM Tris-HCl, pH 7.4, 50 mM NaCl, 1 mM dithiothreitol, 10 mM MgCl2, 25 μM ATP (for CDK4-cyclin D1, CDK6-cyclin D2, and CDK6-cyclin D3) or 12 μM ATP (for CDK2-cyclin E, CDK2-cyclin A, and CDC2-cyclin B) containing 0.25 μCi of [γ-32P]ATP, 20 ng of enzyme, 1 μg of GST·RB-Cterm, and PD 0332991 (0.001-0.1μM). All components except the [γ-32P]ATP are added to the wells, and the plate is placed on a plate mixer for 2 min. The reaction is started by adding the [γ-32P]ATP and the plate is incubated at 25 °C for 15 min. The reaction is terminated by addition of 0.1 mL of 20% trichloroacetic acid and the plate is kept at 4  °C for at least 1 hour to allow the substrate to precipitate. The wells are then washed 5 times with 0.2 mL of 10% trichloroacetic acid and radioactive incorporation is determined with a β plate counter.
細胞試験:

[1]

- 合併
  • 細胞株: Tumor cell lines including MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM and K562
  • 濃度: 0.01-1 μM
  • 反応時間: 24 hours
  • 実験の流れ:

    Cells are seeded at 2 × 104 per well in a 96-well plate and incubated overnight. PD 0332991 (0.01-1 μM) is added to the wells and incubated at 37 °C for another 24 hours. [14C]Thymidine (0.1 μCi) is added to each well and incorporation of the radiolabel is allowed to proceed for 72 hours. Incorporated radioactivity is determined with a β plate counter.


    (参考用のみ)
動物試験:

[1]

- 合併
  • 動物モデル: Advanced stage human tumor xenografts including Colo-205, MDA-MB-435 breast, SF-295 glioblastoma, ZR-75-1 breast, PC-3 prostate, H125 lung, SW-620 colon, H23 lung and MDA-MB-468 breast (Rb negative) are established in severe combined immunodeficient mice.
  • 製剤: Dissolved in sodium lactate buffer (50 mM, pH 4.0)
  • 投薬量: 0-150 mg/kg
  • 投与方法: Given by gavage
    (参考用のみ)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
Saline
混合させたのち直ちに使用することを推奨します。
6 mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 483.99
化学式

C24H29N7O2.HCl

CAS No. 827022-32-2
保管
in solvent
別名 N/A
Smiles Cl.CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03870919 Not yet recruiting Drug: Palbociclib|Other: locoregional treatment Breast Cancer Stage IV|Radiotherapy|Surgery UNICANCER|Pfizer October 15 2019 Not Applicable
NCT03900884 Not yet recruiting Drug: Venetoclax|Drug: Palbociclib|Drug: Letrozole Breast Neoplasm Female Peter MacCallum Cancer Centre Australia September 2019 Phase 1
NCT03844997 Recruiting Drug: Palcociclib|Drug: CPX-351 Acute Myeloid Leukemia|AML Aziz Nazha|Case Comprehensive Cancer Center May 31 2019 Phase 1|Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

CDKシグナル伝達経路

CDK Inhibitors with Unique Features

相関CDK製品

Tags: Palbociclib (PD-0332991) HClを買う | Palbociclib (PD-0332991) HCl ic50 | Palbociclib (PD-0332991) HCl供給者 | Palbociclib (PD-0332991) HClを購入する | Palbociclib (PD-0332991) HCl費用 | Palbociclib (PD-0332991) HCl生産者 | オーダーPalbociclib (PD-0332991) HCl | Palbociclib (PD-0332991) HCl化学構造 | Palbociclib (PD-0332991) HCl分子量 | Palbociclib (PD-0332991) HCl代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID