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シグナル伝達経路

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1501 Mycophenolate Mofetil <1 mg/mL 86 mg/mL <1 mg/mL
S2776 CPI-613 <1 mg/mL 77 mg/mL 77 mg/mL
S1247 Leflunomide <1 mg/mL 54 mg/mL 54 mg/mL
S2487 Mycophenolic acid <1 mg/mL 64 mg/mL 5 mg/mL
S7185 AGI-5198 <1 mg/mL 24 mg/mL 14 mg/mL
S5425 Phenylglyoxal hydrate -1 mg/mL 30 mg/mL -1 mg/mL
S5097 Methotrexate disodium 99 mg/mL <1 mg/mL -1 mg/mL
S3652 3-Nitropropionic acid 23 mg/mL 23 mg/mL 23 mg/mL
S1158 MK-8245 <1 mg/mL 93 mg/mL <1 mg/mL
S1680 Disulfiram <1 mg/mL 59 mg/mL 59 mg/mL
S8076 PluriSIn #1 (NSC 14613) <1 mg/mL 43 mg/mL <1 mg/mL
S2376 Ammonium Glycyrrhizinate 5 mg/mL 168 mg/mL <1 mg/mL
S2055 Gimeracil <1 mg/mL 29 mg/mL <1 mg/mL
S8382 ML390 <1 mg/mL 81 mg/mL 60 mg/mL
S4116 Isovaleramide <1 mg/mL 20 mg/mL 20 mg/mL
S7900 SW033291 <1 mg/mL 83 mg/mL 32 mg/mL
S7241 AGI-6780 <1 mg/mL 96 mg/mL 96 mg/mL
S7941 NCT-501 <1 mg/mL 32 mg/mL 25 mg/mL
S8405 RRx-001 <1 mg/mL 53 mg/mL 23 mg/mL
S2289 Daidzin <1 mg/mL 83 mg/mL 4 mg/mL
S7262 Vidofludimus <1 mg/mL 100 mg/mL 1 mg/mL
S2295 Emodin <1 mg/mL 54 mg/mL 2 mg/mL
S2296 Enoxolone <1 mg/mL 94 mg/mL <1 mg/mL
S2302 Glycyrrhizin (Glycyrrhizic Acid) <1 mg/mL 100 mg/mL 100 mg/mL
S2303 gossypol-Acetic acid <1 mg/mL 100 mg/mL 10 mg/mL
S8615 Sodium dichloroacetate (DCA) 30 mg/mL 30 mg/mL 30 mg/mL
S8611 Vorasidenib (AG-881) <1 mg/mL 82 mg/mL 82 mg/mL
S8619 NCT-503 <1 mg/mL 81 mg/mL 81 mg/mL
S8205 AG-221 (Enasidenib) <1 mg/mL 94 mg/mL 94 mg/mL
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1501

Mycophenolate Mofetil

Mycophenolate Mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.

S2776

CPI-613

CPI-613, a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line, disrupts tumor cell mitochondrial metabolism. Phase 2.

S1247

Leflunomide

Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD, used as an immunosuppressant agent.

S2487

Mycophenolic acid

Mycophenolic acid is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.

S7185

AGI-5198

AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.

S5425

Phenylglyoxal hydrate

Phenylglyoxal is a potent inhibitor of mitochondrial aldehyde dehydrogenase. It reacts with arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.

S5097

Methotrexate disodium

Methotrexate sodium, an inhibitor of tetrahydrofolate dehydrogenase, is an antineoplastic antimetabolite with immunosuppressant properties.

S5146

3-Methylpyrazole

3-Methylpyrazole (3-MP) is a weak or non-inhibitor of alcohol dehydrogenase.

S3652

3-Nitropropionic acid

3-Nitropropionic acid (3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain.

S1158

MK-8245

MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Phase 2.

S1680

Disulfiram

Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol.

S8076

PluriSIn #1 (NSC 14613)

PluriSIn #1 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.

S2376

Ammonium Glycyrrhizinate

Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses.

S2055

Gimeracil

Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.

S8382

ML390

ML390 is a human DHODH inhibitor that induces differentiation in acute myeloid leukemia.

S4116

Isovaleramide

Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases.

S7900

SW033291

SW033291 is a selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) with IC50 and Kiapp of 1.5 nM and 0.1 nM, respectively.

S7241

AGI-6780

AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.

S7941

NCT-501

NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.

S8405

RRx-001

RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. It inhibits glucose 6-phosphate dehydrogenase(G6PD) in human tumor cells, binds hemoglobin and drives RBC-mediated redox reactions under hypoxia.

S2289

Daidzin

Daidzin, a natural organic compound in the class of phytochemicals known as isoflavones, is a potent and selective inhibitor of human mitochondrial aldehyde dehydrogenase and inhibits ALDH-I selectively (Ki=20 nM); at least 500 times less effective against ALDH-Ⅱ, the cytosolic isozyme (Ki=10 μM).

S7262

Vidofludimus

Vidofludimus is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH. Phase 2.

S2295

Emodin

Emodin is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica).

S2296

Enoxolone

Enoxolone is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.

S2302

Glycyrrhizin (Glycyrrhizic Acid)

Glycyrrhizin (Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).

S2303

gossypol-Acetic acid

Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.

S1717

Fomepizole

Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.

S8615

Sodium dichloroacetate (DCA)

Dichloroacetate, a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.

S8611

Vorasidenib (AG-881)

Vorasidenib (AG-881) is an orally available inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2).

S8619

NCT-503

Gilteritinib(ASP2215) is a small-molecule FLT3/AXL inhibitor with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. It inhibits FLT3 at an IC50 value that was approximately 800-fold more potent than the concentration required to inhibit c-KIT (230 nM).

S8205

AG-221 (Enasidenib)

Enasidenib (AG-221) is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzyme with IC50 of 12 nM.

Tags: Dehydrogenase inhibition | Dehydrogenase activity | Dehydrogenase assay | Dehydrogenase reaction | Dehydrogenase enzyme activity | pyruvate dehydrogenase inhibition | pyruvate dehydrogenase activity | pyruvate dehydrogenase assay | pyruvate dehydrogenase phosphorylation | pyruvate dehydrogenase cancer | pyruvate dehydrogenase pathway | pyruvate dehydrogenase activation | dihydropyrimidine dehydrogenase activity | stearoyl-CoA desaturase pathway | Dehydrogenase inhibitor review