Romidepsin (FK228, Depsipeptide)

For research use only. Not for use in humans.

製品コードS3020 別名:FR 901228, NSC 630176

Romidepsin (FK228, Depsipeptide)化学構造

CAS No. 128517-07-7

Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 273900
JPY 28000
JPY 115300
JPY 228000
最寄りの販売代理店を探す

お探しのディーラーが見当たらない場合は直接こちらのメールアドレスまでお問い合わせください:[email protected]

バルク問合せ

文献中Selleckの製品使用例(150)

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.
特性 More effective than other classical HDAC inhibitors such as TSA, TPX, and butyrate.
ターゲット
HDAC1 [1]
(Cell-free assay)
HDAC2 [1]
(Cell-free assay)
36 nM 47 nM
体外試験

Unlike TSA, the active form redFK of Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. Romidepsin is 17-23 times weaker than redFK in inhibiting these HDACs with IC50 of 36 nM, 47 nM, 510 nM, and 14 μM, respectively. Romidepsin treatment in HeLa cells induces histone acetylation and p21 expression with EC50 of 3.0 nM, more strongly than redFK with EC50 of 11 nM due to the instability of redFK. [1] In addition to G2/M arrest, Romidepsin treatment causes cyclin D1 downregulation and a p53-independent p21 induction, leading to inhibition of CDK and dephosphorylation of Rb resulting in growth arrest in the early G1 phase. [2] Romidepsin is 100 times more potent than TSA and 1,000,000 times more potent than butyrate in inhibiting the proliferation of the A549 cells. [3] Romidepsin inhibits the growth of U-937, K562, and CCRF-CEM cells with IC50 of 5.92 nM, 8.36 nM, and 6.95 nM, respectively. [5] Romidepsin promotes apoptosis in chronic lymphocytic leukemia (CLL) cells at a concentration corresponding to that at which H3 and H4 acetylation and HDAC inhibition occurs, selectively involving activation of caspase 8 and effector caspase 3, as well as down-regulation of c-FLIP protein. [6] In 11 of 13 (85%) renal cell carcinoma cell lines and in 16 of 37 (43%) other cancer cell lines, Romidepsin treatment up-regulates tumor death receptors, and potentiates natural killer (NK)-mediated tumor killing. [7] Romidepsin exhibits concentration-dependent cytotoxicity against a panel of mantle cell lymphoma (MCL) cell lines. [9]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SU-DHL4 M4LVNGNmdGxiVnnhZoltcXS7IFHzd4F6 M4rNOlIvPS1zNTDuUS=> NFnIXms4OiCq NUHTVI1mcW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= M1mwOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{mwPVA4Lz5{NUe5NFkxPzxxYU6=
U2932  NITxdnFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NXfuXJVpOi53LUG1JI5O MYW3NkBp MoSwbY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>? NV7UV4w3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVA6ODdpPkK1O|kxQTB5PD;hQi=>
OCI-LY7 NUfUN4l2S2WubDDWbYFjcWyrdImgRZN{[Xl? NG\1S4gzNjVvMUWgcm0> NUnac2ZSPzJiaB?= NYDibIZzcW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= MkTZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUC5NFcoRjJ3N{mwPVA4RC:jPh?=
Farage MnTVR4VtdCCYaXHibYxqfHliQYPzZZk> NVi2[HJMOi53LUG1JI5O NYK1elQ4PzJiaB?= MknPbY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MEmwO{c,OjV5OUC5NFc9N2F-
LY7/EBV MmPBR4VtdCCYaXHibYxqfHliQYPzZZk> MlzjNk42NTF3IH7N MXy3NkBp NXPqTZRTcW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= M4HqU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{mwPVA4Lz5{NUe5NFkxPzxxYU6=
U2932/EBV MmTmR4VtdCCYaXHibYxqfHliQYPzZZk> M3vtXlIvPS1zNTDuUS=> NUPDTZJnPzJiaB?= MYXpcoR2[2W|IHP5eI91d3irY3n0fUBqdiCjIHPvcoNmdnS{YYTpc44u\GWyZX7k[Y51KG2jbn7lduKh NUPhc3duRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVA6ODdpPkK1O|kxQTB5PD;hQi=>
HCT116 NXvKU3JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[1MVUxODBibl2= M{KzfVI1KGh? M4HBbWROW09? MlfObY5lfWOnczDj[YxtKGSnYYToJIlvKGFiY3;uZ4VvfHKjdHnvck1l\XCnbnTlcpQhdWGwbnXy NIj0TpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS5NlUyPSd-MkW0PVI2OTV:L3G+
ACH-2 NWPzUGlqTnWwY4Tpc44hSXO|YYm= M4nEO|EuQSCwTR?= MUSyOEBp M1L6dYlv\HWlZYOgTGlXNTFiRX72JIV5eHKnc4Ppc44> NWfkTVJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWxOFk1PjdpPkK1NVQ6PDZ5PD;hQi=>
MCF-10A M13nW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HtfGlEPTB;MD6xO:KyOC5yMTDuUS=> M3;NNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
MCF-7 NEnpeGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT2TWM2OD1zLkGwxtExNjJyIH7N MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
SK-BR-3 M2nxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTFwMEFCtVAvOzVibl2= M1O4dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
MDA-MB-231 Mn;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;pXVlKSzVyPUCuOljDuTBwMUSgcm0> MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
PC3 MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjDTWM2OD1zLk[1xtExNjN3IH7N MkPuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
HCT116 MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFwMEFCtVAvODBibl2= MkjtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
HCT116-p21-/- MoH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTFwMkdCtVAvOzdibl2= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
S1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7QXIpKSzVyPUeuOlfDuTBwMkmgcm0> M1fnRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUW0PFU3Lz5{NEm1OFg2PjxxYU6=
SW620 NF;TR4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXPTWM2OD1yLkmzxtExNjJ7IH7N NGDHZVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
LOX-IMVI NHjlcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mly3TWM2OD1yLki3xtExNjB|IH7N NEDtdHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
UACC-62 M{XHW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHWTWM2OD1yLkW2xtExNjF4IH7N MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
MDA-MB-435 NVLy[IRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwOUFCtVAvODZibl2= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
SF-295 M1X3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnFTWM2OD1yLki4xtExNjF3IH7N Mm[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
A549 NHvY[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlexTWM2OD1zLkK2xtExNjJ2IH7N MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
H460 NGSyfmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTJwNUlCtVAvQDBibl2= NG[5WIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
EKVX M2\JdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\PXWlEPTB;MT6zN:KyOC5|NDDuUS=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
H146 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;Pe2lEPTB;MD6yNuKyOC5yNzDuUS=> MoLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUS4OVYoRjJ2OUW0PFU3RC:jPh?=
H526 MnGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjqTWM2UUN3ME2wMlE2yrFyLkCzJI5O MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3NEi1Okc,OjR7NUS4OVY9N2F-
HuT-78 NV\1bIFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIf1XmxKSzVyPUGuO|PDuTBwNESgcm0> NF;4UIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1OFg2Pid-MkS5OVQ5PTZ:L3G+
HA NVLKeI9VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP2NE43OjVvMUDuUS=> Ml;OOFghcA>? MVfpcoR2[2W|IHGgd4lodmmoaXPhcpRtgSC|dILvcodmeiCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckBkdy22cnXheIVlKHerdHigZo9zfGW8b33pZi=> NXW5cGVWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3O|E2OTBpPkK0O|cyPTFyPD;hQi=>
MS-275 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGT6SWwxNjZ{NT2xNI5O NITxW3I1QCCq M2XPSIlv\HWlZYOgZUB{cWewaX\pZ4FvfGy7IIP0do9v\2W{IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGOxLYTy[YF1\WRid3n0bEBjd3K2ZYrvcYlj M4jWOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{exOVExLz5{NEe3NVUyODxxYU6=
CD4 T MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVK0PEBp MYfFR|UxRTRwNdMxNU4xKG6P M1;WTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{KyOFU1Lz5{NEeyNlQ2PDxxYU6=
CD4 T NFzJdIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnmwOFghcA>? NY\JUGRmS0N3ME2xNFfDuTF{NjDuUS=> Mn3FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5MkK0OVQoRjJ2N{KyOFU1RC:jPh?=
CD4+ T MkPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjFR|UxRTNibl2= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR7NUGwOUc,OjR2OUWxNFU9N2F-
A549 M1myb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i1bFEx6oDVMUCwxsBvVQ>? MWqyOE8{Pi92ODDo MX;pcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJINwdmOnboTyZZRqd25vIHHu[EB1cW2nLXTldIVv\GWwdDDtZY5v\XJ? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR6NUe5PUc,OjR2OEW3PVk9N2F-
JJN3 MnyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{joelI1NzR6IHi= MXnFR|UxRDIkgJnuUVshPDkkgJno NH7oXnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN|AyPTB:L3G+
OPM-2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn1NlQwPDhiaB?= M3;hZmVEPTC|PUJihKlvVTtiNElihKlp NV;mR5BRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwN|AyPTBpPkK0NFMxOTVyPD;hQi=>
RPMI-8226 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIKxVZIzPC92ODDo MXzFR|Uxez1zLklihKlvVTtiNElihKlp NH[xT5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN|AyPTB:L3G+
U266 NVrvNWhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDvemwzPC92ODDo M4OzRmVEPTC|PUGw5qCKdk19IES45qCKcA>? NHjLSY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzNFE2OCd-MkSwN|AyPTB:L3G+
CA46 M2\HNGFxd3C2b4Ppd{BCe3OjeR?= MWO2JIg> MYLpcoR2[2W|IHLseY51KGGyb4D0c5Nqew>? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4NkG2OEc,OjN7Nk[xOlQ9N2F-
DG75 MYfBdI9xfG:|aYOgRZN{[Xl? NIDL[HI3KGh? NUDR[ZFvcW6mdXPld{BvdyCjcH;weI9{cXN? M1Lrd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OU[2NVY1Lz5{M{m2OlE3PDxxYU6=
Ramos NIX1WYxCeG:ydH;zbZMhSXO|YYm= M4njW|YhcA>? NELuPIlqdmS3Y3XzJIV5fGWwc3n2[UBieG:ydH;zbZM> NHixSJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2OlE3PCd-MkO5OlYyPjR:L3G+
ST486 NWCwU5NISXCxcITvd4l{KEG|c3H5 MlTuOkBp MYTpcoR2[2W|IHX4eIVve2m4ZTDhdI9xfG:|aYO= MojaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7Nk[xOlQoRjJ|OU[2NVY1RC:jPh?=
HuT78 MVHBdI9xfG:|aYOgRZN{[Xl? Ml3MNU8yOC9zMECgcm0> NIrSRXA1QCCq NI\wWZlqdmS3Y3XzJIFxd3C2b4Ppd{BifCBzIH7N MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV|MkezNkc,OjN3M{K3N|I9N2F-
DpVp35 NHPxXY5CeG:ydH;zbZMhSXO|YYm= M4LWOFEwOTBxMUCwJI5O MWi0PEBp MWrpcoR2[2W|IHLseY51KGGyb4D0c5Nqew>? MlTKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3M{K3N|IoRjJ|NUOyO|MzRC:jPh?=
DpVp50 MUHBdI9xfG:|aYOgRZN{[Xl? NEG1bm4yNzFyL{GwNEBvVQ>? MX60PEBp NITqZ2xqdmS3Y3XzJIJtfW62IHHwc5B1d3Orcx?= NUDIdoV1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1N|I4OzJpPkKzOVMzPzN{PD;hQi=>
DpP75  MXzBdI9xfG:|aYOgRZN{[Xl? MYKxM|ExNzFyMDDuUS=> M3f0NVQ5KGh? MWPpcoR2[2W|IHLseY51KGGyb4D0c5Nqew>? NVvIeHpoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1N|I4OzJpPkKzOVMzPzN{PD;hQi=>
SKOV-3 NEDsXXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3i2TlHjiJN{MH7N MYG3NkBp NITz[JVFVVOR NESzbI1z\WS3Y3XzJINmdGxidnnhZoltcXS7IHHsc45mKGGwZDDjc41jcW6nZDD3bZRpKGOrc4DsZZRqdg>? NUC5WlZzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVA{PDhpPkKzNFExOzR6PD;hQi=>
Brca1 WT MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjYNgKBmzJybl2= M4DtRlczKGh? NFW5ZWhFVVOR MnXvdoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4> MkTEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUCzOFgoRjJ|MEGwN|Q5RC:jPh?=
Brca1 Null NYrF[4dRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfDdoUy6oDVMkDuUS=> MofDO|IhcA>? M3j2NGROW09? NVG4cmgzemWmdXPld{Bk\WyuII\pZYJqdGm2eTDhcI9v\SCjbnSgZ49u[mmwZXSge4l1cCClaYPwcIF1cW5? NYTo[mdnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVA{PDhpPkKzNFExOzR6PD;hQi=>
OVCAR-8  MlLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVmx5qCUOjCwTR?= NX\KOWE2PzJiaB?= NYDDZmpWTE2VTx?= MljNdoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4> M3SzZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEGwN|Q5Lz5{M{CxNFM1QDxxYU6=
NCI/ADR-RES MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L2OFHjiJN{MH7N M4rvR|czKGh? NITscmNFVVOR MofrdoVlfWOnczDj[YxtKH[rYXLpcIl1gSCjbH;u[UBidmRiY3;tZolv\WRid3n0bEBkcXOybHH0bY4> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzMEO0PEc,OjNyMUCzOFg9N2F-
HCT116 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i1SVUhdk1vNUCg{txO MXSyOEBp M1XG[2ROW09? NH3udYpqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5meg>? NVrRUZZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NlQ6PThpPkKyPVI1QTV6PD;hQi=>
RKO MoHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXy1JI5ONTVyIN88US=> NVGwVZZZOjRiaB?= NIq4eW5FVVOR M1LHUIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz M{TBSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUK0PVU5Lz5{MkmyOFk2QDxxYU6=
CO115 NHHxTVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUS1JI5ONTVyIN88US=> MUeyOEBp MUDEUXNQ NFPnXYVqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJINwdmOnboTyZZRqd25vZHXw[Y5l\W62IH3hco5meg>? NHSwZWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyOFk2QCd-MkK5NlQ6PTh:L3G+
HFS MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPaOUBvVQ>? NYDYNY9LOjRxNEivO|IhcA>? MYrpcohq[mm2czDj[YxtKGe{b4f0bEB1cW2nLXTldIVv\GWwdHz5 NVvJUmN4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNFYzQDJpPkKyNVA3Ojh{PD;hQi=>
LNCaP MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzPTZNiPSCwTR?= NXfleHhCOjRxNEivO|IhcA>? NV3EU5FEcW6qaXLpeJMh[2WubDDndo94fGhidHnt[U1l\XCnbnTlcpRtgQ>? NVvEcYs4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNFYzQDJpPkKyNVA3Ojh{PD;hQi=>
A549 MnW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvWNpA6PSCwTR?= MkPpNlQwPDhxN{KgbC=> M2rV[4lvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWt[IVx\W6mZX70cJk> M3mycVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUC2NlgzLz5{MkGwOlI5OjxxYU6=
697  NVrvNVFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LBPWlEPTEkgJm95qCKOi53wrDuUS=> NIC1Zmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWzPFIyPid-MkG1N|gzOTZ:L3G+
697-R NHiwbVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEOwVHVKSzVy4pEJQgKBkThwNtMgcm3DqA>? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV|OEKxOkc,OjF3M{iyNVY9N2F-
HUT78 M4jw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIW2UnFKSzVyPUGgcm0> NYHzXWxkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxPVg2PDVpPkKxNVk5PTR3PD;hQi=>
THJ-16T Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\EVFEhdk1? NXnZTpBDOjRiaB?= NEPWNmtqdmirYnn0d{Bk\WyuIHfyc5d1cA>? NH2yUIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixNFU3QCd-MkC4NVA2Pjh:L3G+
HCT116 NVH3ZnhUTnWwY4Tpc44hSXO|YYm= M1LDbFIxKG6P NYL1UZFiQCCq M{XhSI1w\HWuYYTld{B1emGwc3PybZB1KGyndnXsd{Bnd3JiaIXu[JJm\HNib3[g[4Vv\XNiaX6g[Yl1cGW{IHTpdoVkfGmxbh?= NWnSVmVXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC3N|k1PTRpPkKwO|M6PDV2PD;hQi=>
B104  MXvGeY5kfGmxbjDBd5NigQ>? MViyJI5O MYKyOE81QC95MjDo MmXKbY5kemWjc3XzJJRp\SC|dYLmZYNmKGW6cILld5Nqd25ib3[gR2QzOMLi NWrvXm46RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2PFY2ODVpPkKwOlg3PTB3PD;hQi=>
HL-60  MmOyR5l1d3SxeHnjbZR6KEG|c3H5 MnTDNU02ODBibl2= NWH3RYhlOjRiaB?= NV6wXFZvcW6mdXPld{BkgXSxdH;4bYNqfHliaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XMEoB?= NXm4UJFSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2NlQyPjNpPkKwOlI1OTZ|PD;hQi=>
HP100 MlfMR5l1d3SxeHnjbZR6KEG|c3H5 NEjaXmsyNTVyMDDuUS=> NIW0TnAzPCCq MnL6bY5lfWOnczDjfZRwfG:6aXPpeJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZLDqA>? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{NEG2N{c,OjB4MkSxOlM9N2F-
HL-60  MWLGeY5kfGmxbjDBd5NigQ>? MXmxNEBvVQ>? MUW0M|YwOTZiaB?= NGG3fJZqdmS3Y3XzJJRp\SCpZX7ldoF1cW:wIH;mJIh6\HKxZ3XuJJBmem:6aXTlJIZzd21iNHi= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{NEG2N{c,OjB4MkSxOlM9N2F-
HP100 MlL3SpVv[3Srb36gRZN{[Xl? M2[5flExKG6P MVe0M|YwOTZiaB?= NFWyeJdqdmS3Y3XzJJRp\SCpZX7ldoF1cW:wIH;mJIh6\HKxZ3XuJJBmem:6aXTlJIZzd21iNHi= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{NEG2N{c,OjB4MkSxOlM9N2F-
HL-60  MUTGeY5kfGmxbjDBd5NigQ>? NXm3UVkyOTBvNUCwJI5O MVW0JIg> NFXlV4tl\WO{ZXHz[ZMhfGinIHjpd5RwdmViZHXhZ4V1gWyjc3WgLGhFSUNrIHHjeIl3cXS7wrC= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{NEG2N{c,OjB4MkSxOlM9N2F-
HP100 NHzKcWlHfW6ldHnvckBCe3OjeR?= M{DjN|ExNTVyMDDuUS=> Mn7YOEBp NIPQV5Rl\WO{ZXHz[ZMhfGinIHjpd5RwdmViZHXhZ4V1gWyjc3WgLGhFSUNrIHHjeIl3cXS7wrC= NHnU[nk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yOFE3Oyd-MkC2NlQyPjN:L3G+
11z NFnEfY1McW6jc3WgRZN{[Xl? MYSzMVExOCCwTR?= MXfy[YR2[2W|IFjERWMh\W68eX3heIlkKGGldHn2bZR6KCiLQ{WwxsA:KDZwNTFCtUAxNjZibn3vcE9NMQ>? NEjtTms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[wOVE1PCd-MkC2NFUyPDR:L3G+
SKOV-3 MnHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu0cZhJPC96L{G2JI5O M2fUVVQ5KGh? MX;pcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHPvcoNmdnS{YYTpc44u\GWyZX7k[Y51KG2jbn7ldi=> NUi5XmdqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFQ2PjRpPkKwOFA1PTZ2PD;hQi=>
OVCAR-3 NV7hXJc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2G5PVQwQC9zNjDuUS=> NEnle|E1QCCq NVLPSIRHcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XJ? M4Ts[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEC0OVY1Lz5{MESwOFU3PDxxYU6=
HBL-2 MoPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWiyMVExKG6P NHjwblEzPCCq NYL1XY9{UUN3ME20MlMhdk1? M{K4[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyME[4NFgxLz5{MEC2PFA5ODxxYU6=
Jeko-1 NFHNVHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD2UZgyOi13MDDuUS=> M1L6[FI1KGh? MUnJR|UxRTFzIH7N NEXp[3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC2PFA5OCd-MkCwOlgxQDB:L3G+
Granta-519 MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPwNlE2NTRyIH7N M2DDSVI1KGh? NE\ydmxKSzVyPUW4MlUhdk1? NV\4OmxnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOlgxQDBpPkKwNFY5ODhyPD;hQi=>
L1236 MWXDfZRwfG:6aXPpeJkhSXO|YYm= NUDTR|QxOSCwTT2xNFAh|ryP Mlj0OFghcA>? M2fRUmVEPTB;MD6wO{DPxE1? M2C5bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkOzOFcxLz5zOUKzN|Q4ODxxYU6=
L428 NV\5bXJYS3m2b4TvfIlkcXS7IFHzd4F6 NXLmdVA5OSCwTT2xNFAh|ryP NHLUOXM1QCCq Mo\3SWM2OD1yLkSzJO69VQ>? NV;TS45PRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|M1PzBpPkG5NlM{PDdyPD;hQi=>
KM-H2 Mki4R5l1d3SxeHnjbZR6KEG|c3H5 MkCyNUBvVS1zMECg{txO NGqxNpI1QCCq MWTFR|UxRTBwNUig{txO M1f0UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkOzOFcxLz5zOUKzN|Q4ODxxYU6=
L540Cy NUThd4xxS3m2b4TvfIlkcXS7IFHzd4F6 NX;wWW1iOSCwTT2xNFAh|ryP MVO0PEBp MmjySWM2OD1yLkG2JO69VQ>? MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|M{S3NEc,OTl{M{O0O|A9N2F-
G401 MkLVSpVv[3Srb36gRZN{[Xl? NXHaOllEOTBibl2= NHzzO5czPC92OD:3NkBp MV7EUXNQ MoX3bY5kemWjc3XzJGNFU05zQzDlfJBz\XO|aX;u MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MUW4Okc,OTl{MkG1PFY9N2F-
STM91-01 NF7IUlFHfW6ldHnvckBCe3OjeR?= MUOxNEBvVQ>? M1PGdlI1NzR6L{eyJIg> MW\EUXNQ NEDLd|ZqdmO{ZXHz[ZMhS0SNTkHDJIV5eHKnc4Ppc44> MmrvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{MkG1PFYoRjF7MkKxOVg3RC:jPh?=
SJSC  MmfOSpVv[3Srb36gRZN{[Xl? MWqxNEBvVQ>? NF;RbIozPC92OD:3NkBp NUf4bIl{TE2VTx?= M2r6U4lv[3KnYYPld{BETEuQMVOg[ZhxemW|c3nvci=> Mkm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{MkG1PFYoRjF7MkKxOVg3RC:jPh?=
BT16  NU\Zcms4TnWwY4Tpc44hSXO|YYm= M1fMeVExKG6P MX[yOE81QC95MjDo MVfEUXNQ NUTDTGZ2cW6lcnXhd4V{KEOGS16xR{BmgHC{ZYPzbY9v MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MUW4Okc,OTl{MkG1PFY9N2F-
NCI-H1299 NU\JPVd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHE[|NNUUN3ME20MlbDuTBwMjDu[{9udA>? M2f0bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUe5PFkxLz5zOUG3PVg6ODxxYU6=
NCI-2882 NXe5RYxVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn5NYJKSzVyPUGuOuKyOC5yNDDu[{9udA>? NFPibYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG3PVg6OCd-MUmxO|k5QTB:L3G+
HCC95 NU\Be3VlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvNfWxKSzVyPUKuOeKyOC5yNTDu[{9udA>? M1XBUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUe5PFkxLz5zOUG3PVg6ODxxYU6=
NCI-H23 NE\OU4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfLNJhFUUN3ME2yMlnDuTBwMjDu[{9udA>? NXH6S4p3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxO|k5QTBpPkG5NVc6QDlyPD;hQi=>
NCI-H157 NWTSblVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37wUWlEPTB;MT62xtExNjB{IH7nM41t NHz3N2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG3PVg6OCd-MUmxO|k5QTB:L3G+
NCI-H460 NIi4R4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLFe5NKSzVyPUKuNeKyOC5yNzDu[{9udA>? MoHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzN{m4PVAoRjF7MUe5PFkxRC:jPh?=
NCI-H1975 M{DHfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHpfINKSzVyPUGuN:KyOC5yNDDu[{9udA>? NGnkdnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG3PVg6OCd-MUmxO|k5QTB:L3G+
NCI-H820 NX7lfJVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTjTWM2OD1{LkVCtVAvOSCwZz;tcC=> NWf1ZWpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxO|k5QTBpPkG5NVc6QDlyPD;hQi=>
NCI-H1650 NHu0W|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLtdYJ{UUN3ME20MlnDuTBwMzDu[{9udA>? NVjH[mlkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxO|k5QTBpPkG5NVc6QDlyPD;hQi=>
DTC1 MmLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoezTWM2OD1yLkWxJI5O M3[yUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
KAO M{H3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrI[Wo3UUN3ME2wMlkyKG6P NUX5TGVGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlYzPDZpPkG4OVY3OjR4PD;hQi=>
SU-CCS-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO3TWM2OD1yLki5JI5O Moj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
SYO-1 M1W4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;qN2lEPTB;MD62O{BvVQ>? NH3WOZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
FUJI NFe2TW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTJWHFKSzVyPUGuN|Ehdk1? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV4NkK0Okc,OTh3Nk[yOFY9N2F-
SKNMC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFwMUegcm0> NYi0XnRnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlYzPDZpPkG4OVY3OjR4PD;hQi=>
402-91 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInDc2pKSzVyPUGuNlYhdk1? NFLaS4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
1765-92 M3jJc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTFwN{egcm0> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV4NkK0Okc,OTh3Nk[yOFY9N2F-
JN-DSRCT-1 NHvBTWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{CyT2lEPTB;MT6yOUBvVQ>? NIXyOY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
NMS-2PC M4\Rdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13kXGlEPTB;MD64NUBvVQ>? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV4NkK0Okc,OTh3Nk[yOFY9N2F-
HL60 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWG1WHZGUUN3ME2xMlg3KG6P M2O5R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
A549 M3nmWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrJTWM2OD1|LkK0JI5O M13NcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
SW480 Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJwNkmgcm0> NYPib4V[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlYzPDZpPkG4OVY3OjR4PD;hQi=>
MCF7 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XTS2lEPTB;Mz61OUBvVQ>? MorNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
PC-3 M3\pXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPkTWM2OD1{LkWxJI5O NETacIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW2OlI1Pid-MUi1OlYzPDZ:L3G+
MMRU NHr5ZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJwNUegcm0> M{XYSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[2NlQ3Lz5zOEW2OlI1PjxxYU6=
Hs68 Mm\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;BdGlEPTB;PkGwJI5O MlTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3Nk[yOFYoRjF6NU[2NlQ3RC:jPh?=
hMSC-001F NGfqb3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zWdmlEPTB;PkGwJI5O MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV4NkK0Okc,OTh3Nk[yOFY9N2F-
mammalian cells MUPGeY5kfGmxbjDhd5NigQ>? M3jU[2lvcGmkaYTpc44hd2ZiSHnzeI9v\SCmZXHj[ZR6dGG|ZTC0JIlvKG2jbX3hcIlidiClZXzsd{whUUN3MDC9JFAvPTFizszNMi=> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV6NEmzNkc,OTR3OES5N|I9N2F-
mammalian cells M4XNNGZ2dmO2aX;uJIF{e2G7 MX3Jcohq[mm2aX;uJI9nKEirc4TvcoUh\GWjY3X0fYxie2ViMTDpcoR2[2WmIHHj[ZR6dGG2ZXSgbIl{fG:wZTDpckBu[W2vYXzpZY4h[2WubIOuMEBGSzVyIE2gN|Yh|ryPLh?= M{PpZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2NUi0PVMzLz5zNEW4OFk{OjxxYU6=
MCF7 M1\vO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NE\HRWZIem:5dHigbY5pcWKrdHnvckBw\iCPQ1[3JINmdGy|LDDJR|UxKD1iMD6wNFA4PSEQvF2u NWXCZnFVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5OVg{PDJpPkG3PVU5OzR{PD;hQi=>
A498 MVfDfZRwfG:6aXPpeJkh[XO|YYm= NGD4No83KGSjeYO= M{PycWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1QThiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhXEeLIE2gNE4xOjhizszNMi=> NUfDeW9LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
COLO205 NWWz[YZpS3m2b4TvfIlkcXS7IHHzd4F6 MkTqOkBl[Xm| NF3CSXZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEV0yRMkC1JINmdGy|IHHmeIVzKDZiZHH5d{BjgSCPVGSgZZN{[XluIGTHTUA:KDBwMEOxJO69VS5? M4K1WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
U251 NVjEVW46S3m2b4TvfIlkcXS7IHHzd4F6 MU[2JIRigXN? M1fm[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHUzPTFiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhXEeLIE2gNE4xOzFizszNMi=> MlLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
RXF393 NWr1N|I{S3m2b4TvfIlkcXS7IHHzd4F6 NFnLU2o3KGSjeYO= MlXXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVnhHOzl|IHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKFSJSTC9JFAvODZ{IN88UU4> M2HiUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-468 MX3DfZRwfG:6aXPpeJkh[XO|YYm= MkLVOkBl[Xm| M4jkNGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20Olgh[2WubIOgZYZ1\XJiNjDkZZl{KGK7IF3UWEBie3OjeTygWGdKKD1iMD6wPUDPxE1w M1fmbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
COLO205 NFfoSJVEgXSxdH;4bYNqfHliYYPzZZk> MoewOkBl[Xm| MoS1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR29NVzJyNTDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCOQ{WwJF0hOC5yOUKg{txONg>? NXu1dVc1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
UACC257 NELMZYZEgXSxdH;4bYNqfHliYYPzZZk> NUno[nNIPiCmYYnz M1z6Z2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHVCS0N{NUegZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiVFfJJF0hOC5yOUWg{txONg>? MlrLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
U251 NG\VN|VEgXSxdH;4bYNqfHliYYPzZZk> NF7kdW43KGSjeYO= MoDKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVI2OSClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBNSzVyIE2gNE4yOyEQvF2u MoXPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
A498 MUTDfZRwfG:6aXPpeJkh[XO|YYm= M{PZVFYh\GG7cx?= MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFk5KGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJGxEPTBiPTCwMlIh|ryPLh?= NYj3U4ViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
NCI-H322M M{DBS2N6fG:2b4jpZ4l1gSCjc4PhfS=> MnXLOkBl[Xm| MnfNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh|MkLNJINmdGy|IHHmeIVzKDZiZHH5d{BjgSCPVGSgZZN{[XluIGTHTUA:KDBwMkOg{txONg>? MmTPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
SF295 MmPaR5l1d3SxeHnjbZR6KGG|c3H5 M13aWlYh\GG7cx?= MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTSlI6PSClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBVT0liPTCwMlI2KM7:TT6= M1jKZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
RXF393 MVHDfZRwfG:6aXPpeJkh[XO|YYm= MVW2JIRigXN? MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDSXGY{QTNiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhVEN3MDC9JFAvOyEQvF2u NWq1RVliRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
NCI60 NInscWZEgXSxdH;4bYNqfHliYYPzZZk> NEnncWQ3KGSjeYO= M3jQdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUTZyIHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKFSJSTC9JFAvOzNizszNMi=> M2H6NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
SN12C MofTR5l1d3SxeHnjbZR6KGG|c3H5 MWm2JIRigXN? NFvXN3hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUVjF{QzDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCWR1mgQUAxNjN2IN88UU4> M{TFZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-231 M4PrWWN6fG:2b4jpZ4l1gSCjc4PhfS=> NF23VIs3KGSjeYO= NGLhZVVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJHRIUSB;IECuN|Uh|ryPLh?= M4rWUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
ACHN NGn1V3FEgXSxdH;4bYNqfHliYYPzZZk> NGXOSmQ3KGSjeYO= NVHV[IFlS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSUOKTjDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCWR1mgQUAxNjd|IN88UU4> NWK4NXV7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
SN12C NXTCR4h6S3m2b4TvfIlkcXS7IHHzd4F6 M3HqNlYh\GG7cx?= M3zsVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNPOTKFIHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEyFNUCgQUAyNjVizszNMi=> M3ux[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
UO31 NYLqcIdpS3m2b4TvfIlkcXS7IHHzd4F6 NUS0c|JJPiCmYYnz M17xUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHVQOzFiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhXEeLIE2gNU42PSEQvF2u NWTiT5I{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
Caki1 MoS3R5l1d3SxeHnjbZR6KGG|c3H5 NWT1OW44PiCmYYnz NGrzNJlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[WurMTDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCWR1mgQUAyNjh7IN88UU4> M4PLSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
NCI60 M2j1OmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3[wRVYh\GG7cx?= NIPoRWdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0l4MDDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCOQ{WwJF0hOy53IN88UU4> M2rzVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-231 NX3Mb3ZPS3m2b4TvfIlkcXS7IHHzd4F6 NGDa[HM3KGSjeYO= NXTwbJBbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBNSzVyIE2gOE4xQCEQvF2u M4fvcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-468 NES0N2lEgXSxdH;4bYNqfHliYYPzZZk> MUi2JIRigXN? NU\NN4FJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBNSzVyIE2gOE4yPCEQvF2u MkHkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
ACHN NI\vV5VEgXSxdH;4bYNqfHliYYPzZZk> M2nNRVYh\GG7cx?= MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBR2hPKGOnbHzzJIFnfGW{IE[g[IF6eyCkeTDNWHQh[XO|YYmsJGxEPTBiPTC1MlM4KM7:TT6= NYHT[W02RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlcyPDZpPkKxPVY4OTR4PD;hQi=>
UACC257 NYP6dY8zS3m2b4TvfIlkcXS7IHHzd4F6 M335Z|Yh\GG7cx?= Mm\QR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWWFESzJ3NzDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCOQ{WwJF0hPS52NjFOwG0v M4S1S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
NCI-H322M NVz5RXpvS3m2b4TvfIlkcXS7IHHzd4F6 NFj6cpU3KGSjeYO= MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDN{Ml2gZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiTFO1NEA:KDlwMEKg{txONg>? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
SF295 M4nRNGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVX2d|BjPiCmYYnz NWP6PJNwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0Z{OUWgZ4VtdHNiYX\0[ZIhPiCmYYnzJIJ6KE2WVDDhd5NigSxiTFO1NEA:KDFyLkKg{txONg>? MkX0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
Caki1 NV7wWGlMS3m2b4TvfIlkcXS7IHHzd4F6 NVzRSI5LPiCmYYnz M2S5OmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNic2lzIHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEyFNUCgQUAzOC57IN88UU4> MoTYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
NCI-H23 NFi3W|BCdnSrdIXtc5Ih[XO|YYm= M1TKblEvPiC2bzCyMlQhdWdxa3e= M1rUR5VxKHSxIEWg[IF6ew>? NIm2Wm5CdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDJ|IHPlcIx{KGmvcHzhcpRm\CCrboTyZZBmemm2b37lZYxtgSCrbjDtc5V{\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHS3bX;yJINmdGxiZ4Lve5RpKGG2IEGuOkB1dyB{LkSgcYcwc2duIHnwJIFldWmwaYP0[ZJm\CCxbjDkZZkhOSC2bzC0JI1m[XO3cnXkJI9vKGSjeTC1JIJ6KGixbHzve{BncWKncjDhd5NigQ>? M4nRRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
NCI-H522 MULBcpRqfHWvb4KgZZN{[Xl? MmjZNU43KHSxIEKuOEBu\y:tZx?= NHLHS4Z2eCC2bzC1JIRigXN? MlPDRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg2OjJiY3XscJMhcW2ybHHueIVlKGmwdILhdIVzcXSxbnXhcIx6KGmwIH3veZNmKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhfHWvb4KgZ4VtdCCpcn;3eIgh[XRiMT62JJRwKDJwNDDt[{9s\yxiaYCgZYRucW6rc4TldoVlKG:wIHThfUAyKHSxIESgcYVie3W{ZXSgc44h\GG7IEWgZpkhcG:ubH;3JIZq[mW{IHHzd4F6 MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
OVCAR5 M3fOc2FvfGm2dX3vdkBie3OjeR?= NHzNbJUyNjZidH:gNk41KG2pL3vn MW\1dEB1dyB3IHThfZM> NHLqR4JCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDPWmNCWjViY3XscJMhcW2ybHHueIVlKGmwdILhdIVzcXSxbnXhcIx6KGmwIH3veZNmKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhfHWvb4KgZ4VtdCCpcn;3eIgh[XRiMT62JJRwKDJwNDDt[{9s\yxiaYCgZYRucW6rc4TldoVlKG:wIHThfUAyKHSxIESgcYVie3W{ZXSgc44h\GG7IEWgZpkhcG:ubH;3JIZq[mW{IHHzd4F6 MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
SW620 NWjHO2dlSW62aYT1cY9zKGG|c3H5 M3PaRVEvPiC2bzCyMlQhdWdxa3e= NX;lRnRVfXBidH:gOUBl[Xm| NXeyVIduSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV3c3OjBiY3XscJMhcW2ybHHueIVlKGmwdILhdIVzcXSxbnXhcIx6KGmwIH3veZNmKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhfHWvb4KgZ4VtdCCpcn;3eIgh[XRiMT62JJRwKDJwNDDt[{9s\yxiaYCgZYRucW6rc4TldoVlKG:wIHThfUAyKHSxIESgcYVie3W{ZXSgc44h\GG7IEWgZpkhcG:ubH;3JIZq[mW{IHHzd4F6 M4OyXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-435 NH7PVY9CdnSrdIXtc5Ih[XO|YYm= NUHrbnRSOS54IITvJFIvPCCvZz;r[y=> M4n5WJVxKHSxIEWg[IF6ew>? M{PvcmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi12M{WgZ4VtdHNiaX3wcIFvfGWmIHnueJJieGW{aYTvcoVidGy7IHnuJI1wfXOnIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidIXtc5Ih[2WubDDndo94fGhiYYSgNU43KHSxIEKuOEBu\y:tZzygbZAh[WSvaX7pd5RmemWmIH;uJIRigSBzIITvJFQhdWWjc4Xy[YQhd25iZHH5JFUh[nliaH;scI94KG[rYnXyJIF{e2G7 MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
COLO205 MXvBcpRqfHWvb4KgZZN{[Xl? MV2xMlYhfG9iMj60JI1oN2up MoPreZAhfG9iNTDkZZl{ MknaRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1;MU|IxPSClZXzsd{BqdXCuYX70[YQhcW62cnHw[ZJqfG:wZXHscJkhcW5ibX;1d4Uh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB1fW2xcjDj[YxtKGe{b4f0bEBifCBzLk[geI8hOi52IH3nM4toNCCrcDDh[I1qdmm|dHXy[YQhd25iZHH5JFEhfG9iNDDt[YF{fXKnZDDvckBl[XliNTDifUBpd2yub4eg[olj\XJiYYPzZZk> M362WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
LOXIMVI MVnBcpRqfHWvb4KgZZN{[Xl? MUexMlYhfG9iMj60JI1oN2up NImxR4l2eCC2bzC1JIRigXN? M2nSVGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzPXGlOXkliY3XscJMhcW2ybHHueIVlKGmwdILhdIVzcXSxbnXhcIx6KGmwIH3veZNmKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhfHWvb4KgZ4VtdCCpcn;3eIgh[XRiMT62JJRwKDJwNDDt[{9s\yxiaYCgZYRucW6rc4TldoVlKG:wIHThfUAyKHSxIESgcYVie3W{ZXSgc44h\GG7IEWgZpkhcG:ubH;3JIZq[mW{IHHzd4F6 MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
UACC62 NU\CeoZiSW62aYT1cY9zKGG|c3H5 MYSxMlYhfG9iMj60JI1oN2up MV;1dEB1dyB3IHThfZM> NUPRemZISW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gWWFESzZ{IHPlcIx{KGmvcHzhcpRm\CCrboTyZZBmemm2b37lZYxtgSCrbjDtc5V{\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHS3bX;yJINmdGxiZ4Lve5RpKGG2IEGuOkB1dyB{LkSgcYcwc2duIHnwJIFldWmwaYP0[ZJm\CCxbjDkZZkhOSC2bzC0JI1m[XO3cnXkJI9vKGSjeTC1JIJ6KGixbHzve{BncWKncjDhd5NigQ>? M3LqXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[3NVQ3Lz5{MUm2O|E1PjxxYU6=
MDA-MB-231 MULBcpRqfHWvb4KgZZN{[Xl? M3izXVEvPiC2bzCyMlQhdWdxa3e= MojJeZAhfG9iNTDkZZl{ M3z4d2FvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiaX3wcIFvfGWmIHnueJJieGW{aYTvcoVidGy7IHnuJI1wfXOnIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidIXtc5Ih[2WubDDndo94fGhiYYSgNU43KHSxIEKuOEBu\y:tZzygbZAh[WSvaX7pd5RmemWmIH;uJIRigSBzIITvJFQhdWWjc4Xy[YQhd25iZHH5JFUh[nliaH;scI94KG[rYnXyJIF{e2G7 MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4N{G0Okc,OjF7NkexOFY9N2F-
SF295 NUTWe3lXSW62aYT1cY9zKGG|c3H5 MVyxMlYhfG9iMj60JI1oN2up MoLmeZAhfG9iNTDkZZl{ NXnqUJVmSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gV2YzQTViY3XscJMhcW2ybHHueIVlKGmwdILhdIVzcXSxbnXhcIx6KGmwIH3veZNmKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhfHWvb4KgZ4VtdCCpcn;3eIgh[XRiMT62JJRwKDJwNDDt[{9s\yxiaYCgZYRucW6rc4TldoVlKG:wIHThfUAyKHSxIESgcYVie3W{ZXSgc44h\GG7IEWgZpkhcG:ubH;3JIZq[mW{IHHzd4F6 MnXkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
U251 MoTsRY51cXS3bX;yJIF{e2G7 M33oSVEvPiC2bzCyMlQhdWdxa3e= NGjPcpN2eCC2bzC1JIRigXN? M17UWmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGWyOVEh[2WubIOgbY1xdGGwdHXkJIlvfHKjcHXybZRwdmWjbHz5JIlvKG2xdYPlJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geJVud3JiY3XscEBoem:5dHigZZQhOS54IITvJFIvPCCvZz;r[{whcXBiYXTtbY5qe3SncnXkJI9vKGSjeTCxJJRwKDRibXXhd5Vz\WRib36g[IF6KDViYomgbI9tdG:5IH\pZoVzKGG|c3H5 NI[2UpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2O|E1Pid-MkG5OlcyPDZ:L3G+
OVRAC3 M1fKT2FvfGm2dX3vdkBie3OjeR?= Mk\jNU43KHSxIEKuOEBu\y:tZx?= M{PMNZVxKHSxIEWg[IF6ew>? NXHnd2I6SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gU3ZTSUN|IHPlcIx{KGmvcHzhcpRm\CCrboTyZZBmemm2b37lZYxtgSCrbjDtc5V{\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHS3bX;yJINmdGxiZ4Lve5RpKGG2IEGuOkB1dyB{LkSgcYcwc2duIHnwJIFldWmwaYP0[ZJm\CCxbjDkZZkhOSC2bzC0JI1m[XO3cnXkJI9vKGSjeTC1JIJ6KGixbHzve{BncWKncjDhd5NigQ>? MmLQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkexOFYoRjJzOU[3NVQ3RC:jPh?=
LLC NXT2V45STnWwY4Tpc44h[XO|YYm= M4ixUmlvcGmkaYTpc44hd2ZiSFTBR{1u\WSrYYTl[EBJUUZvMXHsdIhiKGGldHn2bZR6KGmwIH3veZNmKEyOQzDj[YxteyxiSVO1NEA:KDJizszNMi=> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjNyNU[xNkc,OjJ|MEW2NVI9N2F-
NCI-H522 M{Oxbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHqwZXNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyNkBk\WyuczDifUB{fWyob4Loc4RidWmwZTDCJINwdG:{aX3leJJq[yCvZYToc4QtKEeLNUCgQUAxNjByMUig{txONg>? NFH1NXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
LOXIMVI NXn2ZWVHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXP5U2JVT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVE:[SV3WTUBk\WyuczDifUB{fWyob4Loc4RidWmwZTDCJINwdG:{aX3leJJq[yCvZYToc4QtKEeLNUCgQUAxNjByMkWg{txONg>? MmLzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
A549 MlfhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3;WRmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFI3KM7:TT6= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
OVCAR5 Mn7RS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFHtfItIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBQXkODUkWgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODJ6IN88UU4> MojuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
MKN74 MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFjPfIRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOU055NDDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxOyEQvF2u M2jyclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
NCI-H460 MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1PWRmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODB|IN88UU4> M1PrcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
HCT116 M13vWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NU[yNmc4T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODB|MTFOwG0v MmLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
HCC2998 MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3zuUWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhESzJ7OUigZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDjc4xwemmvZYTybYMhdWW2aH;kMEBIUTVyIE2gNE4xODNzIN88UU4> NIfJclU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
MKN1 NEjld5BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXjHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNT24yKGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMECzNkDPxE1w MnfIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
SKOV3 M{[3O2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MULHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTT29XOyClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwN|Mh|ryPLh?= NXz5XlF1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
HT-29 MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIWE0zQSClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwN|Mh|ryPLh?= NV[zR|J7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
KM12 M4q2fmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDLUVEzKGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMECzOEDPxE1w MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
DMS114 MlzuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXLJOIF5T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hTE2VMUG0JINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODB|NjFOwG0v NYTJRmo4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
SF539 M3nNV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTSlU{QSClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwN|Yh|ryPLh?= NFvjNYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
U251 MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWjHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDVNlUyKGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMECzPUDPxE1w NHG5UnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
SF295 Mkm5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{PFN2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHNHOjl3IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA1KM7:TT6= MlfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
MCF7 Mm\wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEP1ZoRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOS0Z5IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA1OiEQvF2u MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
NCI-H23 NEe0SpZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOR2kuUDJ|IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA1PiEQvF2u NFX5NZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
OVCAR3 NUDZbpl1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4nwNmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GUMzDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxPDZizszNMi=> NF3sZpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
MKN7 MknKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX7Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNT244KGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMEC0PUDPxE1w NHmzfXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
SF268 M1\5Omdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1\KR2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHNHOjZ6IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA1QSEQvF2u NEX3VoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
MDA-MB-231 MlPHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV3Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODB3NTFOwG0v Ml7KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
OVCAR8 MmL4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlvtS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gU3ZESVJ6IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFA2PSEQvF2u MkLGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
DMS273 NES2NFlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{fhNGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGROWzJ5MzDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxPThizszNMi=> NEf2XWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
DU145 MkLGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDEWVE1PSClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwOkDPxE1w M2q2VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
RXF631L NWDxcVBST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEfQPItIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBTYEZ4M{HMJINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODB4NjFOwG0v NVvhWJdyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
HBC4 NWK0VJl2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkLaS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGJEPCClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwOlkh|ryPLh?= NVzWOHJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
SNB75 NEfDZWlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnWxS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gV25DPzViY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNFczKM7:TT6= MlXlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
BSY1 MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWHmb2pmT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSlO\MTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAxQDVizszNMi=> NWXaW4R2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
NCI-H226 NX3BRoFnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2[4Umdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkK2JINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODB6OTFOwG0v NGixPJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OxN|Y{QCd-MkOzNVM3Ozh:L3G+
SNB78 M{XSXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTUmI4QCClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCwPVYh|ryPLh?= MlLuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
HBC5 M3rVNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4HoXGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhDSzViY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiClb3zvdolu\XS{aXOgcYV1cG:mLDDHTVUxKD1iMD6wNVMh|ryPLh?= M1uyelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
MKN45 NUnx[41FT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{PCbmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1MVjR3IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiY3;sc5JqdWW2cnnjJI1mfGixZDygS2k2OCB;IECuNFE1KM7:TT6= MoXHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
MKN28 NVvYUlh2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NETyZVNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOU05{ODDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHPvcI9zcW2ndILpZ{Bu\XSqb3SsJGdKPTBiPTCwMlAyPyEQvF2u MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
PC3 NYLIfpZqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWPHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDQR|Mh[2WubIOgZpkhe3WuZn;ybI9l[W2rbnWgRkBkd2yxcnnt[ZRzcWNibXX0bI9lNCCJSUWwJF0hOC5yMUig{txONg>? NYiwXlZRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
ACHN M2\DbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmTRS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRWNJViClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkCyJO69VS5? Mom0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO2N|goRjJ|M{GzOlM5RC:jPh?=
OVCAR4 NWLBXXJQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYX2dnF7T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWK0JINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZ49td3KrbXX0dolkKG2ndHjv[EwhT0l3MDC9JFAvODJizszNMi=> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{[zPEc,OjN|MUO2N|g9N2F-
St-4 M1fSb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUfHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTeE01KGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[2:ub4LpcYV1emmlIH3leIhw\CxiR1m1NEA:KDBwMEKyJO69VS5? M1r3fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{GzOlM5Lz5{M{OxN|Y{QDxxYU6=
HCT15 Mk\HS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUPHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIR3QyPSClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGOxbH;ybY1mfHKrYzDt[ZRpd2RuIFfJOVAhRSByLkS1JO69VS5? NV;FPHhQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNVM3OzhpPkKzN|E{PjN6PD;hQi=>
CD4+ T NGPtbnFHfW6ldHnvckBie3OjeR?= NVnwTZVsPyCmYYnz M3y2R3Jm[WO2aY\heIlwdiCxZjDsZZRmdnRiSFnWNUBPVDRvMz3MeYMh\XiycnXzd4lwdiCrbjDoeY1idiCwYXn2[UBETDRtIGSgZ4VtdHNidILlZZRm\CB5IHThfZMheG:|dD3pcoZm[3Srb36gcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IHz1cYlv\XOlZX7j[UBxdGG2ZTDy[YFl\XJiYX7hcJl{cXNuIFXDOVAhRSByLkCwN{DPxE1w NX\uTWE6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0PVUyODVpPkK0OFk2OTB3PD;hQi=>
NCI-H522 MnvkR5l1d3SxeHnjbZR6KGG|c3H5 NInTcnFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEWyNkBk\WyuczDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjByMUig{txONg>? NGC1U|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
LOXIMVI M{fLUWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGX5boREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNV1iLTW\JJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB{NTFOwG0v MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
A549 Ml[2R5l1d3SxeHnjbZR6KGG|c3H5 MnSyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCwNlYh|ryPLh?= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
OVCAR5 NUXHNlNkS3m2b4TvfIlkcXS7IHHzd4F6 M3m3TmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9XS0GUNTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOjhizszNMi=> MkC3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
NCI-H460 M1nEeWN6fG:2b4jpZ4l1gSCjc4PhfS=> NHWybJNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSES2NEBk\WyuczDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjByMzFOwG0v MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
MKN74 NXrYc4FkS3m2b4TvfIlkcXS7IHHzd4F6 M1m1bWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1MVjd2IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA{KM7:TT6= M4\QeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
HCC2998 NILPWJNEgXSxdH;4bYNqfHliYYPzZZk> MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR2MzQTl6IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA{OSEQvF2u M2rle|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
HCT116 NFTzeI1EgXSxdH;4bYNqfHliYYPzZZk> MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFMyKM7:TT6= MlG0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
MKN1 NI\G[FJEgXSxdH;4bYNqfHliYYPzZZk> MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNT24yKGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMECzNkDPxE1w NFXR[pY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
HT-29 MXPDfZRwfG:6aXPpeJkh[XO|YYm= MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCwN|Mh|ryPLh?= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
SKOV3 M1X2[2N6fG:2b4jpZ4l1gSCjc4PhfS=> NUHlNWpGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4xODN|IN88UU4> NHvRO3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
KM12 NEHTOVVEgXSxdH;4bYNqfHliYYPzZZk> MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLUVEzKGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMECzOEDPxE1w MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
SF539 NVvENIplS3m2b4TvfIlkcXS7IHHzd4F6 NHzPb|NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUTjV|OTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOzZizszNMi=> NHK2Xnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
293T MnTGSpVv[3Srb36gZZN{[Xl? NFvhR|I{OCCvaX7z NFjoU25KdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOxJIV5eHKnc4Pl[EBqdiCqdX3hckAzQTOWIHPlcIx{KHW|aX7nJGFkNUuJTFfLLGFkMS2PQ1GgZZMhe3Wkc4TyZZRmKGGodHXyJFMxKG2rboOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwJF0hOC5yMEO2JO69VS5? NXLlOYt{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
DMS114 M3PSZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> M4e4[2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGROWzFzNDDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOzZizszNMi=> NWnFdGRwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
U251 MmLPR5l1d3SxeHnjbZR6KGG|c3H5 NV;yb5JDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTJ3MTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxOzlizszNMi=> NUexS5UxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
SF295 MUXDfZRwfG:6aXPpeJkh[XO|YYm= M3TNOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNHOjl3IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA1KM7:TT6= NGnhcFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
MCF7 MlztR5l1d3SxeHnjbZR6KGG|c3H5 NVO2U3AxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxPDJizszNMi=> M17TXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
OVCAR3 M1:1O2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3H0U2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG9XS0GUMzDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxPDZizszNMi=> Mo\3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
NCI-H23 NWPFeGxFS3m2b4TvfIlkcXS7IHHzd4F6 MlPVR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh{MzDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxPDZizszNMi=> NF;Pe4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
SF268 M{TmPGN6fG:2b4jpZ4l1gSCjc4PhfS=> M{jKXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNHOjZ6IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA1QSEQvF2u MmXRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
MKN7 NFPQWZJEgXSxdH;4bYNqfHliYYPzZZk> NUPlXVg3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUuQNzDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxPDlizszNMi=> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
OVCAR8 MUHDfZRwfG:6aXPpeJkh[XO|YYm= MlfER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3ZESVJ6IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA2PSEQvF2u MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
MDA-MB-231 NH;QNotEgXSxdH;4bYNqfHliYYPzZZk> M2\LWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOC5yMEW1JO69VS5? NHO5UWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
DMS273 NWPjZWRlS3m2b4TvfIlkcXS7IHHzd4F6 NXzC[WY2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTE2VMkezJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODB3ODFOwG0v M3HrXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
DU145 MmPaR5l1d3SxeHnjbZR6KGG|c3H5 NEOyUINEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAxPiEQvF2u Mm[yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
RXF631L MlfzR5l1d3SxeHnjbZR6KGG|c3H5 NX\NVplXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWliINkOxUEBk\WyuczDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjByNk[g{txONg>? NWTD[YpWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
HBC4 MXLDfZRwfG:6aXPpeJkh[XO|YYm= NFTCO4ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJSkN2IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA3QSEQvF2u MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
SNB75 MYrDfZRwfG:6aXPpeJkh[XO|YYm= MmLLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV25DPzViY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNFczKM7:TT6= NYnUeVAzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1PFk1QDZpPkK0OVg6PDh4PD;hQi=>
BSY1 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NHnKcZhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDW1lzIHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA5PSEQvF2u MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
NCI-H226 NHGwUJZEgXSxdH;4bYNqfHliYYPzZZk> NIGzV41EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEKyOkBk\WyuczDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjByOEmg{txONg>? NEizOZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
SNB78 NUjaWYo1S3m2b4TvfIlkcXS7IHHzd4F6 M3PiVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNPSjd6IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFA6PiEQvF2u NIPI[nA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
HBC5 MnjlR5l1d3SxeHnjbZR6KGG|c3H5 MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIRmM2KGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMEGzJO69VS5? M3;QXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
MKN45 M{PxemN6fG:2b4jpZ4l1gSCjc4PhfS=> NX7VRWxrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUuQNEWgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4xOTRizszNMi=> NEjUPHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
MKN28 MnHIR5l1d3SxeHnjbZR6KGG|c3H5 MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNT24zQCClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCxO{DPxE1w MlzlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
PC3 Mmj6R5l1d3SxeHnjbZR6KGG|c3H5 MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOC5yMUig{txONg>? MmXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OEm0PFYoRjJ2NUi5OFg3RC:jPh?=
ACHN NV62bIo{S3m2b4TvfIlkcXS7IHHzd4F6 Ml;wR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRWNJViClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCyJO69VS5? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OUS4Okc,OjR3OEm0PFY9N2F-
OVCAR4 MkHDR5l1d3SxeHnjbZR6KGG|c3H5 NH3jZ3FEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBQXkODUkSgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4xOiEQvF2u M{jr[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
St-4 M3e4XWN6fG:2b4jpZ4l1gSCjc4PhfS=> M2TITWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHN1NTRiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNlIh|ryPLh?= NEDEW5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
293T NFvid2FHfW6ldHnvckBie3OjeR?= NXrwenF{OzBibXnudy=> M2P6bWlvcGmkaYTpc44hd2ZibX;1d4UhUESDQ{[g[ZhxemW|c3XkJIlvKGi3bXHuJFI6O1RiY3XscJMhfXOrbnegRYMuU0eOR1uoRYMqNU2FQTDhd{B{fWK|dILheIUh[W[2ZYKgN|AhdWmwczDifUBndHWxcnXzZ4Vv[2ViYYPzZZktKEmFNUCgQUAxNjN7IN88UU4> M{TX[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi5OFg3Lz5{NEW4PVQ5PjxxYU6=
HCT15 M1\rXWN6fG:2b4jpZ4l1gSCjc4PhfS=> MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyPSClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkS1JO69VS5? NEHCfpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW4PVQ5Pid-MkS1PFk1QDZ:L3G+
mink Mv1Lu MWHGeY5kfGmxbjDhd5NigQ>? M4XBflI1KGi{cx?= Mle5TY5kemWjc3WgbY4hcHWvYX6ge4lt\CC2eYDlJJAzOSCycn;0[YlvKGW6cILld5Nqd25iaX6gcYlvcyCPdkHMeUBk\WyuczDh[pRmeiB{NDDodpMh[nlicEKxJJBzd22xdHXyJIF{e2G7IHnuJJBz\XOnbnPlJI9nKDBwMTDtUUBlcXSqaX;0bJJmcXSxbDygSWMyODByIE2gNE4xOTV5IN88UU4> NUjmZWI5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5PVc2PzhpPkK0PVk4PTd6PD;hQi=>
HCT116 NF3M[oxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnrpOFghcHK| NHXEc2ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC0PEBpenNiaX6gdJJme2WwY3Wgc4YhTFSWIHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODB|IN88UU4> MmHUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzNEe2NVIoRjJ3MUS3OlEzRC:jPh?=
MOLT4 MkTFRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MmrYO|IhcHK| MmXrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPT1zUOEBk\WyuczDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygS2k2OCB;IECuNFAzODZizszNMi=> NF6zVYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOzNVM{PCd-Mk[zN|E{OzR:L3G+
DU145 MYHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MnPOO|IhcHK| MlrCRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGVUG0OUBk\WyuczDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygS2k2OCB;IECuNFAzPTVizszNMi=> MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN|MUOzOEc,OjZ|M{GzN|Q9N2F-
U937 NGf1dGxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MWS3NkBpenN? MnHHRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOUO3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFM1OSEQvF2u NWPsO3BVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zN|E{OzRpPkK2N|MyOzN2PD;hQi=>
HLF NFu0[mdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NEPkbZU4OiCqcoO= MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiORjDj[YxteyCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NEA:KDBwMEC0PFkh|ryPLh?= NFzYWY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOzNVM{PCd-Mk[zN|E{OzR:L3G+
WI38 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NEn4RWk4OiCqcoO= NVj0WoE1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDXTVM5KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG|c3H5MEBIUTVyIE2gNE4xODV|OTFOwG0v MmGzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|M{GzN|QoRjJ4M{OxN|M1RC:jPh?=
U937 MmP0SpVv[3Srb36gZZN{[Xl? NIrEbZYzPCCqcoO= MnG2TY5pcWKrdHnvckBw\iCKRFHDOkBqdiCqdX3hckBWQTN5IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBidHCqYT30eYJqdGmwIHHj[ZR6dGG2aX;uJIF1KDVibl2geI8hPSC3TTDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz Ml3HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|M{GzN|QoRjJ4M{OxN|M1RC:jPh?=
HCT116 NGrRSmtCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYnrO29VPzJiaILz MnLKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliY3;1cJRmeiClb4XueIVzKG2ndHjv[EwhUUN3MDC9JFAvODJ6IN88UU4> NEXQV3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS4NVY2QSd-Mk[0PFE3PTl:L3G+
IGROV1/Pt1 MkK3RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1nmeFczKGi{cx?= NFnJNIVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFnHVm9XOS:SdEGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkh[2:3bITldkBkd3WwdHXyJI1mfGixZDygTWM2OCB;IECuNFgh|ryPLh?= NHO1N2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS4NVY2QSd-Mk[0PFE3PTl:L3G+
IGROV1 MV\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MX23NkBpenN? M2\3VmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSVfSU3YyKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IHPveYx1\XJiY3;1cpRmeiCvZYToc4QtKEmFNUCgQUAxNjJ{IN88UU4> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR6MU[1PUc,OjZ2OEG2OVk9N2F-

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ
Methods Test Index PMID
Western blot
p21 / Cyclin D1; 

PubMed: 19682393     


NIH 3T3 cells stably expressing the indicated proteins were treated with DMSO (Vehicle) or the indicated concentration of romidepsin for 24 h. Cell lysates were analyzed by western blotting with antibodies to cyclin D1, p21 and β-actin (loading control). Data shown are representative of at least two independent experiments.

AcH3(K9) / Ac-α-Tubulin(K40) / Ac-NFκB2(K310) p65 / 3MeH3(K27); 

PubMed: 26473529     


Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot.

HDAC3 / HDAC4 / HDAC6 / HDAC2; 

PubMed: 26473529     


Effects of romidepsin (Rom) on the levels of acetylated proteins and related enzymes. Cells were exposed to romidepsin for 48 h and total cell extracts were analyzed by western blot.

γH2AX / PARP1 / Cleaved caspase3 / BAK / p21(waf1/cip1) / XIAP; 

PubMed: 26473529     


Western blot analysis of proteins involved in DNA-damage response and apoptosis. Established cell lines were exposed to different concentrations of romidepsin (Rom) for 48 h and total cell extracts were analyzed.

Cyclin E1 / BRCA1 / E2F1 / Cleaved PARP / H3Ac; 

PubMed: 27444036     


Western blot analysis of the effects of panobinostat (25 nM), vorinostat (5 µM) and romidepsin (10 nM) on expression of cyclin E1, E2F1, BRCA1, cleaved PARP and acetylated histone H3 in OVCAR-3 cells. Actin and histone H3 were loading controls. 

pAKT(S473) / pAKT(T308) / AKT; 

PubMed: 25492515     


Western blot analysis of phosphorylated AKT in PC3 cells. Cells were treated for 3 h with various concentrations of FK228. 

19682393 26473529 27444036 25492515
Growth inhibition assay
Cell viability; 

PubMed: 27444036     


Concentration-dependent effects of panobinostat and vorinostat in SRB viability assays in OVCAR-3 cells (72 h). Values are mean+SE of 3 independent experiments. 

27444036
Immunofluorescence
SS18/TLE1; 

PubMed: 27120803     


A significant decrease in detectable PLA signal following HDAC inhibition in SYO-1 cells.

Cleaved caspase-3; 

PubMed: 22531354     


TDP-B activates cleaved caspase-3 by immunofluorescence. Representative immunofluorescence staining for cleaved caspase 3 (green) in SKOV-3 ovarian cancer cells treated with 10 nM FK228, TDP-A or TDP-B after 24 h of exposure. The nuclei are stained with DAPI (blue).

27120803 22531354
体内試験 Romidepsin treatment potently inhibits the neovascularization of chick embryo and that of adult mice in the Matrigel plug assay. [4]Administration of Romidepsin at 0.1-1 mg/kg twice a week significantly prolongs the survival of mice bearing U-937 lymphoma, with median survival times of 30.5 (0.56 mg/kg) and 33 days (0.32 mg/kg), respectively (vs. 20 days in control mice). [5]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

- 合併

HDAC-inhibitory activity:

For the enzyme assay, 10 μL of [3H]acetyl-labeled histones (25,000 cpm/10 μg) are added to 90 μL of the HDAC enzyme fraction extracted from 293T cells overexpressing HDAC1 or HDAC2 in the presence of increasing concentrations of Romidepsin, and the mixture is incubated at 37 °C for 15 minutes. The enzyme reaction is linear for at least 1 hour. The reaction is stopped by the addition of 10 μL of concentrated HCl. The released [3H]acetic acid is extracted with 1 mL of ethylacetate, and 0.9 mL of the solvent layer is taken into 5 mL of aqueous counting scintillant II solution for determination of radioactivity. The IC50 values are determined from at least three independent dose-response curves.
細胞試験:

[3]

- 合併
  • 細胞株: HL60, Jurkat, A549, and MCF-7
  • 濃度: Dissolved in DMSO, final concentrations ~10 μM
  • 反応時間: 72 hours
  • 実験の流れ:

    Cells are exposed to various concentrations of Romidepsin for 72 hours in 96-well plates. 20 μL of 5 mg/mL MTT solution in PBS is added to each well for 4 hours. After removal of the medium, 170 μL of DMSO is added to each well to dissolve the formazan crystals. The absorbance at 540 nm is determined. In addition, cells are incubated with trypan blue, and the numbers of blue (dead) cells and transparent (live) cells are counted in a hemocytometer. For cell cycle analysis, cells are incubated for 30 minutes in propidium iodide staining solution containing 0.05 mg/mL propidium iodide, 1 mM EDTA, 0.1% Triton X-100, and 1 mg/mL RNase A in PBS. The suspension is then passed through a nylon mesh filter and analyzed on a Becton Dickinson FACScan.


    (参考用のみ)
動物試験:

[5]

- 合併
  • 動物モデル: Male scid mice inoculated i.p. with U-937 cells
  • 投薬量: ~1 mg/kg once or twice a week
  • 投与方法: Treated i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 10 mg/mL (18.49 mM)
Water Insoluble
Ethanol Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5%Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
5mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 540.7
化学式

C24H36N4O6S2

CAS No. 128517-07-7
Storage powder
in solvent
別名 FR 901228, NSC 630176
Smiles CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)
% DMSO % % Tween 80 % ddH2O
計算リセット

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03770000 Active not recruiting Drug: Tenalisib|Drug: Romidepsin T Cell Lymphoma Rhizen Pharmaceuticals SA March 12 2019 Phase 1|Phase 2
NCT02616965 Recruiting Drug: Romidepsin|Drug: Brentuximab vedotin Cutaneous T-cell Lymphoma (CTCL) Fox Chase Cancer Center|Seagen Inc.|Celgene Corporation February 22 2017 Phase 1
NCT02616874 Completed Drug: MVA.HIVconsv vaccine|Drug: Romidepsin HIV IrsiCaixa|Germans Trias i Pujol Hospital|Fundación FLS de Lucha Contra el Sida las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia|Hospital Clinic of Barcelona|Hospital de Sant Pau|HIVACAT|University of Oxford|BCN Checkpoint February 2016 Phase 1
NCT03141203 Active not recruiting Drug: Romidepsin|Drug: Carfilzomib Peripheral T Cell Lymphoma University of Birmingham|Bloodwise|Celgene|Amgen July 13 2015 Phase 1|Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

HDACシグナル伝達経路

HDAC Inhibitors with Unique Features

相関HDAC製品

Tags: Romidepsin (FK228, Depsipeptide)を買う | Romidepsin (FK228, Depsipeptide) ic50 | Romidepsin (FK228, Depsipeptide)供給者 | Romidepsin (FK228, Depsipeptide)を購入する | Romidepsin (FK228, Depsipeptide)費用 | Romidepsin (FK228, Depsipeptide)生産者 | オーダーRomidepsin (FK228, Depsipeptide) | Romidepsin (FK228, Depsipeptide)化学構造 | Romidepsin (FK228, Depsipeptide)分子量 | Romidepsin (FK228, Depsipeptide)代理店
×
細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID