Methyl Dihydrojasmonate

別名：Hedione, Kharismal

製品コード：S5139 純度：98%

Methyl dihydrojasmonate (Hedione, Kharismal) is a flavouring ingredien with the smell vaguely similar to jasmin.

CAS No. 24851-98-7

サイズ（液体）	価格(税別)	在庫状況
25uL	JPY 15900	国内在庫あり

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

製品安全説明書

現在のバッチを見る： S513901 純度： 98%

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関連化合物ライブラリー	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Bioactive Compound Library-Ⅱ Express-Pick Library	もっと見る

生物活性

製品説明	Methyl dihydrojasmonate (Hedione, Kharismal) is a flavouring ingredien with the smell vaguely similar to jasmin.

In Vitro
In vitro	Methyl dihydrojasmonate inhibits the growth of leukemia cells as well as lung, breast, and prostate cancer cells. It opens the mitocondrial permeability transition-pore complex, allowing cytochrome C release and induction of apoptosis, and the expression of reactive oxygen species. Jasmonate-derivative compounds, including jasmonic acid (JA) and methyl dihydrojasmonate (MJ), also induces the suppression of cell proliferation in human and mouse cancer cell lines, such as prostate cancer and breast cancers, melanoma, leukemia, lymphoid, and myeloid^[2].
細胞実験	細胞株	MCF-7 cells
	濃度	0, 5, 12.5, 25, 50 μl/ml
	反応時間	48 h
	実験の流れ	Measurement of potential cytotoxicity is performed by SRB assay where Cells are plated in 96-multiwell plate (10⁴ cells/well) for 24 h before exposure to the compound(s) to allow attachment of the cells to the wall of the plate. Different concentrations of the compound under test; 0, 5, 12.5, 25, 50 μl/ml for the Pure MDHJ (Oily liquid) and 0, 25, 50, 75, 100 μl/ml for the used formulation are added to the cell monolayer triplicate wells; which are prepared for each individual concentration. A monolayer cells are incubated together with the compound(s) for 48 h at 37 °C and in atmosphere of 5% CO₂. After 48 h, cells are fixed, washed and stained with Sulfo-Rhodamine-B stain (SRB). Excess stain is washed with acetic acid and the attached stain is recovered with Tris EDTA buffer. Color intensity is measured utilizing an ELISA reader.

In Vivo
In Vivo	Methyl dihydrojasmonate (MDHJ) is a promising anti-cancer drug of a plant origin (jasmine plant)^[1]. Jasmonate-derivative compounds are poorly water-soluble, and cannot be administered intravenously or adequately absorbed by the body^[2]. The oral LD50 of Methyl dihydrojasmonate in rats exceeds 5.0 g/kg. By the dermal route, the rabbit LD50 also exceeds 5.0 g/kg. By the intraperitoneal route in ICR mice, the LD50 is 1397.2 mg/kg. While in rats, an intraperitoneal injection of Methyl dihydrojasmonate in corn oil produces clinical signs at 1000 mg/kg and mortality at 2000 mg/kg. Methyl dihydrojasmonate is not considered to possess a mutagenic or genotoxic potential^[3].
動物実験	動物モデル	Sprague-Dawley rats
	投与量	0, 40, 80 or 120 mg/kg/day
	投与経路	oral

参考
[1] Yehia R, et al. Colloids Surf B Biointerfaces. 2017, 155:512-521. [2] da Silva GB, et al. Int J Nanomedicine. 2014, 9:867-76. [3] Politano VT, et al. Int J Toxicol. 2008, 27(3):295-300.

参考

化学情報

分子量	226.31	化学式	C₁₃H₂₂O₃
CAS No.	24851-98-7	SDF	--
密度	0.998 g/mL at 25 °C
Smiles	CCCCCC1C(CCC1=O)CC(=O)OC
保管	2 years -80°C liquid	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
保管	2 years -80°C liquid	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1个月-20°Cin solvent

In vitro
Batch:

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量	濃度	体積	分子量
=	×	×

希釈計算器分子量計算器

投与溶液組成計算機(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

投与量 mg/kg 動物平均体重 g 投与体積（動物毎）μL 動物数匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

計算結果：

投与溶媒濃度： mg/ml;

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH₂O，を加え完全に溶解させます。

投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

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Handling Instructions

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* 必須

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C8=C7/X	C8:	LOG(C8):