Palbociclib (PD-0332991) HCl

For research use only. Not for use in humans.

Licensed by Pfizer 製品コードS1116

CAS No. 827022-32-2

Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.

サイズ

価格(税別)

在庫

5mg	JPY 20200	あり
10mg	JPY 30200	あり
50mg	JPY 96600	あり

最寄りの販売代理店を探す

東京
北海道
東北
北関東
南関東
東海
北信越
近畿
中国
四国
九州

お探しのディーラーが見当たらない場合は直接こちらのメールアドレスまでお問い合わせください：[email protected]

バルク問合せ

代表番号: 03-5615-9297 | 電子メール：[email protected]

文献中Selleckの製品使用例(260)

製品安全説明書

CDK阻害剤の選択性比較

生物活性

製品説明

特性

Non-cytotoxic, and halts cancer cell growth & could be used in glioblastoma that has relapsed after temozolomide treatment (a chemotherapeutic used to treat many cancers).

ターゲット

CDK4/CyclinD3 ^[1] (Cell-free assay)	CDK4/CyclinD1 ^[1] (Cell-free assay)	CDK6/CyclinD2 ^[1] (Cell-free assay)
9 nM	11 nM	15 nM

体外試験

PD 0332991 has little effect on other protein kinases including EGFR, FGFR, PGFR, IR. PD 0332991 is a non-ATP competitive inhibitor of Cdk4. PD 0332991 inhibits MDA-MB-435 breast carcinoma cells with IC50 of 66 nM, which is due to reduced Rb phosphorylation at Ser⁷⁸⁰. PD 0332991 inhibits thymidine incorporation into the DNA of Rb-positive human breast, colon, and lung carcinomas as well as human leukemias, with IC50 values ranging from 0.04-0.17 μM. PD 0332991 shows no activity in Rb-negative cells. PD 0332991 causes an accumulation of cells in G1 in MDA-MB-453 breast and Colo-205 carcinoma cells. ^[1] PD 0332991 also shows activity in 5T33MM myeloma cells (immunocompetent model) and sensitizes the cells to killing by bortezomib. ^[2] PD 0332991 inhibits luminal ER-positive as well as HER2-amplified breast cancer cell lines including MDA-MB-175, ZR-75-30, CAMA-1, MDA-MB-134, HCC-202 and UACC-893. PD 0332991 enhances the activity of tamoxifen and trastuzumab in these cell lines. PD 0332991 enhances the sensitivity of tamoxifen in the MCF7 tamoxifen-resistant cells. ^[3] A recent study shows that PD 0332991 could suppress malignant rhabdoid tumor (MRT) cell lines including MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS and the sensitivity of the MRT cell lines to PD 0332991 is inversely correlated with expression of p16. ^[4]

細胞データ

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
MOLM13	M1nTSWtqdmG\|ZTDBd5NigQ>?		MVSyOEBp		MWfJcohq[mm2aX;uJI9nKEOGS{SgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDSZkBxcG:\|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMECyJO69VQ>?	M3e4VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkSxNVA{Lz5{NE[0NVExOzxxYU6=
COLO205	M13kSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NYTjVJk2PzJiaB?=		NEH0PHNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt\|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEO2JO69VQ>?	M2DTTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkSxNVA{Lz5{NE[0NVExOzxxYU6=
U937	MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NWrweWwzPzJiaB?=		NWjzTJZCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|ZYPz[YQh[XNiaX7jc5Jxd3KjdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlvfG9iRF7BJJdqfGhiSVO1NEBw\iByLkG0JO69VQ>?	NIjPSHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[0NVExOyd-MkS2OFEyODN:L3G+
MOLM13	NVnQPHNLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NIL5T4g4OiCq		NWnT[5pZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNU2xOOTNiY3XscJMhcGG{Yn;ybY5oKE[OVEOgTXRFKG23dHHueEBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt\|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEm2JO69VQ>?	M2jvWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkSxNVA{Lz5{NE[0NVExOzxxYU6=
MOLM13	NIXZbnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		Mon4O\|IhcA>?		MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IIPvdoFn\W6rYj3y[ZNqe3SjboSgbJVu[W5iTV;MUVE{KGOnbHzzJIF{e2W\|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5yOU[g{txO	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ2MUGwN{c,OjR4NEGxNFM9N2F-
MDA-MB-435	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M{HLR\|I1KGh?		NVnPdXBDUUN3ME2wMlE3KM7:TR?=	MkmxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV6MEG4N\|EoRjF3OECxPFMyRC:jPh?=
K562	NHvWblJEgXSxdH;4bYMhSXO\|YYm=		NIThfms6PiCq	NXrDdpZUTE2VTx?=	NITYUJhKSzVyPUKg{txO	M2jIflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEG3OVY3Lz5{NESxO\|U3PjxxYU6=
DU145	NVLRSWZ2S3m2b4TvfIlkKEG\|c3H5		MV:5OkBp	MlzHSG1UVw>?	M3\vNmlEPTB;Nz61JO69VQ>?	NE\4VpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NESxO\|U3Pid-MkS0NVc2PjZ:L3G+
MDA-MB-231	NFPaSIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUjOfFNjOSEQvF2=	M3TkZVI1KGh?	MljUSG1UVw>?	MnXPR4VtdCCleXPs[UBienKnc4SgZZN{\XO\|ZXSgZZMh[WOldX31cIF1cW:wIHH0JGcyKHCqYYPl	NGXtVpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NESxO\|U3Pid-MkS0NVc2PjZ:L3G+
MCF7	M1;GWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHewWWcyKM7:TR?=	MYKyOEBp	NWH4UWJHTE2VTx?=	M{TFVmNmdGxiY4njcIUh[XK{ZYP0JIF{e2W\|c3XkJIF{KGGlY4XteYxifGmxbjDheEBIOSCyaHHz[S=>	M2Xp[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEG3OVY3Lz5{NESxO\|U3PjxxYU6=
MCF7	M3rKeWtqdmG\|ZTDBd5NigQ>?	MWq1JO69VQ>?	NVu2fVVUOjRiaB?=	NXnHNo8yTE2VTx?=	MVjJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFPET\|Qw[3mlbHnuSFEh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBz\XSrbn;icIF{fG:vYTDwbI9{eGixconsZZRqd25iYYSgV4VzPzhy	M1;zRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEG3OVY3Lz5{NESxO\|U3PjxxYU6=
MDA-MB-231	M1e5bmtqdmG\|ZTDBd5NigQ>?	M3fqT\|Uh\|ryP	M1LVdlI1KGh?	NIDqTndFVVOR	NV;yS5pTUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBETEt2L3P5Z4xqdkRzIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicnX0bY5w[myjc4TvcYEheGixc4Doc5J6dGG2aX;uJIF1KFOncke4NC=>	M3v2eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEG3OVY3Lz5{NESxO\|U3PjxxYU6=
MDA-MB-231	NEjzZWdHfW6ldHnvckBCe3OjeR?=	NVfPcGFGOS1zMDFOwG0>	MWmyOEBp	NX\RXo55TE2VTx?=	M{jp[IRw\XNibn;0JIlv\HWlZTDhdI9xfG:\|aYOgZZN{\XO\|ZXSgZZMhWEGUUDDjcIVifmGpZR?=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDRzN{W2Okc,OjR2MUe1OlY9N2F-
MCF7	MofPSpVv[3Srb36gRZN{[Xl?	M4mxT\|EuOTBizszN	M1\wPVI1KGh?	M13J[GROW09?	M{[3SYRw\XNibn;0JIlv\HWlZTDhdI9xfG:\|aYOgZZN{\XO\|ZXSgZZMhWEGUUDDjcIVifmGpZR?=	M1zHelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEG3OVY3Lz5{NESxO\|U3PjxxYU6=
MDA-MB-231	MX3GeY5kfGmxbjDBd5NigQ>?	NIn5cXMxNjVvMTFOwG0>	MWO0PEBp	Mn;FSG1UVw>?	MWToZZMhdm9iQ3XscEBkgWOuZTDhdpJme3RiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IIP1Zk1IOSCyaHHz[S=>	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDRzN{W2Okc,OjR2MUe1OlY9N2F-
MCF7	NYTPc4ZKTnWwY4Tpc44hSXO\|YYm=	Ml:zNE42NTFizszN	NXHvUWxOPDhiaB?=	M{\1cWROW09?	NELiVXpp[XNibn:gR4VtdCCleXPs[UBienKnc4SgZZN{\XO\|ZXSgZZMh[WOldX31cIF1cW:wIHH0JJN2[i2JMTDwbIF{\Q>?	NGjSU2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NESxO\|U3Pid-MkS0NVc2PjZ:L3G+
MOLM13	NUP6OoMzS0SNNDDpcohq[mm2aX;uJIF{e2G7		MY[yOEBp		MV;JR\|UxKD1iMD6wNVEh\|ryP	M2D1WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkSxNVA{Lz5{NE[0NVExOzxxYU6=
A2780	MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MoDaO\|IhcA>?		MkHUS2k2OCB;IECuNFMzKM7:TR?=	NYT1VI9FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOVYyOTFpPkK4NVU3OTFzPD;hQi=>
COLO205	NXzhOYpnSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		NXXzZ4ljPzJiaB?=		NF\GeGtKSzVyIE2gNE4xOzZizszN	NUfMcmk{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OFEyODNpPkK0OlQyOTB\|PD;hQi=>
MV4-11	MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MnTlO\|IhcA>?		MoH0S2k2OCB;IECuNFUh\|ryP	M1fFPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUW2NVEyLz5{OEG1OlEyOTxxYU6=
MOLM13	NYmwZXBrT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NFWzUGc4OiCq		Mlj5S2k2OCB;IECuNFYzKM7:TR?=	MkLFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNU[xNVEoRjJ6MUW2NVEyRC:jPh?=
NB4	MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MmfCO\|IhcA>?		M{[0b2dKPTBiPTCwMlA3PiEQvF2=	MnTxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNU[xNVEoRjJ6MUW2NVEyRC:jPh?=
PC3	NGTpR25Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MUO3NkBp		M1v5dGdKPTBiPTCwMlA4OSEQvF2=	M2\SbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUW2NVEyLz5{OEG1OlEyOTxxYU6=
MOLM13	M{DVfWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		MmPRO\|IhcA>?		MV3JR\|UxKD1iMD6wPVYh\|ryP	NXjuZ41SRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OFEyODNpPkK0OlQyOTB\|PD;hQi=>
MOLM13	NFe4dopCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MYe3NkBp		NF7nPVZKSzVyIE2gNE4xQTZizszN	NX;keoIxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OFEyODNpPkK0OlQyOTB\|PD;hQi=>
MDA-MB-453	NF7oRWZEgXSxdH;4bYNqfHliYYPzZZk>		M1j0fFQ5KGh?		NV7EdGZYUUN3MDC9JFAvOTN5IN88US=>	NUPCWJA3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke0OFg6OTNpPkK3OFQ5QTF\|PD;hQi=>
U937	NFXITJNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NFLlPHc4OiCq		NWi4OW04UUN3MDC9JFAvOTRizszN	NIC1NmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[0NVExOyd-MkS2OFEyODN:L3G+
MDA-MB-435	NWW2TWo3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		MnTJNlQhcA>?		MXjJR\|UxKD1iMD6xOkDPxE1?	M3rPbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUG1OVcyLz5{NkGxOVU4OTxxYU6=
MCF7	MljKR5l1d3SxeHnjbZR6KGG\|c3H5		M2XENVQ5KGh?		MX;JR\|UxKD1iMD6yOEDPxE1?	M{\t[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NES4PVE{Lz5{N{S0PFkyOzxxYU6=
MDA-MB-453	Mn7rS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NH;v[Io4OiCq		NH62[3lIUTVyIE2gNE4{OjZizszN	MlXwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNU[xNVEoRjJ6MUW2NVEyRC:jPh?=
MCF7	MkO5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M3jGc\|czKGh?		NIjBVZpIUTVyIE2gNE42PTdizszN	NF3aW5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG1OlEyOSd-MkixOVYyOTF:L3G+
MDA-MB-231	NIHjZ3BEgXSxdH;4bYNqfHliYYPzZZk>		MVe0PEBp		M{fKeWlEPTBiPTCwMlU5KM7:TR?=	NGrJVHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{S0PFkyOyd-Mke0OFg6OTN:L3G+
M229	NGHFTW1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NYnsbHR5PzJiaB?=		M3XmTGdKPTBiPTCxMlIzKM7:TR?=	NYrxenlDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOVYyOTFpPkK4NVU3OTFzPD;hQi=>
M238	Mn3DS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NIToWnk4OiCq		M1jVNGdKPTBiPTCxMlk4KM7:TR?=	Mme2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNU[xNVEoRjJ6MUW2NVEyRC:jPh?=
M249	MmHBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		MnLHO\|IhcA>?		M4DjWmdKPTBiPTCxMlk6KM7:TR?=	M4HDW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUW2NVEyLz5{OEG1OlEyOTxxYU6=
K562	NGXFdZBEgXSxdH;4bYNqfHliYYPzZZk>		MlzsPVYhcA>?		MnvjTWM2OCB;IEKg{txO	NYfG[IJyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0NVc2PjZpPkK0OFE4PTZ4PD;hQi=>
M249R	M2myUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NVLZNoVZPzJiaB?=		MY\HTVUxKD1iMj65OkDPxE1?	M4LKUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUW2NVEyLz5{OEG1OlEyOTxxYU6=
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MDA-MB-468	NF3FVHVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NYTuWXdPOjRiaB?=		NVq3VFVIUUN3MDC9JFMh\|ryP	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjFzNUW3NUc,OjZzMUW1O\|E9N2F-
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D-263MG	M3r6TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1PuOWlEPTB;N{G3MlEzKG6P	NEnKZVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
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NBsusSR	NGrCXXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnXzTWM2OD15NEKuPVkhdk1?	MnPyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
NCI-H520	MoDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIXrOFlKSzVyPUe0Ok42OiCwTR?=	NXHlTIJDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
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T-24	MmjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFvMWGlKSzVyPUe3PE44OSCwTR?=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
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EW-3	MlnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlfOTWM2OD16MEiuO\|Yhdk1?	M4nP[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
RXF393	M3fYWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlLOTWM2OD16MUKuO\|khdk1?	NVH6XINHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
U251	NUXVd283T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGqwV4lKSzVyPUixN{45QCCwTR?=	NX;uNFEyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
CAMA-1	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFHTdVhKSzVyPUizN{46PCCwTR?=	MnnsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
JVM-3	M3S1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NG\VZXVKSzVyPUi1NU44QCCwTR?=	NVzVeWwzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
COLO-800	MmXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUjBN\|hnUUN3ME24PVcvPzhibl2=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
OVCAR-5	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmLQTWM2OD17MECuNUBvVQ>?	NHLNRnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
LB1047-RCC	M1nTSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYHJR\|UxRTl{Nz61OkBvVQ>?	NF;KUWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
SW954	MkDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4fUeWlEPTB;OUK5MlQyKG6P	NYnFVGZZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
J-RT3-T3-5	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWTtR3E{UUN3ME25N\|YvODZibl2=	NU\wRW9IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
Mewo	NEjyfY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYXJR\|UxRTl\|Nj62JI5O	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
NCI-H1770	MlfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVLz[GdrUUN3ME25OFAvPTVibl2=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
HO-1-N-1	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYrJR\|UxRTl4Mj64NUBvVQ>?	NUXOflJDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
HSC-3	M37Fe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{HXdWlEPTB;OU[2MlQ5KG6P	M2XvVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
TYK-nu	MnH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2XCeGlEPTB;OUm4MlI2KG6P	NXLvO\|V[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
KYSE-150	MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGDmb4JKSzVyPUGuNFAxPzZizszN	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
SN12C	NX3pSos2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NY[1Z2lsUUN3ME2xMlAxQDd3IN88US=>	NIrRZ409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
MOLT-13	NX\1RWpTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV;ZT4NmUUN3ME2xMlAyPDJzIN88US=>	NWXlemxZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
TE-11	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{nxXGlEPTB;MT6wOFgyOiEQvF2=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
DB	Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV;ibJBxUUN3ME2xMlA4Ojd\|IN88US=>	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
CAL-39	NX\aWXFyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH7KXHhKSzVyPUGuNFc2OjJizszN	MoPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
A3-KAW	Mke1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmPpTWM2OD1zLkC4OFA5KM7:TR?=	NGT1NoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
CHP-134	NH7GSmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXS5U3hmUUN3ME2xMlEyQDB5IN88US=>	NV:4WIZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
TGW	NVzRfFJqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnmzTWM2OD1zLkGyN\|k2KM7:TR?=	MkPjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
QIMR-WIL	NV\PTHFCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn;KTWM2OD1zLkGzNVM1KM7:TR?=	NWLVV5p3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
NCI-SNU-1	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYPJR\|UxRTFwMU[zOVQh\|ryP	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
CGTH-W-1	MkXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml7YTWM2OD1zLkG3NVg3KM7:TR?=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
MHH-ES-1	NIrXOIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1v3[2lEPTB;MT6xO\|k5PiEQvF2=	MomxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
LB2241-RCC	MnnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmLSTWM2OD1zLkG4OlIh\|ryP	NV7kUFhVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
ML-2	NITxbG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGPIdFJKSzVyPUGuNlA4OzRizszN	NF7UXHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
COR-L23	MlriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGD0XYFKSzVyPUGuNlI6OzNizszN	NX:zbW41RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
BFTC-905	NU\yeFY2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWLJR\|UxRTFwMkSyOlch\|ryP	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
Hs-578-T	M1LPUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmO4TWM2OD1zLkK1PFE4KM7:TR?=	NV\ES4k5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
KG-1	M3\pUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHLiNGlKSzVyPUGuNlY3QDZizszN	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
HEL	MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXPJR\|UxRTFwMkmzN\|gh\|ryP	MkfLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
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COLO-741	MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mly1TWM2OD1zLkOyNFg6KM7:TR?=	MmnOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
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CAL-54	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NH3DPItKSzVyPUKuNlA1OTNizszN	NIfuO2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
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RCC10RGB	MkTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3fHfGlEPTB;MUiuNVY6PyEQvF2=	NIjHR289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
HD-MY-Z	M33wPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml65TWM2OD1zOD6yNlU1KM7:TR?=	M3LVflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
A427	NULpR25tT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1jLT2lEPTB;MUiuOVA6PCEQvF2=	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
HCC2998	M3LDb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFrYZllKSzVyPUG4MlYxPTFizszN	Mn;yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
EPLC-272H	MkTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3;NVWlEPTB;MUmuNFQ{PCEQvF2=	NWGyUWZHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
C32	NHP4[pRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUjYW2ZyUUN3ME2xPU4xPDVizszN	M1jrc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
UMC-11	NU\Ie2U4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkL3TWM2OD1zOT6yNVI{KM7:TR?=	M4XzZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
CaR-1	MnvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH;YeZZKSzVyPUG5MlY5ODRizszN	M1vRVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
KYSE-410	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVjJR\|UxRTF7LkmxN\|kh\|ryP	M2jNUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
HuCCT1	NF;wSHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIjKNXFKSzVyPUKwMlYzQTRizszN	MmHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
LB996-RCC	M2LBcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFnuWHdKSzVyPUKwMlcyPjhizszN	NXLhc3pvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
KYSE-70	NHW3bplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MULJR\|UxRTJyLkiwOVkh\|ryP	MoTYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
CAL-72	M1j2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHfGSIdKSzVyPUKwMlkyPSEQvF2=	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
Capan-2	MoHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3LKWmlEPTB;MkGuNFQyOyEQvF2=	NXGyOHJMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
PANC-08-13	M4HEWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnTuTWM2OD1{MT6yOVE2KM7:TR?=	MkXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
SBC-1	MnTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnLHTWM2OD1{MT6zNFgyKM7:TR?=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
MFM-223	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVfGboFvUUN3ME2yNU4{OzR{IN88US=>	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
BB49-HNC	M1jBcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYHYVYFYUUN3ME2yNU42PzF4IN88US=>	M3r0SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
SH-4	M2P4bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYHpeI01UUN3ME2yNU43PjF6IN88US=>	NXfPe3JqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
HuO9	M{nHXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NX7xTWZFUUN3ME2yNU46QDJ3IN88US=>	M3\lflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
AM-38	MlTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIDMdWVKSzVyPUKyMlA1QDVizszN	NY\xVVZiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
A431	NYq2V2FMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1uxWmlEPTB;MkOuNlEyQSEQvF2=	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
YAPC	NXW4[GZJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4mzbWlEPTB;MkOuNlY2OSEQvF2=	MmToQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
LU-139	M4jJdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIXaTGZKSzVyPUKzMlQ5ODlizszN	NIn3eHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
HEC-1	NFG0NoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnXrTWM2OD1{Mz60PVM4KM7:TR?=	NUfLUGptRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
SCC-25	NGfiVXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3TldGlEPTB;MkSuN\|AxPiEQvF2=	MmS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
HT-29	MmDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIDJbmdKSzVyPUK0MlM5OjNizszN	MkXJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
PC-14	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{HtXGlEPTB;MkSuOlU4OSEQvF2=	M4PsT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
Calu-6	NYW0VoVzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlH5TWM2OD1{NT61NFcyKM7:TR?=	NIL3SI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
SJRH30	M3\mNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mln4TWM2OD1{NT62OFk3KM7:TR?=	NGTMbFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
ChaGo-K-1	NIjwfIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWD1boRLUUN3ME2yOk4yPjJ7IN88US=>	NVTOeXZnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
IA-LM	NF\0ZnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUfJR\|UxRTJ4LkO2OFUh\|ryP	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
GP5d	MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1X6NGlEPTB;Mk[uOFQ6OSEQvF2=	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
NCI-H2291	MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFvR[WZKSzVyPUK2MlY2PDFizszN	MkjmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
BALL-1	MkeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVLJZ3ZxUUN3ME2yOk46Ozl5IN88US=>	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
HCC1954	NV\LZlRtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV\Pbo03UUN3ME2yOk46QDB6IN88US=>	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
NCI-H2452	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkT1TWM2OD1{Nz60NVY{KM7:TR?=	M32yXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
LU-99A	NEDs[GxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUPEdZdWUUN3ME2yO{42PTh{IN88US=>	MnzNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
NTERA-S-cl-D1	NXTac\|l5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkL2TWM2OD1{Nz63Nlk6KM7:TR?=	MljWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
PANC-10-05	NUfNTFJOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3PVSWlEPTB;MkeuO\|c4PSEQvF2=	NULKVGVmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
NCI-H2405	NFfSXoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVzJR\|UxRTJ5LkmzPFch\|ryP	NHjMSos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
MDA-MB-415	NIT6e29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYn4[YlpUUN3ME2yPE41OTN5IN88US=>	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
NCI-H2342	MnHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHfWfZNKSzVyPUK4MlUzQDFizszN	NUmxT3lkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
TGBC24TKB	MmLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUOwOnM4UUN3ME2yPE44OTF5IN88US=>	M4nPSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
LU-134-A	M2DobGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1LtWGlEPTB;MkiuPVI3OSEQvF2=	NWXzcFFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
SCC-4	NF;o[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUTJR\|UxRTNzLkC0PVQh\|ryP	Mlr4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
Saos-2	M3;YPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWrJb5V3UUN3ME2zNU46OzB4IN88US=>	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
RERF-LC-MS	MnzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGXqW3NKSzVyPUOyMlgzOzFizszN	NFLxS5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
M14	MorDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml71TWM2OD1\|Mj65O\|Y1KM7:TR?=	M1XEVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
HPAF-II	M2X3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWLJR\|UxRTN\|LkWwNVEh\|ryP	M2TBeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
NCI-H1755	NG\sV\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYjJR\|UxRTN2LkOzNFUh\|ryP	MoPKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
D-392MG	MkPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MojQTWM2OD1\|NT64Olc1KM7:TR?=	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
A704	M2jiOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYrsdJdCUUN3ME2zOk4xPDJ5IN88US=>	MlTKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
CP50-MEL-B	NWDtZopJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWPVe\|lEUUN3ME2zOk4yQTFzIN88US=>	NFH0OFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
EW-18	M4OyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4rzTGlEPTB;M{[uOFUzKM7:TR?=	NVLZToJiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
WM-115	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV7JR\|UxRTN4LkiwPVkh\|ryP	NH7KXZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
LU-65	NYHleppjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHyySlRKSzVyPUO3MlE1OTdizszN	MmPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
NCI-H1563	M4i5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MX3JR\|UxRTN5LkK0PFQh\|ryP	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
DBTRG-05MG	M2Tyd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHflPZJKSzVyPUO4MlA3QTFizszN	M1nwU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
NCI-H630	NV\HNo8zT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1frbmlEPTB;M{iuOFcyPCEQvF2=	M2HXSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
NCI-H1155	MlnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVvJR\|UxRTN7LkK0NkDPxE1?	NHX0cJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
OVACR-3	NGnp[JNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVHOO5QxUUN3ME2zPU46OTl3IN88US=>	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
OAW-42	M2rJTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWS4XYJEUUN3ME20NE41OjV6IN88US=>	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
JVM-2	M320[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1rTcWlEPTB;NEGuNlQyPSEQvF2=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
C3A	MnXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mlr3TWM2OD12MT6zOFQ4KM7:TR?=	MnyzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
HT55	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYTJR\|UxRTR{LkK4OFEh\|ryP	NYHobmpvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
OVCAR-4	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXjJR\|UxRTR{LkK5O\|Qh\|ryP	MmDVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
MEG-01	NV3iOYZXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MV7JR\|UxRTR{LkS2NVYh\|ryP	NHqxOJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
NCI-H82	MnTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH7jfopKSzVyPUSzMlk5QTJizszN	NIL6Tlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
JEG-3	MlO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4\6dGlEPTB;NESuPVQ4KM7:TR?=	Mkn2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg6QTZ\|Lze+V2FPT0WUPD;hQi=>
BPH-1	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{P5fGlEPTB;NE[uN\|k6QCEQvF2=	M2HFNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
MPP-89	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGXuUFJKSzVyPUS3MlI5QThizszN	M2qxSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
ALL-PO	M3PzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoXHTWM2OD12Nz60NVg5KM7:TR?=	M3fvb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QTl4Mz:nQnNCVkeHUkyvZV4>
HT	NUTaRXVpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUnJR\|UxRTR5LkS5NkDPxE1?	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFk6PjNxJ{7TRW5ITVJ:L3G+
NCI-H2347	NXTsNFZLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWi4XGFTUUN3ME20PE4xPzF3IN88US=>	NUDITHliRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
A2780	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Moe4TWM2OD12OT60NlI5KM7:TR?=	NXKxfHdZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh7OU[zM{c,W0GQR1XSQE9iRg>?
KARPAS-299	NHy4fplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlTaTWM2OD12OT61NVE6KM7:TR?=	NF2zclQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,
NCI-H1651	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXvJR\|UxRTR7Lki4NlEh\|ryP	NI\henE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDl7NkOvK\|5USU6JRWK8M4E,

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ

Methods	Test Index	PMID
Western blot	RB1 (pT821) / RB1 (pS780) / RB1 / CDK6 / CCND2 / RUNX1 / ETO; PubMed: 30300583 Cancer Cell Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells. pRb(S807, 811) / CDK4 / CDK6 / PARP; PubMed: 28453226 Mol Oncol Effects of palbociclib on CDK4/6-Rb pathway. HCC cells were treated with different doses of palbociclib for 24 h, and then, the cells were subjected to western blot analysis. CF, cleaved fragment. LC3-I / LC3-II; PubMed: 28453226 Mol Oncol Palbociclib increases LC3-II amount in a dose-dependent manner in HCC cell lines. pAMPKα(T172) / pULK1(S317); PubMed: 28453226 Mol Oncol Dose-dependent response of palbociclib on AMPK-related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. SMAD2 (pS255); PubMed: 30343527 Cancer Sci T47D cells were treated with indicated concentrations of palbociclib for 24 h to evaluate substrate phosphorylation.	30300583 28453226 30343527
Growth inhibition assay	Cell viability; PubMed: 29670090 Cell Death Dis Cell viability was determined by MTT assays after palbociclib exposure for 2, 4, and 6 days. The cell cycle of SYO-1 and Fuji cells was assessed after exposure to palbociclib (1 µM) for 24 h by flow cytometry analysis.	29670090
Immunofluorescence	SAHF/ATRX; PubMed: 26988987 Cancer Res DAPI staining for senescence-associated heterochromatic foci (SAHF, left panel) and ATRX staining (right panel) in 1205Lu cells +/− palbociclib for 8 days. LC3B; PubMed: 28453226 Mol Oncol LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3-positive autophagosomes. Nuclei were counterstained with DAPI (blue).	26988987 28453226
ELISA	PGE2; PubMed: 26540629 Oncotarget The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.	26540629

体内試験

PD 0332991 indicates complete tumor stasis in a MDA-MB-435 xenograft at 150 mg/kg. PD 0332991 also shows broad-spectrum antitumor activity in multiple human tumor xenografts by eliminating phospho-Rb and the proliferative marker Ki-67 from tumor tissue and down-regulation of genes under the transcriptional control of E2F. ^[1]

お薦めの試験操作（参考用のみ）

キナーゼ試験： ^[1]	- 合併 Cdk Assays: A stock solution of PD0332991 is prepared in DMSO. CDK assays are performed in 96-well filter plates. All CDK-cyclin kinase complexes are expressed in insect cells through baculovirus infection and purified. The substrate for the assays is a fragment (amino acids 792–928) of pRb fused to GST (GST·RB-Cterm). The total volume in each well is 0.1 mL containing a final concentration of 20 mM Tris-HCl, pH 7.4, 50 mM NaCl, 1 mM dithiothreitol, 10 mM MgCl₂, 25 μM ATP (for CDK4-cyclin D1, CDK6-cyclin D2, and CDK6-cyclin D3) or 12 μM ATP (for CDK2-cyclin E, CDK2-cyclin A, and CDC2-cyclin B) containing 0.25 μCi of [γ-³²P]ATP, 20 ng of enzyme, 1 μg of GST·RB-Cterm, and PD 0332991 (0.001-0.1μM). All components except the [γ-³²P]ATP are added to the wells, and the plate is placed on a plate mixer for 2 min. The reaction is started by adding the [γ-³²P]ATP and the plate is incubated at 25 °C for 15 min. The reaction is terminated by addition of 0.1 mL of 20% trichloroacetic acid and the plate is kept at 4 °C for at least 1 hour to allow the substrate to precipitate. The wells are then washed 5 times with 0.2 mL of 10% trichloroacetic acid and radioactive incorporation is determined with a β plate counter.
細胞試験： ^[1]	- 合併細胞株： Tumor cell lines including MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM and K562 濃度： 0.01-1 μM 反応時間： 24 hours 実験の流れ： Cells are seeded at 2 × 10⁴ per well in a 96-well plate and incubated overnight. PD 0332991 (0.01-1 μM) is added to the wells and incubated at 37 °C for another 24 hours. [¹⁴C]Thymidine (0.1 μCi) is added to each well and incorporation of the radiolabel is allowed to proceed for 72 hours. Incorporated radioactivity is determined with a β plate counter. (参考用のみ)
動物試験： ^[1]	- 合併動物モデル： Advanced stage human tumor xenografts including Colo-205, MDA-MB-435 breast, SF-295 glioblastoma, ZR-75-1 breast, PC-3 prostate, H125 lung, SW-620 colon, H23 lung and MDA-MB-468 breast (Rb negative) are established in severe combined immunodeficient mice. 投薬量： 0-150 mg/kg 投与方法： Given by gavage (参考用のみ)

参考

[4] Katsumi Y, et al. Biochem Biophys Res Commun, 2011, 413(1), 62-68.

- 合併

溶解度 (25°C)

体外	Water	30 mg/mL (61.98 mM)
	DMSO	3 mg/mL warmed (6.19 mM)
	Ethanol	Insoluble
体内	左から（NMPから）右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ): Saline 混合させたのち直ちに使用することを推奨します。	6 mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報 Palbociclib (PD-0332991) HCl SDFをダウンロードする

分子量	483.99
化学式	C₂₄H₂₉N₇O₂.HCl
CAS No.	827022-32-2
Storage	3 years-20°C powder 2 years-80°C in solvent
別名	N/A
Smiles	CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl

投与溶媒組成計算器(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

投与量

mg/kg

動物平均体重

投与体積（動物毎）

動物数

匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO+ % + % Tween 80+ % ddH₂O

計算リセット

計算結果:

投与溶媒濃度： mg/ml；

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL，注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。）

投与溶媒調製方法：μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH₂O，を加え完全に溶解させます。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

便利ツール

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

質量

濃度

体積

分子量
=

×

×

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA（製品ページで利用可能な）。

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます：

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます：C1V1 = C2V2 ( 入力出力 )

C1

V1

C2

V2
×

=

×

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA（オンラインで利用できる）で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

連続希釈剤
初めの濃度：
稀釈倍数：

計算結果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください：

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量	濃度	体積	分子量
=	×	×

臨床試験 (data from https://clinicaltrials.gov, updated on 2020-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04669587	Not yet recruiting	Drug: ZB716\|Drug: Palbociclib	Estrogen Receptor-Positive\|HER2-Negative\|Advanced\|Metastatic Breast Cancer	EnhancedBio USA Inc.\|Zenopharm LLC\|EnhancedBio Inc.	February 1 2021	Phase 1\|Phase 2
NCT04671615	Active not recruiting	Drug: palbociclib	Metastatic Breast Cancer	Pfizer	December 6 2020	--
NCT04567420	Not yet recruiting	Drug: Palbociclib\|Drug: Fulvestrant\|Drug: Adjuvant Therapy	Breast Cancer	Criterium Inc.	December 15 2020	Phase 2
NCT04654208	Not yet recruiting	Drug: palbociclib	Malignant Neoplasm of Breast	Pfizer	November 30 2020	--
NCT04483505	Recruiting	Drug: Combination Rogaratinib + palbociclib + fulvestrant	Breast Cancer Metastatic\|Hormone Receptor Positive Malignant Neoplasm of Breast	Fundacion CRIS de Investigación para Vencer el Cáncer\|Bayer\|Pfizer\|Apices Soluciones S.L.	November 25 2020	Phase 1

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

CDKシグナル伝達経路

CDK Inhibitors with Unique Features

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LY2835219 : CDK4, IC50=2 nM; CDK6, IC50=10 nM.
CDK Inhibitor in Clinical Trial

Dinaciclib (SCH727965) : Phase III for Chronic Lymphocytic Leukemia (CLL).
Newest CDK Inhibitor

NU6027 : Potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with K_i of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.

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Features:The 1st specific inhibitor for CDK4/6 to show promise in multiple cancers.
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Dinaciclib (SCH727965, PS-095760) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation. Dinaciclib induces apoptosis through the activation of caspases 8 and 9. Phase 3.
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研究分野別

製品類型

Palbociclib (PD-0332991) HCl

文献中Selleckの製品使用例(260)

製品安全説明書

CDK阻害剤の選択性比較

生物活性

お薦めの試験操作（参考用のみ）

参考

溶解度 (25°C)

化学情報 Palbociclib (PD-0332991) HCl SDFをダウンロードする

投与溶媒組成計算器(クリア溶液)

便利ツール

モル濃度計算器

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

希釈計算器

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

連続希釈計算器方程式

連続希釈剤

計算結果

分子量计算器

総分子量：g/mol

モル濃度計算器

臨床試験 (data from https://clinicaltrials.gov, updated on 2020-01-06)

技術サポート

CDKシグナル伝達経路

CDK Inhibitors with Unique Features

相関CDK製品