Ribociclib (LEE011)

For research use only. Not for use in humans.

製品コードS7440

CAS No. 1211441-98-3

Ribociclib (LEE011) is an orally available, and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM. Phase 3.

サイズ

価格(税別)

5mg	JPY 34700
10mg	JPY 51300
25mg	JPY 86960

最寄りの販売代理店を探す

東京
北海道
東北
北関東
南関東
東海
北信越
近畿
中国
四国
九州

お探しのディーラーが見当たらない場合は直接こちらのメールアドレスまでお問い合わせください：[email protected]

バルク問合せ

代表番号: 03-5615-9297|電子メール：[email protected]|よく尋ねられる質問

文献中Selleckの製品使用例(58)

製品安全説明書

CDK阻害剤の選択性比較

生物活性

製品説明

Ribociclib (LEE011) is an orally available, and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM. Phase 3.

特性

Orally bioavailable CDK4/6-selective inhibitor that has been tested in Phase III clinical trials for treatment of advanced breast cancer.

ターゲット

CDK4 ^[2] (Cell-free assay)	CDK6 ^[2] (Cell-free assay)
10 nM	39 nM

体外試験

LEE011, as dual CDK4/CDK6 inhibitor, significantly inhibits the growth of 12 of 17 neuroblastoma cell lines with mean IC50 of 307 nM. The growth inhibition of neuroblastoma cell lines is primarily cytostatic and is mediated by a G1 cell-cycle arrest and cellular senescence. ^[1]

細胞データ

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
DFSP105	NXTSWFlwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MVuyOEBp		NHOwUXlIUTVyPUK3OkBvVQ>?	NIPQS\|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi1NlA2QCd-MkW4OVIxPTh:L3G+
Myoblast	MoG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NFnqbFE4OiCq		NVP2SnVSUUN3ME2xNFM2KG6P	M1v1OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEGwN\|c2Lz5{NUixNFM4PTxxYU6=
IMRS	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NUjGdGNNPzJiaB?=		M3H2fGlEPTB;OEezJI5O	M1jxPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEGwN\|c2Lz5{NUixNFM4PTxxYU6=
SKNAS	M36zSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MYO3NkBp		MV3JR\|Ux97zgMUCwNFAhdk1?	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPThzMEO3OUc,OjV6MUCzO\|U9N2F-
Rh28	M{jBb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NXjN[VJ1PzJiaB?=		NXzsemhzUUN3ME24OFUhdk1?	MkXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MUCzO\|UoRjJ3OEGwN\|c2RC:jPh?=
Rh41	NYHjXVVPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M1LCS\|czKGh?		NULwSIRmUUN3ME23NVg4KG6P	NVH6d\|NMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NVA{PzVpPkK1PFExOzd3PD;hQi=>
CW9019	M1jPS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M4\TVVczKGh?		NGWwU3VKSzVyPUm5NVIhdk1?	M1zWTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEGwN\|c2Lz5{NUixNFM4PTxxYU6=
Rh5	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NF7sPI04OiCq		MUDJR\|Ux97zgMUCwNFAhdk1?	Mn;GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MUCzO\|UoRjJ3OEGwN\|c2RC:jPh?=
Rh30	MkX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MX:3NkBp		MWfJR\|Ux97zgMUCwNFAhdk1?	NFjoZ4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixNFM4PSd-MkW4NVA{PzV:L3G+
778	M4rwOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MoXYO\|IhcA>?		NHn4PG9qdmirYnn0d{Bk\WyuIHfyc5d1cCCmb4PlJIRmeGWwZHXueIx6	NVfGc\|dCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwNlg1PjlpPkK1NFI5PDZ7PD;hQi=>
449	NHfpUIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MWm3NkBp		NHLS[FVqdmirYnn0d{Bk\WyuIHfyc5d1cCCmb4PlJIRmeGWwZHXueIx6	M3nwZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEK4OFY6Lz5{NUCyPFQ3QTxxYU6=
LP3	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M2jvTVczKGh?		NI\acZFqdmirYnn0d{Bk\WyuIHfyc5d1cCCmb4PlJIRmeGWwZHXueIx6	Ml7WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMki0OlkoRjJ3MEK4OFY6RC:jPh?=
LP6	NUT3dnRvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MkXTO\|IhcA>?		MWLpcohq[mm2czDj[YxtKGe{b4f0bEBld3OnIHTldIVv\GWwdHz5	M1fJPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEK4OFY6Lz5{NUCyPFQ3QTxxYU6=
LP8	MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M37ublczKGh?		MorVbY5pcWKrdIOgZ4VtdCCpcn;3eIgh\G:\|ZTDk[ZBmdmSnboTsfS=>	Ml3sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMki0OlkoRjJ3MEK4OFY6RC:jPh?=
LPS141	M4XZbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M{nxU\|czKGh?		MWDpcohq[mm2czDj[YxtKGe{b4f0bEBld3OnIHTldIVv\GWwdHz5	NFH2WVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCyPFQ3QSd-MkWwNlg1Pjl:L3G+
778	NHT1T5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVWzMlM{KM7:TR?=	M1W4e\|I1KGh?		NXfCNmQ{\GWlcnXhd4V{KHSqZTDwdo9xd3K2aX;uJI9nKGOnbHzzJIlvKFNicHjhd4U>	M3zhelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEK4OFY6Lz5{NUCyPFQ3QTxxYU6=
449	NEf2cGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVOzMlM{KM7:TR?=	NGn2dpozPCCq		NIPrfGNl\WO{ZXHz[ZMhfGinIIDyc5BwenSrb36gc4Yh[2WubIOgbY4hWyCyaHHz[S=>	MonSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMki0OlkoRjJ3MEK4OFY6RC:jPh?=
LP3	M3zSbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWXFbHBiOy5\|MzFOwG0>	MYWyOEBp		NYD6R4xo\GWlcnXhd4V{KHSqZTDwdo9xd3K2aX;uJI9nKGOnbHzzJIlvKFNicHjhd4U>	NV[3cVlJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwNlg1PjlpPkK1NFI5PDZ7PD;hQi=>
LP6	MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4SxbFMvOzNizszN	MlvaNlQhcA>?		MkLz[IVkemWjc3XzJJRp\SCycn;wc5J1cW:wIH;mJINmdGy\|IHnuJHMheGijc3W=	NH\qOHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCyPFQ3QSd-MkWwNlg1Pjl:L3G+
LP8	M4XKOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Moq3N{4{OyEQvF2=	NFm5dGYzPCCq		NUnTbFg1\GWlcnXhd4V{KHSqZTDwdo9xd3K2aX;uJI9nKGOnbHzzJIlvKFNicHjhd4U>	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB{OES2PUc,OjVyMki0Olk9N2F-
LPS141	MnPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1;rOFMvOzNizszN	NGDL[FkzPCCq		NU\GPYlm\GWlcnXhd4V{KHSqZTDwdo9xd3K2aX;uJI9nKGOnbHzzJIlvKFNicHjhd4U>	MkjVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMki0OlkoRjJ3MEK4OFY6RC:jPh?=
IMR5	NIXWUoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NHi5[IYzPCCq	MX7EUXNQ	M3ridGlEPTB;MUK2JI5O	NX73bIdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwOFUyPzlpPkK0NFQ2OTd7PD;hQi=>
BE2C	NGH0fIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NGi2U20zPCCq	M1TEXGROW09?	NXHnO5JnUUN3ME2xN\|Qhdk1?	M4GybVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MES1NVc6Lz5{NEC0OVE4QTxxYU6=
1643	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NV;XdXV3OjRiaB?=	NYXOSI9ZTE2VTx?=	NGXRUHlKSzVyPUG0O{BvVQ>?	NWS2emY3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwOFUyPzlpPkK0NFQ2OTd7PD;hQi=>
SKNSH	NVjNfYNmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		Mn2yNlQhcA>?	MlLRSG1UVw>?	MmG4TWM2OD1zNEigcm0>	M3foU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MES1NVc6Lz5{NEC0OVE4QTxxYU6=
SY5Y	M{nhVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MnSyNlQhcA>?	MWPEUXNQ	NUT4dVh1UUN3ME2xOVQhdk1?	M2nL[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MES1NVc6Lz5{NEC0OVE4QTxxYU6=
NGP	MlPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MUSyOEBp	MnnYSG1UVw>?	NVHMTnFyUUN3ME2xO\|Uhdk1?	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB2NUG3PUc,OjRyNEWxO\|k9N2F-
KELLY	NYXaUpAzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M{PZSFI1KGh?	MYHEUXNQ	NWXpPVQ3UUN3ME2yNlAhdk1?	NXLaOoNVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwOFUyPzlpPkK0NFQ2OTd7PD;hQi=>
CHP134	NITYSWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M2rSNVI1KGh?	MXPEUXNQ	NFTxdmFKSzVyPUK3N{BvVQ>?	NEmwbFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC0OVE4QSd-MkSwOFUyPzl:L3G+
NLF	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NWHGXYxSOjRiaB?=	M121dWROW09?	MXTJR\|UxRTN{ODDuUS=>	M1zweFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MES1NVc6Lz5{NEC0OVE4QTxxYU6=
LAN5	NHO1VHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M4nFVFI1KGh?	NYXaPWZKTE2VTx?=	NW\peJlTUUN3ME20Nlkhdk1?	NHHOemg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC0OVE4QSd-MkSwOFUyPzl:L3G+
NB69	MnfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NWf4eoZNOjRiaB?=	NITNdmpFVVOR	MmnHTWM2OD15M{igcm0>	NXznU3I3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwOFUyPzlpPkK0NFQ2OTd7PD;hQi=>
SKNDZ	NXfMb4ozT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MoPUNlQhcA>?	NYm1WotZTE2VTx?=	MWjJR\|UxRThyMTDuUS=>	M17HOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MES1NVc6Lz5{NEC0OVE4QTxxYU6=
NBSD	NGjDPHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M3q1VFI1KGh?	NVfsW5BbTE2VTx?=	NVvyfoltUUN3ME2xPVAxKG6P	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB2NUG3PUc,OjRyNEWxO\|k9N2F-
SKNF1	MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NYTPS3VkOjRiaB?=	NGThcYVFVVOR	M{TpfmlEPTB;M{WwNEBvVQ>?	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB2NUG3PUc,OjRyNEWxO\|k9N2F-
EBC1	NGjWXIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MkfhNlQhcA>?	Mm\uSG1UVw>?	NWPYe20yUUN3ME22OFAxKG6P	Mmi3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyNEWxO\|koRjJ2MES1NVc6RC:jPh?=
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Sf21	NH7J[HpHfW6ldHnvckBie3OjeR?=		NXfN[4VpOTBibXnudy=>		MnLPTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCodXzsJIxmdme2aDDOMZRmem2rbnHsJGdUXC22YXfn[YQhS0SNND;DfYNtcW5vREOgZ48u\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJJNnOjFiY3XscJMhfXOrbnegVoIhe3Wkc4TyZZRmKGmwIIDy[ZNmdmOnIH;mJHto[W2vYUOzVH1CXFBiYX\0[ZIhOTBibXnud{BjgSC\|Y3nueIltdGG2aX;uJINwfW62aX7nJI1mfGixZDygTWM2OCB;IECuNFE{KM7:TT6=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTVzOEOxNkc,Ojl3MUizNVI9N2F-
Sf21	NVLnem9pTnWwY4Tpc44h[XO\|YYm=		MUCxNEBucW6\|		NGnsWnVKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIH\1cIwhdGWwZ4ToJGMufGW{bXnuZYwhPkircz30ZYdo\WRiQ1TLPU9EgWOuaX6tWFEh[29vZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKHOoMkGgZ4VtdHNidYPpcochWESNdHnk[UB{fWK\|dILheIUhcW5icILld4Vv[2Vib3[gX4didW2jM{PQYWFVWCCjZoTldkAyOCCvaX7zJIJ6KHOlaX70bYxt[XSrb36gZ492dnSrbnegcYV1cG:mLDDJR\|UxKD1iMD6xPVch\|ryPLh?=	M4H1PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUG4N\|EzLz5{OUWxPFMyOjxxYU6=
HepG2	NY[xXot2SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MnjOO\|IhcHK\|		NXS0[VFRSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgR4VtXGm2ZYKtS4xwKGG\|c3H5MEBGSzVyIE2gNE4zQDZ{IN88UU4>	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTRyN{m3OUc,Ojl2MEe5O\|U9N2F-
SEM	M{PiWWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NG\hO\|g4OiCqcoO=		M3[yNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1XNJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCFZXzUbZRmei2JbH:gZZN{[XluIFXDOVAhRSByLkS2NFUh\|ryPLh?=	NUnMN5o{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NFc6PzVpPkK5OFA4QTd3PD;hQi=>
KOPN8	MYDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MlnNO\|IhcHK\|		NWrFd2g{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLU3BPQCClZXzsd{Bi\nSncjC3NkBpenNiYomgR4VtXGm2ZYKtS4xwKGG\|c3H5MEBGSzVyIE2gNE42ODB6IN88UU4>	M4SwelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEC3PVc2Lz5{OUSwO\|k4PTxxYU6=
NCI-H1299	M3OzdWN6fG:2b4jpZ4l1gSCjc4PhfS=>		M3KzWFczKGi{cx?=		MnTvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUhzMkm5JINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhUUN3MDC9JFUvPDZizszNMi=>	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTVzOEOxNkc,Ojl3MUizNVI9N2F-
T47D	NX3FXXJjT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NFTQdVM4OiCqcoO=		NWfFS4EzT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hXDR5RDDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBES0t6IHHzd4F6NCCLQ{WwJF0hPi5{Mkeg{txONg>?	NIjBeWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[1NVk4QSd-Mki2OVE6Pzl:L3G+
T47D	NIrZNHZEgXSxdH;4bYNqfHliYYPzZZk>		MVy3NkBpenN?		MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUOFdFKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiSVO1NEA:KDZwMkOg{txONg>?	MkKzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3MUizNVIoRjJ7NUG4N\|EzRC:jPh?=
H1299	MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NVfLfllQPzJiaILz		NXz6cJdoT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUDF{OUmgZ4VtdHNiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhS0ONODDhd5NigSxiSVO1NEA:KDdwNkO3JO69VS5?	MlS4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NUG5O\|koRjJ6NkWxPVc6RC:jPh?=
KOPN8	M17Nc2Fxd3C2b4Ppd{Bie3OjeR?=	NXL0XVNYOC53IIXN	M1XXVlMhcHK\|		M4HBW2lv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iS1;QUlgh[2WubIOgZZN{\XO\|ZXSgZZMhfXC{ZXf1cIF1cW:wIH;mJINt\WG4ZXSgVGFTWCCuZY\lcEBifCByLkWgeW0h[W[2ZYKgN{BpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{	M4\IWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEC3PVc2Lz5{OUSwO\|k4PTxxYU6=
KOPN8	M3PMNGFxd3C2b4Ppd{Bie3OjeR?=	NH3qOWMxNjVidV2=	M{K2N\|I1KGi{cx?=		NWPZ[W9yUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDLU3BPQCClZXzsd{Bie3Onc4Pl[EBieyC3cILl[5Vt[XSrb36gc4Yh[2ynYY\l[EBRSVKSIHzleoVtKGG2IECuOUB2VSCycnWteJJm[XSnZDD3bZRpKE6DQzDmc5IhOSCqcjDhcoQhdWWjc4Xy[YQh[W[2ZYKgNlQhcHK\|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>?	M3\NR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEC3PVc2Lz5{OUSwO\|k4PTxxYU6=
Hep3B	NEPMZ2FE\WyuIHP5Z4xmKGG\|c3H5		NIXQSoMzPCCqcoO=		M{j3WGNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGhmeDOEIHPlcIx{KGG\|c3Xzd4VlKGG\|IHHjZ5VufWyjdHnvckBifCCJMD;HNUBxcGG\|ZTDh[pRmeiB{NDDodpMh[nlicILvdIllcXWvIHnv[Ill\SC\|dHHpcolv\yCkYYPl[EBndG:5IHP5eI9u\XS{eR?=	MniwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3MUizNVIoRjJ7NUG4N\|EzRC:jPh?=
HepG2	MULD[YxtKGO7Y3zlJIF{e2G7		MX2yOEBpenN?		MVzD[YxtKGO7Y3zlJIFzemW\|dDDpckBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzBxR{GgdIhie2ViYX\0[ZIhOjRiaILzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcoch[mG\|ZXSg[oxwfyCleYTvcYV1enl?	NEfF[mQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUWxPFMyOid-Mkm1NVg{OTJ:L3G+
A549	MkPsR4VtdCCleXPs[UBie3OjeR?=		Mn7mNlQhcHK\|		NIOye3pE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBCPTR7IHPlcIx{KGG\|c3Xzd4VlKGG\|IHHjZ5VufWyjdHnvckBifCCJMD;HNUBxcGG\|ZTDh[pRmeiB{NDDodpMh[nlicILvdIllcXWvIHnv[Ill\SC\|dHHpcolv\yCkYYPl[EBndG:5IHP5eI9u\XS{eR?=	M{PBVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUG4N\|EzLz5{OUWxPFMyOjxxYU6=
NCI-H460	MmnoR4VtdCCleXPs[UBie3OjeR?=		NUflO2N{OjRiaILz		M{C2VmNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJG5EUS2KNE[wJINmdGy\|IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDHNE9IOSCyaHHz[UBi\nSncjCyOEBpenNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZzDiZZNm\CCobH;3JIN6fG:vZYTyfS=>	MmrzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3MUizNVIoRjJ7NUG4N\|EzRC:jPh?=
T47D	NGC2SlFE\WyuIHP5Z4xmKGG\|c3H5		M3zDfFI1KGi{cx?=		NVzjVZRuS2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hXDR5RDDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{CvS\|EheGijc3WgZYZ1\XJiMkSgbJJ{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdiYnHz[YQh\myxdzDjfZRwdWW2com=	NGTMPVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUWxPFMyOid-Mkm1NVg{OTJ:L3G+
MDA-MB-231	NVeyU\|Z5S2WubDDjfYNt\SCjc4PhfS=>		MUCyOEBpenN?		M2TUZmNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJG1FSS2PQj2yN\|Eh[2WubIOgZZN{\XO\|ZXSgZZMh[WOldX31cIF1cW:wIHH0JGcxN0dzIIDoZZNmKGGodHXyJFI1KGi{czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nJIJie2WmIH\sc5ch[3m2b33leJJ6	NETRcIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUWxPFMyOid-Mkm1NVg{OTJ:L3G+
Fluc-labeled 4T1	Ml3ORY51cXS3bX;yJIF{e2G7	MWGxN\|AhdWdxa3e=	M3fjcVE5KGSjeYO=		Mn;ERY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViRnz1Z{1t[WKnbHXkJFRVOSClZXzsd{BqdXCuYX70[YQhcW5iQnHsZk9kKG2xdYPlJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjD0eY1weiC5ZXnnbJQh[XRiMUOwJI1oN2upLDDpdEBi\G2rbnnzeIVz\WRiZHHpcJkh\m:{IEG4JIRigXNibXXhd5Vz\WRiYX\0[ZIhQCC2bzCyOUBl[Xm\|	Ml;zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3MUizNVIoRjJ7NUG4N\|EzRC:jPh?=
T47D	NXrnZVk6S2WubDDjfYNt\SCjc4PhfS=>		M2TJXVI1KGi{cx?=		MXfJcoR2[3Srb36gc4Yh[2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hXDR5RDDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG\|ZTDpckBIOC:JMTDwbIF{\SCjY3P1cZVt[XSrb36gbY5kfWKjdHXkJIZweiB{NDDodpMh[nliZnzve{BkgXSxbXX0dpk>	NYniXIpRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVE6PzlpPkK4OlUyQTd7PD;hQi=>

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ

Methods	Test Index	PMID
Western blot	pRb(S807) / Rb / p53 / Cyclin E / Cyclin D1 / CDK4 / CDK6 / p27 / p21 / PARP; PubMed: 29789630 Sci Rep Effect of ribociclib on pRB and G1 cell cycle regulating protein expressions in C666-1 and HK1 cells. Cells were treated with ribociclib in 2 concentrations, one of them near their corresponding IC50, for 24 and 48 hours. Phosphorylation of Rb in all cell䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ⟸෕䐺痖暼瘿⟸෕ᾰƌ ⟸෕Ð㺣痖⟸෕𢡄⟼෕䀷痗⟼෕౴⟼෕	29789630
Growth inhibition assay	Cell viability ; PubMed: 26390342 ACS Chem Biol Effects of palbociclib and ribociclib on viability of H157, H2170, H520 and H596 cells after 72 hours of drug treatment and IC50 values for inhibition of cell viability.	26390342

体内試験

LEE011 (200 mg/kg daily, p.o.) significantly causes tumor growth delay in mice harboring the BE2C or 1643 xenografts with no weight loss or other signs of toxicity. ^[1]

お薦めの試験操作（参考用のみ）

細胞試験： ^[1]	- 合併細胞株： BE2C, IMR5, 1643, SY5Y, CHP134, SKNSH, NGP, KELLY, LAN5, NLF, NB69, SKNDZ, NBSD, NBLS, SKNFI, EBC1, SKNAS, NB16, RPE1 cell lines. 濃度： 10 μM 反応時間： ~100 hours 実験の流れ： A panel of neuroblastoma cell lines, selected based upon prior demonstration of substrate adherent growth, is plated in triplicate on the Xcelligence Real-Time Cell Electronic Sensing system and treated 24 hours later with a four-log dose range of inhibitor or with a dimethyl sulfoxide (DMSO) control. Cell indexes are monitored continuously for ~100 hours, and IC50 values are determined as follows: growth curves are generated by plotting the cell index as a function of time and are normalized to the cell index at the time of treatment for a baseline cell index of 1. The area under the normalized growth curve from the time of treatment to 96 hours posttreatment is then calculated using a baseline area of 1 (the cell index at the time of treatment). Areas are normalized to the DMSO control, and the resulting data are analyzed using a nonlinear log inhibitor versus normalized response function. All experiments are repeated at least once. (参考用のみ)
動物試験： ^[1]	- 合併動物モデル： Mice bearing BE2C, NB-1643, or EBC1 xenografts. 投薬量： ~200 mg/kg daily 投与方法： p.o. (参考用のみ)

細胞試験：

^[1]

- 合併

細胞株： BE2C, IMR5, 1643, SY5Y, CHP134, SKNSH, NGP, KELLY, LAN5, NLF, NB69, SKNDZ, NBSD, NBLS, SKNFI, EBC1, SKNAS, NB16, RPE1 cell lines.
濃度： 10 μM
反応時間： ~100 hours
実験の流れ：
A panel of neuroblastoma cell lines, selected based upon prior demonstration of substrate adherent growth, is plated in triplicate on the Xcelligence Real-Time Cell Electronic Sensing system and treated 24 hours later with a four-log dose range of inhibitor or with a dimethyl sulfoxide (DMSO) control. Cell indexes are monitored continuously for ~100 hours, and IC50 values are determined as follows: growth curves are generated by plotting the cell index as a function of time and are normalized to the cell index at the time of treatment for a baseline cell index of 1. The area under the normalized growth curve from the time of treatment to 96 hours posttreatment is then calculated using a baseline area of 1 (the cell index at the time of treatment). Areas are normalized to the DMSO control, and the resulting data are analyzed using a nonlinear log inhibitor versus normalized response function. All experiments are repeated at least once.

(参考用のみ)

動物試験：

^[1]

- 合併

動物モデル： Mice bearing BE2C, NB-1643, or EBC1 xenografts.
投薬量： ~200 mg/kg daily
投与方法： p.o.
(参考用のみ)

参考

溶解度 (25°C)

体外	DMSO	7 mg/mL (16.1 mM)
	Water	Insoluble
	Ethanol	Insoluble

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報 Ribociclib (LEE011) SDFをダウンロードする

分子量	434.54
化学式	C₂₃H₃₀N₈O
CAS No.	1211441-98-3
Storage	3 years-20°C powder 2 years-80°C in solvent
別名	N/A
Smiles	CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5

投与溶媒組成計算器(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

投与量

mg/kg

動物平均体重

投与体積（動物毎）

動物数

匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO+ % + % Tween 80+ % ddH₂O

計算リセット

計算結果:

投与溶媒濃度： mg/ml；

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL，注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。）

投与溶媒調製方法：μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH₂O，を加え完全に溶解させます。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

便利ツール

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

質量

濃度

体積

分子量
=

×

×

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとSDS/COA（製品ページで利用可能な）。

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます：

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます：C1V1 = C2V2 ( 入力出力 )

C1

V1

C2

V2
×

=

×

常に貯蔵液を準備するとき、小びんラベルとSDS/COA（オンラインで利用できる）で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

連続希釈剤
初めの濃度：
稀釈倍数：

計算結果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください：

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量	濃度	体積	分子量
=	×	×

臨床試験 (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04657679	Recruiting	Drug: Ribociclib	Breast Cancer	Georgetown University\|Medstar Health Research Institute\|Breast Cancer Research Foundation\|Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS)	May 20 2021	--
NCT04315233	Recruiting	Drug: Ribociclib\|Drug: Belinostat	Metastatic Breast Cancer\|Recurrent Ovarian Carcinoma	University of Utah\|Novartis\|Acrotech Biopharma	October 29 2020	Phase 1
NCT04417621	Recruiting	Drug: LXH254\|Drug: LTT462\|Drug: Trametinib\|Drug: Ribociclib	Melanoma	Novartis Pharmaceuticals\|Novartis	October 30 2020	Phase 2

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CDKシグナル伝達経路

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研究分野別

製品類型

Ribociclib (LEE011)

文献中Selleckの製品使用例(58)

製品安全説明書

CDK阻害剤の選択性比較

生物活性

お薦めの試験操作（参考用のみ）

参考

溶解度 (25°C)

化学情報 Ribociclib (LEE011) SDFをダウンロードする

投与溶媒組成計算器(クリア溶液)

便利ツール

モル濃度計算器

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

希釈計算器

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

連続希釈計算器方程式

連続希釈剤

計算結果

分子量计算器

総分子量：g/mol

モル濃度計算器

臨床試験 (data from https://clinicaltrials.gov, updated on 2021-09-06)

技術サポート

CDKシグナル伝達経路

相関CDK製品