Romidepsin (FK228, Depsipeptide)

For research use only. Not for use in humans.

製品コードS3020 別名：FR 901228, NSC 630176

CAS No. 128517-07-7

Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.

サイズ

価格(税別)

10mM (1mL in DMSO)	JPY 273900
1mg	JPY 28000
5mg	JPY 115300
10mg	JPY 228000

最寄りの販売代理店を探す

東京
北海道
東北
北関東
南関東
東海
北信越
近畿
中国
四国
九州

お探しのディーラーが見当たらない場合は直接こちらのメールアドレスまでお問い合わせください：[email protected]

バルク問合せ

代表番号: 03-5615-9297|電子メール：[email protected]|よく尋ねられる質問

文献中Selleckの製品使用例(156)

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明

特性

More effective than other classical HDAC inhibitors such as TSA, TPX, and butyrate.

ターゲット

HDAC1 ^[1] (Cell-free assay)	HDAC2 ^[1] (Cell-free assay)
36 nM	47 nM

体外試験

Unlike TSA, the active form redFK of Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. Romidepsin is 17-23 times weaker than redFK in inhibiting these HDACs with IC50 of 36 nM, 47 nM, 510 nM, and 14 μM, respectively. Romidepsin treatment in HeLa cells induces histone acetylation and p21 expression with EC50 of 3.0 nM, more strongly than redFK with EC50 of 11 nM due to the instability of redFK. ^[1] In addition to G2/M arrest, Romidepsin treatment causes cyclin D1 downregulation and a p53-independent p21 induction, leading to inhibition of CDK and dephosphorylation of Rb resulting in growth arrest in the early G1 phase. ^[2] Romidepsin is 100 times more potent than TSA and 1,000,000 times more potent than butyrate in inhibiting the proliferation of the A549 cells. ^[3] Romidepsin inhibits the growth of U-937, K562, and CCRF-CEM cells with IC50 of 5.92 nM, 8.36 nM, and 6.95 nM, respectively. ^[5] Romidepsin promotes apoptosis in chronic lymphocytic leukemia (CLL) cells at a concentration corresponding to that at which H3 and H4 acetylation and HDAC inhibition occurs, selectively involving activation of caspase 8 and effector caspase 3, as well as down-regulation of c-FLIP protein. ^[6] In 11 of 13 (85%) renal cell carcinoma cell lines and in 16 of 37 (43%) other cancer cell lines, Romidepsin treatment up-regulates tumor death receptors, and potentiates natural killer (NK)-mediated tumor killing. ^[7] Romidepsin exhibits concentration-dependent cytotoxicity against a panel of mantle cell lymphoma (MCL) cell lines. ^[9]

細胞データ

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
SU-DHL4	NELXVZhE\WyuIG\pZYJqdGm2eTDBd5NigQ>?	NUnBdFFVOi53LUG1JI5O	NYTsZ4U3PzJiaB?=		M1rhVYlv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB?	Mo\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUC5NFcoRjJ3N{mwPVA4RC:jPh?=
U2932	Mn;RR4VtdCCYaXHibYxqfHliQYPzZZk>	MYqyMlUuOTVibl2=	NYiwO4c{PzJiaB?=		M3rySYlv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB?	NICzT3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
OCI-LY7	MVTD[YxtKF[rYXLpcIl1gSCDc4PhfS=>	NELPZ2EzNjVvMUWgcm0>	NEXpfFg4OiCq		M323T4lv\HWlZYOgZ5l1d3SxeHnjbZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB?	M4qwdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{mwPVA4Lz5{NUe5NFkxPzxxYU6=
Farage	NUj2RmJkS2WubDDWbYFjcWyrdImgRZN{[Xl?	M3TIV\|IvPS1zNTDuUS=>	MkL6O\|IhcA>?		NFPLO5NqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MEmwO{c,OjV5OUC5NFc9N2F-
LY7/EBV	M3zxc2NmdGxiVnnhZoltcXS7IFHzd4F6	M4D5flIvPS1zNTDuUS=>	NHLuRXk4OiCq		MnXQbY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>?	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MEmwO{c,OjV5OUC5NFc9N2F-
U2932/EBV	MmXxR4VtdCCYaXHibYxqfHliQYPzZZk>	MWWyMlUuOTVibl2=	M{Wzc\|czKGh?		NXvSOItkcW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?=	NGKxR4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NFkxPyd-MkW3PVA6ODd:L3G+
HCT116	Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFjWZZY2NTVyMECgcm0>	Ml73NlQhcA>?	MlvNSG1UVw>?	NXnLfmt[cW6mdXPld{Bk\WyuIHTlZZRpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR7MkWxOUc,OjV2OUK1NVU9N2F-
ACH-2	NIDweJJHfW6ldHnvckBCe3OjeR?=	M4LDeFEuQSCwTR?=	NVPRVFVXOjRiaB?=		M176e4lv\HWlZYOgTGlXNTFiRX72JIV5eHKnc4Ppc44>	M375O\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUS5OFY4Lz5{NUG0PVQ3PzxxYU6=
MCF-10A	MofrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXLjZpJQUUN3ME2wMlE4yrFyLkCxJI5O	NH7vfVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
MCF-7	NWTzemZPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXXJR\|UxRTFwMUFCtVAvOjBibl2=	MoL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
SK-BR-3	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmKwTWM2OD1zLkCwxtExNjN3IH7N	NY\UUGFwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
MDA-MB-231	NVLGN\|VJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NX7Cdox5UUN3ME2wMlY5yrFyLkG0JI5O	NWjLdnliRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OVQ5PTZpPkK0PVU1QDV4PD;hQi=>
PC3	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1W3VmlEPTB;MT62OeKyOC5\|NTDuUS=>	M4DoO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
HCT116	NV\4VIdwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2HYNWlEPTB;MT6wNOKyOC5yMDDuUS=>	M4XsV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
HCT116-p21-/-	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlLBTWM2OD1zLkK2xtExNjN5IH7N	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
S1	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVHJR\|UxRTdwNkhCtVAvOjlibl2=	NFzJVIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
SW620	NUHKb\|VwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVHJR\|UxRTBwOURCtVAvOjlibl2=	NFzMN449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
LOX-IMVI	NFj0RYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIH4eJJKSzVyPUCuPFfDuTBwMEOgcm0>	MmLGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
UACC-62	M4m4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1ntWWlEPTB;MD61OuKyOC5zNjDuUS=>	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
MDA-MB-435	NHG2[nRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml[4TWM2OD1yLkmwxtExNjB4IH7N	NHTjdGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
SF-295	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{ezR2lEPTB;MD64POKyOC5zNTDuUS=>	M1zVelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
A549	NWP3bnpXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXvxcXlpUUN3ME2xMlI3yrFyLkK0JI5O	MmHPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
H460	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVLWd3c{UUN3ME2yMlU5yrFyLkiwJI5O	MnTaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
EKVX	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUj6SWx{UUN3ME2xMlM{yrFyLkO0JI5O	NF[zbWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
H146	NW\MblU4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGXJUHZKSzVyPUCuNlLDuTBwMEegcm0>	M1jS[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
H526	M1f3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1S3S2lEPTB;MD6xOeKyOC5yMzDuUS=>	Mn;JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
HuT-78	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEG5fpBKSzVyPUGuO\|PDuTBwNESgcm0>	MnLNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
HA	Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYK3UoVROC54MkWtNVBvVQ>?	NYnPTFlRPDhiaB?=		NWXPV2tVcW6mdXPld{BiKHOrZ37p[olk[W62bImgd5Rzd26pZYKgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iY3:teJJm[XSnZDD3bZRpKGKxcoTlfo9ucWJ?	NInKcpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe3NVUyOCd-MkS3O\|E2OTB:L3G+
MS-275	Mlr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXiwMlYzPS1zMH7N	M13xTFQ5KGh?		MVzpcoR2[2W\|IHGgd4lodmmoaXPhcpRtgSC\|dILvcodmeiCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckBkdy22cnXheIVlKHerdHigZo9zfGW8b33pZi=>	NIfHNFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe3NVUyOCd-MkS3O\|E2OTB:L3G+
CD4 T	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MWK0PEBp		MXTFR\|UxRTRwNdMxNU4xKG6P	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd{MkS1OEc,OjR5MkK0OVQ9N2F-
CD4 T	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MV:0PEBp		NVe5eIVES0N3ME2xNFfDuTF{NjDuUS=>	M1qwV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{KyOFU1Lz5{NEeyNlQ2PDxxYU6=
CD4+ T	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4\6eWVEPTB;MzDuUS=>	M1LHeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEm1NVA2Lz5{NES5OVExPTxxYU6=
A549	NYG1T2VIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYOxNQKBmzFyMNMgcm0>	NGO5e5kzPC9\|Nj:0PEBp		M13nWIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIgh[2:wY3XueJJifGmxbj2gZY5lKHSrbXWt[IVx\W6mZX70JI1idm6nch?=	M{T5dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEi1O\|k6Lz5{NES4OVc6QTxxYU6=
JJN3	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NVrHWHo{OjRxNEigbC=>		NEfyb21GSzVyPEJihKlvVTtiNElihKlp	NH3XV209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN\|AyPTB:L3G+
OPM-2	NV3pWmNyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MlzSNlQwPDhiaB?=		MnPTSWM2OHN;MfMAjY5OQyB2OPMAjYg>	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB\|MEG1NEc,OjRyM{CxOVA9N2F-
RPMI-8226	MknBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M2mzdFI1NzR6IHi=		M1XNSWVEPTC\|PUGuPQKBkW6POzC0PQKBkWh?	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB\|MEG1NEc,OjRyM{CxOVA9N2F-
U266	NWfNfYtjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NUTZXlFLOjRxNEigbC=>		MoHnSWM2OHN;MUFihKlvVTtiNElihKlp	MljoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyM{CxOVAoRjJ2MEOwNVUxRC:jPh?=
CA46	MWLBdI9xfG:\|aYOgRZN{[Xl?		NHfqd3c3KGh?		MmHSbY5lfWOnczDicJVvfCCjcH;weI9{cXN?	MmniQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7Nk[xOlQoRjJ\|OU[2NVY1RC:jPh?=
DG75	NGjyXJJCeG:ydH;zbZMhSXO\|YYm=		MoW2OkBp		MX;pcoR2[2W\|IH7vJIFxd3C2b4Ppdy=>	NIe3bWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2OlE3PCd-MkO5OlYyPjR:L3G+
Ramos	M37O[WFxd3C2b4Ppd{BCe3OjeR?=		NF;1bmE3KGh?		NH3EdJJqdmS3Y3XzJIV5fGWwc3n2[UBieG:ydH;zbZM>	NIjhXpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2OlE3PCd-MkO5OlYyPjR:L3G+
ST486	MnrVRZBweHSxc3nzJGF{e2G7		MXO2JIg>		MY\pcoR2[2W\|IHX4eIVve2m4ZTDhdI9xfG:\|aYO=	NFvLXnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2OlE3PCd-MkO5OlYyPjR:L3G+
HuT78	NVjmfJNxSXCxcITvd4l{KEG\|c3H5	MVixM\|ExNzFyMDDuUS=>	M1;jSlQ5KGh?		NGfsNpZqdmS3Y3XzJIFxd3C2b4Ppd{BifCBzIH7N	MoK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3M{K3N\|IoRjJ\|NUOyO\|MzRC:jPh?=
DpVp35	NW\R[2FbSXCxcITvd4l{KEG\|c3H5	NVfsWoFwOS9zMD:xNFAhdk1?	NF3MW3U1QCCq		NYfSNohscW6mdXPld{BjdHWwdDDhdI9xfG:\|aYO=	MnPZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3M{K3N\|IoRjJ\|NUOyO\|MzRC:jPh?=
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OVCAR-8	NI\BdYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXn6codGOeLCk{Kwcm0>	NETEZ5A4OiCq	NY\uT3hvTE2VTx?=	Ml\ydoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4>	Mom1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUCzOFgoRjJ\|MEGwN\|Q5RC:jPh?=
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HCT116	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4exNFUhdk1vNUCg{txO	NHj1Nm0zPCCq	MVfEUXNQ	M{G5W4lvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz	MnHIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7MkS5OVgoRjJ{OUK0PVU5RC:jPh?=
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A549	NFv5cINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHXQcYo2KG6P	NFW1NJAzPC92OD:3NkBp		NF2zO2FqdmirYnn0d{Bk\WyuIHfyc5d1cCC2aX3lMYRmeGWwZHXueIx6	NUHRWnl2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNFYzQDJpPkKyNVA3Ojh{PD;hQi=>
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697-R	NFTQbG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkPSTWM2OOLCiU5ihKk5NjcEoH7NxsA>	Mlv1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3M{iyNVYoRjJzNUO4NlE3RC:jPh?=
HUT78	NYruToN7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXrJR\|UxRTFibl2=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF7OEW0OUc,OjFzOUi1OFU9N2F-
THJ-16T	NXPkepdUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1vjNFEhdk1?	NHjW[WQzPCCq		NGTCU41qdmirYnn0d{Bk\WyuIHfyc5d1cA>?	NIrQflQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixNFU3QCd-MkC4NVA2Pjh:L3G+
HCT116	M2K4UWZ2dmO2aX;uJGF{e2G7	Mlr1NlAhdk1?	MnPZPEBp		NH7Cbmtud2S3bHH0[ZMhfHKjboPjdolxfCCuZY\lcJMh\m:{IHj1coRz\WS\|IH;mJIdmdmW\|IHnuJIVqfGincjDkbZJm[3Srb36=	NX;nfWZNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC3N\|k1PTRpPkKwO\|M6PDV2PD;hQi=>
B104	MVzGeY5kfGmxbjDBd5NigQ>?	NYTYOGpEOiCwTR?=	NXrsfJM3OjRxNEivO\|IhcA>?		NYTwdI1VcW6lcnXhd4V{KHSqZTDzeZJn[WOnIHX4dJJme3Orb36gc4YhS0R{MNMg	MnHDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4OE[1NFUoRjJyNki2OVA2RC:jPh?=
HL-60	Mlv5R5l1d3SxeHnjbZR6KEG\|c3H5	NHrYeJgyNTVyMDDuUS=>	NYTmTYZwOjRiaB?=		NFn5VGVqdmS3Y3XzJIN6fG:2b4jpZ4l1gSCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5mesLi	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{NEG2N{c,OjB4MkSxOlM9N2F-
HP100	M2e5T2N6fG:2b4jpZ4l1gSCDc4PhfS=>	NHfrO2MyNTVyMDDuUS=>	MoO5NlQhcA>?		MlnXbY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>?	M3n2WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK0NVY{Lz5{ME[yOFE3OzxxYU6=
HL-60	Mn;TSpVv[3Srb36gRZN{[Xl?	NInxZpIyOCCwTR?=	NETheng1NzZxMU[gbC=>		MnnTbY5lfWOnczD0bIUh\2WwZYLheIlwdiCxZjDofYRzd2enbjDw[ZJwgGmmZTDmdo9uKDSq	MkKxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
HP100	NFPxO4xHfW6ldHnvckBCe3OjeR?=	NEn3dHgyOCCwTR?=	M2LKeVQwPi9zNjDo		MkXxbY5lfWOnczD0bIUh\2WwZYLheIlwdiCxZjDofYRzd2enbjDw[ZJwgGmmZTDmdo9uKDSq	NUnQOZVrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2NlQyPjNpPkKwOlI1OTZ\|PD;hQi=>
HL-60	NUHGTI0yTnWwY4Tpc44hSXO\|YYm=	NUnvNWdxOTBvNUCwJI5O	M{TpTlQhcA>?		M{ewToRm[3KnYYPld{B1cGViaHnzeI9v\SCmZXHj[ZR6dGG\|ZTCoTGRCSyliYXP0bZZqfHoEoB?=	NXvMc49IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2NlQyPjNpPkKwOlI1OTZ\|PD;hQi=>
HP100	M4qxdGZ2dmO2aX;uJGF{e2G7	NXKzZ2NMOTBvNUCwJI5O	MoC2OEBp		NXzRNHlG\GWlcnXhd4V{KHSqZTDobZN1d26nIHTlZYNmfHmuYYPlJEhJTEGFKTDhZ5Rqfmm2edMg	MoLGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4MkSxOlMoRjJyNkK0NVY{RC:jPh?=
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SKOV-3	M{j4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYG0M\|gwOTZibl2=	M2LUSVQ5KGh?		NYHUVJpvcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XJ?	MmOzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MES1OlQoRjJyNEC0OVY1RC:jPh?=
OVCAR-3	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYe0M\|gwOTZibl2=	NVXseYFTPDhiaB?=		MmjkbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZI>	NFvXcW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MESwOFU3PCd-MkC0NFQ2PjR:L3G+
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Jeko-1	MnvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYCyMVUxKG6P	NV;Tc3NDOjRiaB?=		NEnaS4tKSzVyPUGxJI5O	M3;Ke\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyME[4NFgxLz5{MEC2PFA5ODxxYU6=
Granta-519	NV3nTYtTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXTQUoRGPS12MDDuUS=>	NXfmdG9SOjRiaB?=		M13COWlEPTB;NUiuOUBvVQ>?	NUH6XJlQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOlgxQDBpPkKwNFY5ODhyPD;hQi=>
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STM91-01	NYr3e4NLTnWwY4Tpc44hSXO\|YYm=	M3T1VlExKG6P	MlfzNlQwPDhxN{KgbC=>	NFL3XG9FVVOR	M4rJWolv[3KnYYPld{BETEuQMVOg[ZhxemW\|c3nvci=>	NVT5PW1pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlE2QDZpPkG5NlIyPTh4PD;hQi=>
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MKN45	MnrjR5l1d3SxeHnjbZR6KGG\|c3H5				MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNT241PSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCxOEDPxE1w	NWX6WIJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
MKN28	NGDqWoZEgXSxdH;4bYNqfHliYYPzZZk>				MlX4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWtPOjhiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNVch\|ryPLh?=	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
PC3	M3nZPGN6fG:2b4jpZ4l1gSCjc4PhfS=>				NHjZSXdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNVgh\|ryPLh?=	MnHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
ACHN	MVXDfZRwfG:6aXPpeJkh[XO\|YYm=				M361dmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGFEUE5iY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNkDPxE1w	MlywQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
OVCAR4	NVv0WYpRS3m2b4TvfIlkcXS7IHHzd4F6				Mmn0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3ZESVJ2IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFIh\|ryPLh?=	NX;oXGJrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
St-4	NWPncldHS3m2b4TvfIlkcXS7IHHzd4F6				NX\YeIVCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW3RvNDDj[YxteyCkeTDTVmIh[XO\|YYmsJGdKPTBiPTCwMlAzOiEQvF2u	NVrpeYFqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
293T	NXTqVGE2TnWwY4Tpc44h[XO\|YYm=		NFvoR2g{OCCvaX7z		NUSzXm5EUW6qaXLpeIlwdiCxZjDtc5V{\SCKRFHDOkBmgHC{ZYPz[YQhcW5iaIXtZY4hOjl\|VDDj[YxteyC3c3nu[{BC[y2NR1zHT{hC[ylvTVPBJIF{KHO3YoP0doF1\SCjZoTldkA{OCCvaX7zJIJ6KG[udX;y[ZNk\W6lZTDhd5NigSxiSVO1NEA:KDBwM{mg{txONg>?	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
HCT15	MYTDfZRwfG:6aXPpeJkh[XO\|YYm=				NWHTOWpqS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUWgZ4VtdHNiYomgV3JDKGG\|c3H5MEBIUTVyIE2gNE41PSEQvF2u	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
mink Mv1Lu	MmHPSpVv[3Srb36gZZN{[Xl?		M{XQPFI1KGi{cx?=		Mmr5TY5kemWjc3WgbY4hcHWvYX6ge4lt\CC2eYDlJJAzOSCycn;0[YlvKGW6cILld5Nqd25iaX6gcYlvcyCPdkHMeUBk\WyuczDh[pRmeiB{NDDodpMh[nlicEKxJJBzd22xdHXyJIF{e2G7IHnuJJBz\XOnbnPlJI9nKDBwMTDtUUBlcXSqaX;0bJJmcXSxbDygSWMyODByIE2gNE4xOTV5IN88UU4>	NWPqcI9jRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5PVc2PzhpPkK0PVk4PTd6PD;hQi=>
HCT116	NWLDNmFlSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MkeyOFghcHK\|		MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB2ODDodpMhcW5icILld4Vv[2Vib3[gSHRVKGK7IF3UWEBie3OjeTygTWM2OCB;IECuNFA{KM7:TT6=	NYLpV4RERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWxOFc3OTJpPkK1NVQ4PjF{PD;hQi=>
MOLT4	NVLqU3E5SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MmDBO\|IhcHK\|		NGLiU5lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3PUHQ1KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG\|c3H5MEBIUTVyIE2gNE4xODJyNjFOwG0v	M2PieVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{OxN\|M1Lz5{NkOzNVM{PDxxYU6=
DU145	MXnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		Mn;FO\|IhcHK\|		NUfISlV2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhT0l3MDC9JFAvODB{NUWg{txONg>?	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN\|MUOzOEc,OjZ\|M{GzN\|Q9N2F-
U937	MnXORY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NX7nNHlXPzJiaILz		MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV7M{egZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVAhRSByLkCwN\|QyKM7:TT6=	NGn6coY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOzNVM{PCd-Mk[zN\|E{OzR:L3G+
HLF	MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MUe3NkBpenN?		M3XweGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFzGJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFQ5QSEQvF2u	NX;rOWlSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN\|E{OzRpPkK2N\|MyOzN2PD;hQi=>
WI38	NV;ITIZnSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NUDXTlR2PzJiaILz		NHmyb5BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGfJN\|gh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPDT\|gh[XO\|YYmsJGdKPTBiPTCwMlAxPTN7IN88UU4>	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN\|MUOzOEc,OjZ\|M{GzN\|Q9N2F-
U937	M2\2ZWZ2dmO2aX;uJIF{e2G7		M3XqfFI1KGi{cx?=		M4mySWlvcGmkaYTpc44hd2ZiSFTBR\|YhcW5iaIXtZY4hXTl\|NzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh[WyyaHGteJVjcWyrbjDhZ4V1gWyjdHnvckBifCB3IH7NJJRwKDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=>	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN\|MUOzOEc,OjZ\|M{GzN\|Q9N2F-
HCT116	M2fEPWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MV[3NkBpenN?		MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSClb4XseIVzKGOxdX70[ZIhdWW2aH;kMEBKSzVyIE2gNE4xOjhizszNMi=>	NUS5coE6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0PFE3PTlpPkK2OFgyPjV7PD;hQi=>
IGROV1/Pt1	MnPmRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MkPhO\|IhcHK\|		MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEmJUl;WNU9RfDFiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgZ492dHSncjDjc5VvfGW{IH3leIhw\CxiSVO1NEA:KDBwMEig{txONg>?	M2HpXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEixOlU6Lz5{NkS4NVY2QTxxYU6=
IGROV1	M1W5S2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		NUjnbFZNPzJiaILz		NUfhcZFISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDJS3JQXjFiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgZ492dHSncjDjc5VvfGW{IH3leIhw\CxiSVO1NEA:KDBwMkKg{txONg>?	NXf5WXZ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0PFE3PTlpPkK2OFgyPjV7PD;hQi=>

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ

Methods	Test Index	PMID
Western blot	p21 / Cyclin D1; PubMed: 19682393 J Mol Signal NIH 3T3 cells stably expressing the indicated proteins were treated with DMSO (Vehicle) or the indicated concentration of romidepsin for 24 h. Cell lysates were analyzed by western blotting with antibodies to cyclin D1, p21 and β-actin (loading control). Data shown are representative of at least two independent experiments. AcH3(K9) / Ac-α-Tubulin(K40) / Ac-NFκB2(K310) p65 / 3MeH3(K27); PubMed: 26473529 Blood Cancer J Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot. HDAC3 / HDAC4 / HDAC6 / HDAC2; PubMed: 26473529 Blood Cancer J Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot. γH2AX / PARP1 / Cleaved caspase3 / BAK / p21(waf1/cip1) / XIAP; PubMed: 26473529 Blood Cancer J Western blot analysis of proteins involved in DNA-damage response and apoptosis. Established cell lines were exposed to different concentrations of romidepsin (Rom) for 48 h and total cell extracts were analyzed. Cyclin E1 / BRCA1 / E2F1 / Cleaved PARP / H3Ac; PubMed: 27444036 Gynecol Oncol Western blot analysis of the effects of panobinostat (25 nM), vorinostat (5 µM) and romidepsin (10 nM) on expression of cyclin E1, E2F1, BRCA1, cleaved PARP and acetylated histone H3 in OVCAR-3 cells. Actin and histone H3 were loading controls. pAKT(S473) / pAKT(T308) / AKT; PubMed: 25492515 Cancer Sci Western blot analysis of phosphorylated AKT in PC3 cells. Cells were treated for 3 h with various concentrations of FK228.	19682393 26473529 27444036 25492515
Growth inhibition assay	Cell viability; PubMed: 27444036 Gynecol Oncol Concentration-dependent effects of panobinostat and vorinostat in SRB viability assays in OVCAR-3 cells (72 h). Values are mean+SE of 3 independent experiments.	27444036
Immunofluorescence	SS18/TLE1; PubMed: 27120803 Oncotarget A significant decrease in detectable PLA signal following HDAC inhibition in SYO-1 cells. Cleaved caspase-3; PubMed: 22531354 J Ovarian Res TDP-B activates cleaved caspase-3 by immunofluorescence. Representative immunofluorescence staining for cleaved caspase 3 (green) in SKOV-3 ovarian cancer cells treated with 10 nM FK228, TDP-A or TDP-B after 24 h of exposure. The nuclei are stained with DAPI (blue).	27120803 22531354

体内試験

Romidepsin treatment potently inhibits the neovascularization of chick embryo and that of adult mice in the Matrigel plug assay. ^[4]Administration of Romidepsin at 0.1-1 mg/kg twice a week significantly prolongs the survival of mice bearing U-937 lymphoma, with median survival times of 30.5 (0.56 mg/kg) and 33 days (0.32 mg/kg), respectively (vs. 20 days in control mice). ^[5]

お薦めの試験操作（参考用のみ）

キナーゼ試験： ^[1]	- 合併 HDAC-inhibitory activity: For the enzyme assay, 10 μL of [³H]acetyl-labeled histones (25,000 cpm/10 μg) are added to 90 μL of the HDAC enzyme fraction extracted from 293T cells overexpressing HDAC1 or HDAC2 in the presence of increasing concentrations of Romidepsin, and the mixture is incubated at 37 °C for 15 minutes. The enzyme reaction is linear for at least 1 hour. The reaction is stopped by the addition of 10 μL of concentrated HCl. The released [³H]acetic acid is extracted with 1 mL of ethylacetate, and 0.9 mL of the solvent layer is taken into 5 mL of aqueous counting scintillant II solution for determination of radioactivity. The IC50 values are determined from at least three independent dose-response curves.
細胞試験： ^[3]	- 合併細胞株： HL60, Jurkat, A549, and MCF-7 濃度： Dissolved in DMSO, final concentrations ~10 μM 反応時間： 72 hours 実験の流れ： Cells are exposed to various concentrations of Romidepsin for 72 hours in 96-well plates. 20 μL of 5 mg/mL MTT solution in PBS is added to each well for 4 hours. After removal of the medium, 170 μL of DMSO is added to each well to dissolve the formazan crystals. The absorbance at 540 nm is determined. In addition, cells are incubated with trypan blue, and the numbers of blue (dead) cells and transparent (live) cells are counted in a hemocytometer. For cell cycle analysis, cells are incubated for 30 minutes in propidium iodide staining solution containing 0.05 mg/mL propidium iodide, 1 mM EDTA, 0.1% Triton X-100, and 1 mg/mL RNase A in PBS. The suspension is then passed through a nylon mesh filter and analyzed on a Becton Dickinson FACScan. (参考用のみ)
動物試験： ^[5]	- 合併動物モデル： Male scid mice inoculated i.p. with U-937 cells 投薬量： ~1 mg/kg once or twice a week 投与方法： Treated i.p. (参考用のみ)

参考

- 合併

溶解度 (25°C)

体外	DMSO	10 mg/mL (18.49 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	左から（NMPから）右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ): 2% DMSO+30% PEG 300+5%Tween 80+ddH2O 混合させたのち直ちに使用することを推奨します。	5mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量	540.7
化学式	C₂₄H₃₆N₄O₆S₂
CAS No.	128517-07-7
Storage	3 years-20°C powder 2 years-80°C in solvent
別名	FR 901228, NSC 630176
Smiles	CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C

投与溶媒組成計算器(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

投与量

mg/kg

動物平均体重

投与体積（動物毎）

動物数

匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO+ % + % Tween 80+ % ddH₂O

計算リセット

計算結果:

投与溶媒濃度： mg/ml；

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL，注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。）

投与溶媒調製方法：μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH₂O，を加え完全に溶解させます。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

便利ツール

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

質量

濃度

体積

分子量
=

×

×

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA（製品ページで利用可能な）。

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます：

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます：C1V1 = C2V2 ( 入力出力 )

C1

V1

C2

V2
×

=

×

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA（オンラインで利用できる）で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

連続希釈剤
初めの濃度：
稀釈倍数：

計算結果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください：

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量	濃度	体積	分子量
=	×	×

臨床試験 (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03770000	Active not recruiting	Drug: Tenalisib\|Drug: Romidepsin	T Cell Lymphoma	Rhizen Pharmaceuticals SA	March 12 2019	Phase 1\|Phase 2
NCT02616965	Recruiting	Drug: Romidepsin\|Drug: Brentuximab vedotin	Cutaneous T-cell Lymphoma (CTCL)	Fox Chase Cancer Center\|Seagen Inc.\|Celgene Corporation	February 22 2017	Phase 1
NCT02616874	Completed	Drug: MVA.HIVconsv vaccine\|Drug: Romidepsin	HIV	IrsiCaixa\|Germans Trias i Pujol Hospital\|Fundación FLS de Lucha Contra el Sida las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia\|Hospital Clinic of Barcelona\|Hospital de Sant Pau\|HIVACAT\|University of Oxford\|BCN Checkpoint	February 2016	Phase 1
NCT03141203	Active not recruiting	Drug: Romidepsin\|Drug: Carfilzomib	Peripheral T Cell Lymphoma	University of Birmingham\|Bloodwise\|Celgene\|Amgen	July 13 2015	Phase 1\|Phase 2
NCT02296398	Completed	Drug: Romidepsin	Cutaneous T-cell Lymphoma	Northwestern University	January 2015	--

技術サポート

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Handling Instructions

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HDACシグナル伝達経路

HDAC Inhibitors with Unique Features

Pan HDAC Inhibitor

Panobinostat (LBH589) : Pan-HDAC inhibitor, IC50=5 nM.
Most Potent HDAC Inhibitor

Quisinostat (JNJ-26481585) : HDAC1, IC50=0.11 nM; HDAC2, IC50=0.33 nM.
FDA-approved HDAC Inhibitor

Vorinostat (SAHA, MK0683) : Approved by FDA against cutaneous T cell lymphoma.
Newest HDAC Inhibitor

RG2833 (RGFP109) ^New : Brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.

相関HDAC製品

CAY10603

CAY10603 (BML-281) is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs.
Domatinostat (4SC-202)

Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.
Panobinostat (LBH589)

Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.
Vorinostat (SAHA)

Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.
Entinostat (MS-275)

Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. Entinostat induces autophagy and apoptosis. Phase 3.
Trichostatin A (TSA)

Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM in cell-free assays.
Tubastatin A

Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis.

研究分野別

製品類型

Romidepsin (FK228, Depsipeptide)

文献中Selleckの製品使用例(156)

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

お薦めの試験操作（参考用のみ）

参考

溶解度 (25°C)

化学情報

投与溶媒組成計算器(クリア溶液)

便利ツール

モル濃度計算器

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

希釈計算器

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

連続希釈計算器方程式

連続希釈剤

計算結果

分子量计算器

総分子量：g/mol

モル濃度計算器

臨床試験 (data from https://clinicaltrials.gov, updated on 2021-05-17)

技術サポート

HDACシグナル伝達経路

HDAC Inhibitors with Unique Features

相関HDAC製品