Romidepsin (FK228, Depsipeptide)

For research use only. Not for use in humans.

製品コードS3020 別名:FR 901228, NSC 630176

Romidepsin (FK228, Depsipeptide)化学構造

CAS No. 128517-07-7

Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 273900
JPY 28000
JPY 115300
JPY 228000
最寄りの販売代理店を探す

お探しのディーラーが見当たらない場合は直接こちらのメールアドレスまでお問い合わせください:[email protected]

バルク問合せ

文献中Selleckの製品使用例(156)

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.
特性 More effective than other classical HDAC inhibitors such as TSA, TPX, and butyrate.
ターゲット
HDAC1 [1]
(Cell-free assay)
HDAC2 [1]
(Cell-free assay)
36 nM 47 nM
体外試験

Unlike TSA, the active form redFK of Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. Romidepsin is 17-23 times weaker than redFK in inhibiting these HDACs with IC50 of 36 nM, 47 nM, 510 nM, and 14 μM, respectively. Romidepsin treatment in HeLa cells induces histone acetylation and p21 expression with EC50 of 3.0 nM, more strongly than redFK with EC50 of 11 nM due to the instability of redFK. [1] In addition to G2/M arrest, Romidepsin treatment causes cyclin D1 downregulation and a p53-independent p21 induction, leading to inhibition of CDK and dephosphorylation of Rb resulting in growth arrest in the early G1 phase. [2] Romidepsin is 100 times more potent than TSA and 1,000,000 times more potent than butyrate in inhibiting the proliferation of the A549 cells. [3] Romidepsin inhibits the growth of U-937, K562, and CCRF-CEM cells with IC50 of 5.92 nM, 8.36 nM, and 6.95 nM, respectively. [5] Romidepsin promotes apoptosis in chronic lymphocytic leukemia (CLL) cells at a concentration corresponding to that at which H3 and H4 acetylation and HDAC inhibition occurs, selectively involving activation of caspase 8 and effector caspase 3, as well as down-regulation of c-FLIP protein. [6] In 11 of 13 (85%) renal cell carcinoma cell lines and in 16 of 37 (43%) other cancer cell lines, Romidepsin treatment up-regulates tumor death receptors, and potentiates natural killer (NK)-mediated tumor killing. [7] Romidepsin exhibits concentration-dependent cytotoxicity against a panel of mantle cell lymphoma (MCL) cell lines. [9]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SU-DHL4 NELXVZhE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NUnBdFFVOi53LUG1JI5O NYTsZ4U3PzJiaB?= M1rhVYlv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? Mo\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUC5NFcoRjJ3N{mwPVA4RC:jPh?=
U2932  Mn;RR4VtdCCYaXHibYxqfHliQYPzZZk> MYqyMlUuOTVibl2= NYiwO4c{PzJiaB?= M3rySYlv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? NICzT3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
OCI-LY7 MVTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NELPZ2EzNjVvMUWgcm0> NEXpfFg4OiCq M323T4lv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? M4qwdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{mwPVA4Lz5{NUe5NFkxPzxxYU6=
Farage NUj2RmJkS2WubDDWbYFjcWyrdImgRZN{[Xl? M3TIV|IvPS1zNTDuUS=> MkL6O|IhcA>? NFPLO5NqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MEmwO{c,OjV5OUC5NFc9N2F-
LY7/EBV M3zxc2NmdGxiVnnhZoltcXS7IFHzd4F6 M4D5flIvPS1zNTDuUS=> NHLuRXk4OiCq MnXQbY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MEmwO{c,OjV5OUC5NFc9N2F-
U2932/EBV MmXxR4VtdCCYaXHibYxqfHliQYPzZZk> MWWyMlUuOTVibl2= M{Wzc|czKGh? NXvSOItkcW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= NGKxR4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
HCT116 Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjWZZY2NTVyMECgcm0> Ml73NlQhcA>? MlvNSG1UVw>? NXnLfmt[cW6mdXPld{Bk\WyuIHTlZZRpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR7MkWxOUc,OjV2OUK1NVU9N2F-
ACH-2 NIDweJJHfW6ldHnvckBCe3OjeR?= M4LDeFEuQSCwTR?= NVPRVFVXOjRiaB?= M176e4lv\HWlZYOgTGlXNTFiRX72JIV5eHKnc4Ppc44> M375O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUS5OFY4Lz5{NUG0PVQ3PzxxYU6=
MCF-10A MofrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLjZpJQUUN3ME2wMlE4yrFyLkCxJI5O NH7vfVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
MCF-7 NWTzemZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTFwMUFCtVAvOjBibl2= MoL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
SK-BR-3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmKwTWM2OD1zLkCwxtExNjN3IH7N NY\UUGFwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
MDA-MB-231 NVLGN|VJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7Cdox5UUN3ME2wMlY5yrFyLkG0JI5O NWjLdnliRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
PC3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1W3VmlEPTB;MT62OeKyOC5|NTDuUS=> M4DoO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
HCT116 NV\4VIdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HYNWlEPTB;MT6wNOKyOC5yMDDuUS=> M4XsV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
HCT116-p21-/- MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLBTWM2OD1zLkK2xtExNjN5IH7N MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
S1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTdwNkhCtVAvOjlibl2= NFzJVIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
SW620 NUHKb|VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwOURCtVAvOjlibl2= NFzMN449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
LOX-IMVI NFj0RYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH4eJJKSzVyPUCuPFfDuTBwMEOgcm0> MmLGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
UACC-62 M4m4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ntWWlEPTB;MD61OuKyOC5zNjDuUS=> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
MDA-MB-435 NHG2[nRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[4TWM2OD1yLkmwxtExNjB4IH7N NHTjdGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
SF-295 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{ezR2lEPTB;MD64POKyOC5zNTDuUS=> M1zVelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
A549 NWP3bnpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvxcXlpUUN3ME2xMlI3yrFyLkK0JI5O MmHPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
H460 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLWd3c{UUN3ME2yMlU5yrFyLkiwJI5O MnTaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
EKVX MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj6SWx{UUN3ME2xMlM{yrFyLkO0JI5O NF[zbWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
H146 NW\MblU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXJUHZKSzVyPUCuNlLDuTBwMEegcm0> M1jS[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
H526 M1f3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S3S2lEPTB;MD6xOeKyOC5yMzDuUS=> Mn;JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
HuT-78 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEG5fpBKSzVyPUGuO|PDuTBwNESgcm0> MnLNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
HA Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK3UoVROC54MkWtNVBvVQ>? NYnPTFlRPDhiaB?= NWXPV2tVcW6mdXPld{BiKHOrZ37p[olk[W62bImgd5Rzd26pZYKgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iY3:teJJm[XSnZDD3bZRpKGKxcoTlfo9ucWJ? NInKcpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe3NVUyOCd-MkS3O|E2OTB:L3G+
MS-275 Mlr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXiwMlYzPS1zMH7N M13xTFQ5KGh? MVzpcoR2[2W|IHGgd4lodmmoaXPhcpRtgSC|dILvcodmeiCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckBkdy22cnXheIVlKHerdHigZo9zfGW8b33pZi=> NIfHNFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe3NVUyOCd-MkS3O|E2OTB:L3G+
CD4 T MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWK0PEBp MXTFR|UxRTRwNdMxNU4xKG6P MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd{MkS1OEc,OjR5MkK0OVQ9N2F-
CD4 T MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:0PEBp NVe5eIVES0N3ME2xNFfDuTF{NjDuUS=> M1qwV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{KyOFU1Lz5{NEeyNlQ2PDxxYU6=
CD4+ T MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\6eWVEPTB;MzDuUS=> M1LHeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEm1NVA2Lz5{NES5OVExPTxxYU6=
A549 NYG1T2VIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYOxNQKBmzFyMNMgcm0> NGO5e5kzPC9|Nj:0PEBp M13nWIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIgh[2:wY3XueJJifGmxbj2gZY5lKHSrbXWt[IVx\W6mZX70JI1idm6nch?= M{T5dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEi1O|k6Lz5{NES4OVc6QTxxYU6=
JJN3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrHWHo{OjRxNEigbC=> NEfyb21GSzVyPEJihKlvVTtiNElihKlp NH3XV209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN|AyPTB:L3G+
OPM-2 NV3pWmNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzSNlQwPDhiaB?= MnPTSWM2OHN;MfMAjY5OQyB2OPMAjYg> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB|MEG1NEc,OjRyM{CxOVA9N2F-
RPMI-8226 MknBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2mzdFI1NzR6IHi= M1XNSWVEPTC|PUGuPQKBkW6POzC0PQKBkWh? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB|MEG1NEc,OjRyM{CxOVA9N2F-
U266 NWfNfYtjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTZXlFLOjRxNEigbC=> MoHnSWM2OHN;MUFihKlvVTtiNElihKlp MljoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyM{CxOVAoRjJ2MEOwNVUxRC:jPh?=
CA46 MWLBdI9xfG:|aYOgRZN{[Xl? NHfqd3c3KGh? MmHSbY5lfWOnczDicJVvfCCjcH;weI9{cXN? MmniQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7Nk[xOlQoRjJ|OU[2NVY1RC:jPh?=
DG75 NGjyXJJCeG:ydH;zbZMhSXO|YYm= MoW2OkBp MX;pcoR2[2W|IH7vJIFxd3C2b4Ppdy=> NIe3bWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2OlE3PCd-MkO5OlYyPjR:L3G+
Ramos M37O[WFxd3C2b4Ppd{BCe3OjeR?= NF;1bmE3KGh? NH3EdJJqdmS3Y3XzJIV5fGWwc3n2[UBieG:ydH;zbZM> NIjhXpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2OlE3PCd-MkO5OlYyPjR:L3G+
ST486 MnrVRZBweHSxc3nzJGF{e2G7 MXO2JIg> MY\pcoR2[2W|IHX4eIVve2m4ZTDhdI9xfG:|aYO= NFvLXnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2OlE3PCd-MkO5OlYyPjR:L3G+
HuT78 NVjmfJNxSXCxcITvd4l{KEG|c3H5 MVixM|ExNzFyMDDuUS=> M1;jSlQ5KGh? NGfsNpZqdmS3Y3XzJIFxd3C2b4Ppd{BifCBzIH7N MoK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3M{K3N|IoRjJ|NUOyO|MzRC:jPh?=
DpVp35 NW\R[2FbSXCxcITvd4l{KEG|c3H5 NVfsWoFwOS9zMD:xNFAhdk1? NF3MW3U1QCCq NYfSNohscW6mdXPld{BjdHWwdDDhdI9xfG:|aYO= MnPZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3M{K3N|IoRjJ|NUOyO|MzRC:jPh?=
DpVp50 NEDOcXlCeG:ydH;zbZMhSXO|YYm= MoDDNU8yOC9zMECgcm0> M2WxZVQ5KGh? NH33O29qdmS3Y3XzJIJtfW62IHHwc5B1d3Orcx?= M4Hs[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUOyO|MzLz5{M{WzNlc{OjxxYU6=
DpP75  MUnBdI9xfG:|aYOgRZN{[Xl? Ml3UNU8yOC9zMECgcm0> NWLKbYJRPDhiaB?= MV\pcoR2[2W|IHLseY51KGGyb4D0c5Nqew>? M4jrXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUOyO|MzLz5{M{WzNlc{OjxxYU6=
SKOV-3 NEj5W2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrGO24y6oDVMkDuUS=> MUO3NkBp MUDEUXNQ NWLrPVJHemWmdXPld{Bk\WyuII\pZYJqdGm2eTDhcI9v\SCjbnSgZ49u[mmwZXSge4l1cCClaYPwcIF1cW5? NVLBNJFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVA{PDhpPkKzNFExOzR6PD;hQi=>
Brca1 WT NELp[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHxUY1jOeLCk{Kwcm0> NYHWbGI5PzJiaB?= M3XjfGROW09? MXHy[YR2[2W|IHPlcIwhfmmjYnnsbZR6KGGub37lJIFv\CClb33ibY5m\CC5aYToJINqe3CuYYTpci=> M2T6dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEGwN|Q5Lz5{M{CxNFM1QDxxYU6=
Brca1 Null MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX4S4Q1OeLCk{Kwcm0> NWHQWHFPPzJiaB?= MYDEUXNQ MYjy[YR2[2W|IHPlcIwhfmmjYnnsbZR6KGGub37lJIFv\CClb33ibY5m\CC5aYToJINqe3CuYYTpci=> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzMEO0PEc,OjNyMUCzOFg9N2F-
OVCAR-8  NI\BdYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXn6codGOeLCk{Kwcm0> NETEZ5A4OiCq NY\uT3hvTE2VTx?= Ml\ydoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4> Mom1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUCzOFgoRjJ|MEGwN|Q5RC:jPh?=
NCI/ADR-RES Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfLe3gy6oDVMkDuUS=> MoT1O|IhcA>? M2HVTmROW09? MYfy[YR2[2W|IHPlcIwhfmmjYnnsbZR6KGGub37lJIFv\CClb33ibY5m\CC5aYToJINqe3CuYYTpci=> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzMEO0PEc,OjNyMUCzOFg9N2F-
HCT116 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4exNFUhdk1vNUCg{txO NHj1Nm0zPCCq MVfEUXNQ M{G5W4lvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz MnHIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7MkS5OVgoRjJ{OUK0PVU5RC:jPh?=
RKO Mon1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHL5OmU2KG6PLUWwJO69VQ>? NELEdWUzPCCq MmexSG1UVw>? NFHubpNqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5meg>? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl{NEm1PEc,OjJ7MkS5OVg9N2F-
CO115 NYn6WIVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLzOUBvVS13MDFOwG0> MofPNlQhcA>? Mn3HSG1UVw>? M1uwXIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz NELrd4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyOFk2QCd-MkK5NlQ6PTh:L3G+
HFS M3;4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3ROUBvVQ>? MmOwNlQwPDhxN{KgbC=> NG\TcHNqdmirYnn0d{Bk\WyuIHfyc5d1cCC2aX3lMYRmeGWwZHXueIx6 MlO3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzME[yPFIoRjJ{MUC2NlgzRC:jPh?=
LNCaP NFPIcFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H4R|Uhdk1? M3WwfVI1NzR6L{eyJIg> MXTpcohq[mm2czDj[YxtKGe{b4f0bEB1cW2nLXTldIVv\GWwdHz5 MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFyNkK4Nkc,OjJzME[yPFI9N2F-
A549 NFv5cINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXQcYo2KG6P NFW1NJAzPC92OD:3NkBp NF2zO2FqdmirYnn0d{Bk\WyuIHfyc5d1cCC2aX3lMYRmeGWwZHXueIx6 NUHRWnl2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNFYzQDJpPkKyNVA3Ojh{PD;hQi=>
697  MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[4ZlM4UUN3MPMAjV3jiIl{LkZCpI5O M2jIO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUO4NlE3Lz5{MUWzPFIyPjxxYU6=
697-R NFTQbG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPSTWM2OOLCiU5ihKk5NjcEoH7NxsA> Mlv1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3M{iyNVYoRjJzNUO4NlE3RC:jPh?=
HUT78 NYruToN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTFibl2= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF7OEW0OUc,OjFzOUi1OFU9N2F-
THJ-16T NXPkepdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vjNFEhdk1? NHjW[WQzPCCq NGTCU41qdmirYnn0d{Bk\WyuIHfyc5d1cA>? NIrQflQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixNFU3QCd-MkC4NVA2Pjh:L3G+
HCT116 M2K4UWZ2dmO2aX;uJGF{e2G7 Mlr1NlAhdk1? MnPZPEBp NH7Cbmtud2S3bHH0[ZMhfHKjboPjdolxfCCuZY\lcJMh\m:{IHj1coRz\WS|IH;mJIdmdmW|IHnuJIVqfGincjDkbZJm[3Srb36= NX;nfWZNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC3N|k1PTRpPkKwO|M6PDV2PD;hQi=>
B104  MVzGeY5kfGmxbjDBd5NigQ>? NYTYOGpEOiCwTR?= NXrsfJM3OjRxNEivO|IhcA>? NYTwdI1VcW6lcnXhd4V{KHSqZTDzeZJn[WOnIHX4dJJme3Orb36gc4YhS0R{MNMg MnHDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4OE[1NFUoRjJyNki2OVA2RC:jPh?=
HL-60  Mlv5R5l1d3SxeHnjbZR6KEG|c3H5 NHrYeJgyNTVyMDDuUS=> NYTmTYZwOjRiaB?= NFn5VGVqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{NEG2N{c,OjB4MkSxOlM9N2F-
HP100 M2e5T2N6fG:2b4jpZ4l1gSCDc4PhfS=> NHfrO2MyNTVyMDDuUS=> MoO5NlQhcA>? MlnXbY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>? M3n2WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK0NVY{Lz5{ME[yOFE3OzxxYU6=
HL-60  Mn;TSpVv[3Srb36gRZN{[Xl? NInxZpIyOCCwTR?= NETheng1NzZxMU[gbC=> MnnTbY5lfWOnczD0bIUh\2WwZYLheIlwdiCxZjDofYRzd2enbjDw[ZJwgGmmZTDmdo9uKDSq MkKxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
HP100 NFPxO4xHfW6ldHnvckBCe3OjeR?= NEn3dHgyOCCwTR?= M2LKeVQwPi9zNjDo MkXxbY5lfWOnczD0bIUh\2WwZYLheIlwdiCxZjDofYRzd2enbjDw[ZJwgGmmZTDmdo9uKDSq NUnQOZVrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2NlQyPjNpPkKwOlI1OTZ|PD;hQi=>
HL-60  NUHGTI0yTnWwY4Tpc44hSXO|YYm= NUnvNWdxOTBvNUCwJI5O M{TpTlQhcA>? M{ewToRm[3KnYYPld{B1cGViaHnzeI9v\SCmZXHj[ZR6dGG|ZTCoTGRCSyliYXP0bZZqfHoEoB?= NXvMc49IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2NlQyPjNpPkKwOlI1OTZ|PD;hQi=>
HP100 M4qxdGZ2dmO2aX;uJGF{e2G7 NXKzZ2NMOTBvNUCwJI5O MoC2OEBp NXzRNHlG\GWlcnXhd4V{KHSqZTDobZN1d26nIHTlZYNmfHmuYYPlJEhJTEGFKTDhZ5Rqfmm2edMg MoLGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
11z NFO4bXlMcW6jc3WgRZN{[Xl? M4LjclMuOTByIH7N MVvy[YR2[2W|IFjERWMh\W68eX3heIlkKGGldHn2bZR6KCiLQ{WwxsA:KDZwNTFCtUAxNjZibn3vcE9NMQ>? MmP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MEWxOFQoRjJyNkC1NVQ1RC:jPh?=
SKOV-3 M{j4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYG0M|gwOTZibl2= M2LUSVQ5KGh? NYHUVJpvcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XJ? MmOzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MES1OlQoRjJyNEC0OVY1RC:jPh?=
OVCAR-3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYe0M|gwOTZibl2= NVXseYFTPDhiaB?= MmjkbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZI> NFvXcW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MESwOFU3PCd-MkC0NFQ2PjR:L3G+
HBL-2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjlNk0yOCCwTR?= NI\BbnMzPCCq Ml7oTWM2OD12LkOgcm0> M4TmWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyME[4NFgxLz5{MEC2PFA5ODxxYU6=
Jeko-1 MnvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYCyMVUxKG6P NV;Tc3NDOjRiaB?= NEnaS4tKSzVyPUGxJI5O M3;Ke|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyME[4NFgxLz5{MEC2PFA5ODxxYU6=
Granta-519 NV3nTYtTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTQUoRGPS12MDDuUS=> NXfmdG9SOjRiaB?= M13COWlEPTB;NUiuOUBvVQ>? NUH6XJlQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOlgxQDBpPkKwNFY5ODhyPD;hQi=>
L1236 M2P2R2N6fG:2b4jpZ4l1gSCDc4PhfS=> NFLSRWcyKG6PLUGwNEDPxE1? NFPCSJg1QCCq MUDFR|UxRTBwMEeg{txO MmjRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{M{O0O|AoRjF7MkOzOFcxRC:jPh?=
L428 NF;yU2xEgXSxdH;4bYNqfHliQYPzZZk> MYexJI5ONTFyMDFOwG0> MlPmOFghcA>? NGDhW3RGSzVyPUCuOFMh|ryP NGLCepo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKzN|Q4OCd-MUmyN|M1PzB:L3G+
KM-H2 NHPTRWtEgXSxdH;4bYNqfHliQYPzZZk> MnrxNUBvVS1zMECg{txO NFLK[HY1QCCq MVvFR|UxRTBwNUig{txO M4DRXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkOzOFcxLz5zOUKzN|Q4ODxxYU6=
L540Cy NWq2ZXZzS3m2b4TvfIlkcXS7IFHzd4F6 NV;HTYxsOSCwTT2xNFAh|ryP NHzJV441QCCq NFLMSXpGSzVyPUCuNVYh|ryP MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|M{S3NEc,OTl{M{O0O|A9N2F-
G401 M2rpPWZ2dmO2aX;uJGF{e2G7 M1TtR|ExKG6P NF;2[YEzPC92OD:3NkBp NGX0cppFVVOR M1Pxe4lv[3KnYYPld{BETEuQMVOg[ZhxemW|c3nvci=> NVXodGNQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlE2QDZpPkG5NlIyPTh4PD;hQi=>
STM91-01 NYr3e4NLTnWwY4Tpc44hSXO|YYm= M3T1VlExKG6P MlfzNlQwPDhxN{KgbC=> NFL3XG9FVVOR M4rJWolv[3KnYYPld{BETEuQMVOg[ZhxemW|c3nvci=> NVT5PW1pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlE2QDZpPkG5NlIyPTh4PD;hQi=>
SJSC  M3nL[WZ2dmO2aX;uJGF{e2G7 M2T6PVExKG6P NXi5VW5SOjRxNEivO|IhcA>? M1nIVGROW09? MlXabY5kemWjc3XzJGNFU05zQzDlfJBz\XO|aX;u MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MUW4Okc,OTl{MkG1PFY9N2F-
BT16  MYHGeY5kfGmxbjDBd5NigQ>? NV[1b21OOTBibl2= MkHmNlQwPDhxN{KgbC=> MVPEUXNQ NYXs[|J6cW6lcnXhd4V{KEOGS16xR{BmgHC{ZYPzbY9v MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MUW4Okc,OTl{MkG1PFY9N2F-
NCI-H1299 MmK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{CzWmlEPTB;ND62xtExNjJibnevcYw> NHHYfm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG3PVg6OCd-MUmxO|k5QTB:L3G+
NCI-2882 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjmPHlNUUN3ME2xMlbDuTBwMESgcocwdWx? MoXWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzN{m4PVAoRjF7MUe5PFkxRC:jPh?=
HCC95 MkTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJwNdMxNE4xPSCwZz;tcC=> MkL0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzN{m4PVAoRjF7MUe5PFkxRC:jPh?=
NCI-H23 M1ToXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7ZbYxKSzVyPUKuPeKyOC5{IH7nM41t Mm\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzN{m4PVAoRjF7MUe5PFkxRC:jPh?=
NCI-H157 NVHPOINuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTFwNtMxNE4xOiCwZz;tcC=> MknVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzN{m4PVAoRjF7MUe5PFkxRC:jPh?=
NCI-H460 NIXnclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHUfXFKSzVyPUKuNeKyOC5yNzDu[{9udA>? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF5OUi5NEc,OTlzN{m4PVA9N2F-
NCI-H1975 NFG3UJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjsS4dHUUN3ME2xMlPDuTBwMESgcocwdWx? NH;xcmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG3PVg6OCd-MUmxO|k5QTB:L3G+
NCI-H820 M37FRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJwNNMxNE4yKG6pL33s M3rtTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUe5PFkxLz5zOUG3PVg6ODxxYU6=
NCI-H1650 NX\2R2hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHHZ2hKSzVyPUSuPeKyOC5|IH7nM41t MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF5OUi5NEc,OTlzN{m4PVA9N2F-
DTC1 NIfvNJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2O1V2lEPTB;MD61NUBvVQ>? MlHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
KAO MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2i0bWlEPTB;MD65NUBvVQ>? NYjOTZFHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlYzPDZpPkG4OVY3OjR4PD;hQi=>
SU-CCS-1 NIiyOnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwOEmgcm0> M1fUeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
SYO-1 MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNkegcm0> NFHCeHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
FUJI M{O0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u1fmlEPTB;MT6zNUBvVQ>? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV4NkK0Okc,OTh3Nk[yOFY9N2F-
SKNMC NXn4ZZd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkmxTWM2OD1zLkG3JI5O NXS4S4FxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlYzPDZpPkG4OVY3OjR4PD;hQi=>
402-91 NVvxb|VCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnHdGZJUUN3ME2xMlI3KG6P MnS1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
1765-92 NFqySo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3xc2NWUUN3ME2xMlc4KG6P MlHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
JN-DSRCT-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fx[mlEPTB;MT6yOUBvVQ>? NV[y[3p2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlYzPDZpPkG4OVY3OjR4PD;hQi=>
NMS-2PC NUGwdJhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXSdZV4UUN3ME2wMlgyKG6P NH;vWVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
HL60 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnnV|duUUN3ME2xMlg3KG6P NGLOXmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
A549 M1zHO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlOxTWM2OD1|LkK0JI5O MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV4NkK0Okc,OTh3Nk[yOFY9N2F-
SW480 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTJwNkmgcm0> NIjRPFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
MCF7 M4POUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHTTWM2OD1|LkW1JI5O NI\oXJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
PC-3 NXLhcYZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXQWnlKSzVyPUKuOVEhdk1? MkG1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
MMRU MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf5TZhiUUN3ME2yMlU4KG6P NELJ[4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
Hs68 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL0TWM2OD1-MUCgcm0> Mle1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
hMSC-001F M1[3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrTTWM2OD1-MUCgcm0> NUDnO|N2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlYzPDZpPkG4OVY3OjR4PD;hQi=>
mammalian cells MkO4SpVv[3Srb36gZZN{[Xl? Mk\2TY5pcWKrdHnvckBw\iCKaYP0c45mKGSnYXPleJlt[XOnIESgbY4hdWGvbXHsbYFvKGOnbHzzMEBKSzVyIE2gNE42OSEQvF2u MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV6NEmzNkc,OTR3OES5N|I9N2F-
mammalian cells NVz5O2V1TnWwY4Tpc44h[XO|YYm= MXHJcohq[mm2aX;uJI9nKEirc4TvcoUh\GWjY3X0fYxie2ViMTDpcoR2[2WmIHHj[ZR6dGG2ZXSgbIl{fG:wZTDpckBu[W2vYXzpZY4h[2WubIOuMEBGSzVyIE2gN|Yh|ryPLh?= NX\1XXhURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS1PFQ6OzJpPkG0OVg1QTN{PD;hQi=>
MCF7 NX7PRnBPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUf0Vm9JT3Kxd4ToJIlvcGmkaYTpc44hd2ZiTVPGO{Bk\WyuczygTWM2OCB;IECuNFAxPzVizszNMi=> NF70SnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m1PFM1Oid-MUe5OVg{PDJ:L3G+
A498 NVmzR41VS3m2b4TvfIlkcXS7IHHzd4F6 M2XPNVYh\GG7cx?= NXPVeohOS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR7ODDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCWR1mgQUAxNjB{ODFOwG0v NHHiZno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
COLO205 MlrkR5l1d3SxeHnjbZR6KGG|c3H5 NGWzNmM3KGSjeYO= M3WySGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNQVE9{MEWgZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiVFfJJF0hOC5yM{Gg{txONg>? MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
U251 MX;DfZRwfG:6aXPpeJkh[XO|YYm= NEPrZVQ3KGSjeYO= Mo\xR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVI2OSClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBVT0liPTCwMlA{OSEQvF2u NH32PXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
RXF393 NVXvbYtzS3m2b4TvfIlkcXS7IHHzd4F6 M2\ucFYh\GG7cx?= M{\x[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJZTjN7MzDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCWR1mgQUAxNjB4MjFOwG0v M4fWOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-468 MV;DfZRwfG:6aXPpeJkh[XO|YYm= MVS2JIRigXN? M4Dld2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20Olgh[2WubIOgZYZ1\XJiNjDkZZl{KGK7IF3UWEBie3OjeTygWGdKKD1iMD6wPUDPxE1w NXznXYlNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
COLO205 M2fiZWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUPPUYM3PiCmYYnz NE\qZY9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEV0yRMkC1JINmdGy|IHHmeIVzKDZiZHH5d{BjgSCPVGSgZZN{[XluIFzDOVAhRSByLkC5NkDPxE1w NFTUOGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
UACC257 NYf3U5hXS3m2b4TvfIlkcXS7IHHzd4F6 Mn21OkBl[Xm| MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVRWNEOjV5IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKFSJSTC9JFAvODl3IN88UU4> NUTTbmI2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
U251 MkWxR5l1d3SxeHnjbZR6KGG|c3H5 M2\HWlYh\GG7cx?= MYrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVNlUyKGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJGxEPTBiPTCwMlE{KM7:TT6= MoTlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
A498 M1XBXWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFrVNFU3KGSjeYO= M1HwdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1QThiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhVEN3MDC9JFAvOiEQvF2u M13CSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
NCI-H322M M{PsXWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3vaV|Yh\GG7cx?= MnXHR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh|MkLNJINmdGy|IHHmeIVzKDZiZHH5d{BjgSCPVGSgZZN{[XluIGTHTUA:KDBwMkOg{txONg>? NFPXUXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
SF295 M1zB[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NIXqZlA3KGSjeYO= MnH6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2YzQTViY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhXEeLIE2gNE4zPSEQvF2u M3y2e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
RXF393 NGDVPZREgXSxdH;4bYNqfHliYYPzZZk> NWXFNG84PiCmYYnz NHn4PXJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBTYEZ|OUOgZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiTFO1NEA:KDBwMzFOwG0v NEX6dIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
NCI60 MWDDfZRwfG:6aXPpeJkh[XO|YYm= M3rTe|Yh\GG7cx?= MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2k3OCClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBVT0liPTCwMlM{KM7:TT6= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
SN12C MnjIR5l1d3SxeHnjbZR6KGG|c3H5 NYPjNIluPiCmYYnz Mn3zR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV24yOkNiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhXEeLIE2gNE4{PCEQvF2u NFvMSHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
MDA-MB-231 M3nGbGN6fG:2b4jpZ4l1gSCjc4PhfS=> M{PHSFYh\GG7cx?= NXX3[pcyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBVT0liPTCwMlM2KM7:TT6= NWHyfIFxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
ACHN NFi0UGNEgXSxdH;4bYNqfHliYYPzZZk> MY[2JIRigXN? MoewR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRWNJViClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBVT0liPTCwMlc{KM7:TT6= NYOxdm1iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
SN12C NGT3RmdEgXSxdH;4bYNqfHliYYPzZZk> MVS2JIRigXN? MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUlEzSyClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBNSzVyIE2gNU42KM7:TT6= M3XkOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
UO31 NUGxXVhUS3m2b4TvfIlkcXS7IHHzd4F6 M{X5PVYh\GG7cx?= MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVU|MyKGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJHRIUSB;IEGuOVUh|ryPLh?= MojLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
Caki1 MWHDfZRwfG:6aXPpeJkh[XO|YYm= M{jVfVYh\GG7cx?= NVzFSYZyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS2GtaUGgZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiVFfJJF0hOS56OTFOwG0v M1vmeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
NCI60 NYT2[Gk1S3m2b4TvfIlkcXS7IHHzd4F6 MmPzOkBl[Xm| NU\FbWluS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLNkCgZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiTFO1NEA:KDNwNTFOwG0v M1OyR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-231 NVTGfGJQS3m2b4TvfIlkcXS7IHHzd4F6 NGHRO4s3KGSjeYO= NHHoXolEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJGxEPTBiPTC0MlA5KM7:TT6= M3j3SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-468 NXjFXYlsS3m2b4TvfIlkcXS7IHHzd4F6 MXK2JIRigXN? NVnEXZVyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBNSzVyIE2gOE4yPCEQvF2u NYjZZ3plRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
ACHN NFvZ[3pEgXSxdH;4bYNqfHliYYPzZZk> M1LIT|Yh\GG7cx?= NWrwSpV[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSUOKTjDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCOQ{WwJF0hPS5|NzFOwG0v NGf3WWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
UACC257 NHrqeIxEgXSxdH;4bYNqfHliYYPzZZk> MlPZOkBl[Xm| MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVRWNEOjV5IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEyFNUCgQUA2NjR4IN88UU4> MmDMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
NCI-H322M NV3BSI1uS3m2b4TvfIlkcXS7IHHzd4F6 NU[3XlN{PiCmYYnz MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDN{Ml2gZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiTFO1NEA:KDlwMEKg{txONg>? NF6yTY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
SF295 MmL3R5l1d3SxeHnjbZR6KGG|c3H5 NHzpXoE3KGSjeYO= NVXufng4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0Z{OUWgZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiTFO1NEA:KDFyLkKg{txONg>? Ml;FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
Caki1 NE\XNopEgXSxdH;4bYNqfHliYYPzZZk> MkDuOkBl[Xm| NVzmdHdiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS2GtaUGgZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiTFO1NEA:KDJyLkmg{txONg>? NHn6TWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
NCI-H23 M3rsRmFvfGm2dX3vdkBie3OjeR?= NIHSU3QyNjZidH:gNk41KG2pL3vn Mk\yeZAhfG9iNTDkZZl{ NUjoUodmSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUh{MzDj[YxteyCrbYDsZY51\WRiaX70doFx\XKrdH;u[YFtdHliaX6gcY92e2ViYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC2dX3vdkBk\WyuIHfyc5d1cCCjdDCxMlYhfG9iMj60JI1oN2upLDDpdEBi\G2rbnnzeIVz\WRib36g[IF6KDFidH:gOEBu\WG|dYLl[EBwdiCmYYmgOUBjgSCqb3zsc5ch\mmkZYKgZZN{[Xl? MlWyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
NCI-H522 M2PVOmFvfGm2dX3vdkBie3OjeR?= M4e5SFEvPiC2bzCyMlQhdWdxa3e= MVH1dEB1dyB3IHThfZM> MWLBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFUzOiClZXzsd{BqdXCuYX70[YQhcW62cnHw[ZJqfG:wZXHscJkhcW5ibX;1d4Uh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB1fW2xcjDj[YxtKGe{b4f0bEBifCBzLk[geI8hOi52IH3nM4toNCCrcDDh[I1qdmm|dHXy[YQhd25iZHH5JFEhfG9iNDDt[YF{fXKnZDDvckBl[XliNTDifUBpd2yub4eg[olj\XJiYYPzZZk> NXrVOlJORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
OVCAR5 NW\6R3l1SW62aYT1cY9zKGG|c3H5 MUmxMlYhfG9iMj60JI1oN2up NUTUVpM3fXBidH:gOUBl[Xm| M3nRfmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF;WR2FTPSClZXzsd{BqdXCuYX70[YQhcW62cnHw[ZJqfG:wZXHscJkhcW5ibX;1d4Uh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB1fW2xcjDj[YxtKGe{b4f0bEBifCBzLk[geI8hOi52IH3nM4toNCCrcDDh[I1qdmm|dHXy[YQhd25iZHH5JFEhfG9iNDDt[YF{fXKnZDDvckBl[XliNTDifUBpd2yub4eg[olj\XJiYYPzZZk> NXvFU2xxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
SW620 NIW3ToxCdnSrdIXtc5Ih[XO|YYm= NUnaV3ZCOS54IITvJFIvPCCvZz;r[y=> NVzFcmYyfXBidH:gOUBl[Xm| NVv2dFhVSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV3c3OjBiY3XscJMhcW2ybHHueIVlKGmwdILhdIVzcXSxbnXhcIx6KGmwIH3veZNmKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhfHWvb4KgZ4VtdCCpcn;3eIgh[XRiMT62JJRwKDJwNDDt[{9s\yxiaYCgZYRucW6rc4TldoVlKG:wIHThfUAyKHSxIESgcYVie3W{ZXSgc44h\GG7IEWgZpkhcG:ubH;3JIZq[mW{IHHzd4F6 NV3OS4lJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
MDA-MB-435 NEjuVFVCdnSrdIXtc5Ih[XO|YYm= MXKxMlYhfG9iMj60JI1oN2up M1KwcJVxKHSxIEWg[IF6ew>? M3TtTmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi12M{WgZ4VtdHNiaX3wcIFvfGWmIHnueJJieGW{aYTvcoVidGy7IHnuJI1wfXOnIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidIXtc5Ih[2WubDDndo94fGhiYYSgNU43KHSxIEKuOEBu\y:tZzygbZAh[WSvaX7pd5RmemWmIH;uJIRigSBzIITvJFQhdWWjc4Xy[YQhd25iZHH5JFUh[nliaH;scI94KG[rYnXyJIF{e2G7 MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
COLO205 M2e3W2FvfGm2dX3vdkBie3OjeR?= MnPUNU43KHSxIEKuOEBu\y:tZx?= M2e1[ZVxKHSxIEWg[IF6ew>? MXrBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCFT1zPNlA2KGOnbHzzJIlueGyjboTl[EBqdnS{YYDldol1d26nYXzsfUBqdiCvb4Xz[UBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJR2dW:{IHPlcIwh\3Kxd4ToJIF1KDFwNjD0c{AzNjRibXevb4ctKGmyIHHkcYlvcXO2ZYLl[EBwdiCmYYmgNUB1dyB2IH3lZZN2emWmIH;uJIRigSB3IHL5JIhwdGyxdzDmbYJmeiCjc4PhfS=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
LOXIMVI NYDkcm1FSW62aYT1cY9zKGG|c3H5 MUmxMlYhfG9iMj60JI1oN2up NYLucXNmfXBidH:gOUBl[Xm| M1LQXWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzPXGlOXkliY3XscJMhcW2ybHHueIVlKGmwdILhdIVzcXSxbnXhcIx6KGmwIH3veZNmKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhfHWvb4KgZ4VtdCCpcn;3eIgh[XRiMT62JJRwKDJwNDDt[{9s\yxiaYCgZYRucW6rc4TldoVlKG:wIHThfUAyKHSxIESgcYVie3W{ZXSgc44h\GG7IEWgZpkhcG:ubH;3JIZq[mW{IHHzd4F6 NXG2SJhsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
UACC62 NF3qd5RCdnSrdIXtc5Ih[XO|YYm= NV64eHFsOS54IITvJFIvPCCvZz;r[y=> NVToem9ofXBidH:gOUBl[Xm| M{XWOmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGXBR2M3OiClZXzsd{BqdXCuYX70[YQhcW62cnHw[ZJqfG:wZXHscJkhcW5ibX;1d4Uh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB1fW2xcjDj[YxtKGe{b4f0bEBifCBzLk[geI8hOi52IH3nM4toNCCrcDDh[I1qdmm|dHXy[YQhd25iZHH5JFEhfG9iNDDt[YF{fXKnZDDvckBl[XliNTDifUBpd2yub4eg[olj\XJiYYPzZZk> NX7kcJoxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
MDA-MB-231 NVK3ZVJVSW62aYT1cY9zKGG|c3H5 M1:xNFEvPiC2bzCyMlQhdWdxa3e= MVz1dEB1dyB3IHThfZM> MWHBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGmvcHzhcpRm\CCrboTyZZBmemm2b37lZYxtgSCrbjDtc5V{\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHS3bX;yJINmdGxiZ4Lve5RpKGG2IEGuOkB1dyB{LkSgcYcwc2duIHnwJIFldWmwaYP0[ZJm\CCxbjDkZZkhOSC2bzC0JI1m[XO3cnXkJI9vKGSjeTC1JIJ6KGixbHzve{BncWKncjDhd5NigQ>? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
SF295 MXXBcpRqfHWvb4KgZZN{[Xl? M4fJ[lEvPiC2bzCyMlQhdWdxa3e= MmrGeZAhfG9iNTDkZZl{ MXvBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVRkK5OUBk\WyuczDpcZBt[W62ZXSgbY51emGyZYLpeI9v\WGubImgbY4hdW:3c3WgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD0eY1weiClZXzsJIdzd3e2aDDheEAyNjZidH:gNk41KG2pL3vnMEBqeCCjZH3pcol{fGW{ZXSgc44h\GG7IEGgeI8hPCCvZXHzeZJm\CCxbjDkZZkhPSCkeTDoc4xtd3diZnni[ZIh[XO|YYm= M1;mUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
U251 MUfBcpRqfHWvb4KgZZN{[Xl? MWixMlYhfG9iMj60JI1oN2up MkjIeZAhfG9iNTDkZZl{ MU\BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXMkWxJINmdGy|IHntdIxidnSnZDDpcpRz[XCncnn0c45m[WyueTDpckBud3W|ZTDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIT1cY9zKGOnbHyg[5Jwf3SqIHH0JFEvPiC2bzCyMlQhdWdxa3esJIlxKGGmbXnubZN1\XKnZDDvckBl[XliMTD0c{A1KG2nYYP1doVlKG:wIHThfUA2KGK7IHjvcIxwfyCoaXLldkBie3OjeR?= M{jYSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
OVRAC3 MVjBcpRqfHWvb4KgZZN{[Xl? MmPWNU43KHSxIEKuOEBu\y:tZx?= Ml7MeZAhfG9iNTDkZZl{ MXTBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCRVmLBR|Mh[2WubIOgbY1xdGGwdHXkJIlvfHKjcHXybZRwdmWjbHz5JIlvKG2xdYPlJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geJVud3JiY3XscEBoem:5dHigZZQhOS54IITvJFIvPCCvZz;r[{whcXBiYXTtbY5qe3SncnXkJI9vKGSjeTCxJJRwKDRibXXhd5Vz\WRib36g[IF6KDViYomgbI9tdG:5IH\pZoVzKGG|c3H5 NEmwUW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
LLC M{\mZ2Z2dmO2aX;uJIF{e2G7 M3z3[GlvcGmkaYTpc44hd2ZiSFTBR{1u\WSrYYTl[EBJUUZvMXHsdIhiKGGldHn2bZR6KGmwIH3veZNmKEyOQzDj[YxteyxiSVO1NEA:KDJizszNMi=> NF7Ofoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOwOVYyOid-MkKzNFU3OTJ:L3G+
NCI-H522 MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmLsS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKNUh3MkKgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODF6IN88UU4> NUL3[4RrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
LOXIMVI NFLtTHZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFTkRnVIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBNV1iLTW\JJINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODB{NTFOwG0v M4PsS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
A549 M3;TRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWLHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBOVQ6KGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMECyOkDPxE1w M4i3dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
OVCAR5 NGTC[lRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3nVWGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GUNTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxOjhizszNMi=> M{[2SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
MKN74 M{C1NWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnvVS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWtPPzRiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFMh|ryPLh?= M{PV[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
NCI-H460 MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn;FS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKNUh2NkCgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODNizszNMi=> NWjmXHdoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
HCT116 MmX2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYLGb|Y1T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODB|MTFOwG0v MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
HCC2998 M17KPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnezS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNEOjl7ODDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxOzFizszNMi=> NX\JOXJtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
MKN1 NEPaT4xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVjGWnVZT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUuQMTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxOzJizszNMi=> NULuSppbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
SKOV3 NVfJOGNuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlXYS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gV2tQXjNiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFM{KM7:TT6= NEPIdZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
HT-29 NUDlcYNjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHPxRYtIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJXC1{OTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxOzNizszNMi=> MlrGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
KM12 NWPXZoNvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHvlZ3NIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBMVTF{IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA{PCEQvF2u NGTvPYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
DMS114 Mnv4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFPCN|hIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBFVVNzMUSgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODN4IN88UU4> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
SF539 M3n6[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYHKbYFwT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z3M{mgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODN4IN88UU4> NGLZS4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
U251 NHrI[oFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1XYRmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHUzPTFiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFM6KM7:TT6= MmDHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
SF295 MmT5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4HlOWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHNHOjl3IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA1KM7:TT6= M2i4SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
MCF7 NV7pZnBET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn3kS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWNHPyClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwOFIh|ryPLh?= NUnlVXlFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
NCI-H23 NH[2d5FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUfHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOR2kuUDJ|IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA1PiEQvF2u NEf4Xos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
OVCAR3 NYCySHhZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mm\jS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gU3ZESVJ|IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA1PiEQvF2u NXXaXJU5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
MKN7 NI\aOHZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmfxS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWtPPyClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwOFkh|ryPLh?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
SF268 NF\BO|RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHXpd4JIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUTjJ4ODDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxPDlizszNMi=> M2fPXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
MDA-MB-231 NXOwPIdsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX7CUoxIT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwOVUh|ryPLh?= NEPTboo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
OVCAR8 Ml7RS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmXhS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gU3ZESVJ6IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA2PSEQvF2u MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
DMS273 MlK5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{HtV2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGROWzJ5MzDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxPThizszNMi=> NEPJW4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
DU145 NIHVVWJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYLHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDEWVE1PSClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwOkDPxE1w NXX0NIJoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
RXF631L NGjnWGJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoLPS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVnhHPjNzTDDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxPjZizszNMi=> MmP2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
HBC4 M{fqRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXzHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIRmM1KGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMEC2PUDPxE1w MnjiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
SNB75 M{Hhcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4[1PGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHNPSjd3IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA4OiEQvF2u M2ex[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
BSY1 NFW3RXVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUn5doJpT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSlO\MTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxQDVizszNMi=> NYPjOXpXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
NCI-H226 NVrnR3dyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MknMS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKNUh{Mk[gZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODh7IN88UU4> NF3T[Vc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
SNB78 NVXzTlRrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M13EW2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHNPSjd6IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA6PiEQvF2u M2HMUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
HBC5 MmXwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIi2cnFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJSkN3IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFE{KM7:TT6= NILOZmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
MKN45 MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX3Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNT241PSClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCxOEDPxE1w M4POZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
MKN28 NX\se|lKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnGyS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWtPOjhiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNVch|ryPLh?= NFvoSXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
PC3 NEfleJBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkC4S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVGM{KGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMEG4JO69VS5? NH;CeYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
ACHN MnnVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXzUeIV4T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSUOKTjDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAzKM7:TT6= NEjYdYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
OVCAR4 NWLRPIxuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1:1Umdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GUNDDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAzKM7:TT6= NIPzXZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
St-4 MkDUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXz0Nml7T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW3RvNDDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAzOiEQvF2u MlfjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
HCT15 MlrhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUPUUXBnT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUWgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE41PSEQvF2u MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
CD4+ T MlPVSpVv[3Srb36gZZN{[Xl? M3yzbFch\GG7cx?= NH\RSGtT\WGldHn2ZZRqd25ib3[gcIF1\W62IFjJWlEhVkx2LUOtUJVkKGW6cILld5Nqd25iaX6gbJVu[W5ibnHpeoUhS0R2KzDUJINmdGy|IITy[YF1\WRiNzDkZZl{KHCxc4StbY5n\WO2aX;uJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDseY1qdmW|Y3XuZ4UheGyjdHWgdoVi\GW{IHHuZYx6e2m|LDDFR|UxKD1iMD6wNFMh|ryPLh?= MkfSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2OUWxNFUoRjJ2NEm1NVA2RC:jPh?=
NCI-H522 M4DvWGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2HKSGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNUKyJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODBzODFOwG0v MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
LOXIMVI NXfNc5lOS3m2b4TvfIlkcXS7IHHzd4F6 NX;Ncmd[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVE:[SV3WTUBk\WyuczDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjByMkWg{txONg>? M1XzTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
A549 NETkfo1EgXSxdH;4bYNqfHliYYPzZZk> NX7rVHZnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOjZizszNMi=> NUPzWYE6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
OVCAR5 MoHSR5l1d3SxeHnjbZR6KGG|c3H5 MlTrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3ZESVJ3IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFAzQCEQvF2u MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
NCI-H460 NGTIU|JEgXSxdH;4bYNqfHliYYPzZZk> M2PSfWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB|IN88UU4> MmjKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
MKN74 M{nOemN6fG:2b4jpZ4l1gSCjc4PhfS=> MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNT244PCClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCwN{DPxE1w NEC0W3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
HCC2998 NIjhdHFEgXSxdH;4bYNqfHliYYPzZZk> MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR2MzQTl6IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA{OSEQvF2u Ml\oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
HCT116 NFPYSFdEgXSxdH;4bYNqfHliYYPzZZk> NUSz[5NsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB|MTFOwG0v Mk\nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
MKN1 MWDDfZRwfG:6aXPpeJkh[XO|YYm= MmThR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWtPOSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCwN|Ih|ryPLh?= M1vjNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
HT-29 Ml3TR5l1d3SxeHnjbZR6KGG|c3H5 MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCwN|Mh|ryPLh?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
SKOV3 M4fYNGN6fG:2b4jpZ4l1gSCjc4PhfS=> MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCwN|Mh|ryPLh?= M1z0OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
KM12 M1L0TWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYnz[5liS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU01zMjDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOzRizszNMi=> NH76dFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
SF539 Mn3wR5l1d3SxeHnjbZR6KGG|c3H5 M1LSWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNHPTN7IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA{PiEQvF2u Ml\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
293T M4jZOWZ2dmO2aX;uJIF{e2G7 NIjETGE{OCCvaX7z NXe2b4RrUW6qaXLpeIlwdiCxZjDoeY1idiCKRFHDNUBmgHC{ZYPz[YQhcW5iaIXtZY4hOjl|VDDj[YxteyC3c3nu[{BC[y2NR1zHT{hC[ylvTVPBJIF{KHO3YoP0doF1\SCjZoTldkA{OCCvaX7zJIJ6KG[udX;y[ZNk\W6lZTDhd5NigSxiSVO1NEA:KDBwMECzOkDPxE1w NYPOdIpqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
DMS114 NFjQZndEgXSxdH;4bYNqfHliYYPzZZk> M3OwOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGROWzFzNDDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOzZizszNMi=> NVK5ephURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
U251 M3v0WGN6fG:2b4jpZ4l1gSCjc4PhfS=> NXLkdJJHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTJ3MTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOzlizszNMi=> NV\vO3k6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
SF295 NILBW2VEgXSxdH;4bYNqfHliYYPzZZk> M1LNS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNHOjl3IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA1KM7:TT6= NVnLVJFTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
MCF7 MWjDfZRwfG:6aXPpeJkh[XO|YYm= M37DZ2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFQzKM7:TT6= MlvUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
OVCAR3 M2rrU2N6fG:2b4jpZ4l1gSCjc4PhfS=> MlvnR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3ZESVJ|IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA1PiEQvF2u MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
NCI-H23 M{KzWWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUfmb2xQS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLViyN{Bk\WyuczDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjByNE[g{txONg>? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
SF268 MVXDfZRwfG:6aXPpeJkh[XO|YYm= NHLYcI1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUTjJ4ODDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxPDlizszNMi=> NULkbZZxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
MKN7 MWDDfZRwfG:6aXPpeJkh[XO|YYm= NIHyO3REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOU055IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA1QSEQvF2u NEfFO4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
OVCAR8 M{jL[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NETGWWNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQXkODUkigZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4xODV3IN88UU4> NI\aV3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
MDA-MB-231 NHXL[mxEgXSxdH;4bYNqfHliYYPzZZk> M{PpRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOC5yMEW1JO69VS5? NVPIc4RoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
DMS273 NYTKdpRvS3m2b4TvfIlkcXS7IHHzd4F6 M3;WemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGROWzJ5MzDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxPThizszNMi=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
DU145 MmPDR5l1d3SxeHnjbZR6KGG|c3H5 M3nxZ2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA3KM7:TT6= NEe2XnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
RXF631L MVzDfZRwfG:6aXPpeJkh[XO|YYm= MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDSXGY3OzGOIHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA3PiEQvF2u MoW0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
HBC4 NX[2SJVDS3m2b4TvfIlkcXS7IHHzd4F6 MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIRmM1KGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMEC2PUDPxE1w NWjsOWxtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
SNB75 M17ZXWN6fG:2b4jpZ4l1gSCjc4PhfS=> MoO2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV25DPzViY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFczKM7:TT6= NVW1R|ViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
BSY1 M13xR2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1\C[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJUYTFiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFg2KM7:TT6= MkDoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
NCI-H226 MXTDfZRwfG:6aXPpeJkh[XO|YYm= NGfBXIREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEKyOkBk\WyuczDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjByOEmg{txONg>? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
SNB78 NIjYU4dEgXSxdH;4bYNqfHliYYPzZZk> NHTzcmFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUVkJ5ODDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxQTZizszNMi=> M{PyTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
HBC5 MUjDfZRwfG:6aXPpeJkh[XO|YYm= MmG1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGJEPSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCxN{DPxE1w NFvtSI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
MKN45 MnrjR5l1d3SxeHnjbZR6KGG|c3H5 MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNT241PSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCxOEDPxE1w NWX6WIJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
MKN28 NGDqWoZEgXSxdH;4bYNqfHliYYPzZZk> MlX4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWtPOjhiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNVch|ryPLh?= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
PC3 M3nZPGN6fG:2b4jpZ4l1gSCjc4PhfS=> NHjZSXdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNVgh|ryPLh?= MnHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
ACHN MVXDfZRwfG:6aXPpeJkh[XO|YYm= M361dmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGFEUE5iY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNkDPxE1w MlywQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
OVCAR4 NVv0WYpRS3m2b4TvfIlkcXS7IHHzd4F6 Mmn0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3ZESVJ2IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFIh|ryPLh?= NX;oXGJrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
St-4 NWPncldHS3m2b4TvfIlkcXS7IHHzd4F6 NX\YeIVCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW3RvNDDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAzOiEQvF2u NVrpeYFqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
293T NXTqVGE2TnWwY4Tpc44h[XO|YYm= NFvoR2g{OCCvaX7z NUSzXm5EUW6qaXLpeIlwdiCxZjDtc5V{\SCKRFHDOkBmgHC{ZYPz[YQhcW5iaIXtZY4hOjl|VDDj[YxteyC3c3nu[{BC[y2NR1zHT{hC[ylvTVPBJIF{KHO3YoP0doF1\SCjZoTldkA{OCCvaX7zJIJ6KG[udX;y[ZNk\W6lZTDhd5NigSxiSVO1NEA:KDBwM{mg{txONg>? MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
HCT15 MYTDfZRwfG:6aXPpeJkh[XO|YYm= NWHTOWpqS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUWgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE41PSEQvF2u MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
mink Mv1Lu MmHPSpVv[3Srb36gZZN{[Xl? M{XQPFI1KGi{cx?= Mmr5TY5kemWjc3WgbY4hcHWvYX6ge4lt\CC2eYDlJJAzOSCycn;0[YlvKGW6cILld5Nqd25iaX6gcYlvcyCPdkHMeUBk\WyuczDh[pRmeiB{NDDodpMh[nlicEKxJJBzd22xdHXyJIF{e2G7IHnuJJBz\XOnbnPlJI9nKDBwMTDtUUBlcXSqaX;0bJJmcXSxbDygSWMyODByIE2gNE4xOTV5IN88UU4> NWPqcI9jRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5PVc2PzhpPkK0PVk4PTd6PD;hQi=>
HCT116 NWLDNmFlSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkeyOFghcHK| MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB2ODDodpMhcW5icILld4Vv[2Vib3[gSHRVKGK7IF3UWEBie3OjeTygTWM2OCB;IECuNFA{KM7:TT6= NYLpV4RERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWxOFc3OTJpPkK1NVQ4PjF{PD;hQi=>
MOLT4 NVLqU3E5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MmDBO|IhcHK| NGLiU5lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3PUHQ1KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG|c3H5MEBIUTVyIE2gNE4xODJyNjFOwG0v M2PieVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{OxN|M1Lz5{NkOzNVM{PDxxYU6=
DU145 MXnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mn;FO|IhcHK| NUfISlV2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhT0l3MDC9JFAvODB{NUWg{txONg>? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|MUOzOEc,OjZ|M{GzN|Q9N2F-
U937 MnXORY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NX7nNHlXPzJiaILz MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV7M{egZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVAhRSByLkCwN|QyKM7:TT6= NGn6coY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOzNVM{PCd-Mk[zN|E{OzR:L3G+
HLF MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUe3NkBpenN? M3XweGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFzGJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFQ5QSEQvF2u NX;rOWlSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
WI38 NV;ITIZnSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NUDXTlR2PzJiaILz NHmyb5BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGfJN|gh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPDT|gh[XO|YYmsJGdKPTBiPTCwMlAxPTN7IN88UU4> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|MUOzOEc,OjZ|M{GzN|Q9N2F-
U937 M2\2ZWZ2dmO2aX;uJIF{e2G7 M3XqfFI1KGi{cx?= M4mySWlvcGmkaYTpc44hd2ZiSFTBR|YhcW5iaIXtZY4hXTl|NzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh[WyyaHGteJVjcWyrbjDhZ4V1gWyjdHnvckBifCB3IH7NJJRwKDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|MUOzOEc,OjZ|M{GzN|Q9N2F-
HCT116 M2fEPWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MV[3NkBpenN? MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSClb4XseIVzKGOxdX70[ZIhdWW2aH;kMEBKSzVyIE2gNE4xOjhizszNMi=> NUS5coE6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0PFE3PTlpPkK2OFgyPjV7PD;hQi=>
IGROV1/Pt1 MnPmRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MkPhO|IhcHK| MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEmJUl;WNU9RfDFiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgZ492dHSncjDjc5VvfGW{IH3leIhw\CxiSVO1NEA:KDBwMEig{txONg>? M2HpXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEixOlU6Lz5{NkS4NVY2QTxxYU6=
IGROV1 M1W5S2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NUjnbFZNPzJiaILz NUfhcZFISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDJS3JQXjFiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgZ492dHSncjDjc5VvfGW{IH3leIhw\CxiSVO1NEA:KDBwMkKg{txONg>? NXf5WXZ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0PFE3PTlpPkK2OFgyPjV7PD;hQi=>

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ
Methods Test Index PMID
Western blot
p21 / Cyclin D1; 

PubMed: 19682393     


NIH 3T3 cells stably expressing the indicated proteins were treated with DMSO (Vehicle) or the indicated concentration of romidepsin for 24 h. Cell lysates were analyzed by western blotting with antibodies to cyclin D1, p21 and β-actin (loading control). Data shown are representative of at least two independent experiments.

AcH3(K9) / Ac-α-Tubulin(K40) / Ac-NFκB2(K310) p65 / 3MeH3(K27); 

PubMed: 26473529     


Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot.

HDAC3 / HDAC4 / HDAC6 / HDAC2; 

PubMed: 26473529     


Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot.

γH2AX / PARP1 / Cleaved caspase3 / BAK / p21(waf1/cip1) / XIAP; 

PubMed: 26473529     


Western blot analysis of proteins involved in DNA-damage response and apoptosis. Established cell lines were exposed to different concentrations of romidepsin (Rom) for 48 h and total cell extracts were analyzed.

Cyclin E1 / BRCA1 / E2F1 / Cleaved PARP / H3Ac; 

PubMed: 27444036     


Western blot analysis of the effects of panobinostat (25 nM), vorinostat (5 µM) and romidepsin (10 nM) on expression of cyclin E1, E2F1, BRCA1, cleaved PARP and acetylated histone H3 in OVCAR-3 cells. Actin and histone H3 were loading controls. 

pAKT(S473) / pAKT(T308) / AKT; 

PubMed: 25492515     


Western blot analysis of phosphorylated AKT in PC3 cells. Cells were treated for 3 h with various concentrations of FK228. 

19682393 26473529 27444036 25492515
Growth inhibition assay
Cell viability; 

PubMed: 27444036     


Concentration-dependent effects of panobinostat and vorinostat in SRB viability assays in OVCAR-3 cells (72 h). Values are mean+SE of 3 independent experiments. 

27444036
Immunofluorescence
SS18/TLE1; 

PubMed: 27120803     


A significant decrease in detectable PLA signal following HDAC inhibition in SYO-1 cells.

Cleaved caspase-3; 

PubMed: 22531354     


TDP-B activates cleaved caspase-3 by immunofluorescence. Representative immunofluorescence staining for cleaved caspase 3 (green) in SKOV-3 ovarian cancer cells treated with 10 nM FK228, TDP-A or TDP-B after 24 h of exposure. The nuclei are stained with DAPI (blue).

27120803 22531354
体内試験 Romidepsin treatment potently inhibits the neovascularization of chick embryo and that of adult mice in the Matrigel plug assay. [4]Administration of Romidepsin at 0.1-1 mg/kg twice a week significantly prolongs the survival of mice bearing U-937 lymphoma, with median survival times of 30.5 (0.56 mg/kg) and 33 days (0.32 mg/kg), respectively (vs. 20 days in control mice). [5]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

- 合併

HDAC-inhibitory activity:

For the enzyme assay, 10 μL of [3H]acetyl-labeled histones (25,000 cpm/10 μg) are added to 90 μL of the HDAC enzyme fraction extracted from 293T cells overexpressing HDAC1 or HDAC2 in the presence of increasing concentrations of Romidepsin, and the mixture is incubated at 37 °C for 15 minutes. The enzyme reaction is linear for at least 1 hour. The reaction is stopped by the addition of 10 μL of concentrated HCl. The released [3H]acetic acid is extracted with 1 mL of ethylacetate, and 0.9 mL of the solvent layer is taken into 5 mL of aqueous counting scintillant II solution for determination of radioactivity. The IC50 values are determined from at least three independent dose-response curves.
細胞試験:

[3]

- 合併
  • 細胞株: HL60, Jurkat, A549, and MCF-7
  • 濃度: Dissolved in DMSO, final concentrations ~10 μM
  • 反応時間: 72 hours
  • 実験の流れ:

    Cells are exposed to various concentrations of Romidepsin for 72 hours in 96-well plates. 20 μL of 5 mg/mL MTT solution in PBS is added to each well for 4 hours. After removal of the medium, 170 μL of DMSO is added to each well to dissolve the formazan crystals. The absorbance at 540 nm is determined. In addition, cells are incubated with trypan blue, and the numbers of blue (dead) cells and transparent (live) cells are counted in a hemocytometer. For cell cycle analysis, cells are incubated for 30 minutes in propidium iodide staining solution containing 0.05 mg/mL propidium iodide, 1 mM EDTA, 0.1% Triton X-100, and 1 mg/mL RNase A in PBS. The suspension is then passed through a nylon mesh filter and analyzed on a Becton Dickinson FACScan.


    (参考用のみ)
動物試験:

[5]

- 合併
  • 動物モデル: Male scid mice inoculated i.p. with U-937 cells
  • 投薬量: ~1 mg/kg once or twice a week
  • 投与方法: Treated i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 10 mg/mL (18.49 mM)
Water Insoluble
Ethanol Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5%Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
5mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 540.7
化学式

C24H36N4O6S2

CAS No. 128517-07-7
Storage powder
in solvent
別名 FR 901228, NSC 630176
Smiles CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)
% DMSO % % Tween 80 % ddH2O
計算リセット

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03770000 Active not recruiting Drug: Tenalisib|Drug: Romidepsin T Cell Lymphoma Rhizen Pharmaceuticals SA March 12 2019 Phase 1|Phase 2
NCT02616965 Recruiting Drug: Romidepsin|Drug: Brentuximab vedotin Cutaneous T-cell Lymphoma (CTCL) Fox Chase Cancer Center|Seagen Inc.|Celgene Corporation February 22 2017 Phase 1
NCT02616874 Completed Drug: MVA.HIVconsv vaccine|Drug: Romidepsin HIV IrsiCaixa|Germans Trias i Pujol Hospital|Fundación FLS de Lucha Contra el Sida las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia|Hospital Clinic of Barcelona|Hospital de Sant Pau|HIVACAT|University of Oxford|BCN Checkpoint February 2016 Phase 1
NCT03141203 Active not recruiting Drug: Romidepsin|Drug: Carfilzomib Peripheral T Cell Lymphoma University of Birmingham|Bloodwise|Celgene|Amgen July 13 2015 Phase 1|Phase 2
NCT02296398 Completed Drug: Romidepsin Cutaneous T-cell Lymphoma Northwestern University January 2015 --

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

HDACシグナル伝達経路

HDAC Inhibitors with Unique Features

相関HDAC製品

Tags: Romidepsin (FK228, Depsipeptide)を買う | Romidepsin (FK228, Depsipeptide) ic50 | Romidepsin (FK228, Depsipeptide)供給者 | Romidepsin (FK228, Depsipeptide)を購入する | Romidepsin (FK228, Depsipeptide)費用 | Romidepsin (FK228, Depsipeptide)生産者 | オーダーRomidepsin (FK228, Depsipeptide) | Romidepsin (FK228, Depsipeptide)化学構造 | Romidepsin (FK228, Depsipeptide)分子量 | Romidepsin (FK228, Depsipeptide)代理店
×
細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID